• Journal of Korean Neurosurgical Society
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• 제39권2호
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• pp.102-108
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• 2006

Objective : The management of diffuse astrocytomas is one of the most controversial areas in clinical neurooncology. There are numerous reviews and editorials outlining the difficulties in the management of these lesions. In this study, we assess the role of Gamma Knife radiosurgery[GKS] for diffuse astrocytomas. Methods : Twenty-three patients with a diffuse astrocytoma were treated with GKS as a primary or adjuvant method from February 1995 to October 2003. The mean marginal dose was $13.6\;[8.5{\sim}17.5]Gy$ and the mean maximal dose was $27.3\;[17.0{\sim}35.0]Gy$. Local control and the pattern of radiologic response were evaluated. The probable factors affecting local control, such as tumor volume, margin dose, previous history of craniotomy or stereotactic biopsy, and the presence or absence of previous radiotherapy were statistically analyzed. The average duration of follow-up was 39.7 [$11.3{\sim}101.5$] months after GKS. Results : Of the 23 lesions treated, 16 lesions [69.6%] were controlled during the follow-up period. The mean progression-free interval was 57.4 months and the 5-year progression-free rate was 68%. Only tumor volume was found to be a statistically significant factor for local control. Smaller tumors were better controlled by GKS; it was significantly effective in tumors with less than $10cm^3$ volume. Conclusion : GKS could be a valuable therapeutic modality both as a primary treatment and as a postoperative adjuvant therapy in some selected cases.

• The Korean Journal of Physiology and Pharmacology
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• 제19권1호
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• pp.9-14
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• 2015

We investigated the sweating response during passive heating (partial submersion up to the umbilical line in $42{\pm}0.5^{\circ}C$ water, 30 min) after summer and winter seasonal acclimatization (SA). Testing was performed in July during the summer, 2011 [summer-SA; temp, $25.6{\pm}1.8^{\circ}C;$ relative humidity (RH), $82.1{\pm}8.2%$] and in January during the winter, 2012 (winter-SA; temp, $-2.7{\pm}2.9^{\circ};$ RH, $65.0{\pm}13.1%$) in Cheonan ($126^{\circ}52^{\prime}N$, 33.38'E), Republic of Korea. All experiments were carried out in an automated climatic chamber (temp, $25.0{\pm}0.5^{\circ}C$: RH, $60.0{\pm}3.0%$). Fifteen healthy men (age, $23.4{\pm}2.5$ years; height, $175.0{\pm}5.9cm;$ weight, $65.3{\pm}6.1kg$) participated in the study. Local sweat onset time was delayed during winter-SA compared to that after summer-SA (p<0.001). Local sweat volume, whole body sweat volume, and evaporative loss volume decreased significantly after winter-SA compared to those after summer-SA (p<0.001). Changes in basal metabolic rate increased significantly after winter-SA (p<0.001), and tympanic temperature and mean body temperature were significantly lower after summer-SA (p<0.05). In conclusion, central sudomotor acitivity becomes sensitive to summer-SA and blunt to winter-SA in Rebubic of Korea. These results suggest that the body adjusts its temperature by economically controlling the sweating rate but does not lower the thermal dissipation rate through a more effective evaporation scheme after summer-SA than that after winter-SA.

• Advances in concrete construction
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• 제17권4호
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• pp.233-243
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• 2024

The behavior of confined steel fiber-reinforced concrete (including confinement models) with compressive strengths ranging from normal to high strength is still rarely studied. This paper presents the results of an investigation of fifteen confined concrete cylinders containing steel fiber. The design parameters evaluated in the experiment included concrete compressive strength (covers normal to high strength), volume fraction of steel fiber and hoop spacing. The main objective of this study was to evaluate the behavior of confined steel fiber concrete by reviewing several design parameters, such as concrete strength (normal to high strength). It is then developed to be an analytical stress-strain expression for confined steel fiber concrete. The experimental program was carried out by making cylindrical specimens with a diameter of 100 mm and a height of 200 mm. The cylindrical test object is compressed in a monotonic uniaxial loading. Experimental results have shown steel fiber in concrete has an important role in increasing the compressive strength and strain of cylindrical concrete without steel fiber. In addition, the value of strength enhancement of confined concrete (K) along with increasing fiber fraction volume; which applies to normal to high-strength concrete. The value of K also increases if the compressive strength of the concrete tends to decrease and the spacing of the hoops is closer. The comparison of stress-strain behavior between the confined steel fiber concrete proposed by other researchers and the experimental results in general significantly different in post-peak response. The statistical analysis indicates that the value of Coefficient of Variation for the confinement model by Campione is the closest compared to other existing confinement models in predicting the values of K and Toughness Index. Furthermore, the analytic stress-strain expression of confined steel fiber concrete was developed by adopting and modifying several equations from the present models. The proposed analytical expression is then verified with the experimental results. The results of the verification show that the stress-strain behavior of confined steel fiber concrete is relatively close.

• Radiation Oncology Journal
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• 제32권2호
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• pp.77-83
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• 2014

Purpose: To determine the prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases. Materials and Methods: Sixteen patients received whole liver radiotherapy (WLRT) between January 1997 and June 2013. A total dose of 21 Gy was delivered in 7 fractions. Results: The median survival time after WLRT was 9 weeks. In univariate analysis, performance status, serum albumin and total bilirubin level, liver volume and extrahepatic metastases were associated with survival. The mean liver volume was significantly different between subgroups with and without pain relief (3,097 and 4,739 mL, respectively; p = 0.002). Conclusion: A larger liver volume is a poor prognostic factor for survival and also a negative predictive factor for response to WLRT. If patients who are referred for WLRT have large liver volume, they should be informed of the poor prognosis and should be closely observed during and after WLRT.

• 한국정보과학회논문지:데이타베이스
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• 제37권6호
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• pp.300-307
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• 2010

웹이 성장함에 따라 데이터처리 기술도 발전하고 있다. 차세대 웹 환경에서는 다양한 유무선 사용자, USN, RFID를 위한 고속, 대용량데이터 처리기술 또한 발전하고 있다. 본 논문에서는 CEP(Complex Event Processing) 엔진을 이용하여 대용량데이터를 처리하는 기술을 제안한다. CEP는 복잡한 이벤트를 처리하는 기술로 CEP 엔진은 다음과 같은 특정이 있다. 첫째 대용량의 이벤트(데이터)를 받는 작업, 둘째 이를 분석하는 작업, 최종적으로 새로운 액션으로 연결시키는 작업으로 나눌 수 있다. 즉 대용량데이터를 수집하고 이벤트들을 분석, 필터링한다. 또한 이벤트 엔진에 미리 등록해 놓은 이벤트와 새로운 이벤트를 패턴매칭하여 데이터를 추출한다. 추출된 결과를 다른 작업의 입력 이벤트로 사용하거나 요청된 이벤트에 대해 실시간으로 응답할 수 있고 유효한 데이터만 데이터베이스에 트리거할 수도 있다.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제9권6호
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• pp.718-731
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• 2003

높은 가용성, 확장성, 시스템 성능의 요구를 만족시키기 위해 SAN(Storage Area Network)이 등장했다. 대부분의 SAM 운영 S/W들은 SAN을 보다 효과적으로 활용하기 위해서 SAN에 부착된 물리적 저장장치들을 가상적으로 하나의 커다란 볼륨으로 보이게 하는 저장장치 가상화 개념을 지원한다. 저장장치 가상화의 핵심적인 역할을 하는 것이 바로 논리볼륨 관리자이다. 논리볼륨 관리자는 논리주소를 물리 주소로 매핑 시킴으로서 저장장치 가상화를 실현한다. 이 논문에서는 논리볼륨 관리자를 위한 효율적이고 유연한 매핑기법을 설계하고 구현한다. 더불어 매핑 테이블 기반 매핑 방법에서 유연한 매핑을 돕기 위한 자유공간 관리기법을 설계하고 구현한다. 이 논문의 매핑기법은 특정 시점의 볼륨이미지를 유지할 수 있는 스냅샷과 시스템을 정지시키지 않고 SAN에 저장장치를 추가 또는 삭제할 수 있는 온라인 재구성 기능을 지원한다. 또한 이 논문에서 제안한 기법에 대한 성능 평가를 수행하여 제안하는 기법이 매핑 관리자로서 의미가 있음을 보인다.

• Tuberculosis and Respiratory Diseases
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• 제46권2호
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• pp.229-240
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• 1999

연구배경: HSVtk/GCV를 이용한 유전자치료에서 면역반응은 1) adenovirus 혹은 retrovirus와 같이 벡타로 사용된 virus의 단백질, 2) 치료목적으로 이입된 HSVtk 유전자의 생성물, 3) 암세포에 대해서 일어날 수 있다. 그리고 이러한 면역반응은 cytokines의 생성 혹은 cytotoxic tumor-specific T-cell의 생성을 초래하여 bystander effect에 의한 살상효과를 증가시키거나, anti-tumor immunity를 유도하여 tumor vaccine의 효과를 나타낼 수 있다. 한편 이와는 대조적으로 면역반응용 HSVtk 유전자를 발현하는 세포들을 파괴하여 이입된 HSVtk 유전자의 발현기간을 제한함으로서 유전자치료의 효과를 감소시킬 수도 있다. 본 연구는 retrovirus 벡타로 이입한 HSVtk 유전자치료에서 면역체계가 bystander effect에 의한 살상효과에 미치는 영향을 규명하고 면역체계가 이입한 유전자의 발현에 미치는 영향을 조사하고자 하였다. 방 법: Immunocompetent mice인 Balb/c mouse와 immunodeficient mouse인 Balb/c-nude 및 SCID mouse에서 retrovirus 벡타를 사용하여 HSVtk 유전자를 이입하고 치료효과를 조사하였다. 그리고 Balb/c mouse에 면역억제제인 cyclosporin을 투여하여 면역억제제가 bystander effect 및 유전자치료 효과와 유전자의 발현기간에 미치는 영향을 조사하였다. 결 과: Balb/c mouse에 HSVtk 유전자를 이입하고 GCV를 투여한 군은 GCV를 투여하지 않은 대조군에 비해 종양의 성장이 유의하게 억제되었으나 Balb/c-nude mouse와 SCID mouse의 경우 GCV를 투여한 군과 대조군 사이에 유의한 차이가 없었다. 면역억제제인 cyclosporin을 투여한 군에서 유전자 치료 효과가 cyclosporin을 투여하지 않은 정상 mouse에 비해 치료효과가 유의하게 작았다. Cyclosporin 투여에 따른 유전자의 발현기간에는 유의한 차이가 없었다. 결 론: Retrovirus 벡타를 사용한 HSVtk 유전자치료에는 면역증강이 치료효과를 증가시킬 것으로 생각된다.

• The Korean Journal of Physiology
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• 제23권2호
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• pp.401-408
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• 1989

This study was conducted to investigate whether an electrical stimulation of medial amygdaloid nucleus in rats increases pancreatic secretion. And an involvement of vagus nerve or plasma secretin in this process was also studied. In fasting rats anesthetized with urethane, a monopolar stainless steel electrode was stereotaxically inserted into the right medial amygdaloid nucleus. Pancreatic juice was collected for 20 minutes, during which physiological saline or 0.01 N HCI (0.18 ml/min) was perfused into the duodenum with or without bilateral subdiaphragmatic vagotomy. In the medial amygdaloid group, an electrical stimulation was continuously applied to the medial amygdaloid nucleus during the perfusion period. After collection of pancreatic juice, blood was drawn from the abdominal aorta for determination of the plasma secretin level. The results were as follows: 1) The electrical stimulaion of the medial amygdaloid nucleus did not influence the pancreatic secretion in response to intraduodenal saline perfusion. 2) The stimulation of the medial amygdaloid nucleus significantly increased the pancreatic secretory response (volume, bicarbonate output) to the intraduodenal 0.01 N HCI perfusion, and the increases were abolished by vagotomy. 3) The plasma secretin concentration after the intraduodenal 0.01 N HCI perfusion was higher than that after the saline perfusion. However, neither the electrical stimulation of the medial amygdaloid nucleus nor vagotomy affected the plasma secretin concentration during the intraduodenal perfusion with saline or 0.01 N HCI. It is, therefore, suggested that the medial amygdaloid nucleus facilitates the pancreatic secretion (volume, bicarbonate) elicited by intraduodenal HCI perfusion through the vagus nerve.

• 한국환경보건학회지
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• 제38권1호
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• pp.73-81
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• 2012

Objectives: With the goal of quantifying the risk of children contracting gastroenteritis while playing at interactive waterscape facilities and evaluating the adequacy of current water quality regulations, risk assessment was performed with Escherichia coli as pathogen. Methods: Abundances of E. coli in the waters of interactive water features in South Korea were acquired from survey reports. A gamma distribution describing the volume of water swallowed by children during swimming activities was adopted. Exposure rate and risk were calculated by Monte Carlo simulation and dose-response models for various pathogenic E. coli. Results: E. coli was detected in 25 out of 40 facilities, with range of ~1,600 CFU/100 ml. The abundance fitted an exponential distribution. Simulated exposures ranged ${\sim}1.9{\times}10^{10}$ CFU, varying greater along E. coli abundance than the volume of water. Risk of children being infected by enterohemorrhagic E. coli was high, with range of ~0.85. When E. coli abundance was <200 CFU/100 ml, which is the current government threshold, the risk decreased to <0.43. Although the guideline successfully reduced the risk of adults being infected by a less virulent E. coli strains (<0.03), the risk for children could not be quantified due to lack of dose-response models for those pathogens for children. Conclusions: Under the current guideline, children are at risk of being infected if water is contaminated with by enterohemorrhagic E. coli. For other E. coli strains, the risk appears to be considerably less. The result warrants need for developing dose-response models for children for each pathogenic E. coli strain.

• 한국음향학회:학술대회논문집
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• 한국음향학회 1999년도 학술발표대회 논문집 제18권 1호
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• pp.269-273
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• 1999

Combination of mental stress task with noise background is a traditional tool employed in psychophysiology. However, intensity of background noise is a factor affecting both performance on test and psychophysiological responses associated with stress evoked by mental load in noisy environment. In the current study on 7 subjects we analyzed the influence of white noise (WN) intensity (55, 70, and 85 dB[A] ) on psychophysiological responses during word recognition test performed on noise background. There were recorded following physiological variables: electrodermal activity (EDA) , namely, skin conductance level (SCL), skin conductance response (SCR) amplitude (SCR-A), rise time and total number of SCRs (N-SCR); cardiovascular activity, e.g., heart rate (HR), respiratory sinus arrhythmia (RSA) index, pulse transit time (PTT), finger pulse volume (PV), skin temperature (SKT) and respiratory activity, such as respiration rate (RESP-R) and inspiration wane amplitude (RESP-A) during baseline resting state and 40 s long performance on 3 similar Korean word recognition tests with different WN intensity (55, 70, and 85 dB). Electrodermal responses (SCR-A, SCL, N-SCR) demonstrated gradual increment with increased intensity of noise, and this increase of response magnitude with higher intensity of noise was typical also for r skin temperature (phasic SKT decrease) and pulse volume (phasic and tonic PV decrease). However, some cardiovascular and respiratory responses did not exhibit same tendency of gradual increase of reactivity , namely HR, as well as RESP-R and RESP-A showed decrement of response magnitudes. Important finding in terms of cardiovascular reactivity was that 55 and 70dB evoked similar profiles, while 85dB WN resulted in significantly different profile of reactions, suggesting that there exists a threshold level after which intensive auditory stimulation elicits psychophyslological responses pattern of different quality. There are discussed potential autonomic mechanism involved in mediation of observed physiological responses.