• Journal of Chest Surgery
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• 제26권7호
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• pp.521-525
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• 1993

Sixty-three patients who underwent open mitral commissurotomy at Sejong General Hospital during last 10 years from the August, 1983 to June, 1993 were reviewed There were fifty-one women and twelve men, and the mean age was 34.2 years. According to the NYHA classification, the distribution of patient preoperatively was as follows: class I, 5 patients ; class II, 26 patients ; class III, 30 patients ; class IV, 2 patients, and mean duration of symptome was 4.5 years. The mean mitral valvular area measured with echocardiogram preoperatively was 0.92cm2. All patients underwent open mitral commissurotomy and 41 patients required additional procedures for relief of subvalvular stenosis or other valvular disease. There were no operative death. 63 patients had three different types of mitral stenosis : type I, mobile cusps without subvalvular change [21 patients] ; typeII, thickened cusps with subvalvular change [34 patients] ; type III, rigid cusps with severe subvalvular change [8 patients]. The valvular calcification was seen in 11 patients [17%] and 15 patients [24%] had left atrial thrombus. The duration of follow-up was from 1 month to 168 months [mean, 39.6 months] and there were no late death. Six patients required reoperation and one patient had embolic episode. Conclusively,the open mitral commissurotomy represents a safe surgical precedure for treating mitral stenosis, allowing a complete removal of atrial thrombosis if present, and even when associated with subvalvular changes.

• Childhood Kidney Diseases
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• 제3권1호
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• pp.80-87
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• 1999

목 적 : 루프스 신염은 전신성 홍반성 낭창(systemiclupuserythematosus,SLE)의 가장 심각한 합병증 가운데 하나이지만, 소아 연령에서 루프스 신염에 대한 국내 연구는 미약한 실정이다. 본 연구는 루프스 신염 환자를 대상으로 빈도, 임상상, 치료반응, 예후 등에 대한 기초 조사를 실시하여 향후 전국 규모의 다기관 연구를 위한 기반 자료로 사용하기 위함이다. 방 법 : 1986년부터 1997년 11년 동안 서울대학교 어린이병원 소아과에 입원한 SLE환아 53례 중 신생검상 루프스 신염이 확인된 46례를 대상으로 후향적 의무기록 고찰을 시행하였다. 결 과 : 1) 전체 남녀비는 1:2.5, 루프스 신염의 진단 당시 정중연령은 12.8세(2세-15세 8개월)이었다. 2) ARA 분류 기준 중 형광항핵항체($85.7\%$), 항ds-DNA항체($78.0\%$), 나비모양 홍반($60.8\%$) 등이 가장 빈번히 관찰되었으며, 기타 검사 소견중에서는 C3의 감소($88.9\%$)가 흔하였다. 3) 혈뇨($87.0\%$)는 가장 흔한 신장 증상이었고, 신생검상 41례에서 WHO class IV 병변이 확인되었다. 4) Prednisolone, azathioprine, 경구 또는 정맥 cyclophosphamide 등을 단독 또는 병합치료 결과 대부분 환자에서 질환 활성도가 정상 혹은 중증도 이하로 조절되었으며, 치료 종류에 따른 반응도의 차이는 관찰할 수 없었다. 5) 감염은 치료 경과중 가장 흔한 합병증이었으며, 특히 Varicella-Zoster virus와 candida 감염증이 흔하였다. 결 론 : SLE 환아중 루프스 신염의 빈도는 $87.0\%$이었고, 그중 $89.1\%$가 장기적 예후가 불량한 WHO class IV 로 확인되었다. 따라서 신염 초기의 적극적인 면역억제제 사용이 장기적 예후 향상에 도움을 주리라 사료되며, 이에 대한 장기간의 전향적-비교연구를 위하여 다기관 공동연구가 절실히 필요하다.

• Journal of Chest Surgery
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• 제20권2호
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• pp.317-322
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• 1987

Records of 15 patients who underwent operation for constrictive pericarditis at this department from 1976 through 1984 were reviewed. All had hemodynamically significant pericardial constriction preoperatively, and pericardial disease was confirmed at operation. There were 12 males and 3 females in this series. Range of age varied from 7 years to 51 years. Clinical and histological study revealed granulomatous pericarditis compatible with the diagnosis of tuberculosis in 5 patients, non-specific chronic inflammatory changes in 6 patients and pyogenic pericarditis in 2 patients. Pericardiectomy was performed through a median sternotomy [11 cases] or bilateral anterior thoracotomy [4 cases]. The postoperative complications were observed in 4 patients. Low cardiac output was the most common complication [2 patients]. In 13 cases, excluding 2 operative deaths, preoperatively all were in New York Heart Association Class III or IV. At the time of discharge II [85%] were in Class I or II. 4 Cases were reoperated after original pericardiostomy and all resulted in marked improvement. Early surgical intervention is advisable in all patients in whom cardiac constriction is caused by either a thickened pericardium or a pericardial effusion before myocardial dysfunction occurs.

• Journal of Chest Surgery
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• 제20권2호
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• pp.300-308
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• 1987

Clinical and pathologic data were reviewed in 20 patients who had have surgery for isolated aortic valvular heart disease between April 1978 and April, 1987. Hospital mortality was 10%, with no additional late mortality during a mean follow-up period of 24.1 months. Prosthetic valve failure developed in 3 patients and two had reoperation. Niety four percent of the survivors who were in NYHA Funtional class III or IV before operation are now in class I or II. Ninety percent of all patients are still alive at a maximum follow up of 9 years. The clinical histories, gross and histologic examination of valves estabilished the causes for isolated aortic valve disease: 3 rheumatic, 2 congenital bicuspid, 2 hypertention, 2 aortitis and each one case of floppy valve, medial cystic necrosis of aorta, bacterial endocarditis. But etiology was unknown in 8 cases. Sixteen patietns had myxoid degeneration, defined as significant disruption of the valve fibrosa and its replacement by acid mucosaccharides and cystic changes. Myxoid degeneration was also the primary pathologic abnormality in the patients with 2 hypertention, 2 rheumatic, 1 aortitis, 1 bacterial endocarditis, 1 floppy valve, 1 congenital bicuspid. The patients with myxoid degeneration of uncertain origin were 8. Histologic finding of all of them revealed nonspecific patients with myxoid degeneration of uncertain orgin were 8. Histologic finding of all of them revealed nonspecific chronic valvulitis with myxoid degeneration. This finding may indicate that the etiology w uld be infectious.

• Journal of Chest Surgery
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• 제42권3호
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• pp.350-354
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• 2009

배경: 복잡한 흉막강내 공간차지병소(complicated pleural space occupying lesions, SOL)의 치료는 그 병의 진행정도와 상태에 따라 흉막천자, 폐쇄식흉강삽관술, 섬유소용해제의 주입, 그리고 흉강경이나 개흉술을 이용한 수술적 치료 등이 선택될 수 있다. 특히 비디오 흉강경 수술이 발달함에 따라 개흉술의 단점을 극복하여 보다 적극적으로 비디오 흉강경을 이용한 수술(VATS)을 시행하여 좋은 결과를 보고하고 있다. 이에 저자들은 비디오 흉강경을 이용한 흉막 유착박리술과 박피술의 유용성과 조기수술의 효과에 대해 알아보고자 의무기록과 방사선 기록을 후향적으로 조사, 분석하였다. 대상 및 방법: 1996년 5월부터 2006년 4월까지 complicated plerual SOL 환자 64명(평균연령 $41.8{\pm}19.8$세)에서 시행한 65예의 VATS 흉막 박피술과 흉막 유착박리 술을 분석하였다. 결과 분석을 위해 수술후 단순흉부방사선 소견을 임의로 4군(Class)으로 나누었다. Class I: no or minimal pleural lesion, class II: blunting of costophrenic angle and mild pleural thickening, class III: elevated diaphgram or persistent lung collapse, class IV complicated or recurrent effusion. 결과: 수술전 환자들은 진단적, 치료적 시술로 41예에서 흉막천자술, 10예에서 pigtail catheter 삽입술, 11예에서 폐쇄식흉강삽관술, 그리고 10예에서 섬유소용해제 주입을 받았다. 증상발현 후부터 수술까지의 기간이(증상발현기간)평균 18.4일이었고, 심각한 합병증이나 사망예는 없었다. 수술결과 Class I 28예, II 13예, III 19예, IV 5예였으며, 증상발현기간과 수술시간과의 관계에서 통계적으로 유의한 차이를 보였다. 또한 증상발현기간 18일을 기준으로 조기수술군과 지연수술군으로 나누어 비교하면 단순흉부방사선 소견 class별로 빈도수에서 두군간에 유의한 차이를 보였다. 결론: 비디오 흉강경을 이용한 흉막 유착제거 술과 박피술은 Complicated pleural SOL 치료를 위한 안전하고 효과적인 방법이고, 보다 좋은 결과를 위해서 조기에 적극적인 수술이 필요하다.

• Journal of Periodontal and Implant Science
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• 제25권1호
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• pp.121-132
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• 1995

Patients, who have gingival recession and complain of root sensitivity, or esthetic concerns, are candidates for root coverage. When free gingival grafting is used for complete root corverage, the results may not be entirely predictible unless the recession is shallow and narrow because a free gingival graft depends on collateral circulation from the lateral and apical parts of the recipient bed to survive over the avascular root. Various pedicle graft techniques can produce more esthetic results, but these procedures are only indicated when adequate donor tissues are available adjacent to the defect. This case report presents three cases for root coverage using the various connective tissue graft techniques. In the first case(Class III & IV), subepithelial connective tissue grafting was done and resulted in gingival coverage on the two-thirds of exposed root surface and blended with the adjacent tissue in color and texture. In the second case(Class I), connective tissue and partial thickness double pedicle graft resulted in complete coverage of denuded root surface. In the third case(Class I), recession was treated by supraperiosteal envelope technique. The root surface was covered completely and esthetically. Finally, the esthetics in both colors and tissue contours were acceptable to patients in all cases by the connective tissue grafting. However, in the case of the reduced interdental bone, the denuded root surfaces were hardly covered completely.

• Journal of Chest Surgery
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• 제28권4호
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• pp.355-359
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• 1995

A clinical analysis was performed on 48 cases with mitral stenosis who received open mitral commissurotomy from December 1983 to June 1991 at the Department of Thoracic & Cardiovascular Surgery, Chungnam National University Hospital. Fifteen patients were men and 33 were women. the mean age was 35.6 years with the range of 16 to 61 years. The distribution of preoperative NYHA Functional Classes was as follows; class II, 25 patients; class III, 20 patients; class IV, 3 patients. Three patients had cerebral emboli preoperatively, all of whom were in atrial fibrillation. The preoperative electrocardiographic studies revealed that 32 patients had sinus rhythms and 16 had atrial fibrillations. Twenty-six patients had open mitral commissurotomy alone and 22 patients had additional cardiac procedures. Intraoperatively, there were 6 cases of left atrial thrombosis. There was no perioperative death but early postoperative complications were found in 3 cases. The patients were followed up from 2 to 99 months[mean 33.7 months . There was one case of late unexplained sudden death. There was a case of late postoperative cerebral infarction, 5 cases of mitral restenosis and 3 cases of congestive heart failure and/or arrhythmia. Mitral valve replacements were required in 3 patients.But, it is evident that open mitral commissurotomy has many advantages beyond mitral valve replacement concerning the results of the mitral valve replacement underwent during the same period at the Department of Thoracic & Cardiovascular Surgery, Chungnam National University Hospital.

• Journal of Chest Surgery
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• 제25권11호
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• pp.1346-1353
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• 1992

From Febrary 1984 to July 1992, 138 cases of multiple valve replacements were performed at the Department of Thoracic and Cardiovascular Surgery, Dongsan Medical Center, Keimyung University. There were 81 females and 57 males, and their ages ranged from 19 to 60 years [mean age, 40.1$\pm$10.9 years]. Thirteen of these patients had undergone previous cardiovascular procedures, with an average of 76.3 months between procedures[range, 3 to 180 months]. Mitral and aortic valve replacement were done in 135 patients, 2 underwent triple valve replacement and 1 underwent mitral and tricuspid valve replacement. Associated procedures were necessary in 20 patients[14.5%]. The operative mortality was 5.8% and the most common cause was low cardiac output. Late follow-up of 83% has been accomplished in 130 early survivors, with a late mortality of 5.9%. The late mortality was due to valve thrombosis in 2 patients, cerebral infarction in 1, heart failure in 1, arrhythmia in 1, and bleeding in l. Of those patients who survived, New York Heart Association functional class improved significantly[from 70% class III and IV before to 88% class I and II after]. Actuarial survival rate including all deaths was 88.8% at 8 years. The follow-up studies revealed that thromboembolism, reoperation and bleeding rate were 1.2%/patient-year, 0.85% /patient-year and 0.57%/patient-year at 8 years postoperatively. We concluded that valve thrombosis, embolism, and anticoagulant-related hemorrhage were the main risk factors of longterm survival of patients.

• Radiation Oncology Journal
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• 제27권3호
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• pp.140-144
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• 2009

목 적: 전이성 뇌종양 환자에서 전뇌조사를 시행받은 160명의 환자를 대상으로 원발 종양 가중치에 따른 생존율을 후향적으로 분석해보고자 하였다. 대상 및 방법: 2002년부터 2008년 사이에 인하대병원에서 전이성 뇌종양으로 진단받은 암환자들 중 전뇌 조사 방사선 치료 30 Gy를 받은 160명의 환자를 대상으로 후향적으로 분석하였다. 원발성 종양이 유방암인 경우는 20명, 폐암인 경우는 103명이었다. 160명의 환자 중 척수 연수막 전이(leptomeningeal seeding) 환자를 제외한, 142명의 환자를 대상으로 예후 인자 및 Recursive Partitioning Aanalysis (RPA) 분류에 따른 생존율, 중앙생존기간과, RPA 분류에 원발 종양의 종류에 따라 가중치를 둔 새로운 Weighted Partitioning Analysis (WPA) 분류에 따른 생존율과 중앙생존기간을 분석하였고 RPA분류와 비교 분석하였다. 결 과: RPA분류에 의한 중앙생존기간은 분류 I (8명), 분류 II (76명), 분류 III (58명)가 각각 20.0개월, 10.0개월, 3.0개월이었으며(p=0.003), WPA 분류의 경우에는 분류 I (3명), 분류 II (9명), 분류 III (70명), 분류 IV (60명)가 각각 36개월, 23.7개월, 10.9개월, 8.6개월로(p=0.001) RPA 분류보다 더 우위성을 보였다. 결 론: 새로운 예후 지표인 WPA 분류가 기존의 RPA 분류보다 전이성 뇌종양 환자에서 치료 방침을 결정함에 있어 도움을 줄 것으로 생각된다.

• Restorative Dentistry and Endodontics
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• 제42권1호
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• pp.48-53
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• 2017

Objectives: The aim of this study was to investigate the ability of the fluorescence-aided caries excavation (FACE) device to detect residual caries by comparing conventional methods in vivo. Materials and Methods: A total of 301 females and 202 males with carious teeth participated in this study. The cavity preparations were done by grade 4 (Group 1, 154 teeth), grade 5 (Group 2, 176 teeth), and postgraduate (Group 3, 173 teeth) students. After caries excavation using a handpiece and hand instruments, the presence of residual caries was evaluated by 2 investigators who were previously calibrated for visual-tactile assessment with and without magnifying glasses and trained in the use of a FACE device. The tooth number, cavity type, and presence or absence of residual caries were recorded. The data were analyzed using the Chi-square test, the Fisher's Exact test, or the McNemar test as appropriate. Kappa statistics was used for calibration. In all tests, the level of significance was set at p = 0.05. Results: Almost half of the cavities prepared were Class II (Class I, 20.9%; Class II, 48.9%; Class III, 20.1%; Class IV, 3.4%; Class V, 6.8%). Higher numbers of cavities left with caries were observed in Groups 1 and 2 than in Group 3 for all examination methods. Significant differences were found between visual inspection with or without magnifying glasses and inspection with a FACE device for all groups (p < 0.001). More residual caries were detected through inspection with a FACE device (46.5%) than through either visual inspection (31.8%) or inspection with a magnifying glass (37.6%). Conclusions: Within the limitations of this study, the FACE device may be an effective method for the detection of residual caries.