• Journal of Embryo Transfer
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• v.32 no.3
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• pp.227-233
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• 2017

Pig has been known to be one of the most feasible animals as a bioreactor to produce pharmaceuticals in milk and as a mediator in xenotransplantation research. Previously, we generated transgenic pigs for both purposes, which were expressing Factor 8, vWF, hTPA, and hEPO in milk, along with expression of MCP at GalT gene locus ($GalT^{-MCP/-MCP}$) as well as expressing MCP at GalT gene loci with CD73 expression ($GalT^{-MCP/+}/CD73$). In this study, we performed comparative analyses of sperm parameters between wild type male (WT) pig and those transgenic males to examine the effects of transgenes integrated into the pigs on motility, morphology, viability, and acrosome integrity of the spermatozoa. Our results showed that the rates of actively motile spermatozoa of WT, Factor 8, vWF, hTPA, hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs were 85.0%, 83.3%, 82.5%, 83.3%, 82.5%, 77.5%, and 78.7%, respectively. Whereas, the rates of morphologically normal spermatozoa of WT, Factor 8, vWF, hTPA, hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs were 90.0%, 80.0%, 80.0%, 83.3%, 85.0%, 91.8%, and 80.8%, respectively. In addition, the viability in spermatozoa of WT, Factor 8, vWF, hTPA, hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs were 93.9%, 82.4%, 89.9%, 83.9%, 87.4%, 92.8%, and 83.6%, respectively. The rates of spermatozoa with normal acrosome integrity in WT, Factor 8, vWF, hTPA, hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs were 98.1%, 98.6%, 98.6%, 98.7%, 98.1%, 99.5%, and 95.1%, respectively. There were no significant differences in motility, morphology, viability, and acrosome integrity of the spermatozoa among WT, Factor 8, vWF, hTPA, and hEPO, $GalT^{-MCP/+}/CD73$, and $GalT^{-MCP/-MCP}$ pigs. These mean that neither random integration nor targeted integration of the transgene into chromosome of pig effect on characteristics of spermatozoa. Ultimately, the transgenic male pigs subjected in this study could apply to propagate their progenies for production of human therapeutic proteins and advancing the xenotransplantation research.

• The Korean Journal of Food And Nutrition
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• v.16 no.4
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• pp.417-422
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• 2003

Addition of whole soy flour(WSF) to wheat flour(WF) was studies for its effects on dough and noodle characteristics. The WF used was medium grade of strength and WSF was a fine flour of 350 mesh. The addition ratio of WSF to. n was up to 20%. The dough properties and textural properties of wet and cooked noodles were measured with using Farinograph, Amylograph and Rheometer. Farinogram data showed the minimum dough development time and stability at 6% addition of WSF. Amylograph data of initial pasting temperature and time were increased while the maximum and final viscosity and setback were decreased as the WSF added more to W The initial pasting temperature of 2.0∼6.0% WSF added flour were comparable to 100% WF eventhough viscosity was almost half of WF. The water absorption capacity was increased from 81.6% to 92.3% at 6.0% WSF and then decreased as the addition ratio of WSF increased. The extensibility of dough showed a maximal value at 8.0% WSF addition. Strengthness and hardness of wet and cooked noodle were increased to the heighest measurement as the WSF added up to 6.0% followed by a steady decrease thereafter. It was also found that WSF addition resulted an increase in adhesiveness of wet noodle and decrease in hardness and strengthness of cooked noodle.

• Journal of the Korean Wood Science and Technology
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• v.33 no.6 s.134
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• pp.55-62
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• 2005

This study was conducted to evaluate the application of a bio-composite made by the addition recycled fiber board flour as filler. Recycled fiber board (high density fiber board, HDF) flour was added to polyolefin polymer low density polyethylene (LDPE) and polypropylene (PP) for the preparation of bio-composite materials. The mechanical properties and processability of the recycled HDF flour filled LDPE and recycled HDF flour filled PP bio-composites were then measured and compared to those of wood flour (WF) and rice-husk flour (RHF) filled LDPE and PP bio-composites, respectively. The tensile and impact strengths of the recycled HDF flour filled LDPE and PP bio-composites had similar mechanical properties to those of the WF and RHF filled LDPE and PP bio-composites. To measure the processability, torques of the bio-composites were also measured. The torques of the HDF flour filled LDPE and PP bio-composites were lower than those of the WF and RHF filled polyolefin (PP and LDPE) bio-composites with a filler loading of 30 wt.%. This result showed definite processability, which was not related with the distribution of the particle size of the material added. The recycled fiber board flour filled bio-composites showed applicability as substitutes for the bio-composites currently used in the bio-composites industry.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.1
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• pp.36-48
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• 2008

To repair bone defects in the oral and maxillofacial field, bone grafts including autografts, allografts, and artificial bone are used in clinical dentistry despite several disadvantages. The purpose of this study was to evaluate new bone formation and healing in rat calvarial bone defects using hydroxyapatite (HA, $Ca_{10}[PO_4]_6[OH]_2,\;Bongros^{(R)}$, Bio@ Co., KOREA) and tricalcium phosphate (${\beta}-TCP,\;Ca_3[PO_4]_2$, Sigma-Aldrich Co., USA) mixed at various ratios. Additionally, this study evaluated the effects of type I collagen (Rat tail, BD Biosciences Co., Sweden) as a basement membrane organic matrix. A total of twenty, 8-week-old, male Sprague-Dawley rats, weighing 250-300g, were divided equally into a control group (n=2) and nine experimental groups (n=2, each). Bilateral, standardized transosseous circular calvarial defects, 5.0 mm in diameter, were created. In each experimental group, the defect was filled with HA and TCP at a ratio of 100:0, 80:20, 70:30, 60:40, 50:50, 40:60, 30:70, 20:80, and 0:100 with or without type I collagen. Rats were sacrificed 4 and 8 weeks post-operation for radiographic (standardized plain film, Kodak Co., USA), histomorphologic (H&E [Hematoxylin and Eosin], MT [Masson Trichrome]), immunohistochemical staining (for BMP-2, -4, VEGF, and vWF), and elementary analysis (Atomic absorption spectrophotometer, Perkin Elmer AAnalyst $100^{(R)}$). As the HA proportion increased, denser radiopacity was seen in most groups at 4 and 8 weeks. In general radiopacity in type I collagen groups was greater than the non-collagen groups, especially in the 100% HA group at 8 weeks. No new bone formation was seen in calvarial defects in any group at 4 weeks. Bridging bone formation from the defect margin was marked at 8 weeks in most type I collagen groups. Although immunohistochemical findings with BMP-2, -4, and VEGF were not significantly different, marked vWF immunoreactivity was present. vWF staining was especially strong in endothelial cells in newly formed bone margins in the 100:0, 80:20, and 70:30 ratio type I collagen groups at 8 weeks. The calcium compositions from the elementary analysis were not statistically significant. Many types of artificial bone have been used as bone graft materials, but most of them can only be applied as an inorganic material. This study confirmed improved bony regeneration by adding organic type I collagen to inorganic HA and TCP mixtures. Therefore, these new artificial bone graft materials, which are under strict storage and distribution systems, will be suggested to be available to clinical dentistry demands.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.12B
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• pp.1509-1521
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• 2011

WfMC, which is one of the international standardization organizations leading the business process and workflow technologies, has been officially released the BPAF1.0 that is a standard format to record process instances' event logs according as the business process intelligence mining technologies have recently issued in the business process and workflow literature. The business process mining technologies consist of two groups of algorithms and their analysis techniques; one is to rediscover flow-oriented process-intelligence, such as control-flow, data-flow, role-flow, and actor-flow intelligence, from process instances' event logs, and the other has something to do with rediscovering relation-oriented process-intelligence like process-driven social networks and process-driven affiliation networks from the event logs. The current standardized format of BPAF1.0 aims at only supporting the control-flow oriented process-intelligence mining techniques, and so it is unable to properly support the relation-oriented process-intelligence mining techniques. Therefore, this paper tries to extend the BPAF1.0 so as to reasonably support the relation-oriented process-intelligence mining techniques, and the extended BPAF is termed BPAF2.0. Particularly, we have a plan to standardize the extended BPAF2.0 as not only the national standard specifications through the e-Business project group of TTA, but also the international standard specifications of WfMC.

• Journal of Advanced Navigation Technology
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• v.7 no.1
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• pp.59-71
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• 2003

The channel scheduler is suggested the radio resource management method in order to provide service with guaranteeing fairness and throughput to the users who use limited wireless channel. Proportional fairness scheduling algorithm is the channel scheduler used in the AMC(Adaptive Modulation and Coding)/TDM system, and this algorithm increases the throughput considering the user's time fairness. In this paper is suggested the channel scheduler combining CDM scheme available in AMC/TDM/CDM system. Unlike the system which only uses TDM which provide the only one user at the same slot, this scheduler can service a lot of users since this uses the CDM scheme with multi-cord channel. At every moment, allocation of transmission power to multi-channel users is problematic because of CDM scheme. In this paper, we propose a water-filling scheduling algorithm to solve the problem. Water-filling fairness(WF2) scheduling algorithm watches the average channel environment. So, this modified method guarantees fairness for each user in terms of power and service time.

• Journal of the Korean Institute of Gas
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• v.23 no.4
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• pp.10-18
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• 2019

The Interior finishing materials tried to evaluate the combustion characteristics and the dangerous characteristic of Floor finish and Wall finish. We often use, conducting the experiment ISO 5660-1, Cone Calorimeter method, and ISO-TR-9122 FT-IR. According to the result of Cone calorimeter experiment, the tile carpet FF3 of Floor material had the highest THR $74.6mj/m^2$ because of the highest risk, and the PHRR of FF1 was $726kW/m^2$, which was easy to bum. As a result FT-IR test, The CO, $CO_2$ ratio was 8,146 PPM for roll carpet FF1 than tile carpet FF2, FF3 5,996, 5,171 PPM, which was a carpet with a high toxicity risk. In the case of wall finishes, The MDF plate(WF3) was THR $86.7mj/m^2$ with a high risk, PHRR $384kW/m^2$ was easy to ignite and toxicity index was 5.5. The CO, $CO_2$ ratio was 1,340~8,596 PPM, But the WF4 was the most toxic with 8,596 PPM.

• Proceedings of the CALSEC Conference
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• 2004.02a
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• pp.345-349
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• 2004

·Emerging requirements for EC environments ： -At eun-time： Dynamic process composition with various networked resources, i.e., application or participants -At build ＆ maintenance time： Agile technical enhancements. e.g., evolution in standards · Open issues of WfMS(Bussler, 1999： Sayal et al., 2002)： -Heterogeneity ＆ interoperability -Adaptability and flexibility(omitted)

• Proceedings of the Korean Vacuum Society Conference
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• 1992.02a
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• pp.77-78
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• 1992

• Proceedings of the Korean Nuclear Society Conference
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• 2001.10a
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• pp.205.1-205
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• 2001