• Steel and Composite Structures
• /
• v.37 no.4
• /
• pp.431-446
• /
• 2020

This paper presents the flexural performance of double skin composite beams (DSCBs) at different Arctic low temperatures. 12 DSCBs were prepared and tested under two-point loading at different Arctic low temperatures of 20, -30, -50, and -70℃. The studied parameters include low-temperature level (T), steel-faceplate thickness (t), shear span ratio (λ), and spacing of headed studs (S). The experimental investigations under two-point loading tests showed that flexural failure occurred to all DSCBs, even including the specimen designed with the small λ ratio of 2.9. The ultimate strength behaviours of DSCBs were improved due to the improved mechanical properties of constructional materials and the confinement on shear connectors. The DSCB subjected to two-point loading and low temperatures exhibits a five-stage working mechanism. The stiffness and strength indexes of DSCBs increase linearly with temperature and t value increasing, while decreasing as shear span ratio boosts. In the contrast, the change of S value from 150 to 200 mm has little effect on the ultimate strength behavior of DSCB.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.19
• /
• pp.8429-8433
• /
• 2014

Circulating tumor cells (CTCs) are believed to be particularly important and a reliable marker of malignancy. However, the prognostic significance of CTCs detected in patients with small cell lung cancer (SCLC) is still unclear. We therefore aimed to assess the prognostic relevance of CTCs using a meta-analysis. We searched PubMed for relevant studies and statistical analyses were conducted to calculate the hazard ratio (HR) and 95% confidence intervals (CIs) using fixed or random-effect models according to the heterogeneity of included studies. A total of 7 papers covering 440 SCLC patients were combined in the final analysis. The meta-analysis revealed that CTCs were significantly associated with shorter overall survival (HR=1.9; 95%CI: 1.19-3.04; Z=2.67; P<0.0001) and progression-free survival (HR=2.6; 95%CI: 1.9-3.54; Z=6.04; P<0.0001). The results thus suggest that the presence of CTCs indicates a poor prognosis in patients with SCLC. Further well-designed prospective studies are required to explore the clinical applications of CTCs in SCLC.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.19
• /
• pp.8083-8087
• /
• 2014

Purpose: To investigate the association of IL-17F rs763780T>C with cancer risk. Materials and Methods: We searched the Cochrane Central Library, PubMed, MEDLINE, EMBASE, CNKI (China National Knowledge Infrastructure) and WangFang databases until May 2014 for a meta-analysis conducted using RevMan 5.2 software. Results: A total of ten papers were included into this meta analysis, involving 3, 336 cases and 4, 217 healthy people. There were no significant differences on association of IL-17F rs763780T>C polymorphism with cancer risk except in the CC vs TT genetic model. Although the the risk in the gastric cancer group is higher than that in control group, there were no significant differences on the association of IL-17F rs763780T>C polymorphism with other cancers. Conclusions: Our meta analysis reveal the IL-17A rs763780T>C gene polymorphism is involved in risk of gastric cancer but not other tumor types.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.11
• /
• pp.4423-4428
• /
• 2014

A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.

• Structural Engineering and Mechanics
• /
• v.63 no.6
• /
• pp.837-846
• /
• 2017

An accurate calculation of the stochastic wind field is the foundation for analyzing wind-induced structure response and reliability. In this research, the spatial correlation of structural wind field was considered based on the time domain method. A method for calculating the stochastic wind field based on cross stochastic Fourier spectrum was proposed. A flowchart of the proposed methodology is also presented in this study to represent the algorithm and workflow. Along with the analysis of regional wind speed distribution, the wind speed time history sample was calculated, and the efficiency can therefore be verified. Results show that the proposed method and programs could provide an efficient simulation for the wind-induced structure response analysis, and help determine the related parameters easily.

• Smart Structures and Systems
• /
• v.14 no.6
• /
• pp.1105-1129
• /
• 2014

The unscented Kalman filter (UKF) has been developed for nonlinear model parametric identification, and it assumes that the model parameters are symmetrically distributed about their mean values without any constrains. However, the parameters in many applications are confined within certain ranges to make sense physically. In this paper, a constrained unscented Kalman filter (CUKF) algorithm is proposed to improve accuracy of numerical substructure modeling in hybrid testing. During hybrid testing, the numerical models of numerical substructures which are assumed identical to the physical substructures are updated online with the CUKF approach based on the measurement data from physical substructures. The CUKF method adopts sigma points (i.e., sample points) projecting strategy, with which the positions and weights of sigma points violating constraints are modified. The effectiveness of the proposed hybrid testing method is verified by pure numerical simulation and real-time as well as slower hybrid tests with nonlinear specimens. The results show that the new method has better accuracy compared to conventional hybrid testing with fixed numerical model and hybrid testing based on model updating with UKF.

• BMB Reports
• /
• v.38 no.6
• /
• pp.709-716
• /
• 2005

Apoptosis and necrosis are distinguished by modality primarily. Here we show an apoptosis occurred instantly, induced by $300\;{\mu}M$ W-7 ((N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride), inhibitor of calmodulin), which demonstrated necrotic modality. As early as 30 min after W-7 addition, apoptotic (sub-diploid) peak could be detected by fluorescence-activated cell sorter (FACS), “DNA ladders” began to emerge also at this time point, activity of caspase-3 elevated obviously within this period. Absence of mitochondrial membrane potential (MMP) reduction and cytochrome c, AIF (apoptosis inducing factor) release, verified that this rapid apoptosis did not proceed through mitochondria pathway. Activation of caspase-12 and changes of other endoplasmic reticulum (ER) located proteins ascertained that ER pathway mediated this necrosis-like apoptosis. Our findings suggest that it is not credible to judge apoptosis by modality. Elucidation of ER pathway is helpful to comprehend the pathology of diseases associated with ER stress, and may offer a new approach to the therapy of cancer and neurodegenerative diseases.

• Asian Journal of Atmospheric Environment
• /
• v.12 no.3
• /
• pp.215-231
• /
• 2018

In order to understand the variation of air quality and the concentration of atmospheric particulates in Chengdu Second Ring Road renovation project, this paper starts to investigate the surrounding residents' opinions on the influenced environment and their daily lives via questionnaires. Then the study numerically simulates the change rule of atmospheric particulates in terms of time and space by using the Gaussian dispersion-deposition model and the compartment model. The optimized scientific scheme is selected by the improved fuzzy analytical hierarchy process(FAHP) to help decision making for the future urban reconstructions. Finally, the reduced emissions of atmospheric particulates are measured when the improvement scheme is provided. According to the study, it can be concluded that the concentration of atmospheric particulates increases rapidly in central Chengdu city during the renovation project, which results in worsening air quality in Chengdu during March 2012 to March 2013. Taking related measures on energy saving and emission reduction can effectively reduce the concentration of atmospheric particulates and promote economic, environmental and social coordination.

• Journal of Electrical Engineering and Technology
• /
• v.9 no.6
• /
• pp.1921-1927
• /
• 2014

A new method for optimizing the magnetic field gradient in the exciting coil of electronic anti-fouling (EAF) system is presented based on changing exciting coil size. In the proposed method, two optimization expressions are deduced based on biot-savart law. The optimization expressions, which can describe the distribution of the magnetic field gradient in the coil, are the function of coil radius and coil length. These optimization expressions can be used to obtain an accurate coil size if the magnetic field gradient on a certain point on the coil's axis of symmetry is needed to be the maximum value. Comparing with the experimental results and the computation results using Finite Element Method simulation to the magnetic field gradient on the coil's axis of symmetry, the computation results obtained by the optimization expression in this article can fit the experimental results and the Finite Element Method results very well. This new method can optimize the EAF system's anti-fouling performance based on improving the magnetic field gradient distribution in the exciting coil.

• Steel and Composite Structures
• /
• v.28 no.5
• /
• pp.573-588
• /
• 2018

The objective of this paper is to investigate the mechanical performances of polygonal concrete-filled circular steel tubular (CFT) stub columns under axial loading through combined experimental and numerical study. A total of 32 specimens were designed to investigate the effect of the concrete strength and steel ratio on the compressive behavior of polygonal CFT stub columns. The ultimate bearing capacity, ductility and confinement effect were analyzed based on the experimental results and the failure modes were discussed in detail. Besides, ABAQUS was adopted to establish the three dimensional FE model. The composite action between the core concrete and steel tube was further discussed and clarified. It was found that the behavior of CFT stub column changes with the change of the cross-section, and the change is continuous. Finally, based on both experimental and numerical results, a unified formula was developed to estimate the ultimate bearing capacity of polygonal CFT stub columns according to the superposition principle with rational simplification. The predicted results showed satisfactory agreement with both experimental and FE results.