• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.6
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• pp.1034-1041
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• 2010

The oriental medicine Jangwonhwan, which is a boiled extract of 12 medicinal herbs/mushroom, has been prescribed for patients with cognitive dysfunction and it is originally from the Korean medical text, DonguiBogam(amnesia chapter). Recently, a modified recipe of Jangwonhwan (LMK02-Jangwonhwan) consisting of seven medicinal plants/mushroom, was shown to reduce ${\beta}$-amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease. The toxicity of LMK02 was investigated in SD rats by oral repeated adminstration for 4 weeks and we tried to determine test does for 13 weeks repeated study. Quality control of tablet form of LMK02 was established by estimating indicative components, Ginsenoside Rg3 of Red Ginseng and Decursin of Angelicagigas Nakai. The toxicity of LMK02 was investigated in 6 weeks old specific pathogen free (SPF) Sprageu-Dawley rats by oral administration. Each test group were consist of 5 male and 5 female and they received doses of 500, 1,000 and 2,000 mg/kg/day of test substance for 4 weeks. The clinical signs, death rate, body weight, food consumption, ophthalmic examination, urinalysis, hematological and serum biochemistry, organ weight and pathological changes were examined and compared with those of control group. Urinalysis : We observed increase of PRO(p<0.01), SG(p<0.01) in female rats of 1,000 mg/kg/day and 2,000 mg/kg/day(p<0.01). Also, we observed increase of pH and KET in female rats of 1,000 mg/kg/day(p<0.05) and of 2,000 mg/kg/day(p<0.01). WBC in female rats in 1,000 mg/kg/day and 2,000 mg/kg/day were on increase. Hematological test : We observed increase of MCV in male rats of 250 mg/kg/day. (p<0.05) Serum biochemistry test : We found increase of CHO in female rats of 2,000 mg/kg/day(p<0.05). During the experimental period, there were no animals dead or moribund. There were no treatment related changes of general symptom, food and water consumption, organ weight and autopsy According to the results of 4-week repeated dose range finding study, the highest dose was established as 1000 mg/kg for 13-week repeated dose toxicity study and we determined to put 2 more groups by common ratio two.

• Korean Journal of Food Science and Technology
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• v.22 no.5
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• pp.539-542
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• 1990

The effects of immersion temperature $(20,\;40\;and\;60^{\circ}C)$ and immersion times (6. 12 and 18 min) in a distilled water prior to air dehydration upon the browning reaction and pyruvic acid content of air dried onions to a 4.071 moisture content (wet basis) were analyzed by a response surface methodology (RSM). Those values were also predicted by using a second degree polynomial regression model. Immersion temperature had more influence to browning reaction and pyruvic acid content than immersion time in these experimental ranges. The processing conditions to minimize the browning reaction of dried onions at $50^{\circ}C$ of air temperature (O.D.=0.071) were $60^{\circ}C$ of immersion temperature and 18 min of immersion time compared to control (O.D.=0.168) of air dehydration at $50^{\circ}C$ Pyruvic acid contents of dried onions at $50^{\circ}C$ of air temperature were maximized $(39.85{\mu}mole/g\;onion\;solid)$ at $60^{\circ}C$ of immersion temperature and 12 min of immersion time compared to control $(24.08{\mu}mole/g\;onion\;solid)$ of air dehydration at $50^{\circ}C$.

• Geophysics and Geophysical Exploration
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• v.9 no.4
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• pp.261-270
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• 2006

Two-dimensional (2-D) inversion of magnetotelluric (MT) data for two survey lines having south-north direction from Jeju Island has been carried out. Broad band MT sounding curves with good quality could be gathered by performing audio-frequency magnetotelluric (AMT) survey during the MT survey and by operating the remote reference in Kyushu Island, Japan. Comparison of the 2-D inversion model using MT band only and that using both AMT and MT bands for the field data as well as for the data from numerical 2-D modeling said that high frequency information from AMT survey can be useful for interpreting not only the shallow part but also the deep structures, especially when the formation is resistive. The 2-D inversion models of field data show a thick layer having around 10 ohm-m in the depth of a few hundred meters throughout the survey area, which can be considered as the unconsolidated sedimentary layer. And they also show a conductive anomaly at the central part of each survey lines. It can be either the effect of the surrounding sea water, or the structures due to ancient volcanic events. But unfortunately by now, we do not have any further information about the anomaly.

• Journal of Agricultural Extension & Community Development
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• v.16 no.2
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• pp.363-384
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• 2009

This study aimed at finding directions for Korean agriculture to establish a new paradigm of sustainable development. Various problematic issues and concerns in the environment necessitate the transformation of Korea's development paradigm from unconditional growth to "Green Growth" through new policies on green value and review of various advanced researches. In this research, the environment-friendly agriculture's problems, particularly in agribusiness were analyzed. Drawing from Michael Porter's Value Chain Analysis, this research developed a value chain model in agriculture that reflects the environment and the present situations. Future directions in the agriculture sector were also discussed. Korea realized food self-sufficiency through the green revolution in the early 1970s. However, a lot of problems have also occurred, including ground and water pollution and the destruction of ecosystems as a result of the overuse of pesticides and chemical fertilizers. In the late 1970s, the growing interest on environment-friendly agriculture led to the introduction of sustainable methods and techniques. Unfortunately however, these were not innovative enough to foster environment-friendly agriculture. Thereafter, the consumers' distrust on agricultural products has worsened and concerns about health have increased. In view of this, the Ministry of Food, Agriculture, Forestry and Fisheries introduced in December 1993 a system of Quality-Certified Products for organic and pesticide-free agri-foods. Although a fundamental step toward the sustainability of the global environment, this system was not enough to promote environment-friendly agriculture. In 2008, Korea's vision is for "Low Carbon Green Growth" to move forward while also coping with climate change. But primary sectors in a typical value chain do not consider the green value of their operations nor look at production from an environmental perspective. In order to attain sustainable development, there is a need to use less resources and energy than what is presently used in Korean agricultural and value production. The typical value chain should be transformed into a "closed-loop" such that the beginning and the end of the chain are linked together. Such structure allows the flow of materials, products and even wastes among participants in the chain in a sustained cycle. This may result in a zero-waste sustainable production without destroying the ecosystem.

• Food Science and Preservation
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• v.15 no.3
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• pp.332-339
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• 2008

This study was performed to investigate the sorption characteristics and shelf-life of coated ascorbic acid Stability of ascorbic acid, which oxidizes easily during storage and processing, was achieved by applying a fluidized bed coating using Zein-DP and HPMC-FCC as covering materials. The monolayer moisture content calculated using the GAB equation showed a higher level of significance than when calculated using the BET equation. The fit to the isotherm curve was in the order of Halsey, Caurie, Oswin and Khun. The equilibrium relative humidity prediction model was established in terms of time and water activity, it had higher significance. The stability of the coated ascoribic acid during storage was investigated in terms of radical-scavenging activity, which decreased with increasing time of storage and was more affected at higher storage temperatures. The quality reduction rate constant (k) was calculated by a first-order reaction rate. The reaction rate constant increased with increasing storage temperature. The shelf-life of Zein-DP-coated ascorbic acid was estimated to be 45.83 days at 20C and 63.19 days at 10C, and the shelf-life for HPMC-FCC-coated ascorbic acid was estimated to be 28.84 days at 20C and 36.14 days at 10, the ascorbic acid was 24.52 days at $20^{\circ}C$ and 27.22 days at $10^{\circ}C$, respectively. Therefore, the fluidized bed coating effectively increased the stability of ascorbic acid.

• Environmental and Resource Economics Review
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• v.28 no.4
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• pp.645-673
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• 2019

The hypothetical nature of stated preferences can lead to a hypothetical bias that might work as a normative pressure, influencing survey responses. This paper aims to test the impact of social desirability bias by comparing economic estimates based on both subjective and objective valuation questions. The case study is about an urban riverine restoration project in Deajeon, South Korea. As valuation methods both contingent valuation and choice experiments were comparatively applied. Based on a nationally representative sample of 1,000 respondents, the test results offered contrasting conclusions between two test approaches. Accroding to the estimation results based on the conventional valuation, the marginal willingness to pay estimates are 10,500 KRW from CV; and 18,600 KRW for improving water quality, 2,200 KRW for the inside view, 8,900 KRW for the outside view, and 5,800 KRW for biodiversity from CE. A segmentation-based approach is a conventionally used method, which showed a limited impact of social desirability on willingness to pay estimates. The alternative parameterization-based approach measures a model-wide impact of social desirability, proving a significant bias. Although the study positioned a cheap-talk statement before the valuation section of the survey questionnaires, which might have pre-screened the bias, the overall implications of the results suggest a caution in reducing and observing hypothetical bias. There might remain a significant and substantial hypothetical bias even after cheap-talk, particularly in situations with strong social desirability, so that the potential role of objective valuation questions is guaranteed.

• Korean Journal of Environmental Biology
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• v.31 no.4
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• pp.419-428
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• 2013

The objectives of this research were to determine ecological characteristics and chemical gradients in two different loach populations-Misgurnus anguillicaudatus ($M_a$) and Koreocobitis rotundicaudata ($K_r$). Eight chemical parameters were compared to test the chemical preferences between the two species. The population of Kr occurred more in better water quality, compared to the $M_a$-population. The $M_a$-population co-occurred more with tolerant species (TS) and omnivores, whereas the $K_r$-population co-occurred more with sensitive species (SS) and insectivores. The differences in the tolerance and trophic composition matched well with the result of stream health assessment, based on the multi-metric model of Index of Biological Integrity (IBI). The IBI value in habitat with the $M_a$-population was "19.6" (range: 8~40) indicating a fair condition, and the IBI values of $K_r$-population was 29.4 (range: 12~40) indicating good condition. Similar results were found in physical habitat health analysis (QHEI). Overall, data analysis showed that the $M_a$-population belong to the tolerant species and $K_r$-population belong to sensitive species in the tolerance classification.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.6
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• pp.434-445
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• 2020

In this study, the minimization of harbor oscillation using permeable breakwater was applied to the actual harbor and investigated an effect of minimization by computer simulation in order to take into account the water quality problems and measures of harbor oscillation by infragravity waves at the same time. The study site is Mukho harbor located at East coast of Korea that harbor oscillation has been occurred frequently. The infragravity waves obtained by analyzing the observed field data for five years focused on the distribution between wave periods of 40 s and 70 s and wave heights in less than 0.1 m was 94% of analyzing data. The target wave periods was 68.0 s. The most effective method of minimization of harbor oscillation by infragravity waves was to install a detached permeable breakwater with transmission coefficient of 0.3 on the outside harbor and replace some area of the vertical wall in the harbor with wave energy dissipating structure to achieve a reflectivity of 0.9 or less. The amplitude reduction rate of this method shown in 27.4%. And the effect of the difference in transmission coefficient of permeable breakwater on the reduction rate of the amplitude was not significant.

• Korean Journal of Remote Sensing
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• v.39 no.6_3
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• pp.1693-1705
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• 2023

Rural areas, which account for about 90% of the country's land area, are increasing in importance and value as a space that performs various public functions. However, facilities that adversely affect residents' lives, such as livestock facilities, factories, and solar panels, are being built indiscriminately near residential areas, damaging the rural environment and landscape and lowering the quality of residents' lives. In order to prevent disorderly development in rural areas and manage rural space in a planned manner, detection and monitoring of hazardous facilities in rural areas is necessary. Data can be acquired through satellite imagery, which can be acquired periodically and provide information on the entire region. Effective detection is possible by utilizing image-based deep learning techniques using convolutional neural networks. Therefore, U-Net model, which shows high performance in semantic segmentation, was used to classify potentially hazardous facilities in rural areas. In this study, KOMPSAT ortho-mosaic optical imagery provided by the Korea Aerospace Research Institute in 2020 with a spatial resolution of 0.7 meters was used, and AI training data for livestock facilities, factories, and solar panels were produced by hand for training and inference. After training with U-Net, pixel accuracy of 0.9739 and mean Intersection over Union (mIoU) of 0.7025 were achieved. The results of this study can be used for monitoring hazardous facilities in rural areas and are expected to be used as basis for rural planning.

• Progress in Medical Physics
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• v.20 no.4
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• pp.269-276
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• 2009

Radiation treatment techniques using photon beam such as three-dimensional conformal radiation therapy (3D-CRT) as well as intensity modulated radiotherapy treatment (IMRT) demand accurate dose calculation in order to increase target coverage and spare healthy tissue. Both jaw collimator and multi-leaf collimators (MLCs) for photon beams have been used to achieve such goals. In the Pinnacle3 treatment planning system (TPS), which we are using in our clinics, a set of model parameters like jaw collimator transmission factor (JTF) and MLC transmission factor (MLCTF) are determined from the measured data because it is using a model-based photon dose algorithm. However, model parameters obtained by this auto-modeling process can be different from those by direct measurement, which can have a dosimetric effect on the dose distribution. In this paper we estimated JTF and MLCTF obtained by the auto-modeling process in the Pinnacle3 TPS. At first, we obtained JTF and MLCTF by direct measurement, which were the ratio of the output at the reference depth under the closed jaw collimator (MLCs for MLCTF) to that at the same depth with the field size $10{\times}10\;cm^2$ in the water phantom. And then JTF and MLCTF were also obtained by auto-modeling process. And we evaluated the dose difference through phantom and patient study in the 3D-CRT plan. For direct measurement, JTF was 0.001966 for 6 MV and 0.002971 for 10 MV, and MLCTF was 0.01657 for 6 MV and 0.01925 for 10 MV. On the other hand, for auto-modeling process, JTF was 0.001983 for 6 MV and 0.010431 for 10 MV, and MLCTF was 0.00188 for 6 MV and 0.00453 for 10 MV. JTF and MLCTF by direct measurement were very different from those by auto-modeling process and even more reasonable considering each beam quality of 6 MV and 10 MV. These different parameters affect the dose in the low-dose region. Since the wrong estimation of JTF and MLCTF can lead some dosimetric error, comparison of direct measurement and auto-modeling of JTF and MLCTF would be helpful during the beam commissioning.