• Korean Journal of Childcare and Education
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• v.9 no.2
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• pp.117-141
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• 2013

The purpose of this study is to investigate the young children's 'more means more' bias and knowledge change process regarding a lever phenomenon, especially the relationship between the weight of an object and the strength of force and between the length of a lever and the strength of force. Subjects, who were presented with the tasks, were eight young children 5 years of age. Major findings were as followings. First, most of the subjects have a 'more means more' bias about the relationship between the weight of an object and the strength of force and between the length of a lever and the strength of force regarding a lever phenomenon. This meant that young children have similar concepts about a lever phenomenon regardless of whether it is right or wrong physically. Second, young children tried to make sure of their knowledge during experiments. They chose the evidence which confirmed their knowledge. But they tried to change their knowledge, when the evidence presented did not correspond to their knowledge. These findings contribute to understanding young children's 'more means more' bias and knowledge change process about a lever phenomenon and can be used in preschool science education programs and curriculums.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.4
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• pp.762-768
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• 2004

Chromium has been known to be involved in the glucose metabolism, and hence the utilization of cellular glucose is impaired in the chromium deficiency. Chromium has been recognized as an essential nutrient since the finding of low-molecular-weight Cr-binding substance (LMWCr) as a biological modifier of insulin action. Clinical chromium deficiency associated with glucose intolerance that respond to the administration of chromium. The major impediment to the use of orally administered chromium is poor absorption of trivalent chromium in its inorganic form. Trivalent chromium is more available in yeast md, more recently, as chromium picolinate for oral absorption. The widespread use of these supplements has resulted in controversy regarding chromium's role as a nutrient, its use for treatment of insulin resistance, and its potential toxicity. Most recent evidence strongly supports tile conclusion that there is little fear of toxic reactions from chromium consumption. This report reviews the evidence for the potential toxicity of chromium supplements in contrast with its usefulness as a nutrient or therapeutic agent in the treatment or prevention of insulin resistance.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.37 no.5
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• pp.927-940
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• 2017

Landslide has been a major disaster in Indonesia, and recent climate change and indiscriminate urban development around the mountains have increased landslide risks. Java Island, Indonesia, where more than half of Indonesia's population lives, is experiencing a great deal of damage due to frequent landslides. However, even in such a dangerous situation, the number of inhabitants residing in the landslide-prone area increases year by year, and it is necessary to develop a technique for analyzing landslide-hazardous and vulnerable areas. In this regard, this study aims to evaluate landslide susceptibility of Java, an island of Indonesia, by using GIS-based spatial prediction models. We constructed the geospatial database such as landslide locations, topography, hydrology, soil type, and land cover over the study area and created spatial prediction models by applying Weight of Evidence (WoE), decision trees algorithm and artificial neural network. The three models showed prediction accuracy of 66.95%, 67.04%, and 69.67%, respectively. The results of the study are expected to be useful for prevention of landslide damage for the future and landslide disaster management policies in Indonesia.

• Economic and Environmental Geology
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• v.37 no.2
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• pp.207-223
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• 2004

The purpose of this study is to reveal spatial relationships between landslide and geospatial data set, to map the landslide susceptibility using the relationship and to verify the landslide susceptibility using the landslide occurrence data in Boun area in 1998. Landslide locations were detected from aerial photography and field survey, and then topography, soil, forest, and land cover data set were constructed as a spatial database using GIS. Various spatial parameters were used as the landslide occurrence factors. They are slope, aspect, curvature and type of topography, texture, material, drainage and effective thickness of soil. type, age, diameter and density of wood, lithology, distance from lineament and land cover. To calculate the relationship between landslides and geospatial database, Bayesian probability methods, weight of evidence. were applied and the contrast value that is >$W^{+}$->$W^{-}$ were calculated. The landslide susceptibility index was calculated by summation of the contrast value and the landslide susceptibility maps were generated using the index. The landslide susceptibility map can be used to reduce associated hazards, and to plan land cover and construction.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.6
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• pp.370-374
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• 2018

Oriental Diagnosis System(ODS) is an artificial intelligence program that utilize entered diagnosis knowledge, determine patient's disease and decide right medicine. The purpose of this study is to find a correlation between pattern Identification in Korean medicine and each sasang types(Tae-Eum and So-Yang) by analyzing ODS diagnosis result. Eventually our study secure availability of using ODS program at clinical training or developing diagnosis program. Subject of this study is 50 patients who was performed Sasang constitution diagnosis (28 patients were Tae-Eum and 22 patients were So-Yang). We analyize patient's diagnosis records by using ODS program and obtained result about pattern Identification. We used SPSS statistics 23 in analyzing the differences of the scores of Eight Principle Pattern Identification, Qi-Blood Pattern Identification, and Bing-xie Pattern Identification in each Sasang types (Tae-Eum, So-Yang). The Heat and Heat-moisture scores were significantly different(p<0.05) and Qi-Blood Pattern Identification scores were not different in each Sasang types(p>0.05). And Weight was significantly different in each Sasang types(p<0.05). It is hard to generalize the result because subject of this study was not enough and had sample speciality(tinnitus patients). However, we explained correlation between pattern Identification in korean medicine and each sasang types based on quantifiable and objective evidence system. it can be used at education of korean medicine and evidence of practice diagnosis. Futhermore, there have been no studies about anaylizing correlation between pattern Identification in Korean medicine and each sasang types using ODS program. So it is worthy of being utilized at clinical evidence data of ODS program.

• Journal of Veterinary Clinics
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• v.30 no.1
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• pp.45-48
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• 2013

A 12-year-old male poodle weighing 2.0 kg presented for evaluation of right thoracic limb lameness. The owner reported that the dog showed recurrent bilateral shoulder joint luxation after a car accident for a year. Recently, the left shoulder joint appeared well maintained, but right shoulder joint luxation was exacerbated. On physical examination, the dog showed non-weight bearing lameness on the right thoracic limb. Craniocaudal radiographic views revealed medial displacement of the right humerus. Mediolateral radiographic views revealed overlap of the glenoid cavity and humeral head. Muscle atrophy of the right thoracic limb, reduced biceps brachii muscle tendon tone, a tear of the medial glenohumeral ligament, and a rupture of the subscapularis tendon were identified intraoperatively. Transposition of the biceps muscle tendon was performed. However, at 7 days, there was evidence of right shoulder reluxation on radiographs. The second surgery was performed with two $2mm{\times}6mm$ cortical bone anchors and a $4mm{\times}6mm$ cancellous bone anchor placed in the cortical bone of the distal scapula and the cancellous bone of the proximal humerus respectively. Two scapular bone anchors were then connected with a humeral bone anchor using heavy nylon suture to minimize shoulder abduction range of motion. On radiographs right after surgery and 6 weeks after surgery, the affected limb revealed no evidence of medial shoulder luxation. At 6 months, no evidence of lameness was noted on the right thoracic limb.

• Journal of The Geomorphological Association of Korea
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• v.23 no.2
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• pp.29-45
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• 2016

Chemical composition of fine sediments from Jeongdongjin area are analyzed with XRF method. The results are compared with previously reported results of sandstones of the nearest Simgok port. The weight percentage of $SiO_2$ of the samples are far lower than those of sandstones of Simgok. It is supposed to be happened by the selective elution of $SiO_2$ from the sediment layer of coastal terrace, as there's no evidence of selective input or precipitation of other elements from outside. As a result of chemical alteration or weathering of sediment at coastal terrace, weight percentage of $Al_2O_3$ and $Fe_2O_3$ of samples show far higher values than those of Simgok sandstone. In addition, the relative portion of $Al_2O_3$ and $Fe_2O_3$ are decreased to upward within outcrop of terrace sediment layers. It could be caused by the chemical weathering progress with time. However Chemical Index of alteration(CIA) of sediment samples are no larger than 90 and it could be interpreted that it would take over 100ka for total weathering of sediment in this area. Meanwhile the ratio of $SiO_2/Al2O_3$ of terrace sediment showed as 3.48~6.0 and it is far smaller than those of Simgok sandstones(23.9~49.0). The ratio of $SiO_2/Fe_2O_3$ of terrace sediment(19.19~55.85) showed similar pattern with $SiO_2/Al2O_3$ (Simgok sanstone: 119.6~601.8). The ratios have a weak trend of decreasing upwards within the outcrop, there also a huge difference in value among the samples. Chemical composition of reddish brown and gray layers which suspected as the result of psudogleization reveals that reddish brown parts have higher concentration of $Fe_2O_3$ than other parts, while there was no significant difference in concentration of $Al_2O_3$ and CaO.

• Journal of Digestive Cancer Research
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• v.7 no.1
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• pp.18-21
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• 2019

Serine protease inhibitor Kazal-type 1 (SPINK1) is a gene expressed from pancreatic acinar cell which its mutation is known to be associated with chronic pancreatitis (CP) and pancreatic cancer. We report a case of a 47-years-old female with nausea and weight loss with yellow discoloration of skin. Initial imaging and endoscopic study led us to an impression of chronic pancreatitis with pancreatic cancer with common bile-duct dilation. Biopsy result was confirmed with pancreatic adenocarcinoma and additional imaging revealed lymph node and bone metastasis. Our genetic analysis revealed 194+2T>C mutation of SPINK1. Biliary obstruction was successfully decompressed by stent insertion and underwent chemotherapy and radiotherapy. Although there is accumulating evidence of association between SPINK1 mutation and CP, the relationship between SPINK1 mutation and pancreatic cancer in CP patient is an emerging concept. Genetic analysis should be considered in patients with young age especially when diagnosed with both CP and pancreatic cancer.

• Clinical and Experimental Pediatrics
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• v.64 no.5
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• pp.239-246
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• 2021

Background: The consequences of severe acute respiratory syndrome corona virus 2 on mother and fetus remain unknown due to a lack of robust evidence from prospective studies. Purpose: This study evaluated the effect of coronavirus disease 2019 (COVID-19) on neonatal outcomes and the scope of vertical transmission. Methods: This ambispective observational study enrolled pregnant women with COVID-19 in North India from April 1 to August 31, 2020 to evaluate neonatal outcomes and the risk of vertical transmission. Results: A total of 44 neonates born to 41 COVID-19-positive mothers were evaluated. Among them, 28 patients (68.3%) (2 sets of twins) were delivered within 7 days of testing positive for COVID-19, 23 patients (56%) (2 sets of twins) were delivered by cesarean section; 13 newborns (29.5%) had low birth weight; 7 (15.9%) were preterm; and 6 (13.6%) required neonatal intensive care unit admission, reflecting an increased incidence of cesarean delivery and low birth weight but zero neonatal mortality. Samples of cord blood, placental membrane, vaginal fluid, amniotic fluid, peritoneal fluid (in case of cesarean section), and breast milk for COVID-19 reverse transcription-polymerase chain reaction tested negative in 22 prospective delivery cases. Nasopharyngeal swabs of 2 newborns tested positive for COVID-19: one at 24 hours and the other on day 4 of life. In the former case, biological samples were not collected as the mother was asymptomatic and her COVID-19 report was available postdelivery; hence, the source of infection remained inconclusive. In the latter case, all samples tested negative, ruling out the possibility of vertical transmission. All neonates remained asymptomatic on follow-up. Conclusion: COVID-19 does not have direct adverse effects on the fetus per se. The possibility of vertical transmission is almost negligible, although results from larger trials are required to confirm our findings.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.1145-1153
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• 2009

The object of this study was to obtain acute information single oral dose toxicity of Mahwangbujaseshin-tang extracts, with mouse bone marrow cell micronucleus test for detecting possible genotoxicity. In order to observe the 50% lethal dose, approximate lethal dosage, maximum tolerance dosage and target organs, test articles were once orally administered to ICR mice at dose levels of 2000, 1000, 50 mg/kg according to the recommendation of KFDA Guidelines. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing according to KFDA Guidelines with organ weights of 12 types of principle organs. In addition, after twice oral treatment of Mahwangbujaseshin-tang extracts 2000, 1000 and 500 mg/kg, we checked the changes on the number of MNPCE. We could not find any mortality, clinical signs, changes in the body weight and gross findings upto 2000 mg/kg treated group. The limited dosages in rodents except for increases of lymphoid organ weights and hypertrophy encounted as results from pharmacological effects of Mahwangbujaseshin-tang extracts, immune modulator effects with some sporadic accidental findings not toxicological signs. No evidence of increases of MNPCE numbers were also detected in all three different dosages of Mahwangbujaseshin-tang extracts treated mice. The results obtained in this study suggest that the LD50 and ALD of Mahwangbujaseshin-tang extracts in mice were considered as over 2000 mg/kg because no mortalities were detected upto 2000 mg/kg that was the highest dose recommended by KFDA and OECD. And the results of mouse bone marrow micronucleus test of Mahwangbujaseshin-tang extracts is negative results.