• Title/Summary/Keyword: WEE1

Search Result 727, Processing Time 0.029 seconds

A Thiazole and Two ${\beta}$-Carboline Constituents from Panax ginseng

  • Park, Jong-Dae;Kim, Man-Wook;Yoo, Seung-Jo;Wee, Jae-Joon
    • Archives of Pharmacal Research
    • /
    • v.11 no.1
    • /
    • pp.52-55
    • /
    • 1988
  • From the ether soluble alkaloidal fraction of Panax ginseng, 4-methyl-5-thiazoleethanol, norharman and barman were isolated. 4-Methyl-5-thiazoleethanol was isolated for the first time from natural resources.

  • PDF

COVID -19: Protection of Workers at the Workplace in Singapore

  • Ng, Wee Tong
    • Safety and Health at Work
    • /
    • v.12 no.1
    • /
    • pp.133-135
    • /
    • 2021
  • The COVID-19 pandemic has resulted in movement restrictions being instituted globally and the cessation of work at many workplaces. However, during this period, essential services such as healthcare, law enforcement, and critical production and supply chain operations have been required to continue to function. In Singapore, measures were put in place to protect the workers from infection at the workplace, as well as to preserve the operational capability of the essential service in a COVID-19 pandemic environment. This paper critically analyses the measures that were implemented and discusses the extension to broader general industry.

Changes in Activities of Daily Living of Children with Spastic Cerebral Palsy According to Gross Motor Function Classification System After One Year of Physical and Occupational Therapy (물리 및 작업치료 1년 후 대동작 기능분류체계에 따른 경직성 뇌성마비 아동의 일상생활동작 변화)

  • Lee, Kwon-Woo;Kim, Won-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.20 no.8
    • /
    • pp.431-440
    • /
    • 2019
  • This study was conducted to investigate changes in activities of daily living (ADLs) according to the Gross Motor Function Classification System (GMFCS) after one year of physical and occupational therapy and to compare the responsiveness of ADL tools. A total of 48 children with spastic cerebral palsy participated in the study. The GMFCS, Functional Independence Measure for Children (WeeFIM), and Pediatric Evaluation of Disability Inventory (PEDI) were measured. The results showed that the GMFCS was significantly correlated with the PEDI (p<0.05), while there was a significant difference in the change of ADLs measured by the PEDI, but not the WeeFIM. There was a significant difference in the changes in ADLs according to the GMFCS, and the change in ADLs in the high functional level group was significantly higher than in the low functional level group (p<0.05). After physical and occupational therapy, the degree of improvement of ADLs varied according to the GMFCS, but seemed to be improved in a clinically meaningfully way. The PEDI is sensitive to changes in ADLs, so it may be used widely in clinical practice.

Temporal and Spatial Regulation of Cell Cycle Genes during Maize Sex Determination (옥수수 성 결정에 있어서 세포주기 유전자들의 시간적, 공간적 조절)

  • Lee, Jung-Ro;Kim, Jong-Cheol
    • Journal of Life Science
    • /
    • v.16 no.5
    • /
    • pp.828-833
    • /
    • 2006
  • Maize (Zea mays L.) pistil cell death and stamen cell arrest are pivotal process on the sex determination, which diverges from bisexual state of floral meristem to unisexual state in staminate or pistillate floret. We investigated the temporal and spatial distribution of cell cycle gene expression during maize sex determination. The positive regulatory genes of cell cycle, cyclin A, cyclin B, cyclin dependent kinase (CDK) and Mad2 were highly expressed in the developing pistil and stamen but the expression was disappeared in the dying pistil and arresting stamens. In contrast, the negative regulatory genes of cell cycle, Wee1 and CDK inhibitor (CKI) were expressed in the arresting stamens in the wild-type ear and tasselseed2 mutant tassel, however, these genes were not detected in dying pistil although the cyclin B gene expression was disappeared. These results suggest that both the pistil cell death and stamen cell arrest process in maize sex determination are involved in cell cycle regulation, but the different expression patterns of negative regulatory cell cycle genes in the arresting stamens and aborting pistils suggest that the two processes may have distinctive modes of action.

PP2A function toward mitotic kinases and substrates during the cell cycle

  • Jeong, Ae Lee;Yang, Young
    • BMB Reports
    • /
    • v.46 no.6
    • /
    • pp.289-294
    • /
    • 2013
  • To maintain cellular homeostasis against the demands of the extracellular environment, a precise regulation of kinases and phosphatases is essential. In cell cycle regulation mechanisms, activation of the cyclin-dependent kinase (CDK1) and cyclin B complex (CDK1:cyclin B) causes a remarkable change in protein phosphorylation. Activation of CDK1:cyclin B is regulated by two auto-amplification loops-CDK1:cyclin B activates Cdc25, its own activating phosphatase, and inhibits Wee1, its own inhibiting kinase. Recent biological evidence has revealed that the inhibition of its counteracting phosphatase activity also occurs, and it is parallel to CDK1:cyclin B activation during mitosis. Phosphatase regulation of mitotic kinases and their substrates is essential to ensure that the progression of the cell cycle is ordered. Outlining how the mutual control of kinases and phosphatases governs the localization and timing of cell division will give us a new understanding about cell cycle regulation.

Anti-obesity Effects of Tae-Um-Jo-Wee-Tang and Do-Dam-Tang in Female Rats with Diet-induced Obesity (고지방식이로 비만을 유도한 암컷 백서에서 태음조위탕과 도담탕의 항비만 효과 및 기전)

  • Park, Sun-Min;Ahn, Il-Sung;Kim, Da-Sol;Kang, Sun-A;Kwon, Dae-Young;Yang, Hye-Jeong
    • Journal of Applied Biological Chemistry
    • /
    • v.53 no.1
    • /
    • pp.44-50
    • /
    • 2010
  • Tae-Um-Jo-wee-Tang (TUJWT) and Do-Dam-Tang (DDT) have been used as an anti-obesity herbal medicine but their effect and mechanism of action have not been studied. We investigated the effects of TUJWT and DDT on energy and glucose homeostasis using Sprague Dawley female rats with diet-induced obesity. The mechanisms of action of TUJWT and DDT were studied whether they had anti-obesity effects. Rats fed a high-fat diet were divided into 3 groups: rats in each group received 2 g water extracts of modified TUJWT and DDT, or 2 g cellulose per kg body weight (a negative control) on a daily basis. A further group was fed a low-fat diet as a positive control. We found that DDT significantly decreased body weight and body fat (mesenteric fat and retroperitoneal fat) more than the control. This decrease was due to the reduction in energy intake but no changes of energy expenditure. However, DDT increased fat oxidation as a major energy source than the control. In addition, modified TUJWT and DDT improved glucose tolerance without changing serum insulin levels during an oral glucose tolerance test. In conclusion, DDT have a better anti-obesity effect than TUJWT by decreasing energy intake in female rats with diet-induced obesity. It also improves glucose tolerance.

Development of Community Resources Linkage Capability Scale of Counselors (심리상담사의 지역사회자원연계 능력 척도 개발)

  • Seong, Seul-Ah;Bae, Seong-Hoon
    • Korean Journal of School Psychology
    • /
    • v.17 no.3
    • /
    • pp.357-377
    • /
    • 2020
  • This study was intended to develop and investigate reliability and validity of a scale that can measure linkage capability of community resources of counselors. This study prepared a preliminary question consisting of a total of 42 questions in 5 areas. Then, the content validity and facial validity were verified by the counseling experts with a first-degree qualification as a counselor in Korean Counselling Psychological Association, and a total of 20 final questions of 4 areas. The final questions were conducted on psychological counselors(N=306) to investigate reliability and validity. As a result of conducting an exploratory factor analysis, validity of the two-factor structure have been verified. And In the confirmatory factor analysis, two factors were shown to be appropriate. The two-factors were named 'The collection and utilization of information' and 'Association with the Organization of Information'. Also, the scale of final selection of questions were found to have a good degree of concurrent validity, interitem consistency and test-retest reliability. The implications of the present study is significant in that it is a measure of community resources linkage capability scale of counselors. In addition, this scale is expected to be useful in Wee Class, Wee Center, Youth Counseling Welfare Center, and other counseling sites.

The vertebrate fauna along the Hantangang (river) of Korea

  • Jo, Yeong-Seok;Kim, Byung-Jik;Hur, Wee-Haeng;Won, Chang-Man
    • Journal of Species Research
    • /
    • v.1 no.1
    • /
    • pp.87-99
    • /
    • 2012
  • Before the construction of Hantangang dam, we surveyed vertebrate fauna along the Hantangang River and collected samples. We collected 248 specimens (1,394 individuals) of 41 fish species from 10 families in four orders, including 17 endemic species and 5 endangered species. In our herpetofauna survey, we collected 47 amphibian samples of 10 species from 5 families in 2 orders, and 19 reptile samples of 5 species from 2 families in 1 order. We observed 25 species of bird (6 orders, 14 families) inclulding collection of 51 bird specimens (10 species from 5 families in 1 order). We collected 91 mammals of 6 species, and identified 7 species from field sign and direct observation from a total of 10 families in 5 orders. This collection and list comprise the final vertebrate faunal survey of the Hantangang region, and will provide basic scientific information for future research on conservation and restoration of the region.

Design of Two-port MIMO Antennas without Space for Isolation

  • Jo, Hyun-Dong;Park, Wee-Sang
    • International journal of advanced smart convergence
    • /
    • v.1 no.1
    • /
    • pp.1-5
    • /
    • 2012
  • We propose a structure for a multiple input multiple output antenna which has no space for isolation. The antenna operates in a frequency range of 2.4-2.48 GHz and can achieve a high channel capability as a Bluetooth antenna. The MIMO antenna consists of two planar inverted F antennas with symmetric structure. We designed the proposed antenna using HFSS simulator, and we designed the fabricated antenna using PCB fabricator. The MIMO antenna's isolation $S_{21}{\leq}-10dB$ and reflection coefficient $S_{11}{\leq}-20dB$. The proposed antenna's specification satisfies Bluetooth antenna's criteria and has more space than the existing MIMO antennas, which have space for isolation.