• Natural Product Sciences
• /
• v.13 no.4
• /
• pp.369-372
• /
• 2007

Oxidative stress induced by reactive oxygen species (ROS) has been suggested to be the cause of various degenerative diseases as well as aging. To evaluate the antioxidant potential of stilbenes, we have investigated the cytoprotective effect of 10 stilbenes derived from plants on the oxidative stress induced by tertiary butyl hydroperoxide (t-BuOOH). Of the stilbenes tested, piceatannol (3) showed the most potent activity, which was further investigated using an animal model. When 3 (30 or 10 mg/kg) was topically administered prior to UVB irradiation, the amount of the thiobarbituric acid reactive substances (TBARS) was significantly reduced compared to that of the control (vehicle). Our findings suggest that piceatannol is capable of protecting cells and tissues from oxidative stress.

• Education of Primary School Mathematics
• /
• v.6 no.1
• /
• pp.29-40
• /
• 2002

Fairy-tales give students opportunities to build connections between a problem-solving situation and mathematics as well as to communicate solutions through writing, symbols, and diagrams. Therefore, the purpose of this paper is to introduce how to use fairy-tales in elementary mathematics classroom in order to develope student's mathematical concepts and process in terms of the following areas: ⑴ reconstructing literature ⑵ understanding concepts ⑶ problem posing activity. To be useful, mathematics should be taught in contexts that are meaningful and relevant to learners. Therefore using fairy-tales as a vehicle to teach mathematics gives students a chance to develope mathematics understanding in a natural, meaningful way, and to enhance problem posing and problem solving ability. Further, future study will continue to foster how fairy-tales literatures will enhance children's mathematics knowledge and influence on their mathematics performance.

• Proceedings of the KSR Conference
• /
• 1999.11a
• /
• pp.242-255
• /
• 1999

In order to manufacture high quality goods, the engineers who will design them has to have board technical experience as well as profound engineering knowledge. The engineers also be able to design and manufacture well development goods base on new advanced technology. Design process can be defined as transforming activity raw material into finished producted for human needs. The wealth of nation depend on its ability to retrieve natural resources and manufacture goods. Its ability, creation of goods, is most fundamental component of economic wealth of rich country. The rich countries have combine their own design knowledge with computer technology and create new effective design process. In this paper, one of the useful and practice design process created for railway industry is introduced. Base on the concept of this design process, the automatic wheelchair lifter design for railway vehicle is performed.

• Journal of Korean Society of Transportation
• /
• v.27 no.2
• /
• pp.169-178
• /
• 2009

This study is aimed at identifying the association of commuting behavior with health for workers in the Korea Capital Region. The study surveyed a total of 1,285 commuters whose major work is deskwork-oriented; the authors obtained their health status on body form, blood pressure and cholesterol as well as their commuting behavior. The measures of the latter were comprised of a main commuting mode, a use term, out-of-vehicle time, total travel time, transit transfer, and alternative mode in order to identify the amount of physical activity obtained through commuting behavior. The results indicate that non-automobile commuters are positively associated to improve their health status, as compared to car commuters. Specifically, bus commuters and walkers had decreased weight, blood pressure, and cholesterol, while rail commuters are only correlated to relieving cholesterol. In addition, the measures for health are improved as out-of-vehicle time increases. For commuters who drive to work, their health status tends to be worse.

• Proceedings of the Korea Society of Environmental Toocicology Conference
• /
• 2003.05a
• /
• pp.195-195
• /
• 2003

It is well known that diesel exhaust particulate matter contains mutagenic PAHs, such as benzo[${\alpha}$]pyrene, benz[${\alpha}$]anthracene, chrysene, etc. Therefore it is suspected that these chemicals act on estrogen receptor and reveal endocrine-disrupting effects. Recent attention has focused on causative chemicals of endocrine-disrupting effects. We examined the estrogenic activity of respirable diesel exhaust particulate matter derived from diesel powered vehicle. PM2.5 diesel exhaust of vehicle was collected using a high volume sampler equipped with a cascade impactor. Diesel exhaust samples were fractionated according to EPA methods. The presence of estrogenic and antiestrogenic chemicals in PM 2.5 diesel exhaust was determined using E-screen assay. To quantitatively assess the estrogenic and antiestrogenic activities in diesel exhaust particulate matter, estradiol equivalent concentration (bio-EEQ) was calculated by comparing the concentration response curve of the sample with those of the estrogen calibration curve. Weak estrogenic activities and strong antiestrogenic activities were detected in the crude extract and moderately polar fractions. Higher antiestrogenic potency was observed with higher EROD activities in aliphatic and aromatic compounds fraction. In conclusion, estrogenic/antiestrogenic-like activities were present in diesel exhaust particulate matter. However, the health consequences of this observation was unknown, the presence of these activities may contribute to and exacerbate adverse health effect evoked by diesel exhaust particulate matter.

• Journal of Pharmacopuncture
• /
• v.19 no.2
• /
• pp.114-121
• /
• 2016

Objectives: Lung cancer remains a deadly disease with unsatisfactory overall survival. Cisplatin, a standard platinum (Pt)-based chemotherapeutic agent, has the potential to inhibit the growth of lung cancer. Its use, however, is occasionally limited by severe organ toxicity. However, until now, no systematic study has been conducted to verify its efficacy with proper experimental support in vivo. Therefore, we examined whether biosynthesized Pt nanoparticles (NPs) inhibited human lung cancer in vitro and in vivo to validate their use in alternative and complementary medicine. Methods: We evaluated the in vitro and the in vivo anticancer efficiencies of biosynthesized Pt NPs in a subcutaneous xenograft model with A549 cells. Severe combined immune deficient mice (SCID) were divided into four groups: group 1 being the vehicle control group and groups 2, 3 and 4 being the experimental groups. Once the tumor volume had reached $70-75mm^3$, the progression profile of the tumor growth kinetics and the body weights of the mice were measured every week for 6 weeks after oral administration of Pt NPs. Doses of Pt NPs of 500, 1,000 and 2,000 mg/kg of body weight were administered to the experimental groups and a dose of honey was administered to the vehicle control group. The efficacy was quantified by using the delay in tumor growth following the administration of Pt NPs of A549 human-lung-cancer xenografts growing in SCID mice. Results: The in vitro cytotoxicity evaluation indicated that Pt NPs, in a dose-dependent manner, inhibited the growth of A549 cells, and the in vivo evaluation showed that Pt NPs at the mid and high doses effectively inhibited and delayed the growth of lung cancer in SCID mice. Conclusion: These findings confirm the antitumor properties of biosynthesized Pt NPs and suggest that they may be a cost-effective alternative for the treatment of patients with lung cancer.

• Journal of Korean Society for Atmospheric Environment
• /
• v.26 no.1
• /
• pp.48-56
• /
• 2010

Recently it has reported that the motorcycle is a major source of air pollution in urban area by many studies. But the air pollution emission from motorcycle has been high uncertainty due investigation of a lack of activity data and emission factors in Korea. So in this study, the population of moped and VKT (Vehicle kilometers travelled) of motorcycle are investigated for calculation of the emission from this source categories. As the results, the population of moped is estimated as about 400, 000 and corresponded as 23% of registrated motorcycle which is larger than 50 cc in engine displacement. And it is found that the VKT of moped and motorcycle are investigated as 19.1 km/day and 32.3 km/day. Annual air pollution emission from motorcycle and moped are estimated by investigated VKT and updated emission factors. The nationwide emissions of PM_{10}, CO, $NO_x$, VOC are calculated as 910 ton/yr, 208, 198 ton/yr, 3, 032 ton/yr and 25, 575 ton/yr in 2008. The contribution ratio of CO, VOC emission from these sources are estimated as 29%, 24% in on-road transport sector and it is confirmed that motorcycle and moped are major air pollution sources in urban area.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.9 no.9
• /
• pp.1019-1025
• /
• 2014

Recently, the studies of the Unmanned Aerial Vehicle(UAV) has been studied a variety from military aircraft to civilian aircraft and for general hobby activity aircraft. In particular, for small unmanned aircraft research for the ease of turning and hovering and Vertical-Off Take Landing(VTOL), have been studied mainly quadrotor unmanned aircraft is a type suitable for this study of small unmanned aircraft. The studies of these unmanned aircraft is the kinetic analysis requires complex processes, because these support by the aerodynamic forces on the unmanned aircraft study, and the controller design based on these dynamical analysis and experimental model analysis. In this paper, after the implementation of the basic attitude control based on a general PID controller, we propose concept design of the attitude control method on quadrotor attitude control by using the reinforcement learning algorithm of neural networks for non-linear elements not considered in the controller design.

• Biomolecules & Therapeutics
• /
• v.8 no.1
• /
• pp.78-83
• /
• 2000

The objective of this study was to prevalidate the Organization for Economic Cooperation and Development's (OECD) rodent uterotrophic assay as a test method for screening of potential endocrine disrupting chemicals (EDCs). This study was conducted exactly as described in the OECD protocol documents. A positive control substance, 17$\alpha$-ethinyl estradiol (EE), was administered daily for three days to ovariectomized (OVX) Sprague-Dawley rats at various doses for determine the dose-response curve. Additionally, a pure antiestrogenic chemical, ZM189, 154 was administered to OVX rats at the same time EE to determine the effectiveness of the material against blocking the estrogenic effects of EE. At higher concentration of EE (10 $\mu\textrm{g}$/kg), a statistically significant difference in body weight gain and food consumption was observed compared to vehicle controls. In uterine responses, EE produced a dose-related increase in uterus weights compared to vehicle control. These increases were statistically significant at the >1.0 $\mu\textrm{g}$/kg doses. However, a similar dose-response relationship was not observed in vagina weight. A comparison of the two groups receiving ZM189,154 (0.1 and 1.0 mg/kg) with 0.3 $\mu\textrm{g}$/kg of EE and the group receiving only 0.3 $\mu\textrm{g}$/kg of EE showed dose-related decreases in uterus weights. However, statistical significance was shown in 1.0 mg/kg of ZM189,154. In conclusion, administration of EE produced a dose-related increase in uterine (wet and blotted) weights. Additionally, the 1.0mg/kg dose of ZM189,154 was effective in blocking the estrogenic activity of EE. These data suggest 3-day uterotrophic assay using OVX rats may serve as a good tool for EDCs screening.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.16 no.5
• /
• pp.497-506
• /
• 2014

In this study, analysis results described in the companion paper was used to determine shapes of room-and-pillar underground structure. To select optimized shapes, structural stability, space applicability and vehicle applicability were considered. In the structural stability step, ratio between strength and stress of the pillar and the critical strain at the roof span were adopted. The space applicability was used to retain the sufficient space of underground structure as its purpose is for human activity. The vehicle applicability was used to consider a radius for rotation of construction equipments in the room-and-pillar underground structure. From the given procedure in this study, proper shapes of rock pillar and room can be selected to design supports at the pillar and roof.