• Journal of Korean Neurosurgical Society
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• v.58 no.5
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• pp.432-441
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• 2015

Objective : To assess the impact of the complete resection of craniopharyngioma (CP) in adults on oncologic and functional outcomes. Methods : We retrospectively analyzed 82 patients with CP who were surgically treated by the same neurosurgeon at our institution between January 1994 and December 2012. Results : Gross total resection (GTR) was achieved in 71 patients (86.6%), near total resection (NTR) in 7 patients (8.5%), and subtotal resection (STR) in 3 patients (3.7%). The disease-specific overall survival rate was 100% with the exclusion of 2 surgery-related mortalities. The overall recurrence rate was 12.2% (10 of 82 patients), however the recurrence rate according to extent of resection (EOR) was 9.9% (7 of 71 patients) after GTR, 14.3% (1 of 7 patients) after NTR, and 66.7% (2 of 3 patients) after STR. The overall recurrence-free survival (RFS) rates at 5 and 10 years were 87.0% and 76.8%, respectively. Postoperatively, most patients (86.3%) needed hormone replacement for at least 1 hypothalamic-pituitary axis. Vision improved in 56.4% of the patients with preoperative abnormal vision, but deteriorated in 27.4% of patients. Hypothalamic dysfunction developed in 32.9% of patients. There were no significant differences in the risks of pituitary dysfunction, visual deterioration, or hypothalamic dysfunction between the groups with complete vs. incomplete removal. The overall rate of postoperative complications was 22.0%, which did not differ between groups (p=0.053). Conclusion : The complete removal of a CP at first surgery can provide a chance for a cure with acceptable morbidity and mortality risks.

• Journal of English Language & Literature
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• v.55 no.4
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• pp.597-618
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• 2009

Leslie Marmon Silko, in her novel Gardens in the Dunes, primarily focuses on revealing the white colonialists' plan to exterminate and destroy American Indians and their culture. In this regard, this novel is clearly an Indian counter narrative to interrogate and abrogate the authority of the oppressive and destructive discourse of the whites who are full of colonialist impulses to sterilize Indians and their culture. However, it should be noted that Silko is very careful not to insist on cultural exclusivism and reverse ethnocentrism, since these only mean a return to the violent colonialists' discourse based on dualism and cultural authenticity which, she believes, has led to the marginalization and eventual deterioration of Indians and their culture. White values and culture are something to recognize and tolerate as long as they are not the products of witchery, also known as the destroyer or evil for Silko, which promotes disruption and antagonism between races and classes. As she reveals in her interview, her major concern in the novel is to dismantle political and/or racial distinctions like Native Americans versus EuroAmericans and thus to enhance the idea of the reconciliation and coexistence of whites and Indians. Silko's Gardens in the Dunes can be regarded as an experiment in the possibility of the universal and homogeneous (at least in its roots) global culture which tolerates all forms of culture. Global culture does not mean a uniform totalitarian culture but a vision of a harmonious world characterized by hybridity and heterogeneity, in which different cultures associate freely without the notion of inferiority or superiority of any one culture. Silko's belief in syncretism emphasizes the spirit of tolerance and exchange between different cultures, dismantling the authority of exclusive ethnocentrism. The ultimate message implied in Gardens in the Dunes is that the syncretic spirit is not only an effective means to correct the white colonialists' hegemonic desire aimed at the extermination of Indians and their culture but also a source of energy for the life and prosperity of modern Indians and their societies.

• Journal of Korean Neurosurgical Society
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• v.59 no.3
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• pp.314-318
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• 2016

Posterior fossa is a site next to the middle fossa where arachnoid cyst frequently occurs. Generally, most arachnoid cysts are asymptomatic and are found incidentally in most cases. Although arachnoid cysts are benign and asymptomatic lesions, patients with posterior fossa arachnoid cysts often complain of headaches, gait disturbance, and ataxia due to the local mass effects on the cerebellum. We observed a patient with a posterior fossa arachnoid cyst who had visual symptoms and a headache, but did not have gait disturbance and ataxia. We recommended an emergency operation for decompression, but the patient refused for personal reasons. After 7 days, the patient revisited our hospital in a state of near-blindness. We suspected that the arachnoid cyst induced the hydrocephalus and thereby the enlarged third ventricle directly compressed optic nerves. Compressed optic nerves were rapidly aggravated during the critical seven days; consequently, the patient's vision was damaged despite the operation. Considering the results of our case, it is important to keep in mind that the aggravation of symptoms cannot be predicted; therefore, symptomatic arachnoid cysts should be treated without undue delay.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.9 s.351
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• pp.69-79
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• 2006

A number of researches on vision-based traffic monitoring system have been carried out. Most of traffic monitoring schemes belong to one of two categories: analyzing of entire traffic scene and examining of local region. However, the proposed methods suffer from severe performance deterioration when applied in different operating conditions because of the loss of robustness. This paper is aimed at surveying various methods proposed and analyzing the advantages and disadvantages of these methods. Also we propose and investigate appropriate approaches to solve the problems in specific applications.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.14 no.1
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• pp.29-36
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• 2014

Mucopolysaccharidoses (MPSs) are a group of rare inherited metabolic diseases caused by deficiency of lysosomal enzymes. MPSs are clinically heterogeneous and characterized by progressive deterioration in visceral, skeletal and neurological functions. The aim of this article is to review the treatment of MPSs, the unmet needs of current treatments and vision for the future including recent clinical trials. Until recently, supportive care was the only option available for the management of MPSs. Hematopoietic stem cell transplantation (HSCT), another potentially curative treatment, is not routinely advocated in clinical practice due to its high risk profile and lack of evidence for efficacy. From the early 2000s, enzyme replacement therapy (ERT) was approved and available for the treatment of MPS I, II and VI. ERT is effective for the treatment of many somatic symptoms, particularly walking ability and respiratory function, and remains the mainstay of MPS treatment. However, no benefit was found in the neurological symptoms because the enzymes do not readily cross the blood-brain barrier (BBB). In recent years, intrathecal (IT) ERT, substrate reduction therapy (SRT) and gene therapy have been rapidly gaining greater recognition as potential therapeutic avenues. Although still under investigation, IT ERT, SRT and gene therapy are promising MPS treatments that may prevent the neurodegeneration not improved by ERT.

• Brain Tumor Research and Treatment
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• v.6 no.2
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• pp.82-85
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• 2018

Extremely massive sellar xanthogranuloma (XG) are rare, and the surgical outcome and prognosis are not well known. XG remain unknown whether they are derived from Rathke's cleft cysts (RCCs) or craniopharyngiomas (CPs) following extensive inflammation and metaplasia, to the point that no epithelium is readily identifiable. These lesions usually tend to occur in younger patients (mean 28.3 years), have a smaller diameter, and remain primarily intrasellar region with infrequent calcification. This 36-year-old man presented our hospital with visual deterioration. At the time of visit, there were no neurological problems other than visual field defect and hormonal disorder. He visited our hospital in 2007 due to headache and decreased vision, and underwent transphenoid surgery for pituitary RCC. Since then, he has received treatment at our hospital for postoperative hormonal disorders. Through preoperative imaging study, the author suspected CP and underwent surgery. During the operation, the adhesion of the tumor to the surrounding major neurovascular structures was severe in the naked eyes, but the tumor could be removed more easily than expected. The postoperative histological findings were confirmed as XG. The postoperative course was uneventful. Compared to the previous literature, this case is a case where the size of XG is very large in a sellar region and it can be proved that it originated from the RCC. And regular follow-up is necessary to confirm the prognosis after surgery.

• Proceedings of the Korea Information Processing Society Conference
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• 2022.11a
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• pp.541-543
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• 2022

In recent years, retinal disorders have become a serious health concern. Retinal disorders develop slowly and without obvious signs. To avoid vision deterioration, early detection and treatment are critical. Optical coherence tomography (OCT) is a non-invasive and non-contact medical imaging technique used to acquire informative and high-resolution image of retinal area and underlying layers. Disease signs are difficult to detect because OCT images have many areas which are not related to any disease. In this paper, we present a deep learning-based method to perform multi-label classification on a long-tailed OCT dataset. Our method first extracts the region of interest and then performs the classification task. We achieve 98% accuracy, 92% sensitivity, and 99% specificity on our private OCT dataset. Using the heatmap generated from trained convolutional neural network, our method is more robust and explainable than previous approaches because it focuses on areas that contain disease signs.

• Journal of Digital Convergence
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• v.13 no.12
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• pp.203-208
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• 2015

Image degradation will occur depending on hardware characteristics according to the lapse of time between beam projectors when multivision system is installed in the Theme park/Exhibition/Science Museum. In this paper, we have researched the 10-bit High-depth and high-resolution $360^{\circ}$ projection image analysis technique to solve the problems of quality and the maintenance of the theater. The goal is to minimize the economic losses and the development of special theater calibration system that can efficiently support a quality of an image. We proposed the method of image analysis technology, and explained the detailed functions and evaluation methods for image analysis technique. Evaluation method included the performance items, and proposed reasonable value to the experimental method and the goal value.

• Journal of Korean Neurosurgical Society
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• v.61 no.1
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• pp.60-65
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• 2018

Objective : Choroidal metastases (CMs) are the most common intraocular tumor. Management is mainly radiation therapy with goals of pain control and visual improvement. However, many radiation-related complications are reported. Since gamma knife radiosurgery (GKS) for CM was first reported in 1995, few cases have been reported. We report 7 cases of CMs treated with GKS. Methods : From April 2011 to November 2014, 7 patients with CM underwent GKS. Their median age at treatment was 64 years (range, 51-71 years). Four males and three females were treated. Lung cancer was the most common primary pathology, followed by renal cell carcinoma and stomach cancer. Four patients had multiple cerebral lesions and were treated simultaneously for choroidal lesions. The median marginal dose of 20 Gy (range, 15-25 Gy) was administered at the 50% isodose line. Results : Median follow-up period after GKS was 8 months (range, 2-38.3 months). Four patients expired due to underlying malignancy progression. Except for two patients who were not followed with magnetic resonance image after GKS, all patients showed size reduction in the treated lesions, but a new choroidal lesion appeared in one patient and one recurred. Six of seven patients reported subjectively improved visual symptoms. Visual acuity improved in 2 patients, and 2 were stable upon objective examination. One patient showed no improvement in visual acuity, but ocular pain was relieved; another patient showed improved vision and tumor remission, but visual deterioration recurred. Conclusion : GKS was shown to be safe and effective and should be considered for CM treatment.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.11
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• pp.2412-2418
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• 2009

As an astonishing progress of FTTH infrastructure, the new technologies have been widely studied to use the tantalizing benefits of high bandwidth in fiber optic cable. In this paper, a new VONU is presented to perform all necessary optical functions. It can converts digital and analog CATV signals and satellite-based signal transmitted via one fiber optic cable to electrical signals (electric lights). However, most previous VONU systems have the problems such as interference between difference services, signal distortion, and noise increasing rate. These problems cause the quality deterioration in broadcasting. Therefore, we suggest the new VONU system to solve all problems listed above. In addition, we show that how our system performs well by measuring the real data with implemented system.