• Journal of Oriental Neuropsychiatry
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• v.24 no.4
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• pp.419-434
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• 2013

Objectives: The object of this study is to observe the cognition and motor function recovery effects of Joojakwhan (JJW), a traditional Korean poly-herbal formula for treating various neuropsychiatric diseases such as dementia, for the mildly stroke rats, with 60 minutes of reperfusion transient middle cerebral artery occlusion (tMCAO). Methods: In the present study, 125, 250 and 500 mg/kg of JJW were orally administered, once per day for 10 continuous days 2 hours after the tMCAO. The body weight changes, infarct sizes under 2% 2, 3, 5-triphenyl tetrazolium chloride (TTC) stain, sensorimotor functions and cognitive motor behavior tests were serially monitored with cerebral caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP)-immunoreactivities and histopathological changes. The effects of tMCAO on sensorimotor functions were evaluated by using of limb placing and body-swing tests, and the cognitive motor behaviors were also observed with water maze tests. Results: From the results of tMCAO, with marked decreases of body weights, disorders of sensorimotor functions increases the limb placing test scores, and decrease the numbers and percentages of body swings to the ipsilateral sides. The cognitive motor behaviors increases the distances and time to reach the escape platform which included the inhibitions of the decreases with repeated trials that were observed with focal cerebral cortex infarct volumes. In addition, the marked increases of the atrophy, numbers of degeneration, caspase-3- and PARP-immunoreactive cells around peri-infarct ipsilateral cerebral cortex were also observed in tMCAO controls when compared with the sham control rats, respectively. Conclusions: The results obtained from this study suggest that oral administrations of JJW indicate obvious cognitions and motor function recoveries of the rats with tMCAO, mild strokes, which are mediated by neuro-protective effects through known antioxidant effects of components.

• Korean Journal of Community Nutrition
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• v.23 no.4
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• pp.318-332
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• 2018

Objectives: The purpose of this study was to investigate the behavioral modification of obese adults who underwent nutritional and physical activity education. Twenty obese females, aged 20-60 years old, with BMIs (Body Mass Index) >30 or body fat (%) >40 were subjected to this study. Methods: The physical activity education program consisted of doing exercise in a gymnasium together or home exercise. Dietary attitudes and dietary intakes were assessed using weight control, physical activity, and eating habits. The nutrition-exercise educational period was 12 weeks. Results: After the study period, there was significant improvement in physical activity and eating habits score. Furthermore, there was a significant increase in the dietary intakes of fiber, iron, potassium, vitamin A, vitamin $B_6$, and niacin. Blood pressure, blood glucose, and total cholesterol levels showed a tendency to decrease, but there was no significant difference. BMI, fat mass, abdominal circumference, and visceral fat levels were significantly reduced while muscle mass significantly increased. Conclusions: This study suggests that behavioral modification by nutrition and physical activity education with feedback has positive effects on dietary intake and anthropometric biomarkers in obese adults. Therefore, lifestyle interventions of this kind could be recommended as a method for obesity management.

• Korean Journal of Community Nutrition
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• v.23 no.2
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• pp.102-115
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• 2018

Objectives: Although breakfast is important to nutrition balance, prevention of overeating, and weight control, people in their 20s (males: 55.1%, females: 49.9%) were reported to have the highest rate of skipping breakfast in 2016 Korea Health Statistics. This study aims to examine dietary habits and nutrient intake depending on breakfast frequency among young women in Seoul. Methods: The subjects were 655 young women in Seoul from August to October 2016, and the survey was performed by using a questionnaire that included general characteristics, dietary habits, and eating behavior. Body composition was determined by bioelectric impedance analysis. Nutritional status was examined by the 24-hour recall method. Results: The participants were classified by breakfast intake frequency; '${\geq}5times/week$ (n=160)', '1-4 times/week (n=327)', and 'breakfast skipping (n=168)'. The 'breakfast skipping' group had lower frequency and regularity of meals. In addition, the 'breakfast skipping' group had a higher frequency of eating-out and late-night meals. There was no difference in total calories between the 'breakfast skipping' group and other groups, but the 'breakfast skipping' group had significantly low carbohydrate and fiber intakes. The participants showed lower intakes of calories, fiber, vitamin A, vitamin C, niacin, folic acid, calcium, potassium, and zinc in comparison with recommended intakes. Especially, the 'breakfast skipping' group had significantly lower fiber, vitamin A, vitamin C, calcium, potassium levels compared to the '${\geq}5times/week$' group. For Mean Adequacy Ratio (MAR), the 'breakfast skipping' group recorded a ratio of 0.60, which was lower than those of other groups. Index of Nutritional Quality (INQ) including fiber, vitamin C, calcium and phosphorus were significantly lower in the breakfast skipper group, compared to the breakfast eater group. Conclusions: The 'breakfast skipping' group showed low regularity of meals and a high frequency of eating-out and late-night meals. The breakfast regular eater group showed high intake of micronutrients and quality of meals was high in general. Skipping breakfast could lower nutrient intake and quality of meals, which requires attention.

• Macromolecular Research
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• v.11 no.4
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• pp.207-223
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• 2003

For last five years, we are developing the novel local drug delivery devices using biodegradable polymers, especially polylactide (PLA) and poly(D,L-lactide-co-glycolide) (PLGA) due to its relatively good biocompatibility, easily controlled biodegradability, good processability and only FDA approved synthetic degradable polymers. The relationship between various kinds of drug [water soluble small molecule drugs: gentamicin sulfate (GS), fentanyl citrate (FC), BCNU, azidothymidine (AZT), pamidronate (ADP), $1,25(OH)_2$ vitamin $D_3$, water insoluble small molecule drugs: fentanyl, ipriflavone (IP) and nifedipine, and water soluble large peptide molecule drug: nerve growth factor (NGF), and Japanese encephalitis virus (JEV)], different types of geometrical devices [microspheres (MSs), microcapsule, nanoparticle, wafers, pellet, beads, multiple-layered beads, implants, fiber, scaffolds, and films], and pharmacological activity are proposed and discussed for the application of pharmaceutics and tissue engineering. Also, local drug delivery devices proposed in this work are introduced in view of preparation method, drug release behavior, biocompatibility, pharmacological effect, and animal studies. In conclusion, we can control the drug release profiles varying with the preparation, formulation and geometrical parameters. Moreover, any types of drug were successfully applicable to achieve linear sustained release from short period ($1{\sim}3$ days) to long period (over 2 months). It is very important to design a suitable formulation for the wanting period of bioactive molecules loaded in biodegradable polymers for the local delivery of drug. The drug release is affected by many factors such as hydrophilicity of drug, electric charge of drug, drug loading amount, polymer molecular weight, the monomer composition, the size of implants, the applied fabrication techniques, and so on. It is well known that the commercialization of new drug needs a lot of cost of money (average: over 10 million US dollar per one drug) and time (average: above 9 years) whereas the development of DDS and high effective generic drug might be need relatively low investment with a short time period. Also, one core technology of DDS can be applicable to many drugs for the market needs. From these reasons, the DDS research on potent generic drugs might be suitable for less risk and high return.

• The Journal of the Korea Contents Association
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• v.12 no.6
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• pp.317-327
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• 2012

The purpose of present study was to observe the path and influencing effects between socioeconomic class (SEC), health practices and self-rated health(SRH) by the age bracket. The subjects were 4,987 adults over 25 years old who participated in the 2008 Korean National Examination Health and Nutrition Survey and could be classified into SEC in terms of the three characteristics: education, income and occupation. Path analysis was conducted with the effects of health behaviors execution on the differences in SRH, and the complex samples analysis executed by chi-square test, t-test, ANOVA. As the result, lower SRH level paralleled with the lower SEC, and more health behaviors had differed by SEC in the younger and middle aged group. The lower SEC, the lower SRH: non-smoking and weight control for younger women and exercise for aged men had indirect effects as parameters. In conclusion, when planning a health promotion program, to select the correct target populations with consideration of the age bracket, gender and SEC and to establish tailored contents fit for each of the population would be important.

• Korean Journal of Health Education and Promotion
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• v.21 no.2
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• pp.35-54
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• 2004

This study was intended to provide basic data of nutrition education to a prevention of obesity and living patterns of elementary school students. Through the measurment of the actual obesity rate of children for students who were in the fifth and sixth grades of elementary school as well as their mothers, and by analyzing obesity-related factors. Children have started to have the characteristics obesity and obesity problems. 1. There were total 234 children including 133 boys (56.8％) and 101 girls (43.2％) for the study. There were 80 children in the fifth grade (34.2％) and 154 children in the sixth grade (65.8％). 2. Among the subjects 20.1％ were obese. By gender, the obesity rate of boys (27.1％) was higher than that of girls (l0.9％)(p＜0.01). By grade, children in the fifth grade (26.3％) had higher obesity rate than children in the sixth grade (l6.9％)(p＜0.05). 3. In terms of the educational level of parents, the obesity rate of children of parents who received university and／or higher education was 27.5％ (p＜0.05). 44.1％ of parents answered ‘I almost never give snack’s’(p＜0.01). 4. There was 32.8％ for an irregular quantity of meal. There was no obese child who under-ate (p＜0.05). In terms of impulse eating, ‘I eat.’ and ‘I don't eat.’ were 24.4％ and 25.9％ respectively. The obesity rate of the case of ‘I eat only food I like.’ was 10.6％ (p＜0.05). In terms of the obesity rate based on the daily average meal frequency, there was the highest rate of 26.1％ for I average meal frequency per day, 13.0％ for 2 daily average meal frequency, and 7.4％ for over 3 average meal frequency per day (p＜0.05). For a degree of a physical activity, the group of active physical activity (p＜0.05) and the group which liked the physical exercise showed a lower obesity rate (p＜0.001). The obesity rate of children who had regular exercise was 11.8％. It was lower than the obesity rate (24.8％) of children who didn't exercise (p＜0.01). The higher exercise frequency per week was, the lower the obesity rate was(p＜0.01). In terms of the exercise time, there was 8.3％ for over 60 minutes and 28.9％ for less 15 minutes. The group which had the long exercise time showed a lower obesity rate(p＜0.05). As the result, the education for obesity must enable students to recognize the warning signs for obesity and control their own weight with proper living patterns, by modifying behaviors considering the degree of obesity. Obesity must be controlled by the prevention and education connected with the family for all students as one of the school health programs. There must be also the development of a program through individual consultation considering the degree of obesity.

• Journal of Korean Academy of Nursing
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• v.38 no.6
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• pp.822-830
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• 2008

Purpose: The purpose of this study was to analyze effects of a community-based case management program for clients with hypertension living in the community. Methods: The research design was a one group pre and post-test design with 30 participants with hypertension who agreed to participate in the 8-12 week case management program provided by case managers from the National Health Insurance Corporation in 2002. Data were collected three times, before and after the case management services, and 6 months later. Outcomes included changes in blood pressure, knowledge of hypertension and daily life practices, including alcohol consumption, smoking, exercise, and medication adherence. Results: Repeated-measures ANOVA and post-hoc tests of means revealed significant differences before and after service for systolic blood pressure, daily life practices (monitoring body weight and BP, low salt and cholesterol and high vegetable diet, and stress-relief practices), and exercise. The goal for medication adherence was attained after service. Significant improvements from baseline to 6 months after service were observed in measures of salt and vegetables in diet. There were no significant differences on hypertension knowledge, alcohol consumption or smoking behavior between before service and after, and at 6 months. Conclusion: The findings provide preliminary evidence that case management intervention can have positive outcomes on BP control, daily life practices, exercise, and medication adherence for clients with hypertension. However, additional interventions are needed to sustain long-term effects.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.8
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• pp.3500-3512
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• 2012

The purpose of this study is to conduct a comparative analysis of health behaviors, health status, and health care utilization by the homeland of the internationally married women immigrants living in Korea. The subjects of this study were 171 married women immigrants who are registered at 7 multicultural centers in Chungbuk province. The study was conducted from September 2010 to November 2010 by surveying them with structured questionnaires translated in 7 different languages. In health behaviors the results indicated that there were statistically significant differences in high intensity exercise, walking, weight control, and the number of times having breakfast per week depending on the subject's homeland. In health status, there were statistically significant differences in low back pain incidence and obesity rate by the subject's homeland. In health care utilization, the subjects revealed statistically significant differences in utilizing health screening, in selecting primary medical institutes, and in the reasons for avoiding medical institutes depending on the subject's homeland. Health promotion policies that take the results of this research into account would provide suitable health care services for internationally married migrant women.

• Resources Recycling
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• v.21 no.1
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• pp.60-65
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• 2012

The Ti-6Al-4V alloys were prepared by recycling of dental Ti pure scraps using vacuum arc melting process, and their physical properties were evaluated the Ti-6Al-4V alloys with different oxygen concentrations. For the preparation of Ti-6Al-4V alloys, Ti pure scraps used for dental implant were utilized as a raw material, and their different oxygen concentrations were ranged from G1 to G4 grade in ASTM standards. It was confirmed that the weight loss of Al in the composition of Ti-6Al-4V alloy could be controlled under the Ar pressure of 875 torr during the melting of alloy. The oxygen concentrations of the Ti-6Al-4V alloys were ranged from 1170 to 3340 ppm. The vickers hardness change of the Ti-6Al-4V alloys showed a similar behavior with that of pure Ti. As a result, we confirmed a possibility of preparation of Ti-6Al-4V alloy by recycling of dental Ti scraps using vacuum arc melting process in this study.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.9 no.4
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• pp.11-22
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• 1999

Least-mean-square(LMS) adaptive filters have proven to be extremely useful in a number of signal processing tasks. However LMS adaptive filter suffer from a slow rate of convergence for a given steady-state mean square error as compared to the behavior of recursive least squares adaptive filter. In this paper an efficient signal interference control technique is introduced to improve the convergence speed of LMS algorithm with tap weighted vectors updating which were controled by reusing data which was abandoned data in the Adaptive transversal filter in the scheme with data recycling buffers. The computer simulation show that the character of convergence and the value of MSE of proposed algorithm are faster and lower than the existing LMS according to increasing the step-size parameter $\mu$ in the experimentally computed. learning curve. Also we find that convergence speed of proposed algorithm is increased by (B+1) time proportional to B which B is the number of recycled data buffer without complexity of computation. Adaptive transversal filter with proposed data recycling buffer algorithm could efficiently reject ISI of channel and increase speed of convergence in avoidance burden of computational complexity in reality when it was experimented having the same condition of LMS algorithm.