• Journal of the Korean Society of Radiology
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• v.18 no.1
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• pp.1-9
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• 2024

Proton therapy is known for its superior treatment method due to Bragg peak. To enhance the therapeutic effects of protons, research has been conducted on distributing gold nanoparticles within tumors to increase the absorbed dose. While previous studies focused on handling gold nanoparticles at micrometer and nonometer scale, this study proposes a method to computationally estimate the effect of gold nanoparticles at the millimeter scale. The Geant4 toolkit was applied to computational modeling. Assuming a uniform distribution of water, similar to the human body, and gold nanoparticles, the concentration of gold nanoparticles was adjusted using density ratios. When the density ratio was 5%, the gain in absorbed energy due to gold nanoparticles was nearly twice that of the pure water phantom at the Bragg peak. As the density ratio increased, the gain in absorbed energy linearly increased. When gold nanoparticles were distributed in only one voxel at the Bragg peak, the energy of the protons affected only the neighboring voxels. However, in cases where gold nanoparticles were distributed over a wide area, the volume showing 95% of the maximum absorbed energy (9.46 keV) for the pure water phantom (9.95 keV) exhibited an improvement in absorbed energy over a region 16 times larger, and this region increased as the density ratio increased. Further research is needed to quantify the relationship between the density ratio of gold nanoparticles and the relative biological effect (RBE) in the millimeter scale.

• Journal of Life Science
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• v.22 no.2
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• pp.148-155
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• 2012

A cross-sectional analysis of blood pressure (BP) changes and the current prevalence and distribution of hypertension among age groups in Korea were conducted. Systolic (SBP), diastolic (DBP), and pulse (PP) pressures were evaluated. Residents visiting a local Community Health Center for a health check-up and/or participating in the Health Promotion Program were included for the analyses. A total of 6,570 subjects (2,809 men, 3,761 women) were divided into five age groups: 30-39, 40-49, 50-59, 60-69, and $70\leq$ years. Comparisons were made between sex and among age groups. SBP and DBP were continuously elevated, while men showed higher levels than women until their mid-60s; then, the trend was reversed. DBP in men became elevated from their 30s, reaching the highest in the 40s then slowly decreasing. DBP in women increased up to their 40s and 50s, then reached a plateau. PP increased rapidly from the 50s in both sexes. The major contributor of age-related BP elevation may be large artery stiffness in men, particularly from their 50s, while the blood pressure elevation of women may relate to diverse factors including large artery stiffness, stroke volume, and ventricular ejection rate. The rapid elevation of PP after the 50s in both men and women could represent a risk of cardiovascular or coronary mortality, particularly with increasing age. The current data showed a higher rate of hypertension in both sexes compared to previous reports. When those with both high-normal BP and hypertension are looked at in combination, BP management of the target population should be drastically elevated.

• Progress in Medical Physics
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• v.23 no.3
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• pp.127-137
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• 2012

A conversing beam is firstly designed for radiosurgery by a neurosugern Lars Leksell in 1949 with orthogonal x-rays tube moving through horizontal moving arc to focusing the beam at target center. After 2 decades he composits 201 source of the Co-60 for gamma knife which beams focused at locus. Sveral linac-based stereotactic radiosurgery using the circular collimated beam which size range for 0.4~4.0 cm in a diameter by non-coplanar multiarc have been developed over the decades. The irregular lesions can be treated by superimposing with several spherical shots of radiation over the tumour volume. Linac based techniques include the use of between 4 and 11 non-co-planar arcs and a dynamic rotation technique and use photon beam energies in the range of 6~10 MV. Reviews of the characteristics of several treatment techniques can be found in the literature (Podgorsak 1989, Schell 1991). More in recent, static conformal beams defined by custom shaped collimators or a mini- or micro-multileaf collimator (mMLC) have been used in SRS. Finally, in the last few years, intensity-modulated mMLC SRS has also been introduced. Today, many commercial and in-house SRS programs have also introduced non-invasive immobilization systems include the cyberknife and tomotherapy and proton beam. This document will be compared the characteristics of dose distribution of radiosurgery as introduced gamma knife, BrainLab include photon knife in-house SRS program and cyberknife in currently wide used for a cranial SRS.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.104-109
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• 2017

The flooding and deterioration of water quality caused by urbanization and climate change are becoming more serious. In order to respond to this, studies on low impact development (LID) technology, which is designed to restore the hydrological system of the urban basin to its natural state, have been actively pursued all over the world, The announcement of the low carbon green growth law, hydrophilic area special law, etc., highlights the importance of technology such as the LID method. However, whereas various developments have been made in relation to the current LID element technology, there has been little research designed to verify its effectiveness. In this study, we analyzed the optimum spatial distribution of pitcher fire pitcher packing in parking lots using the K - LIDM model to verify the effectiveness of the low impact development (LID) method in the early stages. Using the eight package scenario and the three rain intensity scenarios, it was found that the lower 40% pitcher packaging results in an approximately 90% spill reduction effect, as in the case of the whole pitcher's package. The confirmation of these analyses and experimental verification is expected to ensure that the actual pitcher packaging will be used as a basis for arranging LID facilities such as urban planning and housing development in the future.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.5
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• pp.345-352
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• 2014

In this paper, the CAD data for the optimal shape design obtained by isogeometric shape optimization is directly used to fabricate the specimen by using 3D printer for the experimental validation. In a conventional finite element method, the geometric approximation inherent in the mesh leads to the accuracy issue in response analysis and design sensitivity analysis. Furthermore, in the finite element based shape optimization, subsequent communication with CAD description is required in the design optimization process, which results in the loss of optimal design information during the communication. Isogeometric analysis method employs the same NURBS basis functions and control points used in CAD systems, which enables to use exact geometrical properties like normal vector and curvature information in the response analysis and design sensitivity analysis procedure. Also, it vastly simplify the design modification of complex geometries without communicating with the CAD description of geometry during design optimization process. Therefore, the information of optimal design and material volume is exactly reflected to fabricate the specimen for experimental validation. Through the design optimization examples of elasticity problem, it is experimentally shown that the optimal design has higher stiffness than the initial design. Also, the experimental results match very well with the numerical results. Using a non-contact optical 3D deformation measuring system for strain distribution, it is shown that the stress concentration is significantly alleviated in the optimal design compared with the initial design.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.2
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• pp.161-168
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• 2011

The heating, ventilating, air conditioning (HVAC) system is a very important part of an automotive vehicle: it controls the microclimate inside the passenger's compartment and removes the frost or mist that is produced in cold/rainy weather. In this study, the numerical analysis of the defrost duct in an HVAC system and the de-icing pattern is carried out using commercial CFX-code. The mass flow distribution and flow structure at the outlet of the defrost duct satisfied the duct design specification. For analyzing the de-icing pattern, additional grid generation of solid domain of ice and glass is pre-defined for conductive heat transfer. The flow structure near the windshield, streakline, and temperature fields clearly indicate that the de-icing capacity of the given defrost duct configuration is excellent and that it can be operated in a stable manner. In this paper, the unsteady changes in temperature, water volume fraction, and static enthalpy at four monitoring points are discussed.

• Journal of Food Hygiene and Safety
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• v.13 no.4
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• pp.388-393
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• 1998

Recently there has been an increasing amount of foreign livestock products distributed in the domestic market due to the market opening. Some vicious dealers sell the foreign beef in the trade name of the native beef during the final distribution step to arouse the social criticism frequently. In this report, we investigated a method to distinguish the native beef from the foreign one scientifically using the PCR-RAPD, a recent gene technique. Hygienical safety was also examined using a microbiological test for toxicity of Escherichia coli 0157:H7 and the food poisoning bacteria. The conditions of DNA amplification for the PCR analysis were $1{\times}Taq$ polymerase buffer, 1.5 mM $MgCl_2,\;50\;\mu\textrm{M}$ dNTP, 100 ng primers, 2.5 unit Taq polymerase and 5~20 ng template DNA, with the fmal volume of $50\;\mu\textrm{\ell}$. The size of the amplified product was detected mostly in the range of 0.5~2.0 kbp. The size of DNA, gene marking factor, which could be a criterion distinguishing the native beef from the foreign one, appeared approximately 1.2 kbp. The native beef was distinguished from the foreign beef with more than 90% of confidence by the gene marking factor. This method was expected to be useful in the breed discrimination between the native beef and the foreign one. The hygienical test results showed that, fortunately, neither Salmonella spp. and Listeria monocytogenes which form a principal cause of the food poisoning nor Enterohemorrhagic Escherichia coli : EHEC which have provoked a recent social disturbance, were detected at all.

• Journal of Korea Water Resources Association
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• v.50 no.2
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• pp.89-97
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• 2017

Turbulent flow structure in the high amplitude meandering channel is complex due to secondary recirculation with helicoidal motions and shear layers formed by flow separation from the curved sidewall. In this work, the secondary flow and the superelevation of the water surface produced in the high-amplitude Kinoshita channel are reproduced by the unsteady Reynolds-averaged Navier-Stokes (RANS) computations using the VOF technique for resolving the variation of water surface elevation and three statistical turbulence models ($k-{\varepsilon}$, RNG $k-{\varepsilon}$, $k-{\omega}$ SST). The numerical results computed by a second-order accurate finite volume method are compared with an existing experimental measurement. Among applied turbulence models, $k-{\omega}$ SST model relatively well predicts overall distribution of the secondary recirculation in the Kinoshita channel, while all three models yield similar prediction of water superelevation transverse slope. The secondary recirculation driven by the radial acceleration in the upstream bend affects the flow structure in the downstream bend, which yields a pair of counter-rotating vortices at the bend apex. This complex flow pattern is reasonably well reproduced by the $k-{\omega}$ SST model. Both $k-{\varepsilon}$ based models fail to predict the clockwise-rotating vortex between a pair of counter-rotating vortices which was observed in the experiment. Regardless of applied turbulence models, the present computations using the VOF method appear to well reproduce the superelevation of water surface through the meandering channel.

• Journal of Korea Spatial Information System Society
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• v.7 no.2 s.14
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• pp.47-56
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• 2005

Recently, with the rapid development of mobile computing, wireless positioning technologies, and the generalization of wireless internet, LBS (Location Based Service) which utilizes location information of moving objects is serving in many fields. In order to serve LBS efficiently, the location data server that periodically stores location data of moving objects is required. Formerly, GIS servers have been used to store location data of moving objects. However, GIS servers are not suitable to store location data of moving objects because it was designed to store static data. Therefore, in this paper, we designed and implemented an extended SLDS(Short-term Location Data Subsystem) for real-time Location Based Services. The extended SLDS is extended from the SLDS which is a subsystem of the GALIS(Gracefully Aging Location Information System) architecture that was proposed as a cluster-based distributed computing system architecture for managing location data of moving objects. The extended SLDS guarantees real-time service capabilities using the TMO(Time-triggered Message-triggered Object) programming scheme and efficiently manages large volume of location data through distributing moving object data over multiple nodes. The extended SLDS also has a little search and update overhead because of managing location data in main memory. In addition, we proved that the extended SLDS stores location data and performs load distribution more efficiently than the original SLDS through the performance evaluation.

• Journal of Korean Society of Environmental Engineers
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• v.32 no.9
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• pp.862-869
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• 2010

Numerical analysis was done to evaluate the gas flow distribution in small scale SCR system which has $2.4{\times}2.4{\times}3.1\;m^3$ in volume and 25,300 Sm3/hr in flue gas flow capacity. Various types of baffles proposed for controlling the flow uniformity were evaluated by the CFD analysis to find the optimal geometry of the baffle in the SCR system. By installing baffles in the SCR system, the RMS (%) value was raised up to 6.2% compared with the baffle-uninstalled state. The effect of baffle thicknesses on the RMS (%) value was not shown within 0 and 8 mm in thickness, but the RMS (%) value was raised by 2.5% in 10 mm of baffles thickness, which causes the unstability in flow. By comparison between the shape of baffles, it is known that the lattice type baffle has better performance in controlling the flow uniformity than the circular truncated cone type baffle or mixer type baffle. RMS (%) values have more that 10% difference according to the shape of baffle type.