• 대한본초학회지
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• 제32권4호
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• pp.33-38
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• 2017

Objectives : Termitomyces albuminosus (Berk.) Heim is one of the famous wild edible mushrooms in the southern part of China. It is known that Termitomyces albuminosus, like Aconitum koreanum used in Korean traditional medicine, contains a kind of cerebroside, termitomycesphin, causing a pharmacologic effect on the neuron system. The pharmacologic effect of Termitomyces albuminosus can be used to possibly replace Aconitum koreanum. However, It needs to be certified as safe before it can be used. Here, a single-oral toxicity test and safety classification was conducted to obtain acute information of the toxicity of dried-Termitomyces albuminosus powder and to secure its safety in clinical applications. Methods : In order to calculate approximate lethal dose(ALD), test substance was orally administered to male and female SD-rat at dose levels of 5,000 and 0 (vehicle control) mg/kg (body weight). Based on the result of this toxicity, also the estimation of safety classification was calculated using the HED-based (human equivalent dose) MOS (margin of safety). Results : There were no mortalities, test substances treatment-related clinical signs, no changes in the body or organ weights, and no gross or histopathological findings at 14 days after treatment with test substance. Thus, the approximate lethal dose of dried-Termitomyces albuminosus powder was considered over 5,000 mg/kg in both female and male mice. Conclusions : Based on the limit dose, 5000 mg/kg, it was estimated that dried-Termitomyces albuminosus powder is classified as "Specified class B" indicating that clinical dose is not limited to patients as safe as food.

• 대한약침학회지
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• 제25권3호
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• pp.258-267
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• 2022

Objectives: Hypertrophic scars (HSs) are caused by abnormal wound healing. To date, no standard treatment has been made available for HSs. Scrophularia striata has been reported to accelerate wound healing and has the potential to prevent HS formation. In this study, we investigated the anti-scarring effects of S. striata extract (SSE) in a rabbit ear model of scarring. Methods: In this study, New Zealand white rabbit (weight: 2.3-2.5 kg) were used. In the prevention phase of the study, three test groups received 5%, 10%, and 15% ointments of SSE in the Eucerin base, the fourth group received Eucerin, and the fifth group received no treatment. The samples were obtained on day 35 after wounding. In the treatment phase of the study, the test groups received an intralesional injection of SSE (5%, 10%, and 15%), the fourth group received an intralesional injection of triamcinolone, the fifth group received a solvent (injection vehicle), and the sixth group received no treatment. To evaluate the anti-scarring effects of SSE, the scar elevation index (SEI), epidermis thickness index (ETI), collagen deposition, and MMP2 and MMP9 gene expression were evaluated. Results: A significant reduction in SEI, ETI, and collagen deposition was noted in animals treated with SSE compared with the control groups. In addition, topical SSE stimulated MMP2 and MMP9 gene expression. Conclusion: The findings of this study demonstrate the potential for SSE in the prevention and treatment of HS. SSE could be prepared as an appropriate formulation to treat wounds and prevent abnormal scarring.

• Composites Research
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• 제36권1호
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• pp.59-67
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• 2023

항공우주산업에서 경량화를 위해 사용되는 CFRP 복합재료로 구성된 차체의 충격에 따른 파손은 탑승자의 안전과 직결된다. 따라서 충돌 상황에서 육안으로 확인하기 힘든 재료의 손상거동을 파악하는 것이 중요하며, 이를 구현할 수 있는 유한요소모델을 통한 연구가 필요하다. 본 연구에서는 일방향 적층 복합재료의 충돌 해석에 대해 파손 거동 예측에 적합한 유한요소모델을 구축하였다. 인공신경망 모델을 통해 LS-DYNA에서 제공하는 MAT_54 Enhanced Composite Damage 재료 모델의 교정 파라미터를 역추정하여 획득하였다. 획득한 파라미터에 대한 인공신경망 모델의 결과를 실험결과와 비교하여 신뢰성을 검증하였다. 그 결과, 교정 파라미터의 최적화를 통해 실험에 대한 정확도를 향상시킨 유한요소모델을 구축할 수 있음을 확인하였다.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.578-589
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• 2003

The fuzzy rat that expresses hypersecretion of sebum and hyperplastic sebaceous glands is a genetic mutant for the study of many pharmacological aspects especially human acne. Through this model, we examined the effects of several phospholipids on the secretion of sebum after topical application. The phospholipid derivatives were phosphatidylcholine (PC), hydrogenated phosphatidylcholine (HPC), phosphati dylserine (PS) and hydrogenated phosphatidylserine(HPS). All agents were dissolved into the vehicle (1, 3-Butanediol, ethanol and water) at 0.5％ weight volume and applied on the dorsal area of the fuzzy rat. To observe histological changes, the skin biopsies were stained with Oil Red O and the size and morphology of sebaceous gland was observed under microscope. Topical treatment with PC and/or HPC showed a marked decrease in sebum excretion. Especially hydrogenated PC (HPC) appeared to have more predominant sebosuppressive function than any other treatment. The other agents such as PS and HPS showed a marginal effect on sebum secretion. With the sebosuppressive activity, HPC and PC seem to have a good potential application on acne treatment. In order to obtain more insights into possible mechanisms behind the above observations, effects of each phospholipid on the expression of peroxisome proliferator-activated receptor (PPAR) genes were investigated. Recently, it has been demonstrated that expression and activation of PPAR subtypes appear to modulate the accumulation of cytoplasmic fat droplets that characterizes the sebocyte differentiation(1). It was also previously suggested that PPAR${\gamma}$ antagonist would seem possible to interfere sebum production without side effects (2). In this study we examined the diverse effects of the tested phospholipids on the expression of several PPAR genes based on reverse transcription-polymerase chain reaction (RT-PCR) from the topically treated skin of fuzzy rats. The results and possible implications are discussed.

• 한국ITS학회 논문지
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• 제22권4호
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• pp.78-96
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• 2023

도시부 교통정보 수집은 VDS, DSRC, 레이더 등 다양한 시스템에 의해 수집되고 있다. 최근 딥러닝 기술의 발전으로 스마트교차로시스템이 확대 보급되고 있으며 교통량, 속도, 차종 등 다양한 정보수집이 가능하다. 그러나 관련 문헌을 고찰한 결과 지금까지의 성능평가 기준은 딥러닝 영역을 고려하지 않은 RBS기반 평가체계로 '기준값-측정값'의 퍼센트 오차만 고려하고 있어 기존 평가방식으로는 딥러닝 부분의 평가를 수행할 수 없어 새로운 성능평가 방법이 필요하다. 따라서, 본 연구에서는 데이터 비율 및 가중치를 고려하여 Precision과 Recall 등 딥러닝 성능지표를 고려한 오차산정식을 개발하여 개별오차와 구간 오차, 전체오차를 산정하였다. 연구결과, 측정값 1의 오차율은 3.99와 3.54, 측정값 2는 5.34와 5.07로 기존 산정식과 오차율에 차이가 있는 것으로 나타났으며, 반복측정 분석결과 개발 산정식이 우수한 것으로 나타났다.

• 한국포장학회지
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• 제29권2호
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• pp.129-138
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• 2023

The proportion of agricultural products handled through the Agricultural Products Processing Center (APC) is also steadily increasing every year, and in the case of Seongju Korean melon, a total of 10 APCs of Nonghyup and farming association corporations are in operation, and the distribution ratio is about 60% based on total production. In this study, Seongju Korean melon was selected as a target to analyze the environment load during carrying (production farm ~ APC) in the production area and the transport environment load during distribution of domestic fruits, and to analyze the environmental load for handling at APC. The vertical average vibration intensity (overall G_rms of 1~250 Hz) of truck transport measured at three transport routes from Seongju Korean melon producer ~ APC, Seongju ~ Seoul and Seongju ~ Jeju was about three times larger than that in the lateral direction and 4.5 times larger than that in the longitudinal direction, respectively. The frequency of occurrence of high-amplitude events (G) in the vertical direction compared to the measuring time was deeply related to pavement conditions in the order of unpaved farm-roads, concretepaved farm-roads, and asphalt-paved main-roads, but overall G_rms for the entire frequency band is believed to have a greater impact on vehicle traveling speed than road conditions. On the other hand, the difference in the size and direction of the vibration intensity measured by the forklift truck's main-body and the attachment (fork carrier) during handling at Seongju Korean melon APC was clear, and the vibration intensity of the forklift truck's main-body was largely affected by the stiffness of the fork and the mast according to the handling weight. Based on the field-data of the transport environment during domestic distribution measured through this study, it is believed that it is possible to develop a lab-based simulation protocol for appropriate packaging design.

• International Journal of Computer Science & Network Security
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• 제23권1호
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• pp.153-163
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• 2023

This study is situated in the context of intelligent transport systems, where in-vehicle devices assist drivers to avoid accidents and therefore improve road safety. The vehicles present in a given area form an ad' hoc network of vehicles called vehicular ad' hoc network. In this type of network, the nodes are mobile vehicles and the messages exchanged are messages to warn about obstacles that may hinder the correct driving. Node mobilities make it impossible for inter-node communication to be end-to-end. Recognizing this characteristic has led to delay-tolerant vehicular networks. Embedded devices have small buffers (memory) to hold messages that a node needs to transmit when no other node is within its visibility range for transmission. The performance of a vehicular delay-tolerant network is closely tied to the successful management of the nodes' transit buffer. In this paper, we propose a message transit buffer management model for nodes in vehicular delay tolerant networks. This model consists in setting up, on the one hand, a policy of dropping messages from the buffer when the buffer is full and must receive a new message. This drop policy is based on the concept of intermediate node to destination, queues and priority class of service. It is also based on the properties of the message (size, weight, number of hops, number of replications, remaining time-to-live, etc.). On the other hand, the model defines the policy for selecting the message to be transmitted. The proposed model was evaluated with the ONE opportunistic network simulator based on a 4000m x 4000m area of downtown Bouaké in Côte d'Ivoire. The map data were imported using the Open Street Map tool. The results obtained show that our model improves the delivery ratio of security alert messages, reduces their delivery delay and network overload compared to the existing model. This improvement in communication within a network of vehicles can contribute to the improvement of road safety.

• Composites Research
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• 제21권1호
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• pp.1-7
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• 2008

복합재 고압 용기는 우수한 기계적 강도를 유지하면서 경쟁적인 무게절감을 얻을 수 있는 복합재의 장점으로 인해 최근에 많이 사용되고 있다. 하지만 고압에서 발생하는 복합재의 기밀 문제(permeability)를 보완하기 위해 금속으로 덧대는 Type 3 형태의 구조로 많이 사용된다. 그러나 복잡한 기하학적 형상, 제조공정 변수 등으로 인해 차입 3 형태의 압력용기를 설계하는 데에는 많은 어려움이 뒤따른다. 따라서 본 연구에서는 이러한 변수들을 고려하는 준측지궤적 알고리즘(semi-geodesic algorithm)과 최적화를 위한 유전자 알고리즘을 적용하여 차입 3 복합재 압력용기의 GUI(graphic user interface) 최적설계 프로그램을 개발하였다. 또한 개발된 프로그램을 이용하여 연료 전지 자동차에 적용되는 350/700 바 수소저장용기에 대해 최적 설계를 수행하였다.

• 한국해양학회지:바다
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• 제13권3호
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• pp.222-228
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• 2008

본 논문은 해저 연약지반 위를 주행하는 시험집광기의 동적거동 해석을 다루고 있다. 시험집광기는 단괴채집장치, 무한궤도, 단괴파쇄기, 샤시프레임, 전기 전자 시스템으로 구성되어 있다. 시험집광기의 공기 중 무게는 8,600 kg이며, 수중에서의 시험집광기의 평균접지압은 6.0 kPa이다. 상용해석 프로그램인 RecurDyn-LM과 Visual Fortran 90을 이용하여 시험집광기의 동적거동 해석 모델 및 유체저항력 모델을 구축하였다. 상용해석 프로그램(RecurDyn-LM)에서 제공되는 사용자 정의 서브루틴을 이용하여 연약지반역학 모델 및 유체저항력 모델을 구축하였으며, 이를 통하여 해저 시험집광기의 동적거동 해석을 수행하였다. 궤도속도, 지반조건, 항력계수 및 추가질량 계수의 변화에 따른 시험집광기의 동적응답을 분석하였다.

• 소성∙가공
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• 제33권2호
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• pp.103-111
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• 2024

With the increasing global interest in carbon neutrality, the automotive industry is also transitioning to the production of eco-friendly cars, specifically electric vehicles. In order to achieve comparable driving distances to internal combustion engine vehicles, the application of high-capacity battery packs has led to an increase in vehicle weight. To achieve light-weighting and durability requirements of automotive components simultaneously, there is a demand for research on the application of Ultra-High Strength Steel (UHSS). However, when manufacturing chassis components using UHSS, there are challenges related to fracture defects due to lower elongation compared to regular steel sheets, as well as spring-back issues caused by high tensile strength. In this study, a simulated specimen that is not affected by the property changes of four materials was designed to improve formability of the rear cross member, which is the most challenging automotive chassis component. The influence and correlation of material-specific variables were analyzed through finite element analysis (FEA) for each material with tensile strength of 440, 590, 780, and 980 MPa grades, resulting in the development of a predictive equation. To validate the equation, the simulated specimens of 980 MPa grade were produced from the test molds. Then the reliability of the FEA and predictive equation was verified with measured specimen data using a 3D scanner. The results of this study can be proposed to improve the formability of UHSS chassis components in future researches.