• Journal of Food Hygiene and Safety
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• v.23 no.2
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• pp.169-176
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• 2008

The subcronic toxicity of WK-38, a herbal preparation for the atherosclerosis, was examined in male and female Sprague-Dawley rats. WK-38 is composed of Rhei Rhizoma, Magonoliae Cortx, Moutan Cortex Radicis. Rats were treated with the test substance at a dose of 5 mg/kg, 50 mg/kg and 500 mg/kg intragastrically for 13 weeks. Control rats were treated with vehicle only. No death and abnormal clinical signs were observed throughout the administration period. Also there was no difference in net body weight gain, food and water consumption, organ weight, gross pathological findings, and urine analysis among the groups of rats treated with different doses of the WK-38. Hematological findings and biochemical examination revealed no evidence of specific toxicity related to WK-38. The results suggested that under the condition employed in this study no observation effect level (NOEL) of WK-38 would be 500 mg/kg/day.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.4
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• pp.612-617
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• 2014

Anti-inflammatory effects of turmeric (Curcuma longa L.) rich in polysaccharides, as well as free of curcuminoids and turmerones were investigated in acute and chronic inflammatory models. Activity against the acute phase of inflammation was evaluated in carrageenan-induced paw edema and xylene-induced ear edema models. The results showed that turmeric extract significantly decreased paw edema volume in the first and third hours after carrageenan injection ($P{\leq}0.05$). Turmeric extract at all dose levels also significantly inhibited xylene-induced ear edema formation ($P{\leq}0.05$). Activity against chronic inflammation was also evaluated in cotton pellet-induced granuloma model. Turmeric extract significantly ($P{\leq}0.05$) decreased the weight of granuloma tissue on cotton pellets in a dose-dependent manner when compared to the vehicle control. Thus, the findings of the study suggest that turmeric extract in effective against both acute and chronic inflammation.

• Economic and Environmental Geology
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• v.48 no.3
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• pp.205-212
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• 2015

We have verified applicability of UAV(Unmanned Aerial Vehicle) photogrammetry to a mining engineering. The test mine is a smectite mine located at Gyeongju city in Gyeongnam province, Koera. 448 photos over area of $600m{\times}380m$ were taken with overlapped manner using Cannon Mark VI equipped to multicopter DJI S1000, which were processed with AgiSoft Photoscan software to generate orthophoto and DEM model of the study area. photogrammetry data with 10 cm resolution were generated using 6 ground control positions, which were exported to the 3D geological modeling software to make a topographic surface object. Monitoring of amount of ore production and landsliding could be done with less than 1 hours photographing as well as low cost. A direct link between UAV photogrammetry and 3D geological modeling technology might increase productivity of a mine due to appling the topographical surface change immediately according to the mining operation.

• Korean Journal of Food Science and Technology
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• v.49 no.2
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• pp.203-208
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• 2017

The antioxidant and anti-inflammatory effects of roasted dried radish (RDR) against renal oxidative stress were examined in high-fat diet (HFD)-fed mice. The HFD was prepared by adding lard to chow diet to provide 50% of the calories from fat. Hot water extracts of dried radish (DR) or RDR were administered orally to mice at 237 mg/kg bw/day, whereas distilled water was administered as a vehicle for 12 weeks. Compared to the control group, renal reactive oxygen species, peroxynitrite, and thiobarbituric acid reactive substance level in the DR or RDR group were significantly decreased, whereas the glutathione level was increased (p<0.05). Protein expressions of antioxidant factors such as nuclear factor erythroid 2-related factor-2, heme oxygenase-1, glutathione S-transferase, superoxide dismutase, catalase, and glutathione peroxidase were significantly increased in the DR and RDR groups; however, nuclear factor-kappa B expression was suppressed (p<0.05). These antioxidant and anti-inflammatory effects of RDR were found to be significantly greater than those of DR.

• Toxicological Research
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• v.32 no.2
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• pp.159-173
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• 2016

Crickets have been attracting considerable interest in the field of nutrition and toxicology due to the global exhaustion of food resulting from a growing population. The cricket is normally eaten in several countries after roasting, similar to the grasshopper; however, safety evaluation data on cricket powder is limited. Here, we performed general toxicity studies of cricket powder including a single, 2-week repeated dose range evaluation test, a 13-week repeated oral dose toxicity test in Sprague-Dawley rats, a single oral dose toxicity test in Beagle dogs, and a skin sensitization test in guinea pigs following the Organization for Economic Cooperation and Development test guidelines 406 and 408 in addition to Good Laboratory Practice. To investigate the NOAEL and target organs of cricket powder, Sprague-Dawley rats were allocated to 4 groups: vehicle control, 1,250 mg/kg, 2,500 mg/kg, 5,000 mg/kg dose test groups and cricket powder was administered over 13 weeks after single dose and dose range finding studies in rats based on the results of the single oral administration toxicity study in rats and Beagle dogs. The results of the study showed that the NOAEL of cricket powder was over 5,000 mg/kg for both sexes of rats without adverse effects in a 13-week repeated oral toxicity study and there was no skin hypersensitivity reaction. Therefore, our results reveal that crickets can be widely used as a new substitute food or nutrient resource.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.10 no.4
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• pp.350-357
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• 2017

This study was conducted as a post - study on the development of a centralized controller and a hydraulic lift system including structural analysis and remote control for the development of a vertically elevated car. The safety review was carried out through the structural modification of the elevator lift which was developed during the previous research. 3D modeling was performed with Solidworks, and a model of finite element was created through Hypermesh S / W. In addition, the loading environment of the work vehicle for the evaluation is a condition in which the loading amount is 250 kg per position (total, upper, upper, lower, and lower) on the work table, ), The structural analysis was carried out under the condition that the load was 600 kg, and safety was examined in various aspects. As a result, when the allowable load of 250 kg and the excess load of 600 kg are excluded (except Case-11), the stress level is below the yield strength. In the case of Case-11, there is a region exceeding the yield strength at the center support portion of the safety bar at the upper end even after excluding the component which generates the maximum stress, but it does not affect the safety aspect of the whole structure Respectively. Looking at the deflection results, it can be seen that in all cases the maximum deflection occurs in the same table, and the tendency of sagging in both 250 kg and 600 kg is the same.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.884-891
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• 2020

The collapse of bridges can cause massive casualties and economic losses. Therefore, it is thus essential to evaluate the structural safety of bridges. For this task, structural reliability analysis, considering various bridge-related uncertainty factors, is often used. This paper proposes a new computational platform to perform structural reliability analysis for bridges and evaluate their structural safety under various loading conditions. For this purpose, a software package of reliability analysis, Finite Element Reliability Using MATLAB (FERUM), was integrated with MIDAS/CIVIL, which is a widely-used commercial software package specialized for bridges. Furthermore, a graphical user interface (GUI) control module has been added to FERUM to overcome the limitations of software operation. In this study, the proposed platform was applied to a simple frame structure, and the analysis results of the FORM (First-Order Reliability Method) and MCS (Monte Carlo simulation), which are representative reliability analysis methods, were compared. The proposed platform was verified by confirming that the calculated failure probability difference was less than 5%. In addition, the structural safety of a pre-stressed concrete (PSC) bridge was evaluated considering the KL-510 vehicle model. The proposed new structural reliability analysis platform is expected to enable an effective reliability-based safety evaluation of bridges.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.23 no.4
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• pp.593-607
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• 2013

The In-Vehicle-Networking(IVN) of modern cars is constituted by an small electronic control device called ECU. In the past, there was no way to be able to access the IVN of a driving car. so IVN has been recognized as a closed environment so there is no need to exist authentication protocol between devices which are to configure the internal network and to communicate with other devices. However, constant improvements made it possible to access the IVN in many different ways as the communication technology evolves. This possibility created a need for device authentication in IVN. HB-Family are representative authentication schemes in RFID environment which has similar restrictions to IVN. In this paper, we propose an implementation method of HB-Family for device authentication between ECU considering ECU has low computing power and the message field of CAN protocol has restricted size of 8 bytes. In order to evaluate the efficiency and availability of the authentication schemes adopted our method, we have evaluated the performance based on DSP-28335 device. Further, it was possible to improve the efficiency rate of at lest 10%, up to 36%, and we then analyze this result in various aspects of the IVN.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.1
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• pp.39-47
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• 2016

Repair methods of aging concrete pavement are generally used composite structure pavements, such a composite structure is subjected to a large impact on the mechanical behavior and ensure long-term commonality integrated under vehicle loads, environmental loads of the public in accordance with the bond strength between old and new concrete. A common of bonded concrete overlays that are currently available is Interface arrangements using a variety of equipment to ensure the excellent bond strength between old and new concrete than standard concrete, mixed with a material such as a polymer in order to improve the adhesion with the material itself. However, these method of constructions are being applied, depending on the developer site presents no special specifications apply when a specific application criteria objectively, this is due to the situation of each individual method, which is based on the difficulty in quality control of the site manager. In this study by performing a field test for polymer content via the variables that contribute most significantly to ensure bond strength and the field element core of the interface processing method and materials to ensure bond strength between the old and the new concrete, it was to derive the construction site construction method that can improve the performance of the bond strength through a review of the construction around the correlations and the bond strength according to the effective performance analysis of the conventional surface treatment process and variation of polymer volume fraction.

• The Journal of Internal Korean Medicine
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• v.35 no.1
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• pp.37-49
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• 2014

Objectives & Methods : The objective of this study was to evaluate the single oral dose toxicity of Chongmyung-tang (CMT) in ICR mice. Korean traditional herbal prescription CMT has traditionally been used as a neuroprotective for treatment of learning disability and memory improvement. CMT, lyophilized aqueous extracts (yield=9.7%) were administered to female and male mice with oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for mortality, changes in body weight, clinical signs and gross observation during 14 days after administration upon necropsy; organ weight and histopathology of 14 principle organs were examined. Results : We could not find any CMT extracts treatment related mortalities, clinical signs, changes in body and organ weight, or gross and histopathological observations against 14 principle organs up to 2,000 mg/kg in both female and male mice, except for some accidental sporadic findings which did not show any obvious dose-relations and most of which also demonstrated in both the female and male vehicle control mice in this experiments. Conclusions : Based on the results of this experiment, the 50% lethal dose ($LD_{50}$) and approximate lethal dose (ALD) of CMT extracts after single oral treatment in female and male mice can be considered to be over 2,000 mg/kg, and is likely to be safe in humans.