• Asian-Australasian Journal of Animal Sciences
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• 제9권4호
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• pp.359-362
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• 1996

A study was conducted to assess the influence of copper on the total sulphur amino acid requirements of broiler chickens reared under two growing periods. The TSAA levels used were 0.73, 0.83, 0.93% with copper levels of 0, 125, 250 and 375 mg/kg for the starter period and the TSAA levels of 0.72, 0.79 and 0.86% with copper levels of 0, 125, 250 and 375 mg/kg for the grower period. Total feed consumption, body weight gain and feed L gain ratio were used as the parameters for the assessment. The results showed that adding copper at 250 mg/kg to the diets improved feed : gain ratio of the starter broilers and resulted in small improvement of body weight gain and feed : gain ratio of the grower broilers. Growth was depressed in relation to the reduction of feed intake on the chicks fed diet containing 375 mg/kg copper. There was a significant interaction between dietary TSAA and copper levels for feed intake, hence, indicating that the supplementation of copper at the level of 375 mg/kg increased the TSAA requirement of the starter broilers, although no interference with the requirement of grower broilers.

• 정신신체의학
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• 제6권2호
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• pp.120-125
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• 1998

Objectives : The purposes of present study were to identify weight increment in female psychiatric patients during hospitalization and to evaluate the relationship between weight gain and daily calorie intake, daily activity and other variables of disease itself. Methods : 20 patients were studied. Body weight were measured once a week, and daily activity(total amounts of walking/day) and total amount of daily calorie intake were measured twice a week. We examined psychiatric and medical illness history, eating disorders' history and family history of eating disorders and obesity. Results: Mean body weight and Body Mass Index(BMI) at admission are 49.40kg and 19.59kg/$m^2$. Mean weight increment during hospital stays of mean 65 days is 4.90kg. Mean amounts of daily calorie intake and daily activity(daily walks) were increased during hospital stays, but not statistically significant. The degree of weight increment is higher in longer hospital stay group, but not statistically significant. Mean body weight at admission of mood disorder group is higher than that of schizophrenia group, but not statistically significant. Conclusion : This results suggested that weight increment in female psychiatric hospitalized patients is present. However, it is not resulted by amount of calorie intake and daily activity level.

• 한국임상약학회지
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• 제28권3호
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• pp.204-215
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• 2018

Background: In this systematic review and meta-analysis, the effect of metformin on weight loss was assessed to determine whether metformin should be recommended for the prevention or treatment of weight gain in patients receiving antipsychotic medication for the treatment of schizophrenia or schizoaffective disorder. Methods: The PubMed, Embase, and Cochrane Library databases were searched for all published randomized controlled trials (RCTs) from inception to June 2018. In addition, the references of relevant articles were also examined. Using Review Manager 5, the pooled estimates of the weighted mean difference (WMD) of the changes in body weight and body mass index (BMI) and the corresponding 95 % confidence intervals (CIs) were calculated. Results: The meta-analysis included 15 RCTs. The pooled analysis showed that compared with placebo, metformin led to significant reductions in body weight (WMD: -2.09, 95% CI: -2.59, -1.60; p<0.00001) and BMI (WMD: -0.90, 95% CI: -1.08, -0.72; p<0.00001). The effect of metformin on weight loss was greater in patients receiving olanzapine than in patients receiving clozapine (body weight, WMD: -2.39, 95% CI: -3.76, -1.02; p=0.0006 for olanzapine; -1.99, 95% C: -3.47, -0.51; p=0.009 for clozapine; BMI, WMD: -1.15, 95% CI: -1.74, -0.57, p=0.0001 for olanzapine; WMD: 0.76, 95% CI: -1.23, -0.28; p=0.002 for clozapine). Conclusion: Metformin can be recommended to manage olanzapine-induced weight gain in patients with schizophrenia or schizoaffective disorder. The magnitude of the reductionss in body weight and BMI implieds that the use of metformin to attenuate olanzapine-induced weight gain can minimize the risk of coronary heart disease.

• Food Science and Biotechnology
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• 제16권3호
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• pp.434-438
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• 2007

The aim of the present study was to assess the effects of onion (Allium cepa) skin extract (OSE) on pancreatic lipase (PL), the key enzyme of the digestion and absorption of dietary fat in the small intestine, and to evaluate its potential for the inhibition of body-weight gain. OSE inhibited PL with an $IC_{50}$ of 53.70 mg/mL, which means as potent as 0.07635% of the activity of orlistat. At 3 and 4 hr after administration of OSE, the plasma triacylglycerol concentration was significantly lower in the OSE-treated rats than control. Body-weight gain and parametrial adipose tissue weights were significantly lower in mice fed the high-fat diet (fat comprises 31% of total calories) with 5%(w/w) OSE than in control. The results suggest that OSE may be an effective nutraceutical for the inhibition of body-weight gain.

• Clinical and Experimental Pediatrics
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• 제50권5호
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• pp.484-488
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• 2007

목 적 : VPA치료를 받는 소아 청소년기 간질환자들에서 체중증가의 비율과 체중증가에 관련되는 예측 인자를 알아보고자 하였다. 방 법 : 2001년 1월 1일부터 2004년 12월 31일까지 VPA 치료를 받기 시작한 8세에서 17세까지의 환아를 대상으로 하였다. 제외기준은 치료 시작후 6개월 이내 치료가 중단된 경우, 체중에 영향을 주는 약물을 병합한 경우 등이었다. VPA 치료 시작시와 치료 시작 후 한번이상 재방문시에 체중과 신장이 측정되어 두 시점에서 BMI를 측정한 후 대상 환아들을 백분위수에 따라 4가지의 BMI군으로 분류하여 BMI군의 상승여부를 조사했으며 체중증가율을 의미하는 BMI difference를 계산하였다. 또한 체중증가에 영향을 미치는 여러 인자들을 회귀분석 하였다. 결 과 : 전체 36명중 총 8명의 환아가 VPA 치료전보다 최소 한 단계 이상의 BMI군의 상승변화를 보였으며 대상환아의 72.2%에서 체중증가(BMI difference의 증가)를 나타내었다. 신경정신 발달(P=0.017), 간질 형태(P=0.001), 투약기간(P=0.035)은 통계적으로 유의한 체중증가에 영향을 미치는 예측인자였다. 결 론 : VPA는 간질 환아에서 체중증가를 유발하며 정상 신경정신 발달, 전신 발작형 간질, 12개월 이상의 투약기간이 체중증가의 예측인자로 생각된다. 따라서 VPA 치료를 받는 소아 간질환자에서는 치료 시작 전에 VPA로 인한 체중증가의 가능성을 고려하여 치료 받는 중 BMI의 지속적인 감시측정이 필요할 것으로 생각된다.

• Asian-Australasian Journal of Animal Sciences
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• 제8권3호
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• pp.289-293
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• 1995

The experiment was conducted to study the effect of supplementary urea molasses block lick with rice straw based diet on the performance of sheep. Six indigenous sheep of about two years of age with an average body weight of 12.88 kg, were selected for this experiment They grouped into two by stratified randomization, and the experiment was conducted for a period of 90 days. Sheep of group A was fed rice straw and group B was feed rice straw with urea molasses block lick, beside this both the groups received 66 g wheat bran and 167 g of Ipil-Ipil leaf meat. The study revealed that the average daily gain of live weight per sheep per day was 41 gm and 70 gm in group-A and group-B respectively. From the analysis of variance it was evident that live weight gain in sheep of group B, supplemented with urea molasses block lick was highly significant (p < 0.01). It was also estimated that group A required 8.12 kg DM to gain 1 kg live weight, whereas group B receiving urea molasses block lick required 5.30 kg DM to gain 1 kg live weight. Therefore, feeding rice straw with urea molasses block lick able to utilize more crop-residues efficiently.

• Journal of Nutrition and Health
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• 제29권6호
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• pp.597-607
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• 1996

This study has been investigated the potenial of increased dietary cysteine to alter the effects of cadmium and lead on tissure and bone metal concentrations, excretion and tissue metallothionein(MT) concentrations. Fifty-four male rats of Sprgue-Dawley strain weighing 149$\pm$17g were divided into 9 groups according to body weight. Nine experimental diets with different cadmium (0ppm, 400ppm), lead(0ppm, 710ppm) and cysteine (0.06%, 0.45%, 0.90%) levels were given to rats for 30 days ; Food intake, weight gain, F.E.R, and weights of liver, kidney and femur were decreased in cadmium supplied groups than in cadmium free groups. Urinary and fecal cadmium excretions were increased and MT synthesis we induced in liver, kidney and small intestine in cadmium supplied groups. In lead supplied groups, weight gain and F.E.R were decreased. With cysteine supplementation in cadmium supplied groups, weight gain and F.E.R, and weights of liver, kidney and femur were increased. Cadmium excretion in feces and MT concentrations in liver and kidney were also increased with cysteine supplementation. In lead supplied groups, there was no significant increase in food intake, weight gain and F.E.R with cysteine supplementation. Lead excretion in feces was increased in cysteine supplemented groups. In conclusion, effect of cadmium administration was more toxic than lead adminstration. Cysteine alleviated cadmium and lead toxicity by increasing metallothionein concentration and fecal excretions of heavy metals. Especially, effect of cysteine supplementation was more effective in cadmium groups than in lead groups. Effect of cysteine supplementation was not different with level of cysteine supplementation in both cadmium and lead groups.

• Journal of the Korean Wood Science and Technology
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• 제22권3호
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• pp.32-38
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• 1994

The methods in wood processing are so limited at present that a scope of its utilization is restricted. This often makes wood itself less valuable as a material comparing with other materials, that is, plastics, metals, and glass. Such differences are due to a lack of plasticity in wood, i.e. it cannot be melted, dissolved, or softened sufficiently for molding. However, once plastic properties are added to wood, it becomes more useful material. This further broadens the method in wood processing to a variety of fields. In this way, wooden material which is limited in use can be modified into a high quality product with additional value. Furthermore, utilization of wastes from wood, for example, would be made viable. In this study, thermoplasticization was carried out by benzylation of wood(sawdust). Various factors those affect the reaction were tested to produce benzylated wood with different degrees of substitution. Reaction temperature and time were the quite important factors. Optimum reaction temperature was 110$^{\circ}C$, and weight percent gains(WPG) of final products increased gradually with the increase of reaction time. The pretreatment (or preswelling) of wood with alkaline solution had a critical effect on benzylation. and the concentration of alkaline solution should be above 30% to obtain high weight percent gain. The thermal flow temperature of the benzylated wood decreased with the increase in weight percent gain, that of 80% weight percent gain is about 200$^{\circ}C$.

• Asian-Australasian Journal of Animal Sciences
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• 제9권1호
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• pp.107-111
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• 1996

Studies on the effects of protein levels on the total sulphur amino acid (TSAA) requirements of chickens were conducted on the starter broilers by feeding four levels of crude protein(16, 18, 20 and 23%) at three levels of TSAA (0.83, 0.93 and 1.03%) and on the grower broilers by feeding three levels of crude protein (16, 18 and 20%) at three levels of TSAA(0.72, 0.79 and 0.86%). The metabolisable energy of the diets was maintained constant at 3,200 kcal/kg and the experiments were carried out for two growing periods: starter (0-3 wk) and grower (3-6 wk). The results showed that there were significant differences in body weight gain, feed intake and feed:gain ratio under different protein levels of the starters. Crude protein, ME and TSAA intake were significantly affected by increasing the CP levels. The TSAA requirement of the starter broilers is recommended at 0.93% and it is not influenced by different protein levels used in the experiment. For the grower period, body weight gain and feed:gain ratio improved significantly at higher protein diets. Birds fed higher protein diet consumed greater quantities of protein. Responses to TSAA supplementation for body weight gain, feed intake and feed:gain ratio were not significant. The present results showed that the TSAA level of 0.79 to 0.86% was required for grower diets and that the protein levels of the diet did not influence the TSAA requirement.

• Asian-Australasian Journal of Animal Sciences
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• 제19권10호
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• pp.1470-1477
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• 2006

One hundred and sixty crossbred pigs ($6.62{\pm}0.36kg$) weaned at day $18{\pm}1$ were used to investigate the effects of lactitol and tributyrin on performance, small intestinal morphology and enzyme activity. The pigs were assigned to one of five dietary groups (4 pens/diet with 8 pigs/pen) and were fed the negative control diet or the negative control diet supplemented with 10 g/kg glutamine (as a positive control), or 3 g/kg lactitol (${\beta}$-D-galactopyranosyl-($1{\rightarrow}4$)-D-sorbitol), or 5 g/kg tributyrin (butanoic acid 1,2,3-propanetriyl ester), or 3 g/kg lactitol+5 g/kg tributyrin. Body weight and feed intake were measured weekly during the 4-week study. On day 7, four pigs per dietary treatment were sacrificed to examine small intestinal morphology and enzyme activity. The results showed that: (1) Compared with the negative control diet, the positive control diet improved weight gain and feed efficiency during weeks 1-2 and over the entire study (p<0.05), and also decreased duodenal and ileal crypt depth (p<0.05), but did not alter intestinal enzyme activity (p>0.05). Lactitol improved feed efficiency during weeks 3-4 and over the entire study (p<0.05), but did not improve weight gain and feed intake, intestinal morphology or enzyme activity (p>0.05). Tributyrin improved weight gain and reduced feed/gain during weeks 3-4 and over the entire study. Tributyrin significantly decreased crypt depth in the duodenum and ileum, and increased duodenal lactase and ileal maltase activity (p<0.05). Lactitol+tributyrin increased weight gain during weeks 3-4 and over the entire study, and improved feed efficiency during weeks 1-2 and 3-4 and over the entire study (p<0.05). Lactitol+tributyrin increased the jejunal villus height, and decreased the duodenal and ileal crypt depth (p<0.05). Lactitol+tributyrin also increased jejunal lactase and sucrase activity (p<0.05). (2) Compared with the positive control, tributyrin improved weight gain and reduced feed/gain during weeks 3-4 (p<0.05), decreased the ileal crypt depth, and improved the duodenal lactase and sucrase activity (p<0.05). Lactitol+ tributyrin improved weight gain during weeks 3-4, improved feed efficiency during weeks 3-4 and over the entire study, increased the ileal villus height, and increased jejunal lactase, sucrase and maltase activity (p<0.05). These results showed that tributyrin improved performance, intestinal morphology and enzyme activity, while the effect of lactitol was very limited. These results also showed that, compared with glutamine, tributyrin was more effective in improving intestinal morphology and enzyme activity, and tributyrin exerted a superior effect in improving performance as weaning progressed. These observations suggest that, as a chemical for repairing intestinal atrophy, glutamine and tributyrin should be used in the first and second periods of the starter phase, respectively.