• Biomolecules & Therapeutics
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• v.26 no.4
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• pp.417-423
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• 2018

Extracellular interleukin 1 alpha (IL-$1{\alpha}$) released from keratinocytes is one of the endpoints for in vitro assessments of skin irritancy. Although cells dying via primary skin irritation undergo apoptosis as well as necrosis, IL-$1{\alpha}$ is not released in apoptotic cells. On the other hand, active secretion has been identified in interleukin-1 receptor antagonist (IL-1ra), which was discovered to be a common, upregulated, differentially-expressed gene in a microarray analysis performed with keratinocytes treated using cytotoxic doses of chemicals. This study examined whether and how IL-1ra, particularly extracellularly released IL-1ra, was involved in chemically-induced keratinocyte cytotoxicity and skin irritation. Primary cultured normal adult skin keratinocytes were treated with cytotoxic doses of chemicals (hydroquinone, retinoic acid, sodium lauryl sulfate, or urshiol) with or without recombinant IL-1ra treatment. Mouse skin was administered irritant concentrations of hydroquinone or retinoic acid. IL-1ra (mRNA and/or intracellular/extracellularly released protein) levels increased in the chemically treated cultured keratinocytes with IL-$1{\alpha}$ and IL-$1{\beta}$ mRNAs and in the chemically exposed epidermis of the mouse skin. Recombinant IL-1ra treatment significantly reduced the chemically-induced apoptotic death and intracellular/extracellularly released IL-$1{\alpha}$ and IL-$1{\beta}$ in keratinocytes. Collectively, extracellular IL-1ra released from keratinocytes could be a compensatory mechanism to reduce the chemically-induced keratinocyte apoptosis by antagonism to IL-$1{\alpha}$ and IL-$1{\beta}$, suggesting potential applications to predict skin irritation.

• Fashion & Textile Research Journal
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• v.9 no.2
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• pp.145-150
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• 2007

Recently, active movements are occurring to reestablish our own traditional Korean images in all levels of society. One of them is about Ordinary Hanbok. Academics and business sectors are endeavoring to develop comfortable and Korean traditional Hanbok designs and popularize them as well. Based on the facts, the study focuses on developing Ordinary Hanbok designs for women by applying Korean traditional patchwork in order to present handmade, humane senses. First of all, the backgrounds, history and preference of Ordinary Hanbok are discussed through literatures and precedent studies as study methodology. Then, the study is analyzing the formative beauty of Korean traditional patchwork that contains emotions of women in the Chosun Dynasty. After that, it shows Ordinary Hanbok designs developed for women by using checks, free style, and yeoiju patterns of the fabrics dyed with clay and Chinese ink that recently attract people in particular. The results are like followings; First, the limits that excessive transformation of Hanbok may cause the lack of traditional beauty can be covered through using a variety of images of Korean traditional patchwork. Second, diverse face configuration of patchworks has very unique geometric forms so to be easily applied to modern Ordinary Hanbok designs. Third, the sewing technique of patchworks also plays a role as a design factor as important as face configuration. Fourth, utilizing fabric pieces may result in various unplanned face configuration and help resource recycling. Fifth, it is possible to coordinate Hanbok with other ordinary clothes that people normally wear on. Sixth, using patchworks images can encourage developing more active and refined designs added with traditional beauty. Seventh, natural dying and fabrics are eco-friendly, which is good for human health and environment. Finally, more studies should be done on design development based on precedent studies about Ordinary Hanbok. Also, it is important to foster social atmosphere and circumstances where people accept wearing Ordinary Hanbok as our natural culture.

• The Plant Pathology Journal
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• v.25 no.2
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• pp.121-127
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• 2009

Since July 2005, survey of chestnut ink disease was carried out in chestnut stands located at southern parts of Korea. Dead chestnut trees showing inky ooze on necrotic trunks were found in two different locations. In order to isolate and identify the causal fungus, infected tissues and soil samples around dead or dying trees were collected and placed on Phytophthora-selective medium. Rhododendron and chestnut tree leaves were used as a bait to isolate the fungus from soil samples by attracting zoospores in soil suspensions. On V-8 culture medium, the isolates produced homothallic oogonia with protuberances ($34.0-46.2{\times}21.9-26.7{\mu}m$) abundantly, but did not produced sporangia. Mass production of sporangia was possible by immersing agar plugs with actively growing mycelium in the creek water at $18^{\circ}C$ for 3 days. Sporangia were papillate, and ovoid to obpyriform ($17.0-38.9{\times}14.6-29.2{\mu}m$) in shape. Comparison of the ITS sequences revealed that the isolates had 100% identity to the P. katsurae isolates from Japan and New Zealand and 99.6% identity to other P. katsurae isolates. All of the examined isolates from Korea were completely identical to each other in ITS sequence. Numerous sporangia were formed in filtered as well as unfiltered creek water, but no sporangia formed in sterilized distilled water. Light induced sporangia formation, but has no influence on oospore formation. Amendments of ${\beta}$-sitosterol in culture media have no significant effect on mycelial growth but significantly stimulate oospore and sporangia formation.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6331-6334
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• 2015

Background: The main purpose of this study was to survey the education and training of certified gynecologic oncologists and fellows in Thailand. A secondary objective was to study the problems in fellowship training regarding palliative care for gynecologic cancer patients. Materials and Methods: A descriptive study was conducted by sending a questionnaire regarding palliative care education to all certified gynecologic oncologists and gynecologic oncology fellows in Thailand. The contents of the survey included fellowship training experience, caring for the dying, patient preparation, attitudes and respondent characteristics. Statistics were analyzed by percentage, mean and standard deviation and chi-square. Results: One hundred seventy completed questionnaires were returned; the response rate was 66%. Most certified gynecologic oncologists and fellows in gynecologic oncology have a positive attitude towards palliative care education, and agree that "psychological distress can result in severe physical suffering". It was found that the curriculum of gynecologic oncology fellowship training equally emphasizes three aspects, namely managing post-operative complications, managing a patient at the end of life and managing a patient with gynecologic oncology. As for experiential training during the fellowship of gynecologic oncology, education regarding breaking bad news, discussion about goals of care and procedures for symptoms control were mostly on-the-job training without explicit teaching. In addition, only 42.9 % of respondents were explicitly taught the coping skill for managing their own stress when caring for palliative patients during fellowship training. Most of respondents rated their clinical competency for palliative care in the "moderately well prepared" level, and the lowest score of the competency was the issue of spiritual care. Conclusions: Almost all certified gynecologic oncologists and fellows in gynecologic oncology have a positive attitude towards learning and teaching in palliative care. In this study, some issues were identified for improving palliative care education such as proper training under the supervision of a mentor, teaching how to deal with work stress, competency in spiritual care and attitudes on responsibility for bereavement care.

• Journal of Hospice and Palliative Care
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• v.16 no.1
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• pp.33-41
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• 2013

Purpose: This study was conducted to examine how nurses' death anxiety and terminal care stress affect their terminal care performance in the clinical setting. Methods: The study enrolled 180 registered nurses with experience of attending dying patients at a university hospital located in Seoul, Korea. Collected data were analyzed with descriptive statistics, one-way ANOVA and Pearson's correlation using SPSS 18.0 for Windows. Results: Nurses showed significant differences in the level of death anxiety and terminal care stress as well as terminal care performance by working division, marital status, educational background and hospice training. A significant relationship was found between terminal care stress and terminal care performance. Conclusion: The study results showed that efforts to ease nurses' death anxiety and terminal care stress could improve their terminal care performance. Further study should be conducted to investigate other factors that affect nurses' terminal care performance from various perspectives and develop a terminal care manual which can be used as guidance for nurses in charge of terminal patient care.

• Journal of the Korea Fashion and Costume Design Association
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• v.14 no.4
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• pp.151-162
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• 2012

Regarding experimental study on the dyeing properties of natural dye, I have dyed silk fabric with Styphnolobium japonicum, sappan wood, and indigo. The results of the experiment have been analysed by wavelength of maximum absorption, K/S and CIE Lab chromaticity co-ordinated. The results are as follows: In case of complex dyeing using Styphnolobium japonicum and sappan wood, dyeing with sappan wood, which is red related color, after dyeing with Styphnolobium japonicum, which is yellow related color, is more efficient. When dyeing was maden by complex of Styphnolobium japonicum and sappan wood, Dyeing method by the order of "Styphnolobium japonicum${\rightarrow}$sappan wood${\rightarrow}$mordanting" made the best result of complex dyeing. In case of complex dyeing using Styphnolobium japonicum and Indigo, dyeing with Styphnolobium japonicum after the indigo made the best result. When dyeing with indigo first, and then Styphnolobium japonicum, yellow color was not well dyed, and low level of saturation caused lusterless color. Ordering of Styphnolobium japonicum${\rightarrow}$sappan wood${\rightarrow}$indigo made the best result of complex dyeing in case of complex dying with Styphnolobium japonicum and indigo. Dyeing order, sappan wood first and then indigo last method shown 560~640 nm wavelength of maximum absorption which most color was blue related. In contrast, Indigo first and then sappan wood method shown 460~560nm wavelength of maximum absorption which color was red related. Complex dyeing with sappan wood and indigo was showing lusterless color. In case of dyeing with red and blue, dyeing with sappan wood and indigo was not appropriate.

• Research in Community and Public Health Nursing
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• v.29 no.2
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• pp.244-256
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• 2018

Purpose: This study tried to understand discourses of life-sustaining treatments in general daily and healthcare newspapers. Methods: A text-network analysis was conducted using the NetMiner program. Firstly, 572 articles from 11 daily newspapers and 258 articles from 8 healthcare newspapers were collected, which were published from August 2013 to October 2016. Secondly, keywords (semantic morphemes) were extracted from the articles and rearranged by removing stop-words, refining similar words, excluding non-relevant words, and defining meaningful phrases. Finally, co-occurrence matrices of the keywords with a frequency of 30 times or higher were developed and statistical measures-indices of degree and betweenness centrality, ego-networks, and clustering-were obtained. Results: In the general daily and healthcare newspapers, the top eight core keywords were common: "patients," "death," "LST (life-sustaining treatments)," "hospice palliative care," "hospitals," "family," "opinion," and "withdrawal." There were also common subtopics shared by the general daily and healthcare newspapers: withdrawal of LST, hospice palliative care, National Bioethics Review Committee, and self-determination and proxy decision of patients and family. Additionally, the general daily newspapers included diverse social interest or events like well-dying, euthanasia, and the death of farmer Baek Nam-ki, whereas the healthcare newspapers discussed problems of the relevant laws, and insufficient infrastructure and low reimbursement for hospice-palliative care. Conclusion: The discourse that withdrawal of futile LST should be allowed according to the patient's will was consistent in the newspapers. Given that newspaper articles influence knowledge and attitudes of the public, RNs are recommended to participate actively in public communication on LST.

• Journal of the Korea Fashion and Costume Design Association
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• v.16 no.4
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• pp.205-215
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• 2014

This study analyzed 'The representation of death' as expressed in the fashion photography posted on Facebook. Currently, there is a growing interest in 'Well-dying'. Also contemporary art and fashion is a trend that expressed what about death more than life. And today, Facebook is one of the current worldwide as a powerful communication. Death representation in contemporary fashion photography, as expressed in its first characteristic is 'Vanitas', and the main material was a skull. The shape of a skeleton of the symbol of death. Vanitas of inner meaning is vain, a mortal life's futility and death for the paradoxical emotion. The second characteristic is 'Phantom of the ruins'. This is like the darkness of death, and the shape represented in that space. And the death representation is depressed, gloomy atmosphere, dead-man and warm-less. Inner meaning is curiosity about the ghosts and the decadence romantic about the afterlife. The last characteristic is 'Grotesque'. This characteristic is the destruction of the body, fear of sadistic, and inhuman shape. This is parable with death that pain and fear of death, dark fantasy, the appearance of a contradiction modern society and cut off humanity. Inner meaning is the dark fear of death and the anger of wrong of the present society. At present, we have to reproduce the death, and what we want is eventually no one can escape 'Attention to death'. In addition, by expressing the solidarity between death and life is to want to get a consolation for the anxiety and afraid reality.

• The Journal of the Convergence on Culture Technology
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• v.5 no.4
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• pp.243-249
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• 2019

The purpose of this study is to investigate the factors affecting the respect for life of nursing students and to prepare the basic data for developing educational programs to establish proper awareness of the life of nursing students and nurturing it. This is a descriptive research study. A total of 146 nursing students were included in this study. Data analysis was performed using t-test, ANOVA, Pearson correlation coefficients, and multiple regression. The results of this study confirmed the meaning of life, spiritual wellbeing, and attitude toward death as factors influencing respect and will for life. The explanatory power of these three factors was 26.3%. Therefore, nursing students will be able to cultivate respect for life by increasing their understanding of the meaning of life, improving their level of spiritual well-being, and reducing their negative attitudes about death. Also, in order to improve the respect for life of nursing students, it will be possible to develop an intervention program to improve life respect including the factors identified in this study. Ultimately, it is expected to grow into a nurse who can provide real help to patients who are at the end of life or who are dying.

• Journal of Korean Academy of Nursing
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• v.49 no.4
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• pp.423-436
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• 2019

Purpose: The aim of the study was to explore nurses' experience of person-centered relational care in the context of critical care. Methods: Key interview questions were developed based on the human-to-human relationship model suggested by Travelbee. Data were collected through indepth interviews with a purposive sample of 11 nurses having more than 2 years of working experience in intensive care units. An interpretative phenomenological analysis was conducted to analyze the data. Results: Four super-ordinate and nine sub-ordinate themes were identified. Emerged super-ordinate themes were as follows: (1) encountering a live person via patient monitoring systems; (2) deep empathic connection; (3) humanistic and compassionate care, and (4) accompanying the journey to the end. Study findings revealed that nurses in intensive care units experienced 'balancing emotions' and 'authenticity' in caring when entering human-to-human relationships with dying patients. The phenomenon of person-centered relational care in intensive care units was found to subsume intrinsic attributes of empathy, compassion, and trust, similar to the central concepts of Travelbee's theory. Conclusion: The interpretative findings in this study provide deeper understanding of Travelbee's human-to-human relationship model. The technological environment in intensive care units did not hinder experienced nurses from forming human-to-human relationships. These themes need to be emphasized in critical care nursing education as well as in nursing management. The results of this study will contribute to understanding nurse-patient caring relationships in depth, and help improve the quality of nursing care in intensive care units.