• 대한후두음성언어의학회지
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• 제17권1호
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• pp.28-37
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• 2006

Purpose: Evaluation of vocal cord vibration is very important in cases of voice disorders. There are several equipments for examining the vocal fold vibration such as laryngeal stroboscope, ultra high-speed digital imaging system, and videokymograph. Among these, laryngeal stroboscope is the most popular equipment because of easy to examine the laryngeal pathology. However, current laryngo-stroboscopes are too bulky to move and relatively expensive. The purpose of this research is to develope a portable laryngeal stroboscope of equivalent performance with the current equipments. Methods and Materials: Recently developed high luminescent white LEDs(light emitting diodes) are placed at the head of the endoscope as light sources for the CCD image sensor which is also placed at the head with imaging lens. This arrangement eliminates the bulky light source like expensive halogen or xenon lamps as well as the optical light guiding cables. The LEDs are controlled to flash in phase with the voice frequency of the examinee. The CCD captures these strobo images and converts them into video signals for examinations. Results: There was no functional differences between preexisting stroboscope and the newly developed stroboscope of this study. LED light sources and microprocessor based control circuits of the stroboscope enabled the development of flicker-less, hand-held, portable and battery-operating stroboscope. Conclusion: The developed stroboscope is cost-effective, small-sized, easy to use and very easy desirable to bring and to use in any place.

• Journal of Korean Neurosurgical Society
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• 제29권11호
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• pp.1415-1420
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• 2000

Essential tremor(ET) is the most common movement disorder however there has been little agreement in the neurologic literature regarding diagnostic criteria for ET. Familial ET is an autosomal dominant disorder presenting as an isolated postural tremor. The main feature of ET is postural tremor of the arms with later involvement of the head, voice, or legs. In previous studies, it was reported that ET susceptibility was inherited in an autosomal dominant inheritance. As with previous results, it would suggest that ET might be associated with defect of mitochondrial or nuclear DNA. Recent studies are focusing molecular genetic detection of movement disorders, such as essential tremor and restless legs syndrome. Parkinson's disease(PD) is a neurodegenerative disease involving mainly the loss of dopaminergic neurons in substantia nigra by several factors. The cause of dopaminergic cell death is unknown. Recently, it has been suggested that Parkinson's disease many result from mitochondrial dysfunction. The authors have analysed mitochondrial DNA(mtDNA) from the blood cell of PD and ET patients via long and accurate polymerase chain reaction(LA PCR). Blood samples were collected from 9 PD and 9 ET patients. Total DNA was extracted twice with phenol followed by chloroform : isoamylalcohol. For the analysis of mtDNA, LA PCR was performed by mitochondrial specific primers. With LA PCR, 1/3 16s rRNA~1/3 ATPase 6/8 and COI~3/4 ND5 regions were observed in different patterns. But, in the COI~1/3 ATPase 6/8 region, the data of PCR were observed in same pattern. This study supports the data that ET and PD are genentic disorders with deficiency of mitochondrial DNA multicomplexes.

• 대한중풍순환신경학회지
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• 제13권1호
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• pp.33-42
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• 2012

Object : The aim of this study was to assess the clinical indicators related to Pattern-Identification(PI) in acute cerebral infarction patients. Methods : We studied hospitalized patients within 30days after ictus, who admitted at Korean Medicine Center of Kyung-Hee University from January 2010 to October 2012.(n=290) Two Traditional Korean Medicine(TKM) physicians evaluated the patients independently and diagnosed PI. Inter-rater reliability was measured using simple percentage agreement and the Cohen's kappa(κ) coefficient. To assess the clinical indicators closely related to each PI, we analysed average score of each indicator in each group. Results : Simple percentage agreement of PI between raters was 64.83% and Cohen's kappa(κ) coefficient was 0.526(95% CI: 0.451-0.600). Inter-rater reliability level was fair to good. We analysed the clinical indicators in each group. Significant indicators for Fire-Heat Pattern(FHP) were reddened complexion and strong pulse power, and meaningful indicators for FHP were halitosis and thick tongue fur. Significant indicator for Dampness-Phlegm Pattern(DPP) was overweight and there was no meaningful indicator. Significant indicator for Yin-Deficiency Pattern(YDP) was dry tongue fur and meaningful indicator for YDP was thirst. There was no significant indicator for Qi-Deficiency Pattern(QDP) and pale complexion and faint low voice were meaningful indicators for QDP. Conclusions : This study reveals the significant and meaningful clinical indicators related to each Pattern-Identification in acute cerebral infarction patients. It will contribute to standardization of Korean Medical Diagnosis and Treatment in acute cerebral infarction patients.

• Journal of Korean Neurosurgical Society
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• 제29권2호
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• pp.188-195
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• 2000

Objective : Essential tremor(ET) is the most common movement disorder, however, there has been little agreement in the neurologic literature regarding diagnostic criteria for ET. Familial ET is an autosomal dominant disorder presenting as an isolated postural tremor. The main feature of ET is postural tremor of the arms with later involvement of the head, voice, or legs. In previous studies, it was reported that ET susceptibility was inherited in an autosomal dominant inheritance. As previous results, it would suggest that ET might be associated with defect of mitochondrial or nuclear DNA. Recent studies are focusing on molecular genetic detection of movement disorders, such as essential tremor and restless legs syndrome. Moreover, authors have analysed mitochondrial DNA(mtDNA) from the blood cell of positive control(PC) and ET patients via long and accurate polymerase chain reaction(LA PCR). Materials & Methods : Blood samples were collected from PC and 9 ET patients. Total DNA was extracted twice with phenol followed by chloroform : isoamylalcohol. For the analysis of mtDNA, LA PCR was performed by mitochondrial specific primers. Results : With this technique, deletions of large quantities were detected within several regions of mtDNA in ET patients except for D-loop and CO I regions. Conclusion : The authors believe that ET is a genentic disorder with deficiency of mitochondrial DNA multicomplexes and mitochondiral dysfunction could be one of major causative factors of ET. Mitochondrial dysfunction may play an important role in the pathogenesis and possibility of disease progression among familial group with ET patients.

• 한국산학기술학회논문지
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• 제14권12호
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• pp.6296-6301
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• 2013

본 연구는 후두 손상 후 목소리 장애로 인해 스트레스변화에 미치는 영향을 알아보고자 SD계 랫드에 후두손상을 유발시킨 후 실험동물에서 나타나는 변화와 스트레스 경감효과에 미치는 영향을 진정작용이 있는 칡잎추출물을 투여 후 변화를 보고자 하였다. 실험은 정상군, 대조군, 실험군(1, 2)으로 하여 군당 6마리씩 총 24마리를 이용하였고, 지정된 용량으로 1일 1회 일정한 시간대에 주 6회씩 5주간 경구투여 후 항산화실험과 분자화학적 검사를 하였다. 결과는 정상군에 비하여 대조군에서는 통계적으로 유의성 있게 높았으며(p<0.05), 실험군에서는 대조군에 비해 통계적 유의성 있게 낮아져(p<0.05), 정상군보다도 좋게 나타났다. 실험결과를 종합해 보면 칡잎추출물은 대조군과 비교 할 때 통계적으로 유의성 있는 변화를 확인하였다. 따라서 칡잎추출물 투여 시 스트레스 경감효과에 효과가 있는 것으로 사료된다.

• 대한후두음성언어의학회지
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• 제16권1호
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• pp.10-14
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• 2005

Background and Objectives : Vowels are characterized on the basis of formant patterns. The first formant(F1) is determined by high-low placement of the tongue, and the second formant (F2) by front-back placement of the tongue. The fundamental frequency(F0) of a soprano often exceed the normal frequency of the first formant. And the vocal intensity is boosted when F0 is high and a harmonic coincides with a formant. This is called a formant tuning. Experienced singers thus learned how to tune their formants over a resonable range by lowering the tongue to maximize their vocal intensity. So, the current study aimed to identify the formant tuning in one experienced soprano by comparing the first formants of vowel [i] in three different voice production : speech, ascending scale, and vocalize. Materials and Method : All voices recordings of vowel [i] in speech, ascending scale (from F4 note to A4 note), and vocalize(:Ridente la calam") were made with digital audio tape-corder in a sound treated room. And the captured data were analyzed by the long term average(LTA) power spectrum using the FFT algorithm of the Computerized Speech Lab(CSL, Kay elementrics, Model, 4300B). Results : Although the first formant of vowel [i] in speech was 238Hz, those of ascending scale [i] were 377Hz, 405Hz, 453Hz respectively in F4(349z), G4(392Hz), A4(440Hz) note, and 722Hz, 820Hz, 918Hz respectively in F5 (698Hz), G5(784Hz), A5(880Hz) note. In vocalize, first formants of [i] were 380Hz, 398Hz, 453Hz respectively in F4, G4, A4 note, and 720Hz, 821Hz, 890Hz respectively in F5, G5, A5 note. Conclusion : These results showed that the first formant of ascending scale and vocalize sustained higher frequency than fundamental frequency in high pitch. This finding implicates that the formant tuning of vowel [i] in ascending scale was also noted in vocalize.

• 말소리와 음성과학
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• 제6권4호
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• pp.195-203
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• 2014

The aim of this study was to investigate the effects of phonation types ([+/- aspirated], [+/- fortis]) on aerodynamic measures with Korean bilabial stops. Sixty-three healthy young adults (30 males, 33 females) participated to evaluate the VOEF (Voicing Efficiency) tasks with bilabial stop consonants /$p^h$/, /p/, /p'/ using Phonatory Aerodynamic System (PAS) Model 6600 (Kay PENTAX Corp, Lincoln Park, NJ). All VOEF measures were significantly influenced by phonation types except RANP(pitch range)(p <.01). For sound pressure, maximum SPL, mean SPL, and Mean SPL during Voicing have been shown to be significantly greatest in fortis stop /p'/ than aspirated /$p^h$/ and lenis stop /p/ (p<.001). On the other hand, mean pitch after lenis stop was significantly lower than after aspirated and fortis stops (p<.001). Peak expiratory airflow, Target airflow, and FVC (Expiratory volume) were significantly lowest in fortis stop /p'/ which might be associated with higher aerodynamic resistance while peak air pressure and mean peak air pressure during closure were significantly lower in lenis stop /p/. Additionally, AEFF (Aerodynamic efficiency) was significantly higher in fortis stop /p'/ than lenis stop /p/ as well as aspirated stop /$p^h$/ (p<.001). Thus, sound pressure, airflow parameters, and aerodynamic resistance made crucial roles in distinguishing fortis /p'/ from lenis stop /p/ and aspirated. Additionally, pitch and subglottal air pressure parameters were important aerodynamic characteristics in distinguishing lenis /p/ from fortis /p'/ and aspirated /$p^h$/. Therefore, accurate aspirated /p/ stop consonant should be elicited when collecting the airflow, intraoral pressure related data with patients with voice disorders in order to enhance the reliability and relevance or validity of aerodynamic measures using PAS.

• 정보과학회 논문지
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• 제42권11호
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• pp.1372-1379
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• 2015

본 논문에서는 구개열 환자의 장애 발음과 정상인의 발음을 자동으로 구분하여 판별하는데 사용될 수 있는 특징 추출 방법들의 성능을 분석하는 실험에 대하여 소개한다. 이 연구는 발성 장애인의 복지 향상을 추구하며 수행하고 있는 장애 음성 자동 인식 및 복원 소프트웨어 시스템 개발의 기초과정이다. 실험에 사용된 음성 데이터는 정상인의 발음, 구개열 환자의 발음, 그리고 모의 환자의 발음의 세 그룹으로부터 수집된 한국어 단음절로서 14개의 기본 자음과 5개의 복합 자음, 7개 모음이다. 발음의 특징 추출은 LPCC, MFCC, PLP의 세 가지 방법으로 각각 수행하였고, GMM 음향 모델로 인식 훈련을 한 후, 수집된 단음절 데이터를 대상으로 하여 인식 실험을 실시하였다. 실험 결과, 정상인과 구개열 환자의 장애 발음을 구별하기 위하여 특징을 추출함에 있어서 MFCC 방법이 전반적으로 가장 우수하였다. 본 연구의 결과는 구개열 환자의 부정확한 발음을 자동으로 인식하고 복원하는 연구와 구개열 장애 발음의 정도를 측정할 수 있는 도구에 대한 연구에 도움이 될 것으로 기대된다.

• 음성과학
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• 제1권
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• pp.237-259
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• 1997

Cleft Palate speech appears to have hyper/hyponasality with velopharyngeal insufficiency and articulation disorders. Previous studies on Cleft Palate speech have shown that speech tends to have lower airflow and air pressure. To examine the aerodynamic characteristics of Cleft Palate speech, Aerophone II Voice function Analyzer was used. We measured sound pressure level, airflow, air pressure and glottal power. Three Cleft Palate adults and five normal adults participated in this experiment. The test words are composed of: (1) the sustained vowel /o/ (2) /CiCi/, where C is one of three different stop consonants in Korean (3) /bimi/. Subjects were asked to produce /bimi/ five times without opening their lips. All the data was statistically tested by t-test for Cleft Palate patients before operation groups and control groups and paired t-test for Cleft Palate patients before and after operation groups. The results were as follow: (1) Cleft Palate patients generally speak with incomplete oral closure and lower oral air pressure. As a result, the SPL of Cleft Palate before operation is 3 dB lower than control groups. (2) Airflow of Cleft Palate in phonation and articulation is lower than that of control groups. However, it increased after operation. Lung volume and mean airflow in phonation are significantly increased (p<0.05). (3) Although velopharyngeal function (velar opening rate) of Cleft Palate is poor in comparison with control groups, it was recovered after operation. In this event maximum flow rate and mean airflow rate are significantly increased (p<0.05). (4) Air pressure of Cleft Palate in speech is lower than that of control groups. In general, the air pressure of Cleft Palate increased after operation. In this event air pressure of glottalized consonant is significantly increased (p<0.04). (5) Glottal Power(mean power, mean efficient and mean resistant) of Cleft Palate patients is lower than that of control groups. But mean efficient and mean resistant of Cleft Palate patients increased significantly (p<0.05) after operation.

• 동의생리병리학회지
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• 제20권5호
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• pp.1089-1101
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• 2006

Following conclusions are drawn from study about Yukmigiwhangwon through referring to literatures and reviewing in the point of Hyungsang medicine. Yukmigiwhangwon was prescribed by Jeon Eul in order to cure five kinds of flaccidity of infants, but after since then it has been basically applied to symptoms which was caused by deficiency of the kidney not only infants but also adult. The deficiency of kidney is the lack of vital essence and body fluid stored in kidney, it happens because infants are born in the conditions of lack of receiving in the womb. And it happens because adults infringe the rules of life, especially the sexual life. Main symptoms of the poverty of renal functions are emptiness of the brain marrow, dizziness, forgetfulness, tinnitus, deafness, vertigo and dim eyesight, insomnia, the low back and knees aching and limping, heat on the legs, tibia aching, nocturnal emission, dry mouth, reddened tongue and little coating or non coating of the 'tongue, weak blood meridians. the treating method is nourishing Eum and supplementing kidney. In Dongeuibogam Yukmigiwhangwon is mentioned in the parts of vital essence, blood, voice, kidney, urine, eye, ear, the low back, hair, fire, exhaustion syndrome, cough, polydipsia, infant, etc. The shapes which Yukmigiwhangwon is applied to are the Dam Body Doing deficiency of Eum due to excess of Yang, man, infant, Jung type, Fish group, reverse triangular shape, big headed man, big eared man, big mouthed man, man having prominent cheekbones, man having long waist, man having big hips, man with thick hair or white hair, man with bald on the head, etc. In color it is applied to darkish complexion, flushed tip of the nose, or flushed cheek bones. Through inquiring into the clinical cases on the points of Hyungsang medicine Yukmigiwhangwon is efficacious cure to lumbago, symptoms of tendons and bones, symptoms of eyes and ears, symptoms of respiratory organs, dermatopathia, headache, polydipsia, urinary disorders, etc.