Lee, Joohwan;Lee, Jeongshim;Choi, Jinhyun;Kim, Jun Won;Cho, Jaeho;Lee, Chang Geol
Radiation Oncology Journal
/
v.33
no.2
/
pp.117-125
/
2015
Purpose: To investigate the relationship between early treatment response to definitive chemoradiotherapy (CRT) and survival outcome in patients with limited stage small cell lung cancer (LS-SCLC). Materials and Methods: We retrospectively reviewed 47 patients with LS-SCLC who received definitive CRT between January 2009 and December 2012. Patients were treated with systemic chemotherapy regimen of etoposide/carboplatin (n = 15) or etoposide/cisplatin (n = 32) and concurrent thoracic radiotherapy at a median dose of 54 Gy (range, 46 to 64 Gy). Early treatment volume reduction rate (ETVRR) was defined as the percentage change in gross tumor volume between diagnostic computed tomography (CT) and simulation CT for adaptive RT planning and was used as a parameter for early treatment response. The median dose at adaptive RT planning was 36 Gy (range, 30 to 43 Gy), and adaptive CT was performed in 30 patients (63.8%). Results: With a median follow-up of 27.7 months (range, 5.9 to 75.8 months), the 2-year locoregional progression-free survival (LRPFS) and overall survival (OS) rates were 74.2% and 56.5%, respectively. The mean diagnostic and adaptive gross tumor volumes were 117.9 mL (range, 5.9 to 447 mL) and 36.8 mL (range, 0.3 to 230.6 mL), respectively. The median ETVRR was 71.4% (range, 30 to 97.6%) and the ETVRR >45% group showed significantly better OS (p < 0.0001) and LRPFS (p = 0.009) than the other group. Conclusion: ETVRR as a parameter for early treatment response may be a useful prognostic factor to predict treatment outcome in LS-SCLC patients treated with CRT.
Park, Doh-Hun;Kim, Hyung-Mok;Ryu, Dong-Woo;Synn, Joong-Ho;Song, Won-Kyong
Tunnel and Underground Space
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v.21
no.3
/
pp.164-173
/
2011
In the present study, the stability of a compressed air energy storage cavern was numerically assessed by concrete plug shapes in order to investigate the optimal shape of concrete plug. The concrete plugs were cylindrical, embedded cylindrical, tapered, and wedged in shape. The stability assessment was carried out based on factor of safety through a strength reduction method and a volume ratio which refers to the ratio of the volume of yield regions in concrete induced by internal pressure to all concrete volume. The results from the present study indicated that the embedded cylindrical and taper shaped plugs were mechanically more stable than the cylindrical and wedge shaped plugs. However, from a comparison of stress distributions in rock mass between the embedded cylindrical and taper shaped plugs, the taper shaped plug was found to be more optimal than the embedded cylindrical plug, since the embedded cylindrical plug caused more stress concentration in the interface between the plug and rock mass than the taper shaped plug.
This study was performed to analyze the affect of water supply capacity followed by allocating flood control volume in heightening reservoir, of which Baekgog reservoir was selected as a case study in here. Baekgog reservoir is located in Jincheon county, Chungbuk province, of which full water level will be heightened from EL. 100. 1m to EL. 102.1m, and total storage from 21.75M $m^3$ to 26.67M $m^3$. Flood inflow with 200year frequency was estimated to 997 $m^3$/s in peak flow and 22.54M $m^3$ in total volume. Reservoir flood routing was conducted to determine flood limited water levels, which was determined to have scenarios such as EL 97-98-99m in periods of 6.21.-7.20., 7.21.-8.20., and 8.21.-9.20., respectively, EL 97-97-97m, EL 98-98-98m in present reservoir, and EL 99-100-101m, EL 99-99-99m, and EL 100-100-100m in heightened reservoir. Reservoir inflow was simulated by DAWAST model. Annual paddy irrigation requirement was estimated to 33.19M $m^3$ to 2,975ha. Instream flow was allocated to 0.14mm/d from October to April. Operation rule curve was drawn using inflow, irrigation and instream flow requirements data. In case of withdrawal limit reservoir operation using operation rule curve, reduction rates of annual irrigation supply before and after flood control by reservoir were 2.0~4.3% in present size and 1.5~3.6% in heightened size. Reliability on water supply was decreased from 77.3% to 63.6~68.2% in present size and from 81.6% to 72.7~79.5% in heightened size. And reduction rates of water storage at the end of year before and after flood control by reservoir were 7.3~16.5% in present size and 7.7~16.9% in heightened size. But water supplies were done without any water deficiency through withdrawal limit reservoir operation in spite of low flood regulating water level.
Background : The soft palate functions as a valve and helps generate the oral pressure required for normal speech resonance. Speech problems and nasal regurgitation can result from a soft palatal defect. Reduction of the size of the velopharyngeal orifice is required to compensate for the lack of mobility in a reconstructed soft palate. We suggest a large volume folded free flap for reduction of the caliber and a palmaris longus tendon sling for suspension of the reconstructed palate. Methods : Six patients had total soft palate resection for tonsillar cancer and reconstruction with a large volume folded radial forearm free flap combined with a palmaris longus sling. A single surgeon and speech therapist examined the patients with three standardized speech assessment tools: nasometer test, consonant articulation test, and speech acuity test performed for speech evaluation. Results : Mean nasalance score was 76.20% for sentences with nasal sounds and 43.60% for sentences with oral sounds. Hypernasality was seen for oral sound sentences. The mean score of the picture consonant articulation test was 84% (range, 63% to 100%). The mean score of the speech acuity test was 5.84 (range, 5 to 6). These mean ratings represent a satisfactory level of speech function. Conclusions : The large volume folded free flap with a palmaris longus tendon sling for total soft palate reconstruction resulted in satisfactory prognosis for speech despite moderate hypernasality.
Purpose: In surgical treatment of the medial orbital wall fractures, restoring the original position of the orbital wall is difficult in some cases. Under such condition, the orbital wall is often reconstructed with synthetic material, without bony reduction, which is considered to be the conventional reconstruction. The purpose of this study is to compare the outcomes of anatomical reconstruction, which restores the bony wall to the anatomical position, from that of the conventional reduction in the isolated medial orbital wall fractures. Methods: Thirty patients, who underwent reconstruction surgery for the isolated medial orbital wall fractures from March 2007 to August 2011, were reviewed retrospectively. The surgical outcomes of two groups, the conventional reconstruction group (15 patients) and the anatomical reconstruction group (15 patients), were studied in 2 measurements, a one day before and 6 months after the surgery. The changes of orbital volume were calculated by the images from a computed tomography scan and enophthalmos was measured by a Hertel exophthalmometer. Results: The orbital volume ratio was decreased by an average of 1.05% in the conventional reconstruction group, while in the anatomical reconstruction group, the ratio decreased by 5.90% (p<0.05). The changes in the Hertel scale were 0.20 mm in the conventional reconstruction group, and 0.70 mm in the anatomical reconstruction group. However, the difference in the Hertel scale was statistically insignificant (p>0.05). Conclusion: In conclusion, the anatomical reconstruction technique of the isolated medial orbital wall fracture results in a better outcome than that of the conventional reconstruction, in terms of restoring of the original orbital volume and anatomic position. Thus, it can be considered as a useful method for the isolated medial orbital wall fractures.
Andong-dam was built up in 1967 and it is one of the biggest dams in Korea. Previous studies showed that the sediments are highly contaminated with heavy metals such as arsenic, cadmium, and lead. Many research projects are going on to find out the source of the contamination, to evaluate the toxicities to ecosystem, to estimate the volume of sediment to be treated and to find out a good remediation method. Reports show that the sediment is highly contaminated and the main contamination source is supposed to be abandoned mines and a zinc refinery located upper stream of the river. A magnetic separation has been tested as a treatment method for the dredged sediment. Lab scale test showed that the magnetically captured portion is about 10% in weight but the contamination of heavy metal is much higher than the contamination of the passed portion. This indicates that a magnetic separation could be applied for the purpose of reduction of sediment to be treated and for increasing the volume of low toxic sediments which can be dumped as general waste. A magnetic separation using a HGMS has been tested for the sediment with variable magnetic field and the results showed the higher magnetic field increase the captured portion but the concentrating effect of heavy metal was weakened. Further study is needed to establish a useful technology and optimization between decontamination and reduction of sediment volume.
Background: The compression therapy, which is the standard treatment for lymphedema patients, may be difficult to implement and contraindicated to some patients depending on their health condition. Objects: The purpose of this study is to investigate whether kinesiology taping (KT) can be used effectively and safely in the management of lymphedema as an alternative treatment through systematic review and meta-analysis. Methods: In February 2023, the literature was systematically collected through eight search engines with a combination of terms, 'lymphedema' and 'kinesiology taping.' We qualitatively analyzed the differences and safety of KT methods, and quantitatively meta-analyzed the effects of volume reduction in edema, range of motion (ROM), and pain improvement using Review Manager ver. 5. 4. To assess the risk of bias in the randomized controlled trial (RCT) studies, Risk of Bias was used. Results: A total of 616 articles searched and 20 studies were selected, including 12 RCTs and eight case studies. KT intervention could not replace multilayer compression bandage (MLB), but it demonstrated similar or better results compared to compression garment (CG), with reduced pain and improved intervention comfort. Studies reported skin adverse events ranging from 2.5% to 20.68%, with a total adverse event incidence of 7.7%. There was no significant difference in the application method of KT. As a result of the meta-analysis from the 8 RCTs, the KT intervention showed a mean difference (MD) of -7.18 with a 95% confidence interval (CI) [-12.64 to -1.72] in the volume change of lymphedema, while the pain difference was MD 0.82 with CI 95% [0.50 to 1.15], in comparison to the MLB and CG intervention. Conclusion: KT therapy led to a reduction in edema size, volume, pain, and improved ROM and quality of life. KT may be a viable option for lymphedema patients who have trouble applying traditional compression therapies.
PURPOSES : In this study, noise reduction effect of a two-layer porous asphalt pavement was investigated through site measurement and computer simulation. METHODS : To examine noise reduction effect, a 3 km long quiet pavement was installed by removing previous normal pavement, which had a rather low porosity. The studied site was a high-rise apartment building surrounded by the quiet pavement and Seoul ring road with heavy traffic volume, indicating relatively high background noise. RESULTS : The measurement result before and after installing the quiet pavement showed a noise reduction effect of 4.3 dB(A) at a distance of 7.5 m from the road. After validating the accuracy of simulation using SoundPLAN, the reduction in SPL(sound pressure level) at the facades by the quiet pavement was predicted by considering five different road conditions generating traffic noise from each road or in the combination of the quiet pavement and Seoul ring road. In the case of no noise from Seoul ring road, noise reduction at the facades was 4.2 dB(A) on average for 702 housing units. With background noise from Seoul ring road, however, the average SPL decreased to 2.0 dB(A). Regarding subjective response of noise, the number of housing units with a noise reduction of over 3 dB(A) was 229 out of 706 units (approximately 32%). For 77 housing units, the noise reduction was between 1~3 dB(A), while it was less than 1 dB(A) for 400 housing units. CONCLUSIONS : The overall result indicates that the quiet pavement is useful to reduce noise evenly at low and high floors compared to noise barriers, especially in the urban situation where background noise is low.
Roadside non-point pollution reduction facilities are classified as infiltration, vegetation, reservoir, and wetland types based on their respective pollution reduction mechanisms. However, without a detailed analysis of the road and traffic conditions it is very difficult for civil engineers to determine which category of pollution reduction facility is best suited to their planning requirements. To address this issue, we propose a new decision-making method for the selection of roadside non-point pollution reduction facilities. The principal factors informing the proposed decision-making methods are the road characteristics, including location, structure, number of lanes, and traffic volume. As a result of the study, a total of new pollution reduction plans were developed, with their selection conditions and the corresponding applicable facilities established. The effectiveness of the proposed pollution reduction schemes was demonstrated for roads in Kyounggi-do, providing a valuable basis for future pollution reduction plans.
Purpose: To evaluate the efficacy of a belly-board device (BBD) in reducing the volume of small bowel during four-field pelvic irradiation. Materials and Methods: Twenty-two cancer patients (14 uterine cervical cancer, 6 rectal cancer, and 2 endometrial cancer) scheduled to receive pelvic irradiation were selected for this study. Two sets of CT images were taken with and without the belly-board device using the Siemens 16 channel CT scanner. All patients were set in the prone position. The CT images were transferred to a treatment planning system for dose calculation and volume measurements. The external surfaces of small bowel and the bladder were contoured on all CT scans and the 4-pelvic fields were added. The dose-volume-histogram of the bladder and small bowel, with and without the BBD, were plotted and analyzed. Results: In all patients, the total small bowel volume included in the irradiated fields was reduced when the BBD was used. The mean volume reduction was 35% (range, $1{\sim}79%$) and was statistically significant (p<0.001). The reduction in small bowel volume receiving $10{\sim}100%$ of the prescribed dose was statistically significant when the BBD was used in all cases. Almost no change in the total bladder volume involved was observed in the field (<8 cc, p=0.762). However, the bladder volume receiving 90% of the prescribed dose was 100% in 15/22 patients (68%) and $90{\sim}99%$ in 7/22 patients (32%) with the BBD. In comparison, the bladder volume receiving 90% of the prescribed dose was 100% in 10/22 patients (45%), $90{\sim}99%$ in 7/22 patients (32%), and $80{\sim}89%$ in 5/22 patients (23%) without the BBD. When the BBD was used, an increase in the bladder volume receiving a high dose range was observed Conclusion: This study shows that the use of a BBD for the treatment of cancer in the pelvic area significantly improves small bowel sparing. However, since the BBD pushed the bladder into the treatment field, the bladder volume receiving the high dose could increase. Therefore it is recommended to be considerate in using the BBD when bladder damage is of concern.
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