• 사상체질의학회지
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• 제27권2호
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• pp.254-269
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• 2015

Objectives This study aimed to observe the effect of Taeumjowi-tang on the cisplatin-induced gastrointestinal dysfunctions in rats. Methods Four groups, each of 8 rats per group, were used in this study. Saline and distilled water treated control rats were intact vehicle control group. Delayed gastrointestinal motility was induced by intraperitoneal treatment of cisplatin 2mg/kg, once a week for 5 weeks(Cisplatin control group). Taeumjowi-tang aqueous extracts(TJ) were orally administered in a volume of 5ml/kg, once a day for 14 days from 4th cisplatin treatment(TJ group). Ondansetron 1mg/kg was subcutaneously treated, in a volume of 1ml/kg, as same as TJ(ondansetron group). We measured the body weights, intestinal charcoal transit ratio, fecal parameters, fundus MDA(malondialdehyde), GSH(glutathione) contents and SOD(superoxide dismutase), CAT(catalase) activities, TPH(tryptophanhydroxylase) and MAO(monoamine oxidase) activities, pyloric gastrin and serotonin contents with their immunoreactive cells, colonic serotonin-immunoreactive cells, the histopathology of pylorus, fundus mucosa and colon. Results 1) The body weight gains, the small intestinal charcoal transfer rates, the fecal parameters(numbers, weights and water contents) were increased in TJ, ondansetron group. 2) The inhibit of fundus antioxidant defense systems by cisplatin were decreased in TJ, ondansetron group. 3) The pyloric TPH activities were increased and the pyloric MAO activities were decreased in TJ group. 4) The pyloric gastric contents and the gastrin-immunoreactive cells were increased and the pyloric serotonin contents and the pyloric and colonic serotonin-immunoreactive cells were decreased in TJ group. 5) The pylorus atrophic changes and the gastric surface erosive damage regions by cisplatin were favorably inhibited by treatment of TJ group. Conclusions The results obtained in this study suggest that TJ favorably retarded the cisplatin related GI(gastrointestinal) dysfunctions and constipation through modulations of GI enterochromaffin cells, serotonin and gastrin-producing cells and antioxidative systems.

• 한국재료학회지
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• 제14권2호
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• pp.126-132
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• 2004

The high strength steel sheets has been widely used as the automobile parts to reduce the weight of a vehicle. The aim of this research is to develop the TRIP aided high strength low carbon steels using reverse transformation process. The 0.15C-4Mn and 0.15C-6.5Mn steel sheets were reversely transformed by slow heating to intercritical temperature region and air cooling to room temperature. The stability of retained austenite depends on the enrichment of carbon and manganese by diffusion during the reverse transformation. The amount of retained austenite formed after reversely transformed at $645^{\circ}C$ for 12 hrs. was about 46vol.% in hot rolled 0.lC-6.5Mn steel. The change in volume fraction of retained austenite with a holding temperature was consistent with the changes in elongation and the strength-ductility combination. The tendency of tensile strength to increase with increasing the holding temperature was due to the decrease of retained austenite after cooling from the higher temperature of $670 ^{\circ}C$. The maximum strength-ductility combination was about 4,250 kg/$\textrm{mm}^2$ㆍ% when the hot rolled 0.lC-6.5Mn steel was reversely transformed at $645^{\circ}C$ for 12 hrs.

• Design & Manufacturing
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• 제11권2호
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• pp.37-41
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• 2017

With light vehicle weight gradually becoming ever more importance due to tightened exhaust gas regulations, hot-stamping processing using boron alloyed steel is being applied more and more by major automobile OEMs since process assures both moldability and a high strength of 1.5 GPa. Although laser trimming is generally applied to the post-processing of the hot-stamped process with high strength, there have been many studies of in-die hot trimming using shear dies during the quenching of material in order to shorten processing times. As such, this study investigated the effects of the Shear rate and Shear mechanism on shear processes during the quenching process of hot-stamping material. In case of pad variable, padding force is very weak compared with shear force, so it does not affect the shear surface. In case of shear rate, the higher the shear at high temperatures and the higher the friction effect. As a result the rollover and the fracture distribution decreased, and the burnish distribution increased. Therefore, it is considered that the shear quality is guaranteed when high shear rate is applied in high temperature shear process.

• The Korean Journal of Physiology and Pharmacology
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• 제10권2호
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• pp.85-94
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• 2006

A splanchic artery occlusion for 90 min followed by reperfusion of the mesenteric circulation resulted in a severe form of circulatory shock, characterized by endothelial dysfunction, severe hypotension, marked intestinal tissue injury, and a high mortality rate. The effect of defibrotide, a complex of single-stranded polydeoxyribonucleotides having antithrombotic effect, was investigated in a model of splanchnic artery occlusion (SAO) shock in urethane anesthetized rats. Occlusion of the superior mesenteric artery for 90 min produced a severe shock state, resulting in a fatal outcome within 120 min of reperfusion in many rats. Defibrotide (10 mg/kg body weight) 10 min prior to reperfusion significantly improved mean arterial blood pressure in comparison to vehicle treated rats (p＜0.05). Defibrotide treatment also significantly attenuated in the increase of plasma amino nitrogen concentration, intestinal myeloperoxidase activity, intestinal lipid peroxidation, infiltration of neutrophils in intestine and thrombin induced adherence of neutrophils to superior mesentric artery segments. Superoxide anion and hydrogen peroxide production in $1{\mu}M$ formylmethionylleucylphenylalanine (fMLP)-activated PMNs was inhibited by defibrotide in a dose-dependent fashion. Defibrotide effectively scavenged hydrogen peroxide, but not hydroxyl radical. Treatment of SAO rats with defibrotide inhibited tumor necrosis factor-${\alpha}$, and interleukin-1${\beta}$ productions in blood in comparison with untreated rats. These results suggest that defibrotide partly provides beneficial effects by preserving endothelial function, attenuating neutrophil accumulation, and antioxidant in the ischemic reperfused splanchnic circulation

• 한국안전학회지
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• 제34권6호
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• pp.88-95
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• 2019

It has been only a few years since drones have been introduced to Korea, and as the use of drones has increased in industrial sites as well as in hobby activities, accidents such as workers' body parts coming into contact with rotating propellers have been occurring since 2016. Industrial accident cases are being filed. In the case of a remote control vehicle, if you release the remote controller in the event of an abnormal situation, it stops in place and no further danger occurs but in case of drones flying over the sky is different. Sudden motor stops during flight, uncontrolled changes in flight posture, loss of radio waves, loose propeller, etc, numerous factors can lead to accidents due to unintentional movements. Therefore, drone operators need safety knowledge as well as high knowledge about drones. However, drones with a weight of less than 12 kg can fly without a pilot's certification, and therefore, a minimum accident prevention measure is required. 10 accidents approved as industrial accidents since 2016, 23 accidents surveyed by general drone operator, 40 accidents surveyed by the Korean Consumer Resources Unfortunately for the purpose of writing this paper, drones are a new species and do not have many parameters for analysis but my experience has shown that the type of disaster does not deviate significantly. In addition, there is no paper that analyzes drone related industrial accidents not only in Korea but also in other countries. However, even if you watch an overseas drone accident video through YouTube, it is not much different from the case that occurs in Korea. I hope that this study will be of little help to all the drone pilots as well as the work safety of industrial drones used in industrial sites.

• 한국표면공학회지
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• 제41권3호
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• pp.121-128
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• 2008

High strength 7xxx aluminum alloys have been applied to automotive bump back beam of the some limited model for light weight vehicle. The aluminum bump back beam is manufactured through extrusion, bending and welding. The residual stress given on these processes combines with the corrosive atmosphere on the road spreaded with corrosive chemicals to melt snow to occur the stress corrosion cracking. The composition of commercial 7xxx aluminum has Zn/Mg ratio about 3 and Cu over 2 wt% for better strength and stress corrosion cracking resistivity. But this composition isn't adequate for appling to the automotive bump back beam with high resistance to extrusion and bad weldability. In this study the composition of 7xxx aluminum alloy was modified to high Zn/Mg ratio and low Cu content for better extrusion and weldability. To estimate the resistivity against stress corrosion cracking of this aluminum alloy by slow strain rate test, the corrosion atmosphere and strain rate separate the stress corrosion cracking from conventional corrosion must be investigated. Using 0.6 Mol NaCl solution on slow strain rate test the stress corrosion cracking induced fracture was not observed. By adding 0.3% $H_2O_2$ and 0.6M $Na_2SO_4$ to 1M NaCl solution, the corrosion potential and current density of polarization curve moved to active potential and larger current density, and on the slow strain rate test the fracture energy in solution was lower than that in pre-exposure. These mean the stress corrosion cracking induced fracture can be estimated in this 1M NaCl + 0.3% $H_2O_2$ + 0.6M $Na_2SO_4$ solution. When the strain rate was below $2{\times}10^{-6}$, the stress corrosion cracking induced fracture start to be observed.

• 한국산학기술학회논문지
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• 제7권6호
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• pp.1064-1071
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• 2006

본 논문에서는 최대 견인력 제어를 위해서 부하토크외란관측기와 속도센서리스 벡터제어를 이용하여 점착력 계수를 추정하고 추정한 점착력 계수의 미분치를 PI 토크 제어하는 Anti-slip제어를 제안한다. 점착력 계수를 추정하기 위해서는 전압, 전류값 뿐만 아니라 자속이나 속도정보가 필요하다. 따라서 전동기의 회전속도를 정확하게 검출할 수 있는 속도센서가 필요하게 된다. 그러나 속도검출을 위해 속도센서를 부착하는 것은 여러 가지 면에서 단점을 가지고 있다. 이러한 문제점을 해결하기 위하여 속도센서 없는 센서리스 구동방식에 의한 부하토크외란관측기를 설계하여, 점착력 계수를 추정한다. 이와 같은 제어 알고리즘을 구현하기 위하여 1C1M 철도모의장치를 이용하여 제안된 알고리즘을 실험을 통하여 확인하였다.

• 한국도로학회논문집
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• 제11권1호
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• pp.47-58
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• 2009

요금을 지불하게 되는 유료도로에 대해서는 별도의 가중치를 산정하여 교통계획 모형 내에서 모델링 할 수 있도록 해야 하나 현존하는 유료도로의 가중치 산정방법에서 발생하는 문제점은 현실과 유사한 통행패턴을 설명하기에 부적당하다. 본 연구는 국가교통DB센터에서 이미 정산된 가중치, 차종별 시간가치를 적용한 가중치 그리고 차로수별 교통량 비율로 수정된 가중치로서 총 세 개의 대안을 선정하여 비교 분석하였다. 그 결과 국가교통DB센터에서 정산되어 차로수의 구분없이 동일한 가중치를 적용하였을 경우에는 허용오차범위 내에 포함된 샘플수가 다른 시나리오에 비해 비교적 다수 포함되었으나 현재 유료도로의 차로수별 할인율과 할증률을 반영하지 않고 정산되었다는 점에서 현실에 맞지 않는 방법론으로 분석되었다. 또한 차종별 시간가치를 이용한 가중치는 현재 적용되는 가중치 중에서 가장 이론적으로 정립되었다고 할 수 있으나 가중치의 비율이 낮게 적용됨으로서 배정교통량이 과다예측 되는 결과로 나타났다. 그러나 차종별 시간가치와 차로수별 교통량 비율을 합산하여 재 산정한 가중치를 적용한 결과는 세 개의 대안 중 가장 현실에 근접한 통행배정 결과로 분석되었다. 또한 통행배정 방법에 있어 총량OD평형배정방법이 PCU통행배정방법보다 현실에 가까운 배정결과가 나타나는 것으로 나타났다.

• 한국도로학회논문집
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• 제15권5호
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• pp.47-55
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• 2013

PURPOSES : The purpose of this study is to investigate the optimal joint positions which can minimize distresses of concrete pavement containing box culvert with horizontally skewed angles. METHODS : The concrete pavement containing the box culvert with different skewed angles and soil cover depths was modeled by 3 dimensional finite element method. The contact boundary condition was used between concrete and soil structures in addition to the nonlinear material property of soil in the finite element model. A dynamic analysis was performed by applying the self weight of pavement, negative temperature gradient of slab, and moving vehicle load simultaneously. RESULTS : In case of zero skewed angle ($0^{\circ}$), the maximum tensile stress of slab was the lowest when the joint was positioned directly over side of box culvert. In case there was a skewed angle, the maximum tensile stress of slab was the lowest when the joint passed the intersection between side of the box culvert and longitudinal centerline of slab. The magnitude of the maximum tensile stress converged to a constant value regardless the joint position from 3m of soil cover depth at all of the horizontally skewed angles. CONCLUSIONS : More reasonable and accurate design of the concrete pavement containing the box culvert can be possible based on the research results.

• 한국강구조학회 논문집
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• 제19권2호
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• pp.211-221
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• 2007

교량의 피로파괴에 대한 Miner의 피로손상법칙을 적용하여 여러 확률변수로 표현된 피로파괴 한계상태함수에 대한 신뢰도해석을 국내에서 측정된 통행차량의 통계적 특성을 반영하여 수행하였다. 신뢰도지수의 산정에 필요한 확률변수 가운데 등가모멘트, 충격계수비, 등가하중비는 국내의 최근 측정자료를 분석하여 통계치를 산정하였으며, 피로강도, 활하중 횡분배비, 연행하중비는 국외에서 측정된 문헌자료의 통계치를 적용하였다. 신뢰도해석을 통하여 피로설계트럭의 종류, 교량수명, ADTT, 피로상세, 등가하중비, 피로설계트럭의 총중량 등의 피로손상에 관련된 여러 파라미터가 신뢰도지수에 미치는 영향을 분석하였다. 본 논문의 피로파괴에 대한 신뢰도해석 결과는 국내 LRFD 설계기준의 피로설계트럭모형과 피로한계상태의 하중계수를 결정할 때 기초 자료로 이용할 수 있을 것으로 판단된다.