• 한국산학기술학회논문지
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• 제14권4호
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• pp.1737-1746
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• 2013

본 연구는 농촌지역 중 노년기 여성을 대상으로 건강교육과 운동프로그램을 실시하여 체성분과 혈중지질, 골밀도 및 건강행태에 미치는 영향을 확인하기 위하여 시도하였다. 중 노년기 여성 33명을 대상으로 2012년 3월 5일부터 2012년 5월 31일까지 12주간 건강교육과 운동프로그램을 실시하였으며, 체성분과 혈중지질, 골밀도 및 건강행태에 미치는 효과를 확인하기 위해 단일군 전후설계로 paired t-test, ANCOVA를 실시하였다. 프로그램 적용 후, 평균체중과 BMI, 체지방량, 총콜레스테롤, 중성지방, LDL콜레스테롤, 골밀도, 운동과 음주 및 흡연에 대한 건강행태에서 유의한 변화가 있었다. 따라서 3개월 이상의 강도 높은 유산소운동과 개인별 맞춤 근력운동을 적절하게 병행한 운동프로그램의 기획 및 제공이 필요할 것으로 판단되며, 개인별 건강행태변화를 위해서 대상자에게 초점을 맞춘 건강교육을 횟수를 늘려 제공하는 등 기존의 프로그램을 보완한 체계적인 관리가 지역사회에서 실천되도록 해야 할 것이다.

• 대한수의학회지
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• 제54권1호
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• pp.1-6
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• 2014

Parkinson's disease is known to exhibit progressive degeneration of the dopaminergic neurons in the substantia nigra via inhibition of glutathione metabolism. It is well known that 6-Hydroxydopamine (6-OHDA) induces Parkinson's disease-like symptoms, while resveratrol (3,5,4'-trihydroxystilbene) has been shown to have anti-inflammatory and antioxidant effects. In the present study, we investigated the neuroprotective effects of resveratrol, a phytoalexin found in grapes and various plants, on 6-OHDA-induced cell damage to the SH-SY5Y human neuroblastoma cell line. Resveratrol (5 and 10 ${\mu}M$) inhibited 6-OHDA (60 ${\mu}M$)-induced cytotoxicity in SH-SY5Y cells and induced a reduction of the number of apoptotic nuclei caused by 6-OHDA treatment. Additionally, the total apoptotic rate of cells treated with both resveratrol (10 ${\mu}M$) and 6-OHDA (60 ${\mu}M$) was less than that of 6-OHDA treated cells. Resveratrol also dose-dependently (1, 5 and 10 ${\mu}M$) scavenged reactive oxygen species (ROS) induced by 6-OHDA in SH-SY5Y cells and prevented depletion of glutathione in response to the 6-OHDA-induced cytotoxicity in the glutathione assay. Overall, these results indicate that resveratrol exerts a neuroprotective effect against 6-OHDA-induced cytotoxicity of SH-SY5Y cells by scavenging ROS and preserving glutathione.

• Toxicological Research
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• 제35권1호
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• pp.83-91
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• 2019

Nanoparticles (NPs) have been recognized as both useful tools and potentially toxic materials in various industrial and medicinal fields. Previously, we found that zinc oxide (ZnO) NPs that are neurotoxic to human dopaminergic neuroblastoma SH-SY5Y cells are mediated by lipoxygenase (LOX), not cyclooxygenase-2 (COX-2). Here, we examined whether human bone marrow-derived mesenchymal stem cells (MSCs), which are different from neuroblastoma cells, might exhibit COX-2- and/or LOX-dependent cytotoxicity of ZnO NPs. Additionally, changes in annexin V expression, caspase-3/7 activity, and mitochondrial membrane potential (MMP) induced by ZnO NPs and ZnO were compared at 12 hr and 24 hr after exposure using flow cytometry. Cytotoxicity was measured based on lactate dehydrogenase activity and confirmed by trypan blue staining. Rescue studies were executed using zinc or iron chelators. ZnO NPs and ZnO showed similar dose-dependent and significant cytotoxic effects at concentrations ${\geq}15{\mu}g/mL$, in accordance with annexin V expression, caspase-3/7 activity, and MMP results. Human MSCs exhibited both COX-2 and LOX-mediated cytotoxicity after exposure to ZnO NPs, which was different from human neuroblastoma cells. Zinc and iron chelators significantly attenuated ZnO NPs-induced toxicity. Conclusively, these results suggest that ZnO NPs exhibit both COX-2- and LOX-mediated apoptosis by the participation of mitochondrial dysfunction in human MSC cultures.

• 동의생리병리학회지
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• 제35권5호
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• pp.162-168
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• 2021

This study was conducted to investigate the current status of online classes and evaluations during the COVID-19 pandemic and the satisfaction of students attending the College of Korean Medicine. A survey was conducted with students enrolled in Dongguk University's College of Korean Medicine. The questionnaire was divided into four areas asking about online lectures, laboratory practice, clinical practice, and evaluation experience. The items were composed of multiple-choice, a 5-point scale, and subjective type. After distributing the Google form address through SNS and LMS, only those who agreed to the questionnaire were responded anonymously. 149 out of 457 enrolled students responded. 98.7% of students experienced online lectures, and more frequently experienced real-time online lectures (98.6%) than recorded lectures (43.5%). Overall satisfaction with online lectures was 3.99 on average. 80.5% of the students experienced the online experiment and practice class, and the overall satisfaction with it was 3.29 on average. 1.3% of students experienced online clinical practice. 86.6% of students experienced online evaluation, and when asked about the fairness of the test, the average score was 3.99. Satisfaction with online lectures and evaluations is generally high, so it is expected to be used as an effective learning tool in the future. However, it seems that facility improvement and technical training of instructors are necessary. In experimental and practical education, the satisfaction level is lower than that of online lectures, so it seems necessary to develop a new online program and to prepare a safe offline education system.

• 산업융합연구
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• 제20권3호
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• pp.63-71
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• 2022

본 연구는 지역사회 당뇨병 환자를 대상으로 자가간호에 대한 기능성 게임을 접목한 모바일 헬스케어 앱('롤리폴리 160')의 효과를 검증하고자 시도하였다. 개발된 '롤리폴리 160'의 품질을 자체 평가한 후, G광역시 병의원과 보건소에서 당뇨 진료를 받은 120명의 당뇨환자를 모집하였다. 동구에 거주하는 60명의 당뇨환자를 실험군으로 배치하여 '롤리폴리 160'을 12주 동안 하루 5-10 분, 일주일에 5번 이상 사용하도록 하였고. 서구에 거주하는 60명 대조군은 실험전 집단강의를 받고, 12주 동안 스스로 당뇨관리를 하도록 하였다. 두 군 모두에게 실험 전후 자가간호 수행을 측정하였다. 수집 된 데이터는 빈도분석, 기술통계, t-test, 교차분석하였다. 연구결과 실험군의 약물요법, 발관리, 운동요법, 식이요법 자가간호 점수가 사전보다 사후에 통계적으로 유의미하게 증가하였다. 반면, 대조군의 식이요법 자가간호 점수는 사전보다 사후에 통계적으로 유의미하게 감소한 것으로 나타났다. 따라서 향후 '롤리폴리 160'는 당뇨환자의 자가간호를 위한 간호중재 프로그램으로 활용될 수 있을 것이다.

• 농촌의학ㆍ지역보건
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• 제21권2호
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• pp.151-157
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• 1996

This study was analyze through the reports which published on the subject matter of Su Dong-Myun from year of 1972-1993, and analysis of data in 1994 was performed with medical records on the health subcenter by PC-SAS program. The result are as follows: The number of population in Su-Dong Myun(study area) was 5,707 in 1995, 4,641 in 1985 and 5,424 in 1975. In the composition rate of population "0-14" of age group only showed markedly decreasing tendancy from 42.8% in 1975 to 19.1% in 1995. However, "65 and over" showed markedly increasing tendancy from 5.7% in 1975 to 9.8% in 1995. Annual utilization rate showed rapidly increasing tendency from year of 1972 to 1978, such as 314 per showed rapidly decreasing tendency, such as 708 in 1981, 485 in 1984, 272 in 1987, 309 in 190 and in 1993. In the annual age-specific utilization rate, the age group of "0-14" showed the highest rate of 621 per thousand population in 1975, 1159 in 1980, 1021 in 1985 and 538 in 1990. However the age group of "65 and over" showed the highest rate of 481 in 1994. Age specific annual utilization rate showed markedly decreasing tendency in the age group of "0-14" and "15-44", however showed slightly decreasing tendency or same level in the group of "45-64" and "65 and over" from year of 1980 to 1994. In the age specific utilization rate, the lower down the age was, the higher tendency the rate showed, such as 621 per 1,000 population in "0-14" of the age group, 543 in "15-44", 406 in "45-64" and 294 in "65 and over" in 1975. However, the higher up the age was, the higher tendency the rate showed in 1980, 1985 and 1994, except "0-14" of age group. The 5 major diseases were disease of Respiratory system, Gastrointestinal system, Skin and Subcutaneous tissue, Accidents, Poisoning and Violence and Nervous system and Sense organ, in 1975, 1980 and 1985. However, in 1990 and 1994, the 5 major disease were disease of Respiratory system, Gastrointestinal system. Skin and Subcutaneous tissue, Musculoskeletal system and, Connective tissue and Circulatory system. In Composition rate of patient in Su Dong-Myun Health Subcenter by Charged Medical Fee, medical insurance showed almost all the highest rate of 93.9% in year of 1994 and C.H.D.A. of 100% in 1975. Proportion of insurance showed increasing tendency such as 6.6% in 1980, 21.3% in 1985, 69.0% in 1990 and relatively C.H.D.A. showed decreasing tendency.

• Journal of Preventive Medicine and Public Health
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• 제12권1호
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• pp.13-23
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• 1979

A study was carried out from October 1977 to September 1978 in order to develope health care delively system which will meet to rural area in Korea. For the study objective a model of health care delivery system of Myun (township) area was developed which is adopted the net-work of village health voluntary worker who will play the role of bridge for communication related with health and illness between families or village people and health subcenter, and :he model health care delivery system net-work was set in the area of Soodong Myun, Yangju Gun. which is the rural health demonstration area of Ewha Womans University since 1972. The activities and attitude of 22 village health voluntary workers were observed and analized. during the study period. The results are as follows; 1. For the field activities of village health voluntary workers. a guide line which is described with specific behavioral objectives was developed and used for not only training of the workers but also evaluation of their field activities. 2. During the study period, the number of 971 village people were served primary health care service by village health voluntary worker and the service was classified largely into symptomatic medications (92%) and preventive measures (8%). 3. Comparative percentage of the number of 894 symptomatic cases cared by village health voluntary workers to 5,695 cases of patient treated by Soodong Health Subcenter during the same period was 15.7%. 4. Annual utility rate of village health voluntary worker by Myun total people was 16.1% but utility rate by Rie was varied from 38.2% to 2.8% which shown there were considerable differences in each Rie. In order to settle the village health care service, the obstructive factors of utility should be detected and their counter measure must be taken. 5. As the health need of village people increases, it is expected that the supplement of drug excluding present sit basic drugs is inevitable, but considering the ability of village health voluntary worker, the selection of additional drugs and education, plan should be carefully studied. 6. It is desirable that a financial resource for supplementary purchase of first aid kit, drugs and materials whould be alloted from village public fund like Saemaeul Women's Club fund, which has already practiced in a few villages in the study area. 7. As pointed out by village health voluntary workers, in order to improve the village health, village leaders should be in the center of it and the cooperation of whole village people is a core of healthful village development, and it is reasonable that the health subcenter backs up these voluntary health activities by village people in techniques. 8. It seems effective that a supplementary education for village health voluntary worker be accomplished by a planned education through regular meetings like worker's monthly meeting and irregular post guide when Myun Health Workers can handle the problems found during the round trip of villages. 9. It is desirable that village health voluntary workers, who are recommended by a civil voluntary organization like Saemael Woman's Club, are charged by natural villagc unit, are given a function of village health care service and used through basic education at health subcenter. 10. It is advisable that the village health voluntary worker's service is compensated not by a form of money, but by other way such as an exemption of medical fee of worker herself or her families in health subcenter can be one method. 11. Daily health activities of each village health voluntary worker should be reported to health subcenter by biweekly or monthly in order to get not only for basic data of the program but also for evaluation the program. It is recomandable that the report form should be simple and clear enough for village health voluntary worker to fill it effectively. 12. Village health care service should be developed into a Saemaeul Movement in which village people actively participate. For this, the appointed function of village health voluntary worker should be absorbed into those of living Environment Betterment Section or Family Planning Section of Saemaeul Women's Club or it is desirable that establish a new section, Village Health Promoting Section and make it involve the appointed functions of those sections mentioned above.