• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.4
• /
• pp.2371-2375
• /
• 2013

Breast cancer is one of the most common malignancies in women around the world. Among the various hormonal types of breast cancer, those that are estrogen receptor (ER) positive account for the majority. Among the estrogen related receptors, estrogen related receptor ${\alpha}$ is known to have a potential role in breast cancer and is one of the therapeutic target. Hence, prediction of novel ligands interact with estrogen related receptor alpha is therapeutically important. The present study, aims at prediction and analysis of ligands from the KEGG COMPOUND database (containing 10,739 entries) able to interact against estrogen receptor alpha using a similarity search and molecular docking approach.

• International Journal of Contents
• /
• v.7 no.4
• /
• pp.35-43
• /
• 2011

USN is a technology to detect human external environment. It is an important factor in buildinga ubiquitous computing environment. In this thesis, an authentication method was proposed to allow the sensor nodes, which have weak computing operation capability, to safely communicate with each other in USN and guarantee the anonymity of users for their privacy. In the proposed authentication method that takes into account the characteristics of sensor network, sensor nodes based on a symmetric key algorithm do not transfer keys directly, instead, they mix the random numbers received from AS to generate keys necessary for communications, having a master key and a pseudo-random number generator.In addition, in this thesis, TA was adopted to minimize the leakage of users' information, and a scheme through which virtual IDs received from AS are delivered to sensor nodes was applied to improve anonymity.

• Proceedings of the Korean Institute of Intelligent Systems Conference
• /
• 2003.09a
• /
• pp.500-503
• /
• 2003

The navigation problem of robot is one of the main themes to deal with conficts or interferences between obstacles and the robot itself In this case, while the robot avoids obstacles on the space, the passage route should be determined efficiently. In order to solve problems above, we have come up with the distance field space medel (DFM) and then, under known environment, we have presented the distance field A algorithm for passage route path search. In this research, the method of performing the 3-dimensional passage route path search of robot under unknown environment is proposed. It is shown that the authors can build the distance search model the does not need space division by taking into account of sensor information to a distance field space model, and constructing this information as virtual obstacle information.

• Transactions of Materials Processing
• /
• v.11 no.3
• /
• pp.238-245
• /
• 2002

The spring back taking place after the coiling process of steam generator tube leads to the dimensional inaccuracy. In order to reduce the spring back, tension force was applied to the one end of the tube during forming. In this work, parametric study using FEM was performed to find the appropriate magnitude of tension force. The force that induces minimum spring back was found by simultaneously taking account if spring back amount, cross-sectional ovality, and thickness of the tube wall after deformation. In addition, stress relieving by heat treatment was also simulated as an alternative to the former method. The latter was found to be more effective under the given constraints.

• Steel and Composite Structures
• /
• v.19 no.4
• /
• pp.829-841
• /
• 2015

In this paper, a refined exponential shear deformation beam theory is developed for bending analysis of functionally graded beams. The theory account for parabolic variation of transverse shear strain through the depth of the beam and satisfies the zero traction boundary conditions on the surfaces of the beam without using shear correction factors. Contrary to the others refined theories elaborated, where the stretching effect is neglected, in the current investigation this so-called "stretching effect" is taken into consideration. The material properties of the functionally graded beam are assumed to vary according to power law distribution of the volume fraction of the constituents. Based on the present shear deformation beam theory, the equilibrium equations are derived from the principle of virtual displacements. Analytical solutions for static are obtained. Numerical examples are presented to verify the accuracy of the present theory.

• Steel and Composite Structures
• /
• v.2 no.5
• /
• pp.315-330
• /
• 2002

This paper proposes a model for analysing the non-linear behaviour of steel concrete composite beams prestressed by external slipping cables, taking into account the deformability of the interface shear connection. By assuming a suitable admissible displacement field for the composite beam, the balance condition is obtained by the virtual work principle. The solution is numerically achieved by approximating the unknown displacement functions as series of shape functions according to the Ritz method. The model is applied to real cases by showing the consequences of different connection levels between the concrete slab and the steel beam. Particular attention is focused on the limited ductility of the shear connection that may be the cause of premature failure of the composite girder.

• Structural Engineering and Mechanics
• /
• v.2 no.2
• /
• pp.185-196
• /
• 1994

In this paper a spline function solution for the ultimate strength of steel members and member structures is derived based on total Lagrangian formulation. The displacements of members along longitudinal and transverse directions are interpolated by one-order B spline functions and three-order hybrid spline functions respectively. Equilibrium equations are established according to the principle of virtual work. All initial imperfections of members and effects of loading, unloading and reloading of material are taken into account. The influence of the instability of members on structural behavior can be included in analyses. Numerical examples show that the method of this paper can satisfactorily analyze the elasto-plastic large deflection problems of planar steel member and member structures.

• ETRI Journal
• /
• v.20 no.2
• /
• pp.171-191
• /
• 1998

In this paper, we propose a new heuristic design algorithm for the virtual path (VP)-based ATM network with multiple traffic classes, in which QoS constraints associated with traffic class are taken into account. The minimum bandwidth of VP required to carry given amount of traffic is obtained by utilizing an equivalent bandwidth concept, and the route of each VP is placed so that the network cost is minimized while the QoS requirement is fulfilled To evaluate our design algorithm, we consider two kinds of traffic: voice traffic as low speed service and still picture traffic as high speed service. Through numerical examples, we demonstrate that our design method can achieve an efficient use of network resources, which results in providing a cost-effective VP-based ATM network.

• Nuclear Engineering and Technology
• /
• v.41 no.1
• /
• pp.71-78
• /
• 2009

One of main concepts involved in regional small nuclear reactors is unmanned remote control. Internet-based virtual private networks provide environments for the remote monitoring and control of geographically-dispersed systems, and with the advances in communication technologies, the potential of networks for real time control and automation becomes enormous. However, networked control has some problems. The most critical is delay in signal transmission, which degrades system stability and performance. Therefore, a networked control system should be designed to account for delay. This paper proposes some design approaches for a delay-tolerant system that can guarantee predetermined stability margins and performance. To accomplish this, the reactor plant is modeled with consideration of uncertainties. With this model, three kinds of controllers are developed using different methods. The designed systems are compared with respect to stability and performance, and a second-order controller designed using the table lookup method was found to give the most satisfactory results.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.15 no.12 s.105
• /
• pp.1361-1369
• /
• 2005

Based on a full layerwise displacement shell theory, the nitration and damping characteristics of cylindrical sandwiched panels with viscoelastic layers are investigated. The transverse shear deformation and the normal strain of the cylindrical hybrid panels are fully taken into account for the structural damping modelling. The present finite element model Is formulated by using Hamilton's virtual work principle and the cylindrical curvature of hybrid panels is exactly modeled. Modal loss factors and frequency response functions are analyzed for various structural parameters of cylindrical sandwich panels. Present results show that the full layerwise finite element method can accurately predict the vibration and damping characteristics of the cylindrical hybrid panels with surface damping treatments and constrained layer damping.