• The Journal of Korean Medicine
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• v.33 no.3
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• pp.133-146
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• 2012

Background: Most antitumor agents have the side effect of chemotherapy-induced peripheral neuropathy (CIPN). Cancer patients who take antitumor agents suffer from CIPN, but there is no known treatment for it. Unlike the central nerve system, the peripheral nerve can self-repair, and the Schwann cell takes this mechanism. Objectives: In this study, we researched the effect of YideungJetong-Tang (YJT) extract on taxol-induced sciatic nerve damage, through in vitro and in vivo experiments. Also, we studied the effect of YJT extract on neurite recovery and anti-inflammatory effect after compression injury of sciatic nerve in vivo. Methods: Vehicle, taxol and taxol+YJT were respectively applied on sciatic nerve cells of rat in vitro, then the cells were cultured. The sciatic nerve cells and Schwann cells were then observed using Neurofilament 200, Hoechst, ${\beta}$ -tubulin, S-$100{\beta}$, caspase-3 and phospho-Erk1/2. CIPN was induced by taxol into the sciatic nerve of rat in vivo, then YJT extract was taken orally. The axons, Schwann cells and neurites of the DRG sensory nerve were then observed using Neurofilament 200, ${\beta}$-tubulin, Hoechst, S-$100{\beta}$, phospho-Erk1/2 and caspase-3. YJT was taken orally after sciatic nerve compression injury, and the changes in axon of the sciatic nerve, Schwann cells and TNF-${\alpha}$ concentration were observed. Results: The taxol and YJT treated group showed significant effects on Schwann cell recovery, neurite growth and recovery. In vivo, YJT compared with control group showed Schwann cell structural improvement and axons recovering effect after taxol-induced Schwann cell damage. After sciatic nerve compression injury, recovery of distal axon, changes of Schwann cell distribution, and anti-inflammatory response were observed in the YJT. Conclusions: Through this study, we found that after taxol-induced neurite damage of sciatic nerve in vivo and in vitro, YJT had significant effects on sciatic nerve growth and Schwann cell structural improvement. In vivo, YJT improved recovery of distal axons and Schwann cells and had an anti-inflammatory effect.

• Journal of Digital Contents Society
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• v.17 no.2
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• pp.71-79
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• 2016

This study is intended to compare the performances of sound source localization methods used for stable automobile control by improving voice recognition rate in automobile environment and suggest how to improve their performances. Generally, sound source location estimation methods employ the TDOA algorithm, and there are two ways for it; one is to use a cross correlation function in the time domain, and the other is GCC-PHAT calculated in the frequency domain. Among these ways, GCC-PHAT is known to have stronger characteristics against echo and noise than the cross correlation function. This study compared the performances of the two methods above in automobile environment full of echo and vibration noise and suggested the use of a median filter additionally. We found that median filter helps both estimation methods have good performances and variance values to be decreased. According to the experimental results, there is almost no difference in the two methods' performances in the experiment using voice; however, using the signal of a song, GCC-PHAT is 10% more excellent than the cross correlation function in terms of the recognition rate. Also, when the median filter was added, the cross correlation function's recognition rate could be improved up to 11%. And in regarding to variance values, both methods showed stable performances.

• Journal of Ginseng Research
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• v.30 no.1
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• pp.8-14
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• 2006

This study was carried out to investigate the protective effect of crude saponin from red ginseng efflux (RGE-CS) on biochemical parameters in male rats acutely exposed to 2,3,7,8-tetrachlorodibenzo-$\rho$-dioxin (TCDD). Forty male rats ($200{\pm}20g$) were divided into 4 groups. Normal control group (NC) received vehicle and saline; only TCDD-treated group (TT) received TCDD ($5{\mu}g/kg$, single dose) intrperitoneally; RGE-CS 20 received 20 mg/kg of crude saponin i.p. for 4 weeks from 1 week before TCDD-exposure; RGE-CS 40 also received 40 mg/kg of crude saponin i.p. for 4 weeks from 1 week before TCDD-exposure. Body weight of TT group was significantly decreased after TCDD-exposure. However, body weight of crude saponin groups increased throughout the experimental period, although the increasing rate was slower than that of NC group. Decrease in body weight was not observed during the experimental period in RGE-CS 40. Increases in triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), AST, ALT and $Fe^{2+}$ levels by TCDD intoxication were significantly attenuated by the RGE-CS treatment. Decrease in glucose, amylase, lactate dehydrogenase (LDH) and creatinine kinase (CK) by TCDD also were inhibited by the RGE-CS. These results suggest that saponin from red-ginseng efflux might be a useful protective agent against TCDD, an endocrine disrupter.

• Food Science of Animal Resources
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• v.40 no.5
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• pp.795-812
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• 2020

Novel food sources have enormous potential as nutritional supplements. For instance, edible insects are considered as an alternative food source due to their higher protein content; moreover, they are economically efficient reproducers and have high in nutritional value. In this study, we investigated the toxicity of the freeze-dried powder of Locusta migratoria (fdLM), known to contain rich proteins as well as fatty acids. The objective of the present study was to evaluate the subacute toxicity of fdLM in male and female Sprague-Dawley (SD) rats. The SD rats were divided into four groups based on the dosage of fdLM administered: dosage of 0 (vehicle control), 750, 1,500, and 3,000 mg/kg/day were administered for 28 days. Toxicological assessments including observations on food consumption, body and organ weights, clinical signs, mortality, ophthalmologic tests, urinalyses, hematologic tests, clinical chemistry tests, gross findings, and histopathology tests were performed. Clinical signs, urinalyses, hematology, serum biochemistry tests, and organ weight examinations revealed no fdLM-related toxicity. The no-observed-adverse-effect level for fdLM was higher than 3,000 mg/kg/day in rats of both sexes; therefore, fdLM, in conclusion, can be considered safe as an edible alternative human and animal food source material.

• Korean Journal of Veterinary Research
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• v.45 no.1
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• pp.29-37
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• 2005

13-week orally repeated dose toxicity was investigated to ascertain the toxic effects of Aristolochiae radix in F344 rats at dose levels of 0, 1 (0.003 AA, aristolochic acid, mg/kg), 5 (0.014 AA mg/kg), 25 (0.068 AA mg/kg), 125 (0.34 AA mg/kg), and 500mg/kg (AA 1.36 mg/kg). No mortalities were found in any of the dose groups including vehicle control groups of both sexes during the study period. Hematologic and serum biochemical examinations revealed no changes related to the test item in any of the dose groups of both sexes. However, gross findings at necropsy implicated thickening of the stomach wall. In histopathological examinations, prominent findings related to the test item treatment were observed in the stomach and urinary bladder. There were squamous cell papilloma, squamous cell hyperplasia, ulceration and erosion observed in the non-glandular stomach. Squamouse cell hyperplasia was observed at dose levels of more than 125 mg/kg in both sexes and squamous cell papilloma was observed at dose level of 500 mg/kg in both sexes. The incidence and severity of these proliferating lesions including squamous cell hyperplasia and squamous cell papilloma increased with dose dependency. Transitional cell hyperplasia was also observed in the urinary bladder at dose levels of more than 25 mg/kg in both sexes and the incidence and severity of the lesion increased with dose dependency. In conclusion, the toxic changes related to the test item treatment were observed in the stomach and urinary bladder, and the no-observed-adverse-effect level (NOAEL) was estimated to be 5 mg/kg/day for both males and females in F344 rats.

• The Korean Journal of Air & Space Law and Policy
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• v.28 no.2
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• pp.117-144
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• 2013

The MOLIT is also establishing the flight safety standards for UAV within the current Aviation Law. Accordingly the required flight criteria includes operator location, mission operation limit, equipment, etc. which are the principle and standard applied based on the airspace use for UAV. Also, general flight rules, visual flight rules, instrument flight rules are required to be applied to the actual flight. Besides, an appliance regulation needs to be arranged regarding two-way communication, ATC and communication issue, airspace and area in-flight between UAS(Unmanned Aircraft System) users. An operation of the UAV in the air significantly requires the guarantee of the aircraft's capacity, and also the standardized flight criteria. A safe and smooth use is ensured only if this criteria is applied and understood by the entire airspace users. For the purpose, a standardized military UAV flight operations criteria and a law complementary scheme.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.05a
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• pp.255-257
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• 2017

These days automotive markets are launching models that include a variety of IT technologies. Tesla's Tesla model S and Google's unmanned automobiles are emerging one after another. This type of automobile with IT technology provides various convenience to the driver and the driver is getting benefit by various conveience services. on the contrary, it is also true that defects for errors in electronic components cause accidents that threaten the safety of drivers. There is a sudden unintended acceleration among these accidents. The cause of the accident is not clear yet, but the claim that the ECU device caused by the magnetic field causes accident of the car due is the most reliable. But, in Korea, when occur a car sudden unintended acceleration accident, the char maker often claims that an accident occurred due to driver's pedal malfunction. Also most drivers are responsible for the lack of grounds to refute. In this paper, the pedal operation image of the driver is acquired and the sensor is attached to the control part such as the excel and brake so as to discriminate whether the vehicle sudden unintended acceleration accident is the driver's pedal operation error or the fault of. i have implemented a system that can do this.

• KIPS Transactions on Software and Data Engineering
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• v.3 no.9
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• pp.361-368
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• 2014

The LPR(License plate recognition) system has been developed to efficient control for complex traffic environment and currently be used in many places. However, because of light, noise, background changes, environmental changes, damaged plate, it only works limited environment, so it is difficult to use in real-time. This paper presents a heuristic segmentation algorithm for robust to noise and illumination changes and introduce a real-time license plate recognition system using it. In first step, We detect the plate utilized Haar-like feature and Adaboost. This method is possible to rapid detection used integral image and cascade structure. Second step, we determine the type of license plate with adaptive histogram equalization, bilateral filtering for denoise and segment accurate character based on adaptive threshold, pixel projection and associated with the prior knowledge. The last step is character recognition that used histogram of oriented gradients (HOG) and multi-layer perceptron(MLP) for number recognition and support vector machine(SVM) for number and Korean character classifier respectively. The experimental results show license plate detection rate of 94.29%, license plate false alarm rate of 2.94%. In character segmentation method, character hit rate is 97.23% and character false alarm rate is 1.37%. And in character recognition, the average character recognition rate is 98.38%. Total average running time in our proposed method is 140ms. It is possible to be real-time system with efficiency and robustness.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.19 no.2
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• pp.89-103
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• 2020

As we face an aging society, the demand for personal mobility for disabled and aged people is increasing. In fact, as of 2017, the number of electric wheelchair in the country continues to increase to 90,000. However, people with disabilities and seniors are more likely to have accidents while driving, because their judgment and coordination are inferior to normal people. One of the causes of the accident is the interference of personal vehicle steering control due to unbalanced road surface conditions. In this paper, we introduce a encoder type semantic segmentation algorithm that can recognize road conditions at high speed to prevent such accidents. To this end, more than 1,500 training data and 150 test data including road surface damage were newly secured. With the data, we proposed a deep neural network composed of encoder stages, unlike the Auto-encoding type consisting of encoder and decoder stages. Compared to the conventional method, this deep neural network has a 4.45% increase in mean accuracy, a 59.2% decrease in parameters, and an 11.9% increase in computation speed. It is expected that safe personal transportation will be come soon by utilizing such high speed algorithm.

• Particle and aerosol research
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• v.6 no.1
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• pp.9-20
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• 2010

This study examined the concentration level of the major air pollutants in public transportation. The study was conducted between February 2009 and March 2008 at Suwon-Yeosu line in Korea. $PM_{10}$ concentration level was $100{\mu}g/m^3$ on average. The $PM_{2.5}$ to PM10 ratio in transport is 0.37, which was lower than the results published by other researches. The result also demonstrated that outdoor $PM_{10}$ concentration was about 56~60% level compared to that of the cabin. $CO_2$ concentration level in the cabin was 1,359ppm, which does not exceed 2,000ppm, which is the guideline concentration level according to the Ministry of Environment. $CO_2$ concentration level in the cabin was $CO_2=23.4{\times}N+460.2$, and about 23.4ppm in $CO_2$ concentration level increased every time one passenger was added on. The experiment conducted on the train demonstrated that the average $PM_{10}$ concentration level was $100{\mu}g/m^3$ in case of the reference cabin while average $PM_{10}$ concentration level of the modified vehicle was $68{\mu}g/m^3$. Likewise, effect of the particle reduction device for the reduction of $PM_{10}$ concentration level was approximately 21%. Meanwhile there was almost no difference in the concentration level between reference and modified cabin in case of $PM_{2.5}$. Using zeolite as an adsorbent was made to reduce the $CO_2$ concentration level in the cabin. Number of passengers was factored in, to calculate the effect of the adsorption device, which demonstrated that about 36% of $CO_2$ concentration level was reduced in the modified cabin effect of the $CO_2$ reduction device. This research analyzed the current status concerning the quality of air in the public transportation and technologies were developed that reduces major air pollutants.