• Radiation Oncology Journal
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• v.15 no.3
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• pp.207-213
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• 1997

Purpose : Intracranial germinoma is the most radiocurable tumor of theprimary intracranial neoplasm. But, the optimum radiation dose and target volume remain controversial In this retrospective study, we analysed the spreading pattern at presentation and the pattern of the failure and survival of intracranial germinoma, Materials and Methods : From 1989 to 1996, 23 Patients were treated for intracranial germinoma at Department of Radiation Oncology, Twenty-one Patients were treated at their initial Presentation and 2 Patients were treated for recurrent disease. Six patients had multiple tumor masses on MRI and 7patients had ventricular seeding on MRI. The examination of cerebrospinal fluid cytology was done in 15 patients and 3 out of 15 patients had positive cerebrospinal cytology. In tumor marker study of $\alpha-FP\;and\;\beta-hCG$, 6 patients had mildly elevated $\beta-hCG$ in serum or cerebrospinal fluid. Twentyone Patients were treated with whole craniospinal axis irradiation and 2 Patients were given whole ventricular radiation therapy. The total dose was ranged between 4500cGy and 5600cGy to primary tumor site (median 5580cGy) Dose to the entire ventricular system ranged from 1980cGy to 3960 cGy (median 2700cGy) and dose to the spinal axis ranged from 2160cGy to 3900cGy (median 2700cGy) Results : Of 23 patients, 21 Patients are alive without evidence of diseasefor median 4 years follow-up. One Patient who had markedly elevated $\alpha-FP\;and\;\beta-hCG$, suffered from Persistent disease after radiation therapy and received 2 cycles of chemotherapy. She died 9 months after chemotherapy One patient who developed ventricular seeding after gamma-knife was treated with whole craniospinal irradiation, he died after 1 year due to probably brain necrosis. The hematologic toxicity of 3 or 4 grade were seen in 7 patients and patient's endocrinologic dysfunction was not deteriorated after radiation therapy. One patient had been treated with growth hormone replacement due to short stature. Conclusions : This retrospective study has confirmed the excellent result of radiation therapy in intracranial germinoma. The complication rate during or after radiation therapy is considered within acceptable range. ft is necessary to further investigate the optimal dose and treatment volume of radiation therapy. The role of chemotherapy in the treatment of intracranial germinoma should be further investigated.

• Tuberculosis and Respiratory Diseases
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• v.48 no.4
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• pp.487-499
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• 2000

Background : Acute lung injury is an hypoxic respiratory failure resulting from damage to the alveolar-capillary membrane, which can be developed by a variety of systemic inflammatory diseases. In this study the therapeutic effects of intra-tracheal pulmonary surfactant instillation was evaluated in the intratracheal endotoxin induced acute lung injury model of a rat. Methods : Twenty Sprague-Dawley rats were divided into 4 groups, and normal saline (2 ml/kg, for group 1) or LPS (5 mg/kg, for group 2, 3, and 4) was instilled into the trachea respectively. Either normal saline (2 ml/kg, for group 1 & 2, 30 min later) or bovine surfactant (15 mg/kg, 30 min later for group 3, 5 hr later for group 5) was instilled into the trachea. The therapeutic effect of intratracheal surfactant therapy was evaluated with one chamber body plethysmography (respiratory frequency, tidal volume and enhanced pause), ABGA, BAL fluid analysis (cell count with differential, protein concentration) and pathologic examination of the lung. Results : Intratracheal endotoxin instillation increased the respiration rate decreased the tidal volume and int creased the Penh in all group of rats. Intratracheal instillation of surfactant decreased Penh, increased arterial oxygen tension, decreased protein concentration of BAL fluid and decreased lung inflammation at both times of administration (30 minute and 5 hour after endotoxin instillation). Conclusion : Intratracheal instillation of surfactant can be a beneficial therapeutic modality as discovered in the acute lung injury model of rats induced by intratracheal LPS intillation. It deserves to be evaluated for treatment of human acute lung injury.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.43-43
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• 2011

최근 컴퓨터 기술의 발전으로 수심방향으로 완전한 운동방정식인 Navier-Stokes 방정식을 이용하는 3차원 수치모형에 의한 연구가 기초과학 분야인 수학에서부터 공학은 물론 의학 분야까지 광범위하게 진행되고 있다. 3차원 수치모형을 이용한 연구는 이론적으로 매우 우수하긴 하나 정확도 높은 결과를 얻기 위해서는 매우 조밀한 격자를 필요로 하기 때문에 아직까지 막대한 계산시간이 필요하다는 단점이 있으나 근래의 컴퓨터 기술이 엄청난 속도로 발전하고 있는 점을 감안할 때 적용 가능성은 계속 높아지고 있다. 이러한 흐름에 따라 해안공학 분야에서도 3차원 수치모형을 이용한 다양한 연구가 시도되고 있다. 복잡한 해안구조물로 인한 파랑변형 및 구조물의 안전성 등을 검토할 때 기존의 평면 2차원 수치모형이나 연직 2차원 수치모형으로는 재현이 힘들어 상대적으로 수치모형을 활용한 연구의 효용성이 낮았던 것에 비해 3차원 수치모형을 활용할 경우 복잡한 지형 및 구조물의 형상을 재현할 수 있기 때문에 좀 더 유용하게 사용될 수 있다. 한편, 파랑변형을 다루는 수치모형실험을 수행할 때 외부조파를 사용할 경우 구조물이나 지형에 의해 반사되어 나온 파랑이 조파지점에 도달할 때 실험영역으로 재 반사되는 문제가 발생한다. 이를 해결하기 위해 내부조파기법의 개발에 대한 연구가 필수적이었으며, 2차원 수치모형을 중심으로 그 연구가 매우 활발하게 진행되어 왔으나 Navier-Stokes 방정식 모형의 경우 상대적으로 연구가 미흡하였다. 본 연구에서는 3차원 Navier-Stokes 방정식 모형에서 내부조파기법을 도입하여 목표 파랑을 조파하였다. 수치모형은 Navier-Stokes 방정식을 엇갈림 격자체계에서 계산하는 유한차분모형으로 자유수면 추적에는 2차 정확도의 VOF(volume-of-fluid) 기법을 사용한다. 수치모형실험 결과를 일정한 수심을 전파하는 정현파의 해석해와 비교하였으며, 수치모형실험 결과가 비교적 정확하게 목표 파랑을 조파할 수 있음을 검증하였다.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.251-251
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• 2018

도로설계기준(2012)에 따르면 노면 배수시설은 측구, 집수정, 배수관, 배수구(빗물받이, 맨홀) 등으로 구성되며 중앙분리대 배수에서 구조가 방호벽일 경우 원칙적으로 집수정과 종배수관, 횡배수관을 설치하여 노면수를 배수한다. 최근 기후변화에 따른 국지성 집중호우로 교량 배수시설의 배수능력 부족으로 교량의 노후화, 노면의 체수와 수막현상을 야기한다. 교량 설계 시, 교량의 외관은 점배수에 의한 배수불량으로 막힘부에서의 식물생육, 부식, 배수구의 오염 등으로 심미성에 악영향을 미치고 있다. 따라서 국토교통부 도로 배수시설 설계 및 관리지침에서는 기존의 집수정으로 유도하여 배수하는 점배수 형태에서 우수의 지체시간을 저감하기 위해 배수구로 즉시 배수되어 배수 효율을 증가시켜주는 선배수시설을 권장하고 있다. 그러나 선배수 구조의 일반적인 내용만을 기술하고 있으므로 보다 상세한 설계기준이 필요하다. 또한 국내에서는 교면 배수를 위한 횡배수구의 배수능력에 관한 설계 개념은 미국의 빗물받이 설계 개념을 그대로 적용하고 있어서 교량 배수시설의 배수능력 증대를 위한 수치 및 수리실험에 관한 기술적인 자료가 부족한 실정이다. 따라서 도로의 흐름해석 및 선배수를 위한 측구 횡배수관의 흐름개선에 관한 구체적인 연구가 필요한 실정이다. 본 연구에서는 배수로 전반의 유향 분석 및 횡유입관 유입부에서의 상세한 흐름해석과 통수능력을 분석하기 위해서는 수리실험을 통한 연구가 필요한 실정이다. 그러나 최적 횡배수관의 형상 및 간격 설정에 대한 수리실험의 물리적 및 시간적 한계를 극복하기 위해 Fluent 모형(Ansys Workbench 13.0)을 활용한 수치모의를 수행하여 모형의 적용성을 검토하였다. 다상유동 해석을 위해 VOF(Volume of Fluid)방법을 적용하였고, 수치해석 방법으로는 비정상류, 난류 모형으로는 standard ${\kappa}-{\varepsilon}$모형을 적용했다. 도로 형상에 따른 우수유출량을 비교 분석하기 위하여 횡경사는 2%로 고정하고 종경사를 2%로 선정하여 수치모의를 통한 배수능력을 분석하고 설계에 직접적인 적용성을 검토하였다. 횡배수관의 간격변화 및 배수공의 위치 변화 등에 따른 차집량을 분석하였으며, 개략적인 수리실험 결과와 수치모의의 차집율을 비교 및 분석하여 Fluent 모형의 적용성을 확인하였다. 또한, 횡배수관의 유입부에서의 유속 변화 및 유출부에서의 유속이 모의가 가능하므로 배수시설에서 보다 정확한 흐름 해석이 가능하여 보다 적정한 배수능력 분석이 가능할 것으로 판단된다.

• 한국방재학회:학술대회논문집
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• 2011.02a
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• pp.59-59
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• 2011

파랑의 전파와 변형에 대한 연구에는 수심방향으로 적분한 2차원방정식인 완경사방정식과 Boussinesq 방정식을 기반으로 한 수치모형을 이용한 연구가 최근까지 가장 활발하게 진행되어 오고 있다. 그러나 실제 구조물의 설계에는 2차원 수치모형에서 고려할 수 없는 수심방향 유속에 기인한 정확도의 문제로 인해 구조물의 형상과 재원을 설계하기 위한 정교한 수치모형실험이 어려워 주로 수리모형실험에 의존해 왔다. 수리모형실험은 실제 현상을 가장 잘 재현해낼 수 있어 신뢰성이 매우 높지만 다양한 실험을 수행하기가 어렵고 많은 시간과 비용이 소요되는 단점이 있다. 이에 따라 최근 수심방향으로 완전한 운동방정식인 Navier-Stokes 방정식을 푸는 3차원 수치모형에 대한 연구가 활발히 진행되고 있다. 이론적으로 매우 우수한 모형이긴 하나 정확도 높은 결과를 얻기 위해서는 매우 조밀한 격자를 필요로 하기 때문에 아직까지 막대한 계산시간이 필요하다는 단점이 있으나 컴퓨터 기술이 급격한 속도로 발전하고 있어 Navier-Stokes 방정식 모형의 적용 가능성은 계속 높아지고 있다. 파랑변형을 다루는 수치모형실험을 수행할 때 외부조파를 사용할 경우 구조물이나 지형에 의해 반사되어 나온 파랑이 조파지점에 도달할 때 실험영역으로 재 반사되는 문제가 발생한다. 이를 해결하기 위해 내부조파기법의 개발에 대한 연구가 필수적이었으며, 자유수면변위를 변수로 사용하는 모형의 경우 그 연구가 매우 활발하게 진행되어 왔다. 한편, Navier-Stokes 방정식 모형의 경우 자유수면변위를 변수로 사용하는 2차원 모형에 비해 상대적으로 연구가 미흡하였다. 본 연구에서는 기존의 연직 2차원 Navier-Stokes 방정식 모형에 사용된 연속방정식에 질량 원천항을 추가하는 내부조파기법을 도입하여 3차원 수치모형에서 고립파를 내부조파하고, 급경사에서의 고립파의 처오름 및 처내림 현상을 수리모형 실험결과와 비교 및 분석하였다. 수치모형은 Navier-Stokes 방정식을 엇갈림 격자체계에서 계산하는 동수압 모형으로서, Two-step projection 기법을 사용하는 유한차분모형을 사용하였다. 본 수치모형은 난류의 해석을 위해서 상대적으로 큰 에디(eddy)만을 고려하는 SANS(spatially averaged Navier-Stokes) 방정식을 계산하는 LES(large-eddy-simulation) 기반의 수치모형으로, 난류 모델링을 위해 Smagorinsky LES 모형을 사용한다. 또한, 압력장의 계산을 위해 Bi-CGSTAB 기법을 이용하여 Poisson 방정식의 해를 구하였으며, 자유수면 추적을 위하여 2차 정확도의 VOF(volume-of-fluid) 기법을 사용하였다. 수치모형실험이 전체적으로 수리모형실험에서 관측한 파랑의 처오름 및 처내림 현상을 잘 재현하고 있는 것으로 나타났으며, 정량적인 비교를 통해 수치모형의 성능을 검증하였다.

• Journal of the Korea Organic Resources Recycling Association
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• v.16 no.2
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• pp.57-65
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• 2008

Wastewater containing strong organic matter is very difficult to treat by utilizing general sewage treatment plant. but the wastewater is adequate to generate biomass energy (bio-gas; methane gas) by utilizing anaerobic digestion. EcoDays Plug Flow Reactor (E-PFR), which was already proved as an excellent aerobic wastewater treatment reactor, was adapted for anaerobic food wastewater digestion. This research was performed to improve the efficiency of bio-gas production and to optimize anaerobic wastewater treatment system. Food wastewater from N food waste treatment plant was applied for the pilot scale experiments. The results indicated that the efficiency of anaerobic wastewater treatment and the volume of bio-gas were increased by applying E-PFR to anaerobic digestion. The structural characteristics of E-PFR can cause the high efficiency of anaerobic treatment processes. The unique structure of E-PFR is a diaphragm dividing vertical hydraulic multi-stages and the inversely protruded fluid transfer tubes on each diaphragm. The unique structure of E-PFR can make gas hold-up space at the top part of each stage in the reactor. Also, E-PFR can contain relatively high MLSS concentration in lower stage by vertical up-flow of wastewater. This hydraulic flow can cause high buffering capacity against shock load from the wastewater in the reactor, resulting in stable pH (7.0~8.0), relatively higher wastewater treatment efficiency, and larger volume of bio-gas generation. In addition, relatively longer solid retention time (SRT) in the reactor can increase organic matter degradation and bio-gas production efficiency. These characteristics in the reactor can be regarded as "ideal" anaerobic wastewater treatment conditions. Anaerobic wastewater treatment plant design factor can be assessed for having 70 % of methane gas content, and better bio-gas yielding and stable treatment efficiency based on the results of this research. For example, inner circulation with generated bio-gas in the reactor and better mixing conditions by improving fluid transfer tube structure can be used for achieving better bio-gas yielding efficiency. This research results can be used for acquiring better improved regenerated energy system.

• Journal of Hospice and Palliative Care
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• v.12 no.1
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• pp.27-31
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• 2009

Purpose: Lymphedemas are tissue fluid swellings, usually on the arms or legs, and occur as a result of impaired lymphatic drainage. Presently, the most effective treatment available is complete decongestive physiotherapy (CDP). However, this therapy is ineffective in some patients and surgery may be indicated. Herein, we examined the efficacy of minimally invasive needle aspiration of the most enlarged areas in hypodermic adipose tissues, of patients who had failed CDP. Methods: We included 21 patients who were diagnosed with lymphedema stage II-III in the upper or lower extremities and visited the lymphedema clinic at a university hospital from September 1, 2003 to February 28, 2004. All patients had been treated with CDP at least once, but had failed to respond to the therapy for more than one year. Nine patients had breast cancer and 12 had cervical cancer. We identified the area with the most severe edema by using MRI and performed a 16-gauge angio-needle aspiration on the area. The patients were followed up for 3 months. Effectiveness of the treatment was evaluated by comparing the volume of edema before and after the treatment using Wilcoxon signed rank-test. Results: The mean reduction ratio of the volume of edema comparison normal volume was 41.1${\pm}$35.3% (P=0.001). There were no major or minor operative complications except localized hemorrhage. Conclusion: We conclude that a needle aspiration prior to other surgical treatments is relatively safe and effective for those patients who are unresponsive to CDP.

• Journal of agricultural medicine and community health
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• v.16 no.2
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• pp.134-140
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• 1991

The amino acid constituents of Paragonimus westermani were very imperfectively known. Lee(1964) detected 9 amino acids in the tissue hydrolysates of P. westermani, and 13 amino acids were detected from the cyst content and body fluid constituents of P. ohirai, But, the quantity of amino acids in P. westermani is still unknown. In the present investigation 18 amino acids, the fundamental constituents of proteins, were quantitatively studied by high performance liquid chromatography. The results obtained were as follows : A total of 18 amino acids were recovered in protein hydrolysates of P. westermani obtained from cat. ; They were cystein, aspartic acid, glutamic acid, serine. glycine, histidine. arginine, threonine, alanine, proline, tyrosine, valine, methionine, isoleucine, leucine, phenylalanine, tryptophan and lysin. Among them, glutamic acid was the most abundant form and tryptophan, cystein, methionine, and histidine constitute minor portion of hydrolysates. Compared to the normal P. westermani, the volume of hydrolysates obtained from the praziquantel(PZQ) treated worm-0.lug PZQ/ml saline for 6 hours incubation, and $3{\times}25$mg/kg bwt${\times}$2days in vivo treatment was generally increased except tryptophan. A total of 17 free amino acids were identified and the volume was 174.18 umol/1 gm wet weight P. westermaini. Among them, glycine and alanine constitute 28% of total volume. No significant differences were observed in the material obtained from worm treated with PZQ. However, slight increase of serine, arginine and the slight diminution of glutamic acid and proline was observed.

• Geophysics and Geophysical Exploration
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• v.13 no.1
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• pp.80-87
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• 2010

This study was conducted to develop a reservoir modelling workflow to reproduce the heterogeneous distribution of effective permeability that impacts on the performance of SAGD (Steam Assisted Gravity Drainage), the in-situ bitumen recovery technique in the Athabasca Oil Sands. Lithologic facies distribution is the main cause of the heterogeneity in bitumen reservoirs in the study area. The target formation consists of sand with mudstone facies in a fluvial-to-estuary channel system, where the mudstone interrupts fluid flow and reduces effective permeability. In this study, the lithologic facies is classified into three classes having different characteristics of effective permeability, depending on the shapes of mudstones. The reservoir modelling workflow of this study consists of two main modules; facies modelling and permeability modelling. The facies modelling provides an identification of the three lithologic facies, using a stochastic approach, which mainly control the effective permeability. The permeability modelling populates mudstone volume fraction first, then transforms it into effective permeability. A series of flow simulations applied to mini-models of the lithologic facies obtains the transformation functions of the mudstone volume fraction into the effective permeability. Seismic data contribute to the facies modelling via providing prior probability of facies, which is incorporated in the facies models by geostatistical techniques. In particular, this study employs a probabilistic neural network utilising multiple seismic attributes in facies prediction that improves the prior probability of facies. The result of using the improved prior probability in facies modelling is compared to the conventional method using a single seismic attribute to demonstrate the improvement in the facies discrimination. Using P-wave velocity in combination with density in the multiple seismic attributes is the essence of the improved facies discrimination. This paper also discusses sand matrix porosity that makes P-wave velocity differ between the different facies in the study area, where the sand matrix porosity is uniquely evaluated using log-derived porosity, P-wave velocity and photographically-predicted mudstone volume.

• Korean Circulation Journal
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• v.53 no.7
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• pp.425-451
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• 2023

Most patients with heart failure (HF) have multiple comorbidities, which impact their quality of life, aggravate HF, and increase mortality. Cardiovascular comorbidities include systemic and pulmonary hypertension, ischemic and valvular heart diseases, and atrial fibrillation. Non-cardiovascular comorbidities include diabetes mellitus (DM), chronic kidney and pulmonary diseases, iron deficiency and anemia, and sleep apnea. In patients with HF with hypertension and left ventricular hypertrophy, renin-angiotensin system inhibitors combined with calcium channel blockers and/or diuretics is an effective treatment regimen. Measurement of pulmonary vascular resistance via right heart catheterization is recommended for patients with HF considered suitable for implantation of mechanical circulatory support devices or as heart transplantation candidates. Coronary angiography remains the gold standard for the diagnosis and reperfusion in patients with HF and angina pectoris refractory to antianginal medications. In patients with HF and atrial fibrillation, longterm anticoagulants are recommended according to the CHA₂DS₂-VASc scores. Valvular heart diseases should be treated medically and/or surgically. In patients with HF and DM, metformin is relatively safer; thiazolidinediones cause fluid retention and should be avoided in patients with HF and dyspnea. In renal insufficiency, both volume status and cardiac performance are important for therapy guidance. In patients with HF and pulmonary disease, beta-blockers are underused, which may be related to increased mortality. In patients with HF and anemia, iron supplementation can help improve symptoms. In obstructive sleep apnea, continuous positive airway pressure therapy helps avoid severe nocturnal hypoxia. Appropriate management of comorbidities is important for improving clinical outcomes in patients with HF.