• Advances in Traditional Medicine
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• 제7권2호
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• pp.121-127
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• 2007

Curcumin, a dietary pigment responsible for the yellow color of curry, has been used for the treatment of inflammatory diseases and exhibits a variety of pharmacological effects such as anti- inflammatory, anti-tumor, anti-oxidant, and anti-viral activity. In order to examine the potency of the curcumin in inflammation we used carrageenan induced rat hind paw odema model. As curcumin is practically water insoluble, it is hypothesized that pharmacological activity of curcumin could be improved by enhancing its water solubility. Water soluble complexes of curcumin with cyclodextrins were prepared and screened for greater solubility. Pure curcumin 100 mg/kg body weight along with curcumin complexes equivalent to 100 mg/kg body weight of pure curcumin were tested for the anti-inflammatory activity in Wister rats male rats using carrageenan induced hind paw edema model and compared with that of the reference compound diclofenac sodium at a dose level of 10 mg/kg body weight. Results were statistically analyzed using ANOVA. All the treatment groups showed statistically significant anti-inflammatory activity compared with that of vehicle control and positive control.

• The Korean Journal of Physiology and Pharmacology
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• 제26권1호
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• pp.15-24
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• 2022

The development of selective targeting of drug molecules towards the mitochondria is an important issue related to therapy efficacy. In this study, we report that gallic acid (GA)-mitochondria targeting sequence (MTS)-H₃R₉ exhibits a dual role as a mitochondria-targeting vehicle with antioxidant activity for disease therapy. In viability assays, GA-MTS-H₃R₉ showed a better rescue action compared to that of MTS-H₃R₉. GA-MTS-H₃R₉ dramatically exhibited cell penetration and intercellular uptake compared to MTS and fit escape from lysosome release to the cytosol. We demonstrated the useful targeting of GA-MTS-H₃R₉ towards mitochondria in AC16 cells. Also, we observed that the antioxidant properties of mitochondrial-accrued GA-MTS-H₃R₉ alleviated cell damage by reactive oxygen species production and disrupted mitochondrial membrane potential. GA-MTS-H₃R₉ showed a very increased cytoprotective effect against anticancer activity compared to that of MTS-H₃R₉. We showed that GA-MTS-H₃R₉ can act as a vehicle for mitochondria-targeting and as a reagent for therapeutic applications intended for cardiovascular disease treatment.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 춘계학술대회 논문집
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• pp.521-527
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• 2011

Korea announced GHG reduction goal, 30% reduction compare with 2020 BAU and reduction target for each industry sector is planning. Transportation sector also trying to make effective technical and political counterplan of allocated GHG reduction target such as material lightening, energy efficiency improvement and Modal shift technology and so on. Modal Shift is shifting low energy efficiency vehicle to high energy efficiency vehicle which is economically meaningful under current market conditions. We can get not only energy efficiency improvement but also GHG reduction effect through modal shift. Modal Shift is effectively applying and studied in logistics field in Europe and Japan and one of the Indian companies has been registered CDM project activity involving modal shift from roadways to railways for finished goods. In this study, the scenarios are developed with detail modal shift ratio and fuel type base on state of road and rail use and GHG emission factor for each fuel type from MLTM. This result can be used as basic information to improve policies and promote increasing use of train which is more environment friendly transportation vehicle.

• 디지털융복합연구
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• 제10권1호
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• pp.379-384
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• 2012

조립공정의 상세한 과정을 보여주기 위해 Script 언어를 사용하여 자동차 조립공정을 3D로 시뮬레이션 하였다. 3D 가시화 기술은 산업현장에서의 학습활동을 가시화하는데 최적의 방법이 될 수 있다. 특히 시뮬레이션은 자동차 관련하여 엔진 부분과 타이어부분에 대하여 조립과정을 3D로 자동화하여 보여줄 수 있도록 구현하였다. 특히 터치스크린을 바탕으로 하여 사용자가 실제로 작업도중에 학습할 수 있도록 실험하였다.

• 한국안전학회지
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• 제28권5호
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• pp.66-70
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• 2013

This study examined the relative effects of education and eco-IVIS(in-vehicle information system) to reduce fuel consumption and greenhouse gas emissions. Also the study investigated the increasing of driving workload when drivers interact with intervention technique. Thirty participants randomly assigned into two groups(training and eco-IVIS) and conducted driving before and after the each intervention technique. While driving, we observed three driving behaviors: Frequency of excessive RPM, percent of speeding, and mean fuel efficiency. Also the Driver Activity Load Index was used to rate participants' subjective ratings of driving workload. Although the results showed positive impact of both education and eco-IVIS to increasing the eco-driving behaviors, eco-IVIS was more effective than education. However, we found comparable level of driving workload in the education and eco-IVIS.

• 대한인간공학회지
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• 제15권2호
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• pp.99-111
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• 1996

In today's highly automated aircraft, the role of the pilot has changed from an airplane controller to a system manager. As a system manager in a cockpit, today's pilot is in charge of a management-level activity called cockpit task management( CTM). According to earlier studies, pilot errors in performing CTM activities were significant factors in a large number of aircraft accidents and incidents. The primary objective of this research was to reduce CTM-related pilot errors. A prototype pilot- vehicle interface called the cockpit task management system (CTMS) was developed and its effectiveness in improving CTM performance was evaluated. After the CTMS was implemented, it was integrated into a PC-based flight simulator to perform an experiment to evaluate its effectiveness. Eight volunteer subjects were used to collect performance data. The results of the experiment indicated that a statistically significant improvement was observed when the subjects flew with the assistance of the CTMS.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1992년도 하계학술대회 논문집 A
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• pp.27-30
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• 1992

In this paper, we report the research activities of the technical committee of Electric Vehicle (EV). Recently, environmental pollution has become a world-wide problem. As a practical step to solve this problem, it is sincerely hoped that EVs will become widely used. Here in, we wish to describe an Electric Vehicle research facility with the objectives of developing motor propulsion technology, energy storage technology, control system, battery charging systems, and etc.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2009년도 춘계학술대회 논문집
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• pp.213-218
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• 2009

The Korean railway standards (KRS), formerly managed by Korea Railroad (Korail), have been managed by the Korean Ministry of Land, Transport and Maritime Affairs (ML TM). According to Korean railway safety law and its ordinances, which were established for the guarantee of railway safety, the management of KRS including enactment and revision of technical standards for railway vehicle and components, was committed to Korea Railroad Research Institute (KRRI). Currently, a total of 195 standards has been managed from the various railway applications including track, electrical, and vehicle areas. Moreover, according to the guideline on the management of KRS, the conformity of KRS with international standards is encouraged for the enlargement of international trade. In this investigation, a brief management activity of KRS and the recent activities on conformity of KRS with AAR standards on automatic coupler will be introduced.

• 한국ITS학회 논문지
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• 제22권6호
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• pp.32-48
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• 2023

자율주행기술의 발달은 점차 개인화된 통행을 유도하며, 자율주행차량으로의 전환으로 인한 도로운영 측면에서 교통 영향력은 개인차량을 이용한 수요에 의해 가장 큰 영향력을 받는다. 따라서, 교통 영향력 검토를 위해서는 개인통행특성 이해를 기반한 통행발생량 산정이 필요하다. 개인 통행특성 반영이 가능한 Activity-based model(ABM)은 개인의 모든 이동을 다루므로 통행과 통행 사이의 관계에 대한 이해가 선행되어야 한다. 하지만, ABM은 실제 수요예측에서 데이터 구득문제와 같이 많은 한계점이 있다. 따라서, 본 연구에서는 가구통행실태조사자료를 기반으로 통행간 관계를 설명할 수 있는 Tour-based 모형을 활용하였다. 또한, 샘플조사 자료의 전수화를 위해 차량등록대수 및 인구수 데이터를 활용하여 개인차량발생량 보정방안을 제시하였다. 통행발생량 분석결과, KTDB와 비교하였을 때 본 연구에서 전체통행발생량은 약 13% 높았으며, 업무통행의 경우 약 9% 차이로 합리적인 오차수준으로 분석되었다. 결과적으로 본 연구의 궁극적인 목표인 도로운영 측면의 자율주행차량 도입에 따른 수요예측을 위해 Activity-based 모형 구축에 앞서 개인통행특성을 반영할 수 있는 Tour를 기반으로 발생량 보정방안으로 활용될 수 있다.

• Journal of Nutrition and Health
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• 제47권6호
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• pp.394-402
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• 2014

본 연구는 황칠나무의 부위별 추출물의 항당뇨효능을 평가하기 위해, 황칠나무의 잎과 줄기의 열수추출물과 에탄올추출물을 분리하여 항산화능과 당뇨질환 개선효능을 측정하였다. 그 결과, total polyphenol과 total flavonoid의 농도는 DLW에서 가장 높게 나타났으며, 다음으로 DLE, DSW, DSE 순서로 나타났다. 또한, DPPH 소거능은 DLW가 대부분의 농도에서 가장 높게 나타났으며, DLE는 $500{\mu}g/mL$의 농도에서 가장 높은 DPPH 소거능을 나타내었다. 항산화능이 우수한 DLW와 DLE를 선정하여 STZ로 유도된 당뇨모델동물에 2주간 투여하여 항당뇨 효능을 분석하였다. 그 결과, 체중은 STZ/vehicle 처리군이 급격히 감소하였으나 STZ/DLW와 STZ/DLE 처리군에서 서서히 감소하였다. 혈당량은 STZ/vehicle 처리군에서 급격히 증가하였으며, STZ/DLW 처리군과 STZ/DLE 처리군에서만 유의적인 감소를 나타내었다. 그러나, 혈청 내 인슐린의 농도는 STZ/vehicle 처리군에 비하여 STZ/DLW와 STZ/DLE 처리군에서 증가하였으며, 특히 STZ/DEL-200 처리군에서 가장 높은 농도를 나타내었다. 이러한 변화는 췌장의 조직학적 변화와 면역염색의 결과에서도 동일하게 관찰되었다. 더불어, 뇨당 농도는 STZ/vehicle 처리군에서 급격히 증가하였으며, 오직 STZ/DLW-200 처리군과 STZ/DLE-200 처리군에서만 유의적으로 감소하였다. 이러한 결과는 황칠나무의 잎의 열수추출물과 에탄올추출물은 우수한 항산화효능과 베타세포의 사멸을 억제함으로서 당뇨질환을 개선하는 효능이 있음을 제시하고 있으며, 특히, 200 mg/kg의 농도가 우수한 효능을 나타내는 농도임을 제시하고 있다.