• Journal of the Korean Applied Science and Technology
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• v.30 no.4
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• pp.701-714
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• 2013

Recently, due to the activation policy of biodiesel, the blending biodiesel to petroleum product is increasing. Low-temperature fluidity and oxidation stability are the most significant issues to the marketers and end users of biodiesel. Thus, the way to control the quality of biodiesel blended fuels was investigated by duplicating the real storage situation of biodiesel blended fuels and evaluating the effect of oxidation trend and quality degradation. From the results of oxidation degradation test of biodiesel blended fuels, no special quality degradation has been observed through the evaporation for 18 weeks in a summer season under a storage circumstance without exposure to the sun light. However, the severe quality degradation was observed in PE vessel in only 2 weeks of storage. This oxidation degradation was also verified with FT-IR spectrum change. However, the special symptom cannot be distinguished by the quality test because the quality specifications were satisfied despite of the drastic oxidation degradation. Namely, the problem in a vehicle could be occurred by oxidation materials(polymer, organic acid. etc.) under oxidation even though it satisfied the quality specification.

• KIPS Transactions on Software and Data Engineering
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• v.5 no.12
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• pp.653-662
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• 2016

This paper describes a test case generation algorithm for Simulink/Stateflow models based on the Rapidly exploring Random Tree (RRT) algorithm that has been successfully applied to path finding. An important factor influencing the performance of the RRT algorithm is the metric used for calculating the distance between the nodes in the RRT space. Since a test case for a Simulink/Stateflow (SL/SF) model is an input sequence to check a specific condition (called a test target in this paper) at a specific status of the model, it is necessary to drive the model to the status before checking the condition. A status maps to a node of the RRT. It is usually necessary to check various conditions at a specific status. For example, when the specific status represents an SL/SF model state from which multiple transitions are made, we must check multiple conditions to measure the transition coverage. We propose a unique distance calculation metric, based on the observation that the test targets are gathered around some specific status such as an SL/SF state, named key nodes in this paper. The proposed metric increases the probability that an RRT is extended from key nodes by imposing penalties to non-key nodes. A test case generation algorithm utilizing the proposed metric is proposed. Three models of Electrical Control Units (ECUs) embedded in a commercial vehicle are used for the performance evaluation. The performances are evaluated in terms of penalties and compared with those of the algorithm using a typical RRT algorithm.

• Geophysics and Geophysical Exploration
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• v.23 no.3
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• pp.141-148
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• 2020

A drone platform built by Korea Institute of Geoscience and Mineral Resources (KIGAM) is introduced. The platform consists of various drone systems developed at KIGAM for photogrammetry, remote exploration, physical exploration, field operation methods, a vehicle-based drone control center, as well as a drone data platform for data storage, sharing, analysis, and visualization of the acquired data. The performance of the drone platform is verified using results obtained with the various systems, which are tested individually and in various combined applications. Finally, the possibility of using the KIGAM drone platform for geological surveys and mineral resource exploration is discussed.

• Journal of Ginseng Research
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• v.42 no.2
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• pp.183-191
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• 2018

Background: Ginseng saponin has long been used as a traditional Asian medicine and is known to be effective in treating various kinds of pain. Ginsenoside Rf is one of the biologically active saponins found in ginseng. We evaluated ginsenoside Rf's antinociceptive and anti-inflammatory effects, and its mechanism of action on adrenergic and serotonergic receptors, in an incisional pain model. Methods: Mechanical hyperalgesia was induced via plantar incision in rats followed by intraperitoneal administration of increasing doses of ginsenoside Rf (vehicle, 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, and 2 mg/kg). The antinociceptive effect was also compared in a Positive Control Group that received a ketorolac (30 mg/kg) injection, and the $Na{\ddot{i}}ve$ Group, which did not undergo incision. To evaluate the mechanism of action, rats were treated with prazosin (1 mg/kg), yohimbine (2 mg/kg), or ketanserin (1 mg/kg) prior to receiving ginsenoside Rf (1.5 mg/kg). The mechanical withdrawal threshold was measured using von Frey filaments at various time points before and after ginsenoside Rf administration. To evaluate the anti-inflammatory effect, serum interleukin $(IL)-1{\beta}$, IL-6, and tumor necrotizing $factor-{\alpha}$ levels were measured. Results: Ginsenoside Rf increased the mechanical withdrawal threshold significantly, with a curvilinear dose-response curve peaking at 1.5 mg/kg. $IL-1{\beta}$, IL-6, and tumor necrotizing $factor-{\alpha}$ levels significantly decreased after ginsenoside Rf treatment. Ginsenoside Rf's antinociceptive effect was reduced by yohimbine, but potentiated by prazosin and ketanserin. Conclusion: Intraperitoneal ginsenoside Rf has an antinociceptive effect peaking at a dose of 1.5 mg/kg. Anti-inflammatory effects were also detected.

• Journal of the Korean Society of Marine Environment & Safety
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• v.26 no.4
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• pp.419-428
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• 2020

The flow past a wall mounted square cylinder, a typical and basic shape of building, bridge or offshore structure, was simulated using URANS computation through adoption of three turbulence models, namely, the k-ε model, k-ω model, and the v²-f model. It is well known that this flow is naturally unstable due to the Karman vortex shedding and exhibits a complex flow structure in the wake region. The mean flow field including velocity profiles and the dominant frequency of flow oscillation that was from the simulations discussed earlier were compared with the experimental data observed by Wang et al. (2004; 2006). Based on these comparisons it was found that the v²-f model is most accurate for the URANS simulation; moreover, the k-ω model is also acceptable. However, the k-ε model was found to be unsuitable in this case. Therefore, v²-f model is proved to be an excellent choice for the analysis of flow with massive separation. Therefore, it is expected to be used in future by studies aiming to control the flow separation.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.3
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• pp.12-19
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• 2010

In road network, especially in urban area, inefficiency of travel time is caused by signal control and turn maneuver at intersection and this inefficiency has substantial effects on travel time. When searching for the shortest path, this inefficiency which is caused by turn maneuver must be considered. Therefore, travel time, vehicle volume and delay for each link were calculated by using simulation package, PARAMICS V5.2 for adaptation of turn penalty at 16 intersections of Gangnam-gu. Turn penalty was calculated respectively for each intersection. Within the same intersection, turn penalty differs by each approaching road and turn direction so the delay was calculated for each approaching road and turn direction. Shortest path dealing with 16 intersections searched by Dijkstra algorithm using travel time as cost, considering random turn penalty, and algorithm considering calculated turn penalty was compared and analyzed. The result shows that by considering turn penalty searching the shortest path can decrease the travel time can be decreased. Also, searching the shortest path which considers turn penalty can represent reality appropriately and the shortest path considering turn penalty can be utilized as an alternative.

• Journal of the Korean Institute of Intelligent Systems
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• v.26 no.3
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• pp.208-217
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• 2016

This paper describes a simulation method to generate sensor measurements for location estimation of an underwater robot. Field trial of a navigation method of an underwater robot takes much time and expenses and it is difficult to change the environment of the field trial as desired to test the method in various situations. Therefore, test and verification of a navigation method through simulation is inevitable for underwater environment. This paper proposes a method to generate sensor measurements of range, depth, velocity, and attitude taking the uncertainties of measurements into account through simulation. The uncertainties are Gaussian noise, outlier, and correlation between the measurement noise. Also, the method implements uncertainty in sampling time of measurements. The method is tested and verified by comparing the uncertainty parameters calculated statistically from the generated measurements with the designed uncertainty parameters. The practical feasibility of the measurement data is shown by applying the measurement data for location estimation of an underwater robot.

• Clinical and Experimental Pediatrics
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• v.53 no.10
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• pp.898-908
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• 2010

Purpose: The neuroprotective effects of erythropoietin (EPO) have been recently shown in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity; however, limited data are available for such effects during the neonatal periods. Therefore, we investigated whether recombinant human EPO (rHuEPO) can protect against perinatal HI brain injury via an antiapoptotic mechanism. Methods: The left carotid artery was ligated in 7-day-old Sprague-Dawley (SD) rat pups ($in$ $vivo$ model). The animals were divided into 6 groups: normoxia control (NC), normoxia sham-operated (NS), hypoxia only (H), hypoxia+vehicle (HV), hypoxia+rHuEPO before a hypoxic insult (HE-B), and hypoxia+rHuEPO after a hypoxic insult (HE-A). Embryonic cortical neuronal cell culture of SD rats at 18 days gestation ($in$ $vitro$ model) was performed. The cultured cells were divided into 5 groups: normoxia (N), hypoxia (H), and 1, 10, and 100 IU/mL rHuEPO-treated groups. Results: In the $in$ $vivo$ model, Bcl-2 expressions in the H and HV groups were lower than those in the NC and NS groups, whereas those in the HE-A and HE-B groups were greater than those of the H and HV groups. The expressions of Bax and caspase-3 and the ratio of Bax/Bcl-2 were in contrast to those of Bcl-2. In the $in$ $vitro$ model, the patterns of Bcl-2, Bax, and caspase-3 expression and Bax/Bcl-2 ratio were similar to the results obtained in the in vivo model. Conclusion: rHuEPO exerts neuroprotective effect against perinatal HI brain injury via an antiapoptotic mechanism.

• Fire Science and Engineering
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• v.34 no.1
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• pp.121-126
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• 2020

The aim of this study is to suggest ways to capitalize on the golden period for timely response to fire and emergency victims. To implement a system to effectively capitalize on the golden period, there is a need for policy measures as well as legal and social consensus. Precedent research has relentlessly mentioned the need for and feasibility of the priority traffic system for emergency vehicles. To this end, the present study involved an analysis of pilot cases of the priority traffic signal system for emergency vehicles introduced in a city during 26 days, from April 3 to 28, 2017. Out of 58 cases registered with the local 1-1-9 fire house, the number of cases that took advantage of the priority traffic system stood at 16 in response to fire and 11 to first-aid operations. Owing to the system, on average, the response time reduced by 3 min and 50 s in case of fire and by 3 min and 30 s for first aid. There were four complaints registered owing to traffic congestion, and the number of car accidents declined to one from six over the same period in the previous year. Based on these findings, it is safe to say that the priority traffic signal system would be effective for emergency vehicles to capitalize on the golden period if issues identified during the pilot run are resolved.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.32 no.1 s.55
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• pp.17-22
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• 2006

Phosphatidyiserine (PS) is a phospholipid which plays the structural role in membranes and serves as a cofactor of signaling enzymes for diverse cellular functions. In this study, we observed that topical treatment with PS significantly decreased trans-epidermal water loss (TEWL) induced by tape-stripping in hairless mice. Also, ceramides in epidermis were increased in PS-treated group compared to vehicle-treated one in vivo. the amounts of non-hydroxyl ceramide (NHCER) (1.4 fold) and glucosylceramide (glucosylCER) (1.6 fold), in the skin of hairless mice, were increased by topical treament with PS. Also, we demonstrated that PS stimulated keratinocyte differentiation. We observed that PS treatment morphologically altered normal human keratinocyte (NHK) from the proliferating phase to the differentiating one, suggesting that PS stimulated epidermal differentiation in NHK. We also showed that the expressions of the specific markers for epidermal differentiation, involucrin (INV) (3.5 fold up) and transglutaminase 1 (TG'ase 1) (3 fold up), were significantly increased by PS treatment, compared to untreated control in vitro. In addition, topical treatment with PS resulted in a progressive increase in INV and loricrin protein levels in vivo. In conclusion, we provide the first evidence for the physiological activities of PS in skin, and we suggest that PS strengthen the epidermal permeability harrier by stimulation of keratinocyte differentiation.