• 대한본초학회지
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• 제36권5호
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• pp.59-67
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• 2021

Objectives : Hibiscus (Hibiscus sabdariffa L.) is rich in antioxidants such as flavonoids and anthocyanins and is known to have anti-inflammatory activity and anti-aging function of the skin, but there is no study on its effect on the skin barrier. This study aim to investigate the positive effect on the skin barrier by confirming the effect of water extracts of Hibiscus sabdariffa L. (WEHS) on the tight junction-related gene expression. Methods : The antioxidant efficacy of WEHS was investigated through ABTS and DPPH assays, and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium was performed to examine the effect on cell viability. quantitative Reverse transcription polymerase chain reaction and immunoblot analysis were performed to confirm the effect of WEHS on the expression of tight junction-related genes, and immunofluorescence microscopy was used to confirm the movement of Claudin 1 protein into tight junctions. Results : WEHS showed strong antioxidant activity and induced an increase in both mRNA and protein expression levels of Claudin 1 among tight junction-related genes. The strong localization of Claudine 1 protein increased by WEHS to the tight junction was confirmed by immunofluorescence microscopy. Conclusions : Hibiscus was confirmed through this study to show antioxidant activity and the function of promoting the expression of the tight junction Claudin 1 gene, suggesting that Hibiscus can be used as a material for the prevention and treatment of skin moisturizing and atopy, which have an important influence on tight junction.

• 한국항공우주학회지
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• 제46권4호
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• pp.315-323
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• 2018

캔 위성은 음료수 캔 크기로 위성의 전반적인 시스템을 모사할 수 있어 교육프로그램 일환으로서 큰 각광을 받고 있으며, 국내에서는 2012년도부터 매년 캔 위성 경연대회가 개최되고 있다. 본 논문에서 제안된 캔 위성은 2015년도 국내 캔 위성 경연대회에 출전한 P.P.T CanSat으로 태양에너지 무선전송시스템 및 피에조, 풍력 에너지 하베스팅 시스템을 통해 생성된 전력으로 LED 점멸 및 MEMS기반의 센서 모듈을 자가 구동하는 것을 임무목표로 한다. 본 논문에서는 상기 캔 위성의 시스템 설계 및 주요 임무 탑재체 기능검증 시험, 비행시험, 실패원인 분석 및 재시험에 대해 기술하였다.