• Title/Summary/Keyword: Well differenciated

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Histopathological Observation of Spontaneous Pulmonary Keratinizing Cyst in Sprague-Dawley Rat (Sprague-Dawley 랫트에 자연발생한 Pulmonary Keratinizing Cyst의 병리조직학적 관찰)

  • 손화영
    • Korean Journal of Veterinary Pathology
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    • v.1 no.2
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    • pp.135-138
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    • 1997
  • A pulmonary keratinizing cyst was found incidentally in a 30-week-old female Sprague-Dawley rat. The cyst was lobe of the lung, lined by stratified squamous epithelium and filled with concentric layers of desquamated keratin. The wall consisted of 2-4 layers of well differenciated squamous cells. The adjacent lung tissues were slightly compressed but not otherwise damaged by the cyst. There was no inflammatory reaction or mitotic figures observed in the cyst.

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EXPRESSION OF DOMINANT NEGATIVE p63 ISOFORM IN WELL-DIFFERENCIATED ORAL SQUAMOUS CELL CARCINOMA (분화도 좋은 구강 편평상피세포암종에서 Dominant Negative p63 isoform의 발현)

  • Kim, In-Su;Kim, Chul-Hwan;Kim, Kyung-Wook
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.33 no.3
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    • pp.191-198
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    • 2007
  • The p53 which is well known as tumor suppressor gene is located at 17p13. p53 is a sequence-specific DNA binding transcription factor that responds to certain cytotoxic stresses, such as DNA damage, by enhancing the transcription of genes that regulate cell-cycle progression as well as programmed cell death. The p63 gene that is located at 3q27-29, is recognized members of the p53 family, and responsible for the transcription of 6 isoforms. Three isoforms ($TAp63{\alpha}$, $TAp63{\beta}$, $TAp63{\gamma}$) contain an N-terminal transactivation (TA) domain and can induce apoptosis. The other 3 isoforms (${\Delta}Np63{\alpha}$, ${\Delta}Np63{\beta}$, ${\Delta}Np63{\gamma}$) lack the TA domain and may function in a dominant-negative fashion by inhibiting the transactivation functions of p53 and TAp63 proteins, and thus act as oncoproteins. A number of studies have investigated the role of p63 in human squamous cell carcinomas from different organs. Only a few studies have examined ${\Delta}Np63$ isoform in oral squamous cell carcinoma including normal epithelium. This study aimed to evaluate expression of ${\Delta}Np63$ isoform in human oral squamous cell carcinoma tissue and normal mucosa. The 3 cases of well differenciated oral squamous cell carcinoma specimen including adjacent normal mucosa were examined, and immunohistochemical study with monoclonal antibody(4A4) and tumor cell apoptosis analysis with Transmission Electon Microscopy were studied. And, RT-PCR analysis was done for expression of ${\Delta}Np63$ isoform. The results were as followed. 1. Normal gingiva showed the restricted p63 expression in basal cell layer. 2. Well differentiated squamous cell carcinoma showed mainly p63 expression in overall area of malignancy, especially in basal cell layer to adjacent stromal tissue. 3. Tumor cells around keratinized area with no p63 expression disclosed less micro-organelle in decreased size cytoplasm and severe chromatin margination with nuclear destruction that means apoptosis. 4. Comparison of mRNA expression of ${\Delta}Np63$ isoform by RT-PCR showed variable expression of ${\Delta}Np63$ isoform, but ${\Delta}Np63{\alpha}$ was most highly expressed in all 3 tumor specimen. From theses results, it should be suggested that ${\Delta}Np63$ isoform expression in well differentiated squamous cell carcinoma was closely related to tumor oncogenesis, expecially overexpression of ${\Delta}Np63{\alpha}$ is a most important factor in tumor genesis of oral squamous cell carcinoma.

DOUBLE PULMONARY BLASTOMAS - A CASE REPORT - (다발성폐아세포종 -수술치험 1례 -)

  • 김태식;조원민;류영진;김욱진;최영호;김학제;이주한;김한겸
    • Korean Journal of Bronchoesophagology
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    • v.2 no.2
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    • pp.248-252
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    • 1996
  • Pulmonary blastoma is rare malignant neoplasm usually situated peripherally in lung and composed of epithelial and mesenchymal components that resemble the lung at about 3 months gestation. Fortysix year-old man had no symptoms and signs, but solitary pulmonary nodule was found accidentally in a routine simple chest X-ray occupying right upper lung field. Preoperative chest CT-guided aspiration cytology revealed adenocarcinoma. We had done right upper lobectomy with Iymph node dissecton therapeutically. Final postoperative pathology reported this tumor as double pulmonary blastomas(well differentiated fetal adenocarcinoma). We report a case of pulmonary blastoma with review of literature.

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Influential Factors on Customers Purchasing Intentions of Private Brand Apparel (유통업자상표 의류 구매의도에 미치는 영향요인에 관한 연구)

  • 박진용;권순기;오세조
    • Journal of Distribution Research
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    • v.4 no.2
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    • pp.59-74
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    • 1999
  • Private brands play an important role in formulating the marketing strategies of fashion goods. Merchandisers of Korean department stores are now realizing that the effective marketing of private brands can increase customers store loyalty as well as store profitability. Thus, it is important to better understand customer's decision making processes underlying the purchase of private brand apparels. However, Little research had been undertaken to examine integrated factors influencing purchases of private brand apparel. Therefore, the objective of this study is to propose a model of purchasing intentions of private brand apparel. This study pays attention to (1) perceived value, (2) familarity, (3) store image, (4) differenciated needs, (5) perceived risk, and (6) perceived quality variation of private brand. The proposed model supports all hypotheses presented in the paper. Purchase intentions of private brand increased as perceived money, familiarity, positive store image of private brands, and satisfaction of individuals differentiated needs increase. Furthermore, perceive value of private brand increased as perceived risk and quality variation of private brand increased.

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Characteristics of Social Support at Work Affecting Work Stress (근로자의 스트레스에 영향을 미치는 사회적 지지도 특성에 관한 연구)

  • 박경옥
    • Korean Journal of Health Education and Promotion
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    • v.20 no.3
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    • pp.91-108
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    • 2003
  • Psychological stress is a growing issue in work stress research because work stressors are closely related to depression; and depression, in turn, decreases organizational effectiveness. Considering such causal relationships of work stress, a comprehensive source to control work stress is needed for worksite mental well-being. This study was conducted to identify how social support at work controlled work stress and which characteristics of social support were effective on work stress reduction. The study participants were 240 workers employed in a public hospital in Georgia, U.S.A self-administered survey was given to employees with their pay slips, and followed by a hospital wide voice reminder for 7 days. Surveys were conducted over a 20-day period. The questionnaires asked about job demands, job control, social support at work, depression, job performance, absenteeism, and demographics. The social support construct was structured on the source of support at work and the kinds of support were provided. Statistical analyses were conducted in the structural equation modeling approach. Social support at work was directly related to high job control, low depression, and high job performance. High score of social support at work were significantly associated with high job control, low depressive symptoms, and high job performance. By source of support, only organizational support was positively related to high job control. Organizational support was more effective than supervisor and coworker support. Any stressors and their outcomes were not differenciated by the kinds of support. This result indicated that job control was influenced more by the source of support than the kinds of support provided at work; and the most efficient source of support was the organization. Organizational support was a strong factor in improving workers" perceived controllability of their jobs from a work stress reduction perspective.tive.

A High PErformance Lookup Controller for ATM based IP Packet Forwarding Engine (ATM 기반 IP 패킷 포워딩 엔진을 위한 고성능 룩업 제어기)

  • Choi, Byeong-Cheol;Kwak, Dong-Yong;Lee, Jeong-Tae
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.28 no.4B
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    • pp.298-305
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    • 2003
  • In this paper, we proposed a high performance lookup controller for IP packet forwarding engine of ATM based label edge routers. The lookup controller is designed to provide services such as MPLS, VPN, ELL, and RT services as well as the best effort. For high speed searching for IP addresses, we employed a TCAM based hardware search device not using traditional algorithmic approaches. We also implement lookup control functions into FPGA for fast processing of packet header and lookup control. The proposed lookup controller is designed to support differenciated services for users and to process in pipelined mechanism for performance improvement. A two-step search scheme is also applied to perform lookup for the key combined with multi-field of packet header. We found that the proposed lookup controller provides the performance of about 16M packets per second through simulations.