• Title/Summary/Keyword: Vulnerable Option

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Good Clinical Practice in Neonatal Clinical Research (신생아 임상연구에서의 Good Clinical Practice)

  • Park, Min-Soo
    • Neonatal Medicine
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    • v.15 no.2
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    • pp.119-122
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    • 2008
  • Clinical research is a necessity, not an option, for developing better and new medicines and therapeutic modalities. But in the course of clinical research, there are rules and guidelines that should be followed to ensure the due respect for persons, beneficence, and justice for persons who voluntarily participate in the research as described in the Belmont Report. Good Clinical Practice (GCP) is an "international scientific and ethical quality standard for designing, conducting, recording, and reporting" clinical trials. The main purposes of GCP would be to protect rights, safety, and well-being of trial subjects, in compliance with the principles of Declaration of Helsinki, and to assure that the data obtained from clinical trials are credible. In order to achieve these, investigators must be fully aware of the meanings as well as actual procedures involved in the research and should make the best effort to comply with GCP. For those individuals who belong to vulnerable populations, such as neonates, in addition to the general principles of GCP, further measures to ensure added protection should be implemented. It is our duty to develop and provide better care through clinical research even for neonates. But in doing so, we have to make sure that the importance of protecting the rights, safety, and well-being of the subjects supersede the interests of science and society.

Lateral Supramalleolar Flap for Reconstruction of Soft Tissue Defect around the Ankle Joint

  • Han, Soo-Hong;Kim, Seong-Hui;Lee, Soon-Chul;Lee, Ho-Jae;Kim, Woo-Hyun;Bong, Sun-Tae;Song, Won-Tae
    • Archives of Reconstructive Microsurgery
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    • v.23 no.1
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    • pp.13-17
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    • 2014
  • Purpose: Soft tissue defect on foot and ankle is vulnerable and requires a thin flap for improvement of aesthetic and functional results. Lateral supramalleolar flap is a simple and fast procedure, which can preserve and supply reliable constant blood flow, and causes fewer donor site complications. The authors reviewed our cases and report the clinical results. Materials and Methods: Ten cases of soft tissue defects on the lower leg, around the ankle were treated with lateral supramalleolar flap. There were seven males and three females with a mean age of 54.8 years. The mean size of flaps was $5.9{\times}6.3$ cm and the mean follow-up period was 23 months. Flap survival and postoperative complications were evaluated. Results: Nine flaps survived completely without loss of flap. There was one case of partial wound dehiscence requiring debridement and repair, and another case of necrotic flap change requiring partial bone resection and closure. All patients were capable of weight bearing ambulation at the last follow up. Conclusion: The authors suggest that the lateral supramalleolar flap could be a useful option for treatment of soft tissue defect around the ankle joint.

Analysis of Web Browser Security Configuration Options

  • Jillepalli, Ananth A.;de Leon, Daniel Conte;Steiner, Stuart;Alves-Foss, Jim
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.12 no.12
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    • pp.6139-6160
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    • 2018
  • For ease of use and access, web browsers are now being used to access and modify sensitive data and systems including critical control systems. Due to their computational capabilities and network connectivity, browsers are vulnerable to several types of attacks, even when fully updated. Browsers are also the main target of phishing attacks. Many browser attacks, including phishing, could be prevented or mitigated by using site-, user-, and device-specific security configurations. However, we discovered that all major browsers expose disparate security configuration procedures, option names, values, and semantics. This results in an extremely hard to secure web browsing ecosystem. We analyzed more than a 1000 browser security configuration options in three major browsers and found that only 13 configuration options had syntactic and semantic similarity, while 4 configuration options had semantic similarity, but not syntactic similarity. We: a) describe the results of our in-depth analysis of browser security configuration options; b) demonstrate the complexity of policy-based configuration of web browsers; c) describe a knowledge-based solution that would enable organizations to implement highly-granular and policy-level secure configurations for their information and operational technology browsing infrastructures at the enterprise scale; and d) argue for necessity of developing a common language and semantics for web browser configurations.

Fragility reduction using passive response modification in a Consequence-Based Engineering (CBE) framework

  • Duenas-Osorio, Leonardo;Park, Joonam;Towashiraporn, Peeranan;Goodno, Barry J.;Frost, David;Craig, James I.;Bostrom, Ann
    • Structural Engineering and Mechanics
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    • v.17 no.3_4
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    • pp.527-537
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    • 2004
  • Consequence-Based Engineering (CBE) is a new paradigm proposed by the Mid-America Earthquake Center (MAE) to guide evaluation and rehabilitation of building structures and networks in areas of low probability - high consequence earthquakes such as the central region of the U.S. The principal objective of CBE is to minimize consequences by prescribing appropriate intervention procedures for a broad range of structures and systems, in consultation with key decision makers. One possible intervention option for rehabilitating unreinforced masonry (URM) buildings, widely used for essential facilities in Mid-America, is passive energy dissipation (PED). After the CBE process is described, its application in the rehabilitation of vulnerable URM building construction in Mid-America is illustrated through the use of PED devices attached to flexible timber floor diaphragms. It is shown that PED's can be applied to URM buildings in situations where floor diaphragm flexibility can be controlled to reduce both out-of-plane and in-plane wall responses and damage. Reductions as high as 48% in roof displacement and acceleration can be achieved as demonstrated in studies reported below.

Design and implementation of TELNET protocol supporting security functionalities (보안 기능을 지원하는 TELNET 프로토콜의 설계 및 구현)

  • Seong, Jeong-Ki;Seo, Hye-In;Kim, Eun-Gi
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.20 no.4
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    • pp.769-776
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    • 2016
  • TELNET is vulnerable to network attack because it was designed without considering security. SSL/TLS and SSH are used to solve this problem. However it needs additional secure protocol and has no backward compatibility with existing TELNET in this way. In this paper, we have suggested STELNET(Secured Telnet) which supports security functionalities internally so that has a backward compatibility. STELNET supports a backward compatibility with existing TELNET through option negotiation. On STELNET, A client authenticates server by a certificate or digital signature generated by using ECDSA. After server is authenticated, two hosts generate a session key by ECDH algorithm. And then by using the key, they encrypt data with AES and generate HMAC by using SHA-256. After then they transmit encrypted data and generated HMAC. In conclusion, STELNET which has a backward compatibility with existing TELNET defends MITM(Man-In-The-Middle) attack and supports security functionalities ensuring confidentiality and integrity of transmitted data.

The Great Saphenous Vein-An Underrated Recipient Vein in Free Flap Plasty for Lower Extremity Reconstruction: A Retrospective Monocenter Study

  • Meiwandi, Abdulwares;Kamper, Lars;Kuenzlen, Lara;Rieger, Ulrich M.;Bozkurt, Ahmet
    • Archives of Plastic Surgery
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    • v.49 no.5
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    • pp.683-688
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    • 2022
  • Background Reconstruction of large soft tissue defects of the lower extremity often requires the use of free flaps. The main limiting factor and potential for complications lie in the selection of proper donor and recipient vessels for microvascular anastomosis. While the superficial veins of the lower leg are easier to dissect, they are thought to be more vulnerable to trauma and lead to a higher complication rate when using them instead of the deep accompanying veins as recipient vessels. No clear evidence exists that proves this concept. Methods We retrospectively studied the outcomes of 97 patients who underwent free flap plasty to reconstruct predominantly traumatic defects of the lower extremity at our institute. The most used flap was the gracilis muscle flap. We divided the population into three groups based on the recipient veins that were used for microvascular anastomosis and compared their outcomes. The primary outcome was the major complication rate. Results Overall flap survivability was 93.81%. The complication rates were not higher when using the great saphenous vein as a recipient vessel when comparing to utilizing the deep concomitant veins alone or the great saphenous vein in combination to the concomitant veins. Conclusions In free flap surgery of the lower extremity, the selection of the recipient veins should not be restricted to the deep accompanying veins of the main vessels. The superficial veins, especially the great saphenous vein, offer an underrated option when performing free flap reconstruction.

Gender and healthcare issues related to the Protected Birth Act in Korea (보호출산제 시행과 젠더 및 보건의료 이슈)

  • Jiah Jeong
    • Women's Health Nursing
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    • v.30 no.2
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    • pp.101-106
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    • 2024
  • This paper discusses the implications of the birth notification system and the Protected Birth Act in Korea. Aiming to prevent infanticide and abandonment of infants, the law will enter into force on July 19, 2024 in South Korea. The birth notification system mandates that both parents and the head of the medical institution where the birth occurred must report the event. In parallel, the Protected Birth Act will be implemented, allowing pregnant women in crisis who wish to remain anonymous, the option to give birth outside of a hospital setting in a way that safeguards the life and health of the child. However, many issues are being raised in Korean society in advance of the implementation of the Protected Birth Act. There is widespread concern that the Protected Birth Act fails to protect either women or children, especially as it raises issues regarding the need for legislation to protect children with disabilities and to address gaps for migrant women and children. This paper examines the gender and healthcare issues relating to the Protected Birth Act, focusing on women's health and human rights. The Act continues to perpetuate discrimination against out-of-wedlock pregnancies and upholds the ideology of the traditional family model. Furthermore, the legislative process did not address protective measures for the various reasons behind child abandonment. Critical issues such as women's autonomy, safe pregnancy termination, and paternal responsibility in childbirth are also notably absent. However, with the Act set to take effect soon, it is crucial for healthcare providers to comprehend the rationale and procedures associated with birth notification and the Protected Birth Act, and to prepare for its nationwide implementation. The law defines the socially vulnerable as its main beneficiaries, and it is necessary to strengthen social safety nets to improve their access to healthcare, eliminate prejudice and discrimination against out-of-wedlock pregnancies, and embrace the diversity of our society. We eagerly anticipate future discussions on gender and healthcare issues, as well as amendments to the law that reflect real-world circumstances to provide genuine protection for pregnant women in crisis and their infants.

Improving the Protection and Security System Outside the National Assembly Building (국회 외곽 경호·경비시스템 발전방향에 관한 연구)

  • Choi, O-Ho
    • Korean Security Journal
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    • no.60
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    • pp.113-135
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    • 2019
  • Despite being one of the most important national facilities, the National Assembly building of the Republic of Korea has become increasingly vulnerable to potential terrorist attacks, and the instances of demonstrations occurring around and banned items taken into the building are continuing to rise. In addition, promoting the idea of "open assembly" has led to increased visitors and weakened access control. Furthermore, while there is a significant symbolic value attached to attacking the National Assembly building, the level of security management is relatively very low, making it a suitable target for terrorism. In order to address such vulnerability, an appropriate access control system should be in place from the areas surrounding the building. However, the National Assembly Security Service which oversees security around the building is scheduled to disband in June 2020 following the abolition of the conscripted police force in 2023. Therefore, there needs to be an alternative option to bolster the security system outside the facility. In this research, the perceptions of 114 government officials in charge of security at the National Assembly Secretariat toward the protection and security system of the areas surrounding the National Assembly building were examined. Results showed that the respondents believed it was highly likely that risky situations could occur outside the building, and the use of advanced technologies such as intelligent video surveillance, intrusion detection system, and drones was viewed favorably. Moreover, a mid- to long-term plan of establishing a unified three-layer protection system and designating a department in charge of the security outside the building were perceived positively. Lastly, the participants supported the idea of employing private police to replace the National Assembly Security Service for the short term and introducing parliamentary police for the mid- to long-term.