• Herbal Formula Science
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• v.24 no.4
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• pp.311-321
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• 2016

Chronic or acute alcohol abuse often leads to liver injury associated with alcoholic hepatitis, liver fibrosis, cirrhosis, and liver cancer. In addition to the liver, alcohol abuse also induces a variety of other tissue injuries including pancreatitis, cardiomyopathy, neurotoxicity and muscle loss. Chronic skeletal muscle myopathy, independent of peripheral neuropathy, is well recognised in alcoholic patients. Several mechanisms may be involved in the pathogenesis of alcoholic myopathy. Ethanol is a potent inhibitor of muscle protein synthesis. Gastrocnemius and plantaris muscles are Type II fiber-predominant and usually considered representative of the musculature as a whole. Whereas, soleus muscle is Type I fiber predominant. Shihosogan-san is a traditional Korean medicine that is widely employed to treat indigestion and liver diseases. Muscle diseases are often related to liver diseases and conditions. We therefore tested the hypothesis that treatment with Shihosogan-san could ameliorate the ethanol-induced changes in muscle protein synthesis. Young male Sprague-Dawley rats were orally given 25% ethanol (5ml/kg, body weight) daily with Ethanol for 28 days. Normal group was similarly administrated with saline. In Shihosogan-san treated group, rats were orally administrated Shihosogan-san extract, and rats of EtOH group were given with the vehicle only. After 4 week, the morphology of gastrocnemius and plantaris muscles were assessed by hematoxylin and eosin staining. For comparative purposes, liver function was also investigated. The muscles from rats of EtOH group displayed a significant reduction in average cross section area compared to Normal group. Shihosogan-san treated group had increased fiber compared to the EtOH group. Moreover, Shihosogan-san treated group compared with EtOH group showed significantly decreased pro-apoptotic BAX expression and increased anti-apoptotic Bcl-2 expression. In conclusion, Shihosogan-san extract showed ameliorating effects on chronic alcohol toxicity in skeletal muscle.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.5
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• pp.534-539
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• 2007

The present study was carried out to investigate the potential acute toxicity of Leuconostoc citreum GJ7 (Leu. citreum GJ7), a lactic acid bacterium isolated from Kimchi, in ICR male and female mice. The test article was administered to the mice orally or intraperitoneally. Mortality rates, clinical findings, and body weight changes were monitored for the 2 weeks following administration. The results showed that in 50% of the cases, lethal doses ($LD_{50}$) of Leu. citreum GJ7 were determined as >5, 000 mg/kg (p.o.) and >2500 mg/kg (i.p.) in both sexes. There were no significant changes in general conditions, body weights clinical signs and any gross lesions between vehicle control and Leu. citreum GJ7-treated groups. Hence, it is suggested that Leu. citreum GJ7 does not induce any significant acute toxicity in ICR mice.

• Composites Research
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• v.17 no.3
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• pp.15-22
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• 2004

Acoustic load generated by rocket propulsion system is one of major dynamic loads during lift-off phase so that it causes the structural failure and electronic malfunction of payloads. Acoustic loads can be greatly reduced by an appropriate acoustical design of nose faring structures. This paper deals with the acoustical design of the nose fairing structure for launch vehicle. It is well known that a honeycomb sandwich structure is a poor sound insulator because of its high specific stiffness. In this paper, the sound transmission characteristics of four kinds of honeycomb structures for noise fairing were investigated by means of numerical and experimental ways. In order to estimate transmission loss, infinite plate theory by Moore and Lyon and statistical energy analysis (SEA) method were used. The predicted results showed a good agreement with measured ones. These enabled us to determine a proper core material for nose fairing, which shows good sound insulation performance per weight.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.3
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• pp.639-645
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• 2015

Recently, a study on the commercialization of Rope type Platform Safe Door (RPSD) technology has commenced. The study focuses on RPSD, in which a rope screen ascends to allow safe passage from the platform to the transit vehicle in aboveground stations. Currently, a pilot installation has taken in place with Daegu Metro Line 2 in MoonYang station starting from March of 2013. However, there is a need to select an appropriate pilot installation's object for the improvement in the future RPSD. An appropriate designation would correspond with the needs of the railroad corporation and as a historic railway platform with safe facilities. This study tried to usa Analytic Hierarchy Process (AHP) to determine the priority of the KTX stations to attain a list of appropriate designations for future RPSD installations by analyzing the followings: management of the facilities, operational risks, and intent of business projects. As a case study, it was applied to the evaluation of the KTX stations. For the application, it used relative measurement to calculate the weight of upper level structuring, and absolute measurement for low level structuring instead of pairwise comparisons.

• Environmental Analysis Health and Toxicology
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• v.23 no.2
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• pp.119-127
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• 2008

The purpose of this study was to investigate the effects of frankincense oil in a skin aging animal model. Skin aging was induced by both the irradiation of UVB and the application of squalene monohydroperoxide (Sq-OOH) to the back of experimental animals for 4 weeks. And at the same time experimental materials were applied topically. Six to seven weeks female SHR-1 hairless mice were divided into five groups including normal (N: saline), control (C: UVB+Sq-OOH+saline), vehicle control (VC: UVB+Sq-OOH+jojoba oil), positive control (PC: UVB+Sq-OOH+0.01% retinoic acid) and experimental (E: UVB+Sq-OOH+3% Frankincense oil) groups, five animals each group. The skin erythema index for the PC and E groups were lower than that of the C group. Whereas, both the lipid and water capacities for the PC and E groups were higher than those of the C group. Wrinkles for the C group were formed as a pattern of deep furrows and thick crests. Whereas, wrinkles for the PC and E groups were formed as a pattern of shallow furrows and thin crests which were similar to that of the N group. As for the both absolute and relative weight of the spleen, the PC group were significantly higher than the other groups. In conclusion, frankincense oil can be used practically for the prevention or improvement of skin aging in terms of health promotion and beauty for the people.

• Design & Manufacturing
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• v.13 no.4
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• pp.23-27
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• 2019

People's interest in the environmental problems of the Earth is growing as they come to the modern world, and research is being actively conducted on how to protect the environment. As a result, the automobile industry, one of the causes of environmental pollution, is also affected. Therefore, research is being conducted to improve the fuel economy and light weight of cars, development of pollution-free cars such as electric cars, and aluminium materials that are lighter than ordinary steel sheets and easier to recycle are gaining attention. In this experiment, the material was formed to form a form of aluminium and the material reduction rate of the side wall of the foam was tested according to the amount of side wall. The material used in the experiment was A3003-O, which is less plastic than normal steel plates, but has excellent corrosion resistance, plasticity and weldability compared to aluminium materials, but has poor tensile strength. For tensile testing, a certain array of Forming Shapes was molded and the height of the Forming was set to 5mm, and the height of the Forming was 4.7mm, indicating that the difference between the first 5mm Forming and the height was not large. In addition, the material reduction rate was tested by giving 15, 0, and -0.15 teas, respectively, and was found to be valuable as a product only for -0.15.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.2
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• pp.175-181
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• 2014

A four-link mechanism consisting of torsion bars is used for opening the trunk lid in most midsize sedans. When the weight of the lid is in equilibrium with the spring force exerted by torsion bars, the lid stops opening at a pop-up height. However, the actual pop-up height has large deviations from the specified height even with the same parts in the same car model, which leads to quality issues. Automotive manufacturers have experienced this deviation problem despite much effort to resolve it. In this research, we developed a multi-body dynamics model for the analysis of pop-up deviation of a trunk lid with torsion bars, which can simulate the actual pop-up motion of the trunk lid by considering kinematic constraints of the motion and friction forces in joints. We could also determine the most important factor that governs the pop-up height by sensitivity analysis of all parts. The developed system can be used for the analysis of other trunk lid systems to control the tolerance of parts.

• Journal of Biosystems Engineering
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• v.37 no.5
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• pp.287-295
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• 2012

Purpose: Some of the most representative approaches are to apply next generation technologies to save energy consumption, fully automated control system to appropriately maintain environmental conditions, and autonomous assistance system to reduce labor load and ensure operator's safety. Nevertheless, improvement of upcoming method for soil cultured greenhouse has not been sufficiently achieved. Geometrical complexity of ground in protected crop cultivation might be one of the most dominant factors in design of autonomous vehicle. While there is a practical solution fairly enough to promise an accurate travelling, such as autonomous sprayer guided by rail or induction coil, for various reasons including the limitation of producer's budget, the previously developed sprayer has not been widely distributed to market. Methods: In this study, we developed an autonomous sprayer considering travelling performance on geometrical complexity of ground in soil cultured greenhouse. To maintain a stable travelling and to acquire a real time feedback, common wire with 80 mm thick and body frame and sprayer boom. To evaluate performance of the prototype, tracking performance, climbing performance and spraying boom's uniform leveling performance were individually evaluated by corresponding experimental tests. Results: The autonomous guidance system was proved to be sufficiently suitable for accurate linear traveling with RMS as lower than approximately 10 cm from designated path. Also the prototype could climb $10^{\circ}$ of ground's slope angle with 40 kg of water weight. Uniform leveling of spraying boom was successfully performed within $0.5^{\circ}$ of sprayer boom's slope. Conclusions: Considering more complex pathways and coarse ground conditions, evaluations and improvements of the prototype should be performed for promising reliability to commercialization.

• Reproductive and Developmental Biology
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• v.35 no.2
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• pp.167-174
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• 2011

Acute ischemic stroke results from sudden decrease or loss of blood supply to an area of the brain, resulting in a coinciding loss of neurological function. The antioxidant action of melatonin is an important mechanism among its known effects to protective activity during ischemic/reperfusion injury. The focus of this research, therapeutic efficacy of melatonin on recovery of neurological function following long term treatment in ischemic brain injured rats. Male Sprague-Dawley rats (n=40; 8 weeks old) were divided into the control group, and MCAo groups (Vehicle, MT7 : MCAo+ melatonin injection at 7:00, MT19 : MCAo+melatonin injection at 19:00, and MT7,19 : MCAo+melatonin injection at 7:00 and 19:00). Rat body weight and neurological function were measured every week for 8 weeks. After 8 weeks, the rats were anesthetized with a mixture of zoletil (40 mg/kg) and xylazine (10 mg/kg) and sacrificed for further analysis. Tissues were then collected for RNA isolation from brain tissue. Also, brain tissues were analyzed by histological procedures. We elucidated that melatonin was not toxic in vital organs. MT7,19 was the most rapidly got back to mild symptom on test of neurological parameter. Also, exogenous melatonin induces both the down-regulation of detrimental genes, such as NOSs and the up-regulation of beneficial gene, including BDNF during long term administration after focal cerebral ischemia. Melatonin treatment reduced the loss of primary motor cortex. Therefore, we suggest that melatonin could be act as prophylactic as well as therapeutic agent for neurorehabilitative intervention.

• Journal of Korean Society of Transportation
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• v.25 no.2 s.95
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• pp.83-93
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• 2007

Pedestrians and vehicle users should be treated with equal importance in urban street design. However, current street design suggests that the design criteria for sidewalks is based on the functional hierarchy of the vehicles, therefore it is necessary to develop sidewalk design standards that give more weight to pedestrians rather than vehicles. For this, this study suggests that the level of service of pedestrians should be considered in the process of designing sidewalks. Currently, level of service (LOS) criteria for pedestrians in the Korean Highway Capacity Manual are based on pedestrian volume, but the volume of pedestrians is seldomly estimated in practice. So, the current LOS criteria has limitations in terms of practical use. Also, the study assumes that the pedestrian flow rate is hardly the dominant factor that could affect the LOS of pedestrians at most urban sidewalks. In this context, the study considers a new LOS for sidewalk design based on the comfort of pedestrians while passing pedestrians coming from the opposite direction. Then the study attempts to link the new LOS criteria to the land use patterns using data of pedestrian traffic characteristics acquired from the field. In addition to this, the scope in which the suggested criteria can be applied is suggested.