• 공업화학
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• 제22권1호
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• pp.87-90
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• 2011

열 중량 분석기를 이용하여, 상온에서부터 $600^{\circ}C$까지 10, 20, and $30^{\circ}C/min$의 승온 속도로 바이오매스/플라스틱 혼합물의 혼합열분해를 수행하였다. 바이오매스는 폐목재 우드칩(WWC)을 사용하였고, 플라스틱은 선형저밀도 폴리에틸렌(LLDPE)을 시료로 사용하였다. LLDPE 단독 분해시 $430{\sim}550^{\circ}C$, WWC 단독 분해시는 $230{\sim}600^{\circ}C$에서 분해되었으나, 두 가지 시료를 혼합하여 혼합열분해 한 결과, WWC에 해당하는 분해 온도는 일정한 반면 LLDPE 분해구간의 분해온도가 상승하였다. 이러한 실험결과는 높은 온도범위에서 LLDPE와 WWC이 혼합열분해 되는 동안에 상호작용이 일어났음을 의미한다.

• Molecules and Cells
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• 제43권5호
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• pp.491-499
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• 2020

Hippo signaling acts as a tumor suppressor pathway by inhibiting the proliferation of adult stem cells and progenitor cells in various organs. Liver-specific deletion of Hippo pathway components in mice induces liver cancer development through activation of the transcriptional coactivators, YAP and TAZ, which exhibit nuclear enrichment and are activated in numerous types of cancer. The upstream-most regulators of Warts, the Drosophila ortholog of mammalian LATS1/2, are Kibra, Expanded, and Merlin. However, the roles of the corresponding mammalian orthologs, WWC1, FRMD6 and NF2, in the regulation of LATS1/2 activity and liver tumorigenesis in vivo are not fully understood. Here, we show that deletion of both Wwc1 and Nf2 in the liver accelerates intrahepatic cholangiocarcinoma (iCCA) development through activation of YAP/TAZ. Additionally, biliary epithelial cell-specific deletion of both Lats1 and Lats2 using a Sox9-Cre^ERT2 system resulted in iCCA development through hyperactivation of YAP/TAZ. These findings suggest that WWC1 and NF2 cooperate to promote suppression of cholangiocarcinoma development by inhibiting the oncogenic activity of YAP/TAZ via LATS1/2.

• 한국관개배수회지
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• 25호
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• pp.16-16
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• 2001

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2006년도 학술발표회 논문집
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• pp.1348-1351
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• 2006

Recently human beings face serious water crisis, namely water management at the critical moment because of rapid increasing in population, subordinate part of a national budget, water pollution by domestic use and industrial use or waste, agricultural water use by intensive market farming, excessive development and extraction of water sources, and etc. We become to recognize that water and sanitation is the one of most important part which is threatening us with a drain on the water resources and death around the world and then are making opportunities of discussion for water policies and solutions of water problems through international network such as Global Water Partnership(GWP), World Water council(WWC). World Water Forum(WWF), as one of main water-related activities, aims at sharing knowledge and experience among various stakeholders for accomplishing a holistic water resources management by making common thoughts regarding the necessity of integration among different organizations related with water management, problems and issues. Also the unity of each local area for the holistic approach focuses on showing present local actions and actively supporting them, and suggesting new ideas. With Korea's participation in the 4th WWF this year, Korean government should have consistency in its establishment and implementation of sustainable water resources policies as a more active and future-oriented member of international water network. Finally it will be necessary that we will set up an organization and system which does publicity activities about results of various local actions of Korea around the world through next WWF in the future and contribute to solving global water problems.

• Ocean Systems Engineering
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• 제6권3호
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• pp.265-287
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• 2016

The change of the global performance of a turret-moored FPSO (Floating Production Storage Offloading) with DP (Dynamic Positioning) control is simulated, analyzed, and compared for two different internal turret location cases; bow and midship. Both collinear and non-collinear 100-yr GOM (Gulf of Mexico) storm environments and three cases (mooring-only, with DP position control, with DP position+heading control) are considered. The horizontal trajectory, 6DOF (degree of freedom) motions, fairlead mooring and riser tension, and fuel consumptions are compared. The PID (Proportional-Integral-Derivative) controller based on LQR (linear quadratic regulator) theory and the thrust-allocation algorithm which is based on the penalty optimization theory are implemented in the fully-coupled time-domain hull-mooring-riser-DP simulation program. Both in collinear and non-collinear 100-yr WWC (wind-wave-current) environments, the advantage of mid-ship turret is demonstrated by the significant reduction in heave at the turret location due to the minimal coupling with pitch mode, which is beneficial to mooring and riser design. However, in the non-collinear WWC environment, the mid-turret case exhibits unfavorable weathervaning characteristics, which can be reduced by employing DP position and heading controls as demonstrated in the present case studies. The present study also reveals the plausible cause of the failure of mid-turret Gryphon Alpha FPSO in milder environment than its survival condition.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.75-80
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• 2013

Background: Breast cancer is the most common cancer diagnosed in females in Sri Lanka and early detection can lead to reduction in morbidity and mortality. Aim: To evaluate selected aspects of breast cancer early detection services implemented through well woman clinics (WWCs) in the Gampaha District. Methods: The study consisted of two components. A retrospective descriptive arm assessed clinical breast examination (CBE) coverage of target age group women (TGW) of 35-59 years in all the WWCs in Gampaha district over 2003-2007. A cross sectional descriptive study additionally assessed quality of breast cancer early detection services. The Lot Quality Assurance Sampling (LQAS) technique was used to decide on the lot size and threshold values, which were computed as twenty and six clinics. Checklists were employed in assessing coverage, physical facilities and clinic activities. Client satisfaction on WWC services was assessed among 200 TGW attending 20 WWCs using an interviewer-administered questionnaire. Results: CBE coverage in the Gampaha district increased only from 1.1-2.2% over 2003-2007. With regard to physical facilities, the number of clinics that were rated substandard varied between 7-18 (35-90%). The items that were lacking included dust bins, notice boards, stationary, furniture and linen, and cleanliness of outside premises and toilets. With regard to clinic activities, punctuality of staff, late commencement of clinics, provision of health education, supervision, CBE and breast self-examination (BSE) were substandard in 7-20 clinics (35-100%). Client satisfaction for WWC services was 45.2% (IQR: 38.7-54.8%) and only 11% had a score of ${\geq}70%$, the cut off set for satisfaction. Conclusions: Breast cancer early detection service coverage in the Gampaha district remained low (2.2%) in 2007, 11 years after commencing WWCs. All 20 clinics were substandard for overall CBE and BSE.

• Ocean Systems Engineering
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• 제8권3호
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• pp.247-279
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• 2018

This study aims to investigate the behavioral characteristics of the LWSCR (lazy-wave steel catenary riser) for a turret-moored FPSO (Floating Production Storage Offloading) by using fully-coupled hull-mooring-riser dynamic simulation program in time domain. In particular, the effects of initial geometric profile on the global performance and structural behavior are investigated in depth to have an insight for optimal design. In this regard, a systematic parametric study with varying the initial curvature of sag and arch bend and initial position of touch down point (TDP) is conducted for 100-yr wind-wave-current (WWC) hurricane condition. The FPSO motions, riser dynamics, constituent structural stress results, accumulated fatigue damage of the LWSCR are presented and analyzed to draw a general trend of the relationship between the LWSCR geometric parameters and the resulting dynamic/structural performance. According to this study, the initial curvature of the sag and arch bend plays an important role in absorbing transferred platform motions, while the position of TDP mainly affects the change of static-stress level.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2011년도 학술발표회
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• pp.454-454
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• 2011

녹색성장은 최근 세계적인 이슈가 되고 있다. 세계물위원회(World Water Council, WWC)의 경우 2012년 마르세유에서 개최되는 제6차 세계물포럼(World Water Forum, WWF)에서 물문제 해결을 위한 신개념 패러다임으로서 '녹색성장(Green Growth)'을 채택하기 위한 협력방안의 필요성을 제안하고 있다. 우리나라에서는 이미 녹색성장을 국가 슬로건으로 선정하고 글로벌 녹색성장연구소(Global Green Growth, GGGI)를 설립하는 등 녹색성장을 선도하고 있다. 이는 물의 중요성에 비추어볼 때 녹색성장을 물 분야에 확산시킬 수 있는 적절한 기회로 보인다. 녹색성장은 물 관련 환경서비스가 환경오염 없는 경제성장을 이룩하는 데 주요한 역할을 수행할 수 있다는 가능성과 당위성에서 파생된 최근에 만들어진 개념으로서, 물 분야의 경우 녹색경제에 있어서 중요한 역할을 수행해왔으며 이후 지속적인 인구증가, 물 소비패턴의 변화, 에너지비용 증가, 기후 변화 등으로 물 분야의 중요성은 더욱 커질 것으로 기대된다. 이처럼 물 관리는 경제발전, 재해로부터 보호, 인간의 건강 및 생태계와 삶의 질을 위하여 필수적이기에 녹색성장에 있어 중요한 역할을 수행하고 있다. 하지만 올바른 물 관리가 녹색성장에 기여할 수 있는 방법에 대해서는 아직 명확화 구체화되지 못하고 있는 실정이다. 이에 따라 녹색성장을 새로운 국가 성장 동력의 패러다임으로 구축하기 위해 수자원분야에서의 녹색성장방법론을 정립하고, 선진국과 개도국 정부들의 균형 있는 참여를 통한 글로벌 파트너십 구축이 요구되고 있으며, 이를 세계물위원회 등 국제기구와 공동으로 연계시킨다면 상당한 시너지 효과가 기대된다. 물관리는 국가의 경제발전, 재해로부터 생명과 재산의 보호, 인간의 건강 및 생태계 다양성 및 건전성 유지와 삶의 질을 향상을 위하여 매우 중요하며, 환경보존과 경제성장을 동시에 추구하는 녹색성장을 실현하는 데 있어서도 가장 핵심적인 사항이라고 할 수 있다. 그러나 올바른 물 관리가 녹색성장에 기여할 수 있는 방법에 대해서는 아직 명확하고 구체화 되지 못하고 있는 실정이다. 따라서 본 연구에서는 '물과 녹색성장'의 이론적 배경, 필요성, 개념정립, 벤치마킹 사례, 국제사회에서의 녹색성장과 관련한 논의 기구 및 흐름 등의 이해를 기초로 녹색성장을 통한 경제성장의 상호작용과 선순환구조를 체계화시키기 위한 균형방안을 제시하고자 한다. 또한 수자원 및 하천관리 분야에서의 WGG구현을 위한 정책제안 및 실행방안이 담긴 중장기 로드맵을 구축하여 물을 통한 성장의 발판을 마련하고자 한다.