• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6351-6356
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• 2013

Background: Goshajinkigan (GJG) is used for the treatment of several neurological symptoms. We investigated the efficacy of GJG and mecobalamin (B12) against neurotoxicity associated with docetaxel (DOC) in breast cancer patients. Materials and Methods: Sixty breast cancer patients were treated with DOC. Thirty-three patients (GJG group) received oral administration of 7.5 g/day GJG and 27 patients (B12 group) received oral administration of 1500 ${\mu}g/day$ B12. Neuropathy was evaluated according to DEB-NTC (Neurotoxicity Criteria of Debiopharm), Common Terminology Criteria for Adverse Events (NCI-CTC) ver. 3.0, and a visual analogue scale (VAS). This study employed a randomized open design. Results: The incidence of neuropathy was 39.3% in the GJG group, and 88.9% in the B12 group (p<0.01). In the GJG group, grade 1 DEB-NTC was observed in 2 cases, grade 2 in 5 cases and grade 3 in 5 cases. Grade 1 NCI-CTC was observed in 7 cases, grade 2 in 6 cases, and VAS was $2.7{\pm}2.2$. In the B12 group, grades 1, 2 and 3 DEB-NTC were observed in one case, 12 cases and 12 cases, respectively; and grades 1, 2 and 3 NCI-CTC were observed in 11 cases, 12 cases and one case, and VAS was $4.9{\pm}2.4$. Conclusions: Concomitant administration of GJG is useful in preventing neuropathy in breast cancer patients treated with a DOC regimen.

• 한국자동차공학회논문집
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• 제14권2호
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• pp.158-165
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• 2006

In this paper, a new uni-axial bushing model for vehicle dynamics analysis is proposed. Bushing components of a vehicle suspension system are tested to capture the nonlinear and hysteric behavior of the typical rubber bushing elements using the MTS machine. The results of the tests are used to develop the Bouc-Wen bushing model. The Bouc-Wen model is employed to represent the hysteretic characteristics of the bushing. ADAMS program is used for the identification process and VisualDOC program is also used to find the optimal coefficients of the model. Genetic algorithm is employed to carry out the optimal design. A numerical example is suggested to verify the performance of the proposed model.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2007년도 추계학술대회 논문집
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• pp.262-265
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• 2007

Cooling circuit of injection mold affects part quality and cycle time of injection molding process. Examination on mold cooling circuit is usually omitted in part design stage because cooling circuit is designed in the mold design stage. It is desirable to examine mold cooling circuit with respect to part quality in the part design stage. In order to make the examination process convenient and fast, cooling circuit design should be automated without intervention of skilled designer. In this study, optimization of cooling circuit design is automated with commercial softwares; Visual DOC and Moldflow MPI. Effect of initial value for optimization is examined for the optimization result.

• 한국CDE학회논문집
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• 제9권2호
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• pp.93-101
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• 2004

In mechanical design, optimization procedures have mostly been implemented solely by CAE codes combined by optimization routine, in which the model is built, analyzed and optimized. In the complex geometries, however, CAD is indispensable tool for the efficient and accurate modeling. This paper presents a method to carry out optimization, in which CAD and CAE are used for modeling and analysis respectively and integrated in an optimization routine. Application Programming Interface (API) function is exploited to automate CAD modeling, which enables direct access to CAD. The advantage of this method is that the user can create very complex object in Parametric and automated way, which is impossible in CAE codes. Unigraphics and ANSYS are adopted as CAD and CAE tools. In ANSYS, automated analysis is done using codes made by a script language, APDL(ANSYS Parametric Design Language). Optimization is conducted by VisualDOC and IDESIGN respectively. As an illustrative example, a mold design problem is studied, which is to minimize temperature deviation over a diagonal line of the surface of the mold in contact with hot glass.

• 한국자동차공학회논문집
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• 제14권6호
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• pp.143-150
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• 2006

In this paper, a new bushing model for vehicle dynamics analysis using Bouc-Wen hysteretic model is proposed. Bushing components of a vehicle suspension system are tested to capture the nonlinear behavior of rubber bushing elements using the MTS 3-axes rubber test machine. The results of the tests are used to define parameters in Bouc-Wen bushing model, which was employed to represent the hysteretic characteristics of the bushing. Bushing parameters are obtained by using genetic algorithms and sensitivity analysis of parameters are also carried out. ADAMS program was used for the identification process and VisualDOC program was employed to find the optimal parameters. A half-car simulation was carried out to show the usefulness of the developed bushing model.

• 한국CDE학회논문집
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• 제11권2호
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• pp.128-137
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• 2006

In this paper, a CAD/CAE integrated optimal design system is developed, in which design and analysis process is automated using CAD/CAE softwares for a complex model in which the modeling by parametric feature is not easy to apply. Unigraphics is used for CAD modeling, in which the process is automated by using UG/Knowledge Fusion for modeling itself and UG/Open API function for the other functions respectively. Structural analyses are also carried out automatically by ANSYS using the imported parasolid model. The developed system is applied for the PLS(Plasma Lighting System) consisting of more than 20 components, which is a next generation illumination system that is used to illuminate stadium or outdoor advertizing panel. The analyses include responses by static, wind and impact loads. As a result of analyses, tilt assembly, which is a link between upper and lower body, is found to be the most critical component bearing higher stresses. Experiment is conducted using MTS to validate the analysis result. Optimization is carried out using the software Visual DOC for the tilt assembly to minimize material volume while maintaining allowable stress level. As a result of optimization, the maximum stress is reduced by 57% from the existing design, though the material volume has increased by 21%.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2005년도 춘계 학술발표회 논문집
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• pp.55-62
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• 2005

In this paper, a CAB/CAE integrated optimal design system is developed, in which design and analysis process is automated using CAD/CAE softwares, for a complicated model for which parametric modeling provided by CAD software is not possible. CAD modeling process is automated by using UG/OPEN API function and UG/Knowledge Fusion provided by Unigraphics. The generated model is transferred to the analysis code ANSYS in parasolid format. Visual DOC software is used for optimization. The system is developed for PLS(Plasma Lighting System), which is a next generation illumination system that is used to illuminate stadium or outdoor advertizing panel. The PLS system consists of more then 20 components, which requires a lot of human efforts in modeling and analysis. The analysis for PLS includes static load, wind load and impact load analysis. As a result of analysis, it is found that the most critical component is a tilt assembly, which links lower & upper body assembly. For more reliable analysis, experiment is conducted using MTS and compared with the Finite element analysis result. The objective in the optimization is to minimize the material volume under allowable stresses. The design variables are three parameters in the tilt assembly that are chosen to be the most sensitive in stress values of twelve parameters. Gradient based method and RSM(Response Surface Method) are used for the algorithm and the results are compared. As a result of optimization, the maximum stress is reduced by 57%.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 추계학술대회
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• pp.1340-1345
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• 2003

In this paper, an integrated optimal design software system for structural components has been developed which interfaces existing commercial codes for CAD, CAE and Optimization. They include specialized optimal design software codes such as iSIGHT and VisualDOC, optimization module imbedded in CAD software developed by CAD developers, and optimal design software systems based on API of commercial CAD software. The advantages of the CAD imbedded optimal design approach and those of specialized optimal design software are taken to develop the system. The user defines optimal design formulation in the user interface for problem definition in the CAD control stage, where design variables are directly selectable from the CAD model and various properties and performance functions defined. The commercial CAD codes, Open I-DEAS are used for the development. The resulting software is minimally connected to CAD and CAE systems while keeping maximum independence from each other. This assures flexibility and freedom for problem definition. Fatigue life optimization is taken as a nontrivial application area. As a specific example, the shape design of a knuckle part of an automobile is performed, where the minimum fatigue life over the material domain in terms of the number of cycles of a curb strike are maximized under the constraint of not exceeding the current mass. The fatigue life has been improved by four times of the initial life. The developed software is illustrated to maintain the advantages of existing optimal design software systems while improving independency and flexibility.

• 환경생물
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• 제19권1호
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• pp.59-69
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• 2001

본 연구는 자연수중의 미생물을 식종원으로 하는 TOC-HANDAI법과 OECD 생분해법을 활용하여 자연수 환경내에서 환경호르몬물질인 비스페놀 A와 노닐페놀의 생분해성을 비교평가하였다. TOC-HANDAI법에 의한 BPA분해는 73-78% 이었고 OECD법은 이보다 다소 높은 77-81%를 나타내었다. 두 방법을 통한 BPA의 분해양상은 대체로 2단계를 거쳐 진행되었다. 즉 초기 1주일 이내에는 분해반응속도(k$_1$)가 0.24-0.34day$^{-1}$로 아주 빠르게 분해되었고, 그 후에는 아주 완만한 분해양상을 나타내었다(k$_2$는 0.02-0.05 $day^{-1}$). 이는 BPA가 자연수계에서 TOC로 약 20-25%가 중간생성물로 잔존하고 있음을 시사해 주고 있으며, 이 중간대사물이 완만한 분해과정에 기여하고 있다. 수계 환경에 따라 분해율이 현저하게 차이를 보이지만 노닐페놀은 20-48% 정도 밖에 분해되지 않는 난분해성 환경호르몬 물질임을 알 수 있다. 한편, 금강수계내 조사대상 하천과 대청호수의 조사지점에서 BPA는 모두 불검출되었다. 그러나 공단폐수 종말처리장 유입수에서 평균 25 ppb가 검출되었다.

• Journal of Applied Biological Chemistry
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• 제58권1호
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• pp.39-50
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• 2015

본 연구에서는 오염토양 내 중금속 안정화 효율 평가를 위해 계분(PM), $300^{\circ}C$에서 생산한 바이오차(PBC300), $700^{\circ}C$에서 생산한 바이오차(PBC700)를 2.5, 5.0, 10.0 wt% 수준으로 토양에 처리하고 21일 간 항온배양하였다. 항온배양 후 토양의 pH는 PM 10.0 wt%, PBC300 10.0 wt%, PBC700 10 wt% 처리구에서 각각 7.51, 7.24, 7.88로 나타나 무처리구(pH 6.94)에 비해 유의적으로 증가하였는데 이는 PM, PBC300, PBC700 자체의 알칼리성에 기인한 결과로 판단되었다. 중금속의 TCLP 용출시험 결과 PM 처리구의 경우 용출되는 납(142-408% 증가), 카드뮴(39-77% 증가), 아연(20-24% 증가), 구리(241-955% 증가)의 농도가 모두 증가하였으며, 이는 PM 처리 시 급격하게 증가된 토양 내 DOC와 관련된 것으로 판단되었다. 그러나 PBC700 처리구의 경우 납, 카드뮴, 아연, 구리의 농도가 모두 감소하여 안정화되었으며, 무처리구 대비 감소율은 각각 7-23, 11-38, 11-52, 19-36%으로 나타났다. MINTEQ을 이용한 열역학 모델링 결과 PBC700 10.0 wt% 처리구에서는 납과 구리 화학종의 경우 수산화물인 $Pb(OH)_2$, $Cu(OH)_2$의 침전이 예상되었다. 특히, 납의 경우 매우 낮은 용해도를 보유한 chloropyromorphite [$Pb_5(PO_4)_3Cl$], hydroxypyromorphite [$Pb_5(PO_4)_3OH$] 등의 침전이 예상되었다. 이와 함께 SEM-elemental dot mapping을 이용한 원소분포 조사 결과, 다른 처리구와 달리 PBC700 처리구의 경우 납과 인의 분포부분이 중첩되어 두 원소간의 연관성이 있는 것으로 판단되었다. 이를 종합할 때, PBC700 처리구의 납 용출 농도의 감소는 PBC700이 함유한 인과 오염토양에 존재하는 납이 매우 안정한 형태의 화학종인 chloropyromorphite, hydroxypyromorphite 등을 형성하면서 나타난 결과로 판단된다.