• 대한조선학회논문집
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• 제51권1호
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• pp.1-7
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• 2014

The present study numerically investigated the effect of the advance ratio on the wake characteristics of the marine propeller in the propeller open water test. Therefore, a wide range of the advance ratio(0.2${\kappa}-{\omega}$SST Model are considered. The three-dimensional vortical structures of tip vortices are visualized by the swirl strength, resulting in fast decay of the tip vortices with increasing the advance ratio. Furthermore, to better understanding of the wake evolution, the contraction ratio of the slip stream for different advance ratios is extracted from the velocity fields. Consequently, the slip stream contraction ratio decreases with increasing the advance ratio and successively the difference of the slip stream contraction ratio between J=0.2 and J=0.8 is about 0.1R.

• Nuclear Engineering and Technology
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• 제54권5호
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• pp.1674-1685
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• 2022

The ball valve is an important device in the pipeline transportation system of nuclear power plants. Its operational stability and safety directly affect the normal working of nuclear power plants. In this study, the transient numerical simulation of the opening and closing process of a ball valve was conducted on the basis of the flow interruption capability experiment of the ball valve by using the moving mesh method and inlet and outlet variable boundary conditions. The flow rate and pressure difference with time of the opening and closing process of the ball valve were studied. The internal flow characteristics of the ball valve under different relative openings were analyzed in conjunction with the typical back-step flow structure. Results show that the transient numerical results agree well with the experimental results. The internal flow characteristics of the ball valve are similar at the same opening during opening and closing process. At small opening, the spool and outlet channels easily form a back-step flow structure. The disappearance and generation of backflow vortices during opening and closing occur at 85% opening and 75% opening, respectively. With the decrease in opening degree, the difference in vortex core area in the flow channel of the ball valve spool in the opening and closing process gradually appears. The research results provide some reference value for the design and optimization of ball valves.

• Wind and Structures
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• 제38권1호
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• pp.59-74
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• 2024

Large Eddy Simulation (LES) is used to explore the influence of vibration frequency and amplitude on the aerodynamic performance of a rectangular cylinder with an aspect ratio of B/D=5 (B: breadth; D: depth of cylinder) at a Reynolds number of 22,000 near resonance frequency. In smooth flow conditions, the research employs a sequence of three-dimensional simulations under forced vibration with diverse frequency ratios f_e / f_o = 0.8-1.2 (f_e : oscillation frequency; f_o : Strouhal frequency when the rectangular cylinder is stationary ) and oscillation amplitudes A_h/D = 0.05 - 0.3. The individual influences of f_e / f_o and A_h/D on the characteristics of integrated and distributed aerodynamic forces are the focal points of discussion. For the integrated aerodynamic force, particular emphasis is placed on the analysis of the dependence of velocity-proportional component C₁ and displacement-proportional component C₂ of unsteady aerodynamic force on amplitude and frequency ratio. Near the resonance frequency, the dependencies of C₁ and C₂ on amplitude are stronger than that of frequency ratio. For the distributed aerodynamic force, the increase in frequency and amplitude promotes the position of the main vortex core and reattachment to the leading edge in the streamwise direction. In the spanwise direction, vibration enhances the spanwise correlation of aerodynamic force to weaken the three-dimensional effect of the flow field, and a lower frequency ratio and larger amplitude amplify this effect.

• Journal of Genetic Medicine
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• 제4권1호
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• pp.45-52
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• 2007

목 적 : 패브리병은 X-linked 지질 축적 질환으로 ${\alpha}$-galactosidase A (${\alpha}$-Gal A)의 결손으로 인해 스핑고당지질인 Gb3의 세포내 축적을 일으키는 병이다. 혈장 중 Gb3 측정은 패브리병 환자의 효소대체요법 후의 모니터링이나 진단에 임상적 의의가 크므로 ESI-MS/MS를 이용한 시료 전처리를 위한 노동력이 덜 들면서 간단, 신속, 고감도로 정량할 수 있는 혈장 중 Gb3분석법을 개발하고자 하였다. 방 법 : 혈장을 디옥산으로 50배 희석하여 vortex-mix 및 원심분리를 거쳐 Gb3의 추출 및 분리를 수행한다. 이 때 내부표준액인 C17:0 Gb3를 혈장에 처음부터 첨가한다. 희석과 원심분리된 혈장은 가드컬럼을 통하여 ESI-MS/MS의 다중성분 모니터링 모드에서 분석하여 내부표준액에 대한 8종 Gb3 isoform의 피크면적비를 이용하여 정량한다. 결 과 : 혈장의 바탕성분 하에서 8종의 Gb3 isoform이 완전히 잘 분리됨을 확인할 수 있었다. 혈장 중의 8종의 Gb3 isoform 중 50% 이상 차지하는 종류는 C16:0 Gb3 임이 확인되었다. Gb3 isoform이 직선성을 이루는 농도 범위는 0.001-1.0 ${\mu}g$/mL이었다. 검출한계(S/N=3)는 C16:0 Gb3의 경우 0.001 ${\mu}g$/mL 이었고 정량한계는 0.01 ${\mu}g$/mL 이었으며 회수율의 일내재현성(정확도 87-108%와 정밀도 7% 이하)과 일간재현성(정확도 87-110%와 정밀도 13% 이하)은 매우 양호 하였다. 결 론 : 본 연구에서 개발된 Gb3 분석법은 신속, 정확, 간편하게 패브리병의 1차 스크리닝이나 효소대체요법 전후의 모니터링 및 진단에 유용하게 적용될 수 있을 것이다.