• 한국수의병리학회지
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• 제1권2호
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• pp.135-138
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• 1997

A pulmonary keratinizing cyst was found incidentally in a 30-week-old female Sprague-Dawley rat. The cyst was lobe of the lung, lined by stratified squamous epithelium and filled with concentric layers of desquamated keratin. The wall consisted of 2-4 layers of well differenciated squamous cells. The adjacent lung tissues were slightly compressed but not otherwise damaged by the cyst. There was no inflammatory reaction or mitotic figures observed in the cyst.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권3호
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• pp.191-198
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• 2007

The p53 which is well known as tumor suppressor gene is located at 17p13. p53 is a sequence-specific DNA binding transcription factor that responds to certain cytotoxic stresses, such as DNA damage, by enhancing the transcription of genes that regulate cell-cycle progression as well as programmed cell death. The p63 gene that is located at 3q27-29, is recognized members of the p53 family, and responsible for the transcription of 6 isoforms. Three isoforms ($TAp63{\alpha}$, $TAp63{\beta}$, $TAp63{\gamma}$) contain an N-terminal transactivation (TA) domain and can induce apoptosis. The other 3 isoforms (${\Delta}Np63{\alpha}$, ${\Delta}Np63{\beta}$, ${\Delta}Np63{\gamma}$) lack the TA domain and may function in a dominant-negative fashion by inhibiting the transactivation functions of p53 and TAp63 proteins, and thus act as oncoproteins. A number of studies have investigated the role of p63 in human squamous cell carcinomas from different organs. Only a few studies have examined ${\Delta}Np63$ isoform in oral squamous cell carcinoma including normal epithelium. This study aimed to evaluate expression of ${\Delta}Np63$ isoform in human oral squamous cell carcinoma tissue and normal mucosa. The 3 cases of well differenciated oral squamous cell carcinoma specimen including adjacent normal mucosa were examined, and immunohistochemical study with monoclonal antibody(4A4) and tumor cell apoptosis analysis with Transmission Electon Microscopy were studied. And, RT-PCR analysis was done for expression of ${\Delta}Np63$ isoform. The results were as followed. 1. Normal gingiva showed the restricted p63 expression in basal cell layer. 2. Well differentiated squamous cell carcinoma showed mainly p63 expression in overall area of malignancy, especially in basal cell layer to adjacent stromal tissue. 3. Tumor cells around keratinized area with no p63 expression disclosed less micro-organelle in decreased size cytoplasm and severe chromatin margination with nuclear destruction that means apoptosis. 4. Comparison of mRNA expression of ${\Delta}Np63$ isoform by RT-PCR showed variable expression of ${\Delta}Np63$ isoform, but ${\Delta}Np63{\alpha}$ was most highly expressed in all 3 tumor specimen. From theses results, it should be suggested that ${\Delta}Np63$ isoform expression in well differentiated squamous cell carcinoma was closely related to tumor oncogenesis, expecially overexpression of ${\Delta}Np63{\alpha}$ is a most important factor in tumor genesis of oral squamous cell carcinoma.

• 대한기관식도과학회지
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• 제2권2호
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• pp.248-252
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• 1996

Pulmonary blastoma is rare malignant neoplasm usually situated peripherally in lung and composed of epithelial and mesenchymal components that resemble the lung at about 3 months gestation. Fortysix year-old man had no symptoms and signs, but solitary pulmonary nodule was found accidentally in a routine simple chest X-ray occupying right upper lung field. Preoperative chest CT-guided aspiration cytology revealed adenocarcinoma. We had done right upper lobectomy with Iymph node dissecton therapeutically. Final postoperative pathology reported this tumor as double pulmonary blastomas(well differentiated fetal adenocarcinoma). We report a case of pulmonary blastoma with review of literature.

• 한국유통학회지:유통연구
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• 제4권2호
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• pp.59-74
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• 1999

Private brands play an important role in formulating the marketing strategies of fashion goods. Merchandisers of Korean department stores are now realizing that the effective marketing of private brands can increase customers store loyalty as well as store profitability. Thus, it is important to better understand customer's decision making processes underlying the purchase of private brand apparels. However, Little research had been undertaken to examine integrated factors influencing purchases of private brand apparel. Therefore, the objective of this study is to propose a model of purchasing intentions of private brand apparel. This study pays attention to (1) perceived value, (2) familarity, (3) store image, (4) differenciated needs, (5) perceived risk, and (6) perceived quality variation of private brand. The proposed model supports all hypotheses presented in the paper. Purchase intentions of private brand increased as perceived money, familiarity, positive store image of private brands, and satisfaction of individuals differentiated needs increase. Furthermore, perceive value of private brand increased as perceived risk and quality variation of private brand increased.

• 보건교육건강증진학회지
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• 제20권3호
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• pp.91-108
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• 2003

Psychological stress is a growing issue in work stress research because work stressors are closely related to depression； and depression, in turn, decreases organizational effectiveness. Considering such causal relationships of work stress, a comprehensive source to control work stress is needed for worksite mental well-being. This study was conducted to identify how social support at work controlled work stress and which characteristics of social support were effective on work stress reduction. The study participants were 240 workers employed in a public hospital in Georgia, U.S.A self-administered survey was given to employees with their pay slips, and followed by a hospital wide voice reminder for 7 days. Surveys were conducted over a 20-day period. The questionnaires asked about job demands, job control, social support at work, depression, job performance, absenteeism, and demographics. The social support construct was structured on the source of support at work and the kinds of support were provided. Statistical analyses were conducted in the structural equation modeling approach. Social support at work was directly related to high job control, low depression, and high job performance. High score of social support at work were significantly associated with high job control, low depressive symptoms, and high job performance. By source of support, only organizational support was positively related to high job control. Organizational support was more effective than supervisor and coworker support. Any stressors and their outcomes were not differenciated by the kinds of support. This result indicated that job control was influenced more by the source of support than the kinds of support provided at work； and the most efficient source of support was the organization. Organizational support was a strong factor in improving workers" perceived controllability of their jobs from a work stress reduction perspective.tive.

• 한국통신학회논문지
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• 제28권4B호
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• pp.298-305
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• 2003

본 논문에서는 ATM 기반 레이블 에지 라우터의 IP 패킷 포워딩 엔진을 위한 고성능 룩업 제어기를 제안하였다. 제안한 룩업 제어기는 IP 패킷에 대한 Best Effort 서비스 뿐만 아니라 MPLS(Multiprotocol Label Switching), VPN(Virtual Private Network), ELL(Emulated Leased Line), RT(Real Time) 서비스 등의 차별화된 서비스들을 제공할 수 있도록 설계하였다. 고속의 IP 주소 검색을 위하여 소프트웨어 기반의 알고리즘 방식을 사용하지 않고 TCAM(Ternary Content Addressable Memory) 기반의 하드웨어 방식을 적용하였으며, IP 패킷 헤더 처리 및 룩업 제어 기능을 고속으로 수행하기 위하여 룩업 제어 기능을 FPGA(Field Programmable Gate Array)로 구현하였다. 룩업 제어기는 사용자의 차별화된 다양한 요구를 수용할 수 있으며, 성능 향상을 위하여 파이프라인 기법으로 처리되도록 설계하였다. 또한 패킷 헤더의 여러 영역을 조합한 비교키에 대한 룩업 기능을 수행하기 위하여 2단계 검색 메카니즘을 가지며, 시뮬레이션을 통하여 제안한 룩업 제어기는 약 16Mpps의 성능을 보였다.