• Title/Summary/Keyword: Volume concentration variation

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Evaluation of Variation Method to Improve the Sensitivity of Immunoradiometric Assay (면역방사계수측정법의 민감도 향상을 위한 변법의 평가)

  • Won-Hyun Kwon;Mi-Ji Kang;;Ji-Sol Park;Jung-In Kim;Kyung-Jae Lee
    • The Korean Journal of Nuclear Medicine Technology
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    • v.27 no.1
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    • pp.29-35
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    • 2023
  • Purpose The concentration of PSA (Prostate Specific Antigen) after radical prostatectomy in prostate cancer patients is a predictor of biochemical recurrence, and the AUA (American Urological Association) is defined as biochemical recurrence when the concentration of PSA is measured at 0.2 ng/mL or more, and when the concentration is measured at 0.2 ng/mL or more at the retest. This standard is also applied our hospital. In this laboratory, the PSA reagent using IRMA (Immunoradiometric Assay) is used, and the sensitivity at a very low value was not as good as the reagent used in the department of laboratory medicine. This study aims to increase the reliability of the results by improving the precision and sensitivity of very low values. Materials and Methods As a reagent for the study, PSA reagent using IRMA was used. As a method to improve the precision and sensitivity of very low values, a variation method on the serum volume(25 uL, 50 uL, 100 uL, 200 uL) was studied, and variation usefulness evaluation was conducted. The evaluation items were compared the results of precision, analytical sensitivity, recovery rate, dilution test, high-dose hook effect test, parallel test and very low concentration values(n = 20). Results The validation results were displayed in the order of 25 uL, 50 uL, 100 uL, 200 uL. As the serum volume increased, it was confirmed that CV (Coefficient of Variation)(%) improved. Analytical sensitivity(ng/mL) was 0.038, 0.041, 0.017, 0.015 and recovery rate(%) was 101±3, 101±3, 99±2, 97±4. very low concentration values(ng/mL) between each volume(n=20) were 0.135±0.068, 0.076±0.050, 0.048±0.034, 0.046±0.034. and high dose hook effect appeared as the serum volume increased. Conclusion Through the variation usefulness evaluation, it was confirmed that as the serum volume increased, the precision and sensitivity improved at very low concentration values. However, it is necessary to pay special attention to the occurrence of high-dose hook effect as the serum volume increases. In the case of tests that requires very low concentration values, it is thought that the reliability of the result will be increased if the variation method is properly used after the variation usefulness evaluation.

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A Study on the Correlation between the Volume of Indoor Space and the Measured Concentration of Indoor Radon (실내 체적과 라돈 농도와의 상관관계 연구)

  • Kang, Sung-A;Han, Dong-Hyun;Kim, Chong-Yeal
    • Journal of Radiation Protection and Research
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    • v.32 no.3
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    • pp.97-104
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    • 2007
  • The corelation between the indoor volume and the measured radon concentration has been analyzed by comparing the radon concentration and the indoor volume of apartment rooms in Jeonju City. We also measured the annual exposure dose based on the variation in indoor radon concentration over time. To do this, we took 8 larger rooms and 8 smaller rooms of apartment, respectively, as a sample. The average volume of the larger rooms and that of the smaller rooms were $31.59\;m^3$ and $16.82\;m^3$, respectively. The average radon concentration of the larger rooms and that of the smaller rooms turned out to be $71.73\;Bq/m^3$ and $108.51\;Eq/m^3$, respectively. indicating that indoor volume is in inverse proportion to the radon concentration, i.e., the bigger the ratio of the surface area/volume, the higher the indoor radon concentration. From the measurement of the variation in indoor radon concentration over time fur a single day, the average intraday radon concentration variation was found to be about $46.8\;Bq/m^3$. The highest level of concentration ($114.5\;Bq/m^3$) was measured between 8 and 10 AM and the lowest level of concentration ($67.7\;Bq/m^3$) between 2 and 4 PM. The annual exposure dose turned out to be in the range of 0.3 mSv/yr to 2.16 mSv/yr, showing that the dose in some apartments exceeded 1.3 mSv/yr, the numerical value presented by the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR).

Local nanofiller volume concentration effect on elastic properties of polymer nanocomposites

  • Shin, Hyunseong;Han, Jin-Gyu;Chang, Seongmin;Cho, Maenghyo
    • Multiscale and Multiphysics Mechanics
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    • v.1 no.1
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    • pp.65-76
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    • 2016
  • In this study, an influence of local variation of nanoparticulate volume fraction on the homogenized elastic properties is investigated. It is well known that interface effect is dependent on the radius and volume fraction of reinforced nanofillers. However, there is no study on the multiscale modeling and analysis of polymer nanocomposites including polydispersed nanoparticles with consideration of interphase zone, which is dependent on the volume fraction of corresponding nanoparticles. As results of numerical examples, it is confirmed that an influence of local variation of nanoparticulate volume fraction should be considered for non-dilute system such as cluster of nanoparticles. Therefore representative volume element analysis is conducted by considering local variation of nanoparticle volume fraction in order to analyze the practical size of cell including hundreds of nanoparticles. It is expected that this study could be extended to the multiparticulate nanocomposite systems including polydispersed nanoparticles.

Characteristics of Air Pollution at Kimhae (김해지방의 대기오염 특성)

  • 박종길;김종필;김지형
    • Journal of Environmental Science International
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    • v.8 no.1
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    • pp.33-43
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    • 1999
  • This paper aims to describe the characteristics of air pollution using air pollutants concentration and meteorological data observed at Kimhae from December 1996 to November, 1997. The results are as follows : The concentration distribution of sulfur dioxide($SO_2$), carbon monoxide(CO), particulate matter(PM-10), and nitrogen dioxide($NO_2$) is high during the late fall and winter and low during the summer, but ozone concentration is low during the winter season and high during summer season except Jangma period and these distributions appear to be closely connected with insolation and the number of clear day. Diurnal variation of concentrations for sulfur dioxide, particulate matter, and carbon monoxide are high during the rush hours and nighttime and low during the daytime and these variations are distinct toward the winter season. And diurnal variation of nitrogen dioxide concentration has also same pattern and these patterns are closely related to the increasing traffic volume at rush hours. Diurnal variation of ozone concentration is generally increase for daytime and decrease for the late afternoon and are closely related to the insolation and photochemical reaction. The 24 hour average concentrations of air pollutant observed at Kimhae represented a positive correlation and a negative correlation for $O_3$ and also a negative correlation for the meteorological elements such as wind speed and cloud cover.

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The Variation of Radiation Transmittance by the cw 1.07 ㎛ Fiber Laser and Water Aerosol Interaction

  • Koh, Hae Seog;Shin, Wan Soon;Jeon, Min Yong;Park, Byung Suh
    • Journal of the Optical Society of Korea
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    • v.16 no.3
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    • pp.191-195
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    • 2012
  • Among the atmospheric effect of laser propagation, the variations of the radiation transmittance by water aerosol evaporation have quantitatively been investigated. When the aerosol was exposed by a 1.07 ${\mu}m$ cw fiber laser, the increased amount of the transmittance variation was a maximum of 19.1% and the volume concentration variation of aerosol was observed as an increasing of laser intensity. Also, significant irregularity of refractive index was not found in the heated area during the continuous laser heating.

Air Pollution prediction at Highway Tollgate by Using Real Time Traffic Volume (실시간 교통량을 이용한 고속도로 요금소 대기요염도 예측)

  • 박성규;김신도;이정주
    • Journal of Environmental Health Sciences
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    • v.26 no.4
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    • pp.134-140
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    • 2000
  • The increase in traffic is a worldwide phenomenon. In Korea, it has been increased by 20% per annual in recent 1990’s and approximately 10 millions cars had been registered until 1997. This traffic could easily affect and contribute the local outdoor air quality(QAQ) concerned. The QAQ in highway in one of the examples and the subject in this study. The seoul tollgate located at the north-end of Keypngbu Highway was selected for the study. In case of highway tollgate, the local air pollution could be directly affected by the traffic to approach, wait and start the tollgate. Nitrogen dioxide (NO$_2$) concentration exceeded the EAQS(Environmental Air Quality Standards), but overall indoor air quality was a little better than the outdoor air quality. The measured TSP concentration was much higher than that of the EAQS. To apply a management to a air quality problem of Seoul tollgate, it was predicted air quality with traffic volume and weather condition. It was calculated NO$_2$ emission with traffic volume and predicted in and out of booth by CALINE3 at the Seoul tollgate. To make a comparison between measured and predicted concentration, the prediction was good. It was shown that NO$_2$ concentration was high in the morning at the from Seoul direction and in the evening at the to Seoul direction. it was thought that NO$_2$ concentration variation was reflected according to the traffic volume.

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Variation Pattern of Gaseous Organochlorine Pesticides Concentration in Atmosphere (대기 중에서 가스상 유기염소계 농약의 농도변화 패턴)

  • Choi, Min-Kyu;Chun, Man-Young
    • Environmental Analysis Health and Toxicology
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    • v.22 no.2 s.57
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    • pp.111-118
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    • 2007
  • This study was performed to measure gaseous Organochlorine Pesticides (OCPs : heptachlor epoxide, ${\alpha}/{\gamma}-chlordane$, trans-nonachlor, endosulfan, ${\gamma}-HCH$ and p, p'-DDE) concentration using PUF high volume sampler from June, 2000 to June, 2002 in the semi-rural atmosphere. Using monitoring data for two years, we tried to investigate the annual cycles of gaseous OCPs. We considered three functions to describe the annual cycle: Gaussian, Lorentzian and sinusoidal functions. These functions accounted for $54{\sim}91%$ of the variability in concentration for each gaseous OCPs, and the sinusoidal function gave the best fits. It was seen that the gaseous OCPs concentration increased during the warmer weather while decreased during colder weather. The variation of the gaseous OCPs concentration was closely similar to the variations of ambient temperature. The annual cycle of endosulfan was strongly higher than in comparison with other gaseous OCPs, while for ${\gamma}-HCH$, the cycle was weakly high and did not show apparent seasonal variation. The position of the annual maximum exists generally late July to early August. The period that showed levels more than a half maximum was from late June to early September.

A Study on the Characteristics of Urban Aerosol Concentration in the Size Range of 0.01~$1.0\mu\textrm{m}$ (도시 대기 Aerosol의 입자직경 0.01~$1.0\mu\textrm{m}$ 범위의 농도변화 특성)

  • 김필수;김윤장;이양호;조숙현;안승태
    • Journal of Korean Society for Atmospheric Environment
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    • v.2 no.2
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    • pp.41-50
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    • 1986
  • Urban aerosol concentrations in the size range of $0.01 \sim 1.0 \mum$ have been measured by using an electrical aerosol analyzer from May through October, 1984. The total diurnal variation of the number concentration indicates that a minimum value is observed at 3 hr and a sharp increase is noticed early in the morning with a subsequent slow and continuous increase from around 7 hr until 20 hr. After that it is decreased to reach its minimum by dawn. However, both surface and volume concentrations have shown that their first maxima at 8 hr and their second at about 20 hr simultaneously. It is found that the aerosol number is mainly governed by the particles in the size range of $0.01 \sim 0.1 \mum$, while most volume is in $0.1 \sim 1.0 \mum$ size range. It is known fact that particles of $0.1 \sim 1.0 \mum$ size range affect the visibility reduction in the atmosphere. The monthly variation of aerosol concentration remarks its minimum in summer. The main factors influencing the aerosol concentration are emission of autoexhausts, various processes of production and removal, and meteorological parameters.

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Trace Metals of Ambient TSP in Daegu Area (대구지역 총 부유분진중 중금속)

  • 이찬형
    • Journal of Environmental Health Sciences
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    • v.29 no.1
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    • pp.67-73
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    • 2003
  • This study was carried out to characterize the behavior and sources of particulate trace metal in Daegu city. TSP (Total Suspended Particulate matter) was collected by filters on High Volume Air Sampler from the four areal (reference, residential, commercial, industrial area). The moult were analyzed by AAS after preliminary treatment. The average centration trend of trace metals contained in TSP was shown as follows : Fe > Cu > Pb > Mn > Ni > Cr > Cd. The trace metals showed the highest concentration in the industrial area. This study showed the seasonal variation of trace metals. Fe and Mn showed high concentration in spring, whereas Cr, Ni, Cd and Pb showed high concentration in winter. Also this study showed the regional variation of trace metals. The order of the average concentration of trace metals was : industrial > commercial > residential > reference area. Using Mn as a reference element, the enrichment factor analysis were used for identifying the trace element contributors. The enrichment factors of Cr, Fe < 10 were considered to have a significant dust and soil source and termed nonenriched. Pb, Cd, Cu >>10 were enriched and had a significant fraction which was contributed by anthropogenic sources.

Trend Analysis for Stratospheric Ozone Concentration in the Middle Latitude Northern Hemisphere Using HALOE Data (HALOE 자료를 이용한 중위도 지역의 오존농도 추이분석)

  • Ka, Soo-Hyun;Kwon, Mi-Ra;Oh, Jung-Jin
    • Journal of Korean Society for Atmospheric Environment
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    • v.21 no.4
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    • pp.413-422
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    • 2005
  • The ozone concentration measured by HALOE (Ver 19) from Oct. 1991 to Dec. 2003 is used for analyzing the variation of ozone concentration. The HALOE loaded in UARS is observing several gases in the atmosphere, from 10km to 80km. Fourier analysis of these data in the middle latitude northern hemisphere is reported in this paper. To detect any possible long term trends, the fourier transformed time series was back transformed after removing signals with time periods of less than 6 months. Although the results clearly show the strong annual cycle, it is difficult to show any long term trends from the fourier series. We also compared the ozone volume mixing ratio's from HALOE with that from the ground-based radiometry to evaluate the accuracy of microwave observation at Sookmyung Women's University.