• 제목/요약/키워드: Washington University

검색결과 699건 처리시간 0.03초

Disseminated Juvenile Pilocytic Astrocytoma in Childhood

  • Kima, JI-Hye;Dennis WW Shaw;Richard Ellenbogen;Geyer J Russel
    • 대한자기공명의과학회:학술대회논문집
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    • 대한자기공명의과학회 2003년도 제8차 학술대회 초록집
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    • pp.38-39
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    • 2003
  • To evaluate the clinical characteristics and outcome of the patients with disseminated pilocytic astrocytoma compared to non-disseminated disease and to discuss treatment options for disseminated disease. We Identified patients with disseminated pilocytic astrocytoma from our Tumor Registry over 21 years of period and reviewed medical records and neuroimages to determine location of the tumor, pattern of dissemination, clinical characteristics, treatment, and outcome. 24 controls without dissemination, matched for age at diagnosis, tumor histology, and primary location were selected from the same registry and case/control comparison was done using Kaplan-Meier survival analysis.

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Bioinspired Polymers that Control Intracellular Drug Delivery

  • Allan S. Hoffman;Patrick S. Stayton;Oliver-Press;Niren-Murthy;Chantal A. Lackey;Charles-Cheung;Fiona-Black;Jean Campbell;Nelson Fausto;Themis R. Kyriakides;Paul-Bornstein
    • Biotechnology and Bioprocess Engineering:BBE
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    • 제6권4호
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    • pp.205-212
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    • 2001
  • One of the important characteristics of biological systems os their ability to change im-portant properties in response to small environmental signals. The molecular mechanisms that biological molecules utilize to sense and respond provide interesting models for the development of "smart" polymeric biomaterials with biomimetic properties. An important example of this is the protein coat of viruses, which contains peptide units that facilitate the trafficking of the virus into the cell via endocytosis, then out of the endosome into the cytoplasm, and from there into the nucleus, We have designed a family of synthetic polymers whose compositions have been de-signed to mimic specific peptides on viral coats that facilitate endosomal escape. Our biomimetic polymers are responsive to the lowered pH whinin endosomes, leading to distruption of the en-dosomal membrane and release of important biomolecular druges such as DNA, RNA, peptides and proteins to the cytoplasm before they are trafficked to lysosomes and degraded by lysosomal en-zymes. In this article, we review our work on the design, synthesis and action of such smart, pH-sensitive polymers.

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Comparing the Operation Cost of Washington Safety Rest Areas with Other States Using Performance-Based Method

  • Shrestha, Kishor;Berg, Alix;Tafazzoli, Mohammadsoroush;Kisi, Krishna
    • 국제학술발표논문집
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    • The 9th International Conference on Construction Engineering and Project Management
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    • pp.640-648
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    • 2022
  • In the United States, the Safety Rest Areas (SRAs) were introduced as highway roadside infrastructures in the early 1900s. The State Departments of Transportation (DOTs) operate/maintain their SRAs using different methods. The Washington DOT used the in-house workforce method for over 20 years, whereas some states moved to Performance-Based Contracting (PBC) from the in-house workforce to save cost primarily. Several existing studies claimed that using the PBC approach saved costs on several highway assets. Thus, the principal objective of this study is to compute and compare the unit operating/maintenance cost of SRAs using the in-house workforce method (in Washington state) with the PBC approach (in other states). The findings of this study show that the average annual cost using the PBC approach was much more than the average annual cost using the in-house workforce approach. The findings also show that in Washington state, the 'Labor Cost' category was a key expenditure, which is statistically higher than other categories. The 'Labor Cost' was followed by the 'Other Services', and then 'Materials and Supplies' and 'Equipment.' The study's findings indicated that outsourcing does not always save costs for agencies. The study findings may help transportation construction/maintenance professionals select a cost-effective approach for their future planning.

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Implications of Air Pollution Effects on Athletic Performance

  • Pierson, W.E.;Covert, D.S.;Koenig, J.Q.;Namekata, T.;Kim, Y.S.
    • 한국환경보건학회지
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    • 제11권2호
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    • pp.1-16
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    • 1985
  • There are a large number or chemical compounds that are present in a polluted atmosphere and that alone or in combination are important to consider for their potential effect on the respiratory system and impact on athletic performance. A general categorization or description of the level of pollution in terms of the concentration of one or more compounds or by type such as oxidizing compounds is inadequate and misleading. A useful initial categorization of pollutant compounds according to their mechanism of production, primary or secondary, is often made. For health effects, consideraiions of the physical state, gaseous or particulate, and the solublity and reactivity of the pollutant is also important. Pollutant compounds or substances that are emitted directly from a source and that undergo little or no chemical change in the atmosphere from source to receptor are termed primary pollutants.

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Registration of 3D CT Data to 2D Endoscopic Image using a Gradient Mutual Information based Viewpoint Matching for Image-Guided Medialization Laryngoplasty

  • Yim, Yeny;Wakid, Mike;Kirmizibayrak, Can;Bielamowicz, Steven;Hahn, James
    • Journal of Computing Science and Engineering
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    • 제4권4호
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    • pp.368-387
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    • 2010
  • We propose a novel method for the registration of 3D CT scans to 2D endoscopic images during the image-guided medialization laryngoplasty. This study aims to allow the surgeon to find the precise configuration of the implant and place it into the desired location by employing accurate registration methods of the 3D CT data to intra-operative patient and interactive visualization tools for the registered images. In this study, the proposed registration methods enable the surgeon to compare the outcome of the procedure to the pre-planned shape by matching the vocal folds in the CT rendered images to the endoscopic images. The 3D image fusion provides an interactive and intuitive guidance for surgeon by visualizing a combined and correlated relationship of the multiple imaging modalities. The 3D Magic Lens helps to effectively visualize laryngeal anatomical structures by applying different transparencies and transfer functions to the region of interest. The preliminary results of the study demonstrated that the proposed method can be readily extended for image-guided surgery of real patients.