• BMB Reports
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• v.52 no.11
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• pp.659-664
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• 2019

Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs) obtained from Vav1-deficient ($Vav1^{-/-}$) and wild-type (WT) mice to differentiate into mature OCs upon stimulation with macrophage colony stimulating factor and receptor activator of nuclear kappa B ligand in vitro. Our results suggested that Vav1 deficiency promoted the differentiation of BMMCs into OCs, as indicated by the increased expression of tartrate-resistant acid phosphatase, cathepsin K, and calcitonin receptor. Therefore, Vav1 may play a negative role in OC differentiation. This hypothesis was supported by the observation of more OCs in the femurs of $Vav1^{-/-}$ mice than in WT mice. Furthermore, the bone status of $Vav1^{-/-}$ mice was analyzed in situ and the femurs of $Vav1^{-/-}$ mice appeared abnormal, with poor bone density and fewer number of trabeculae. In addition, Vav1-deficient OCs showed stronger adhesion to vitronectin, an ${\alpha}_v{\beta}_3$ integrin ligand important in bone resorption. Thus, Vav1 may inhibit OC differentiation and protect against bone resorption.

• Journal of Environmental Health Sciences
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• v.23 no.4
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• pp.57-66
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• 1997

Successful energy conservation and good indcfor air quality (IAQ) are highly dependent on ventilation system. Air filtration is a primary solution of indoor air control strategies in terms of reducing energy consumption and improving ihdoor air quality. A conventional system with bypass filter, as it is called variable-air-volume/bypass filtration system (VAV/BPFS), is a variation of the conventional variable air volume (VAV) systems, which is designed to eliminate indoor air pollutant and to save energy. Bypass filtration system equipped with a high-efficiency particulate filter and carbon absorbent provides additional cleaned air into indoor environments and maintain good IAQ for human health. The objectives of this research were to compare the relative total decay rate of indoor air pollutant concentrations, and to develop a mathematical model simulating the performance of VAV/BPFS. All experiments were performed in chamber under the controlled conditions. The specific conclusions of this research are: 1. The VAV/BPFS system is more efficient than the VAV system in removing indoor air pollutant concentration. The total decay rates of aerosol, and total volatile organic compound (TVOC) for the VAV/BPFS system were higher than those of the conventional VAV system. 2. IAQ model predictions of each pollutant agree closely with the measured values. 3. According to IAQ model evaluation, reduction of outdoor supply air results in decreased dilution removal rate and on increased bypass filtration removal rate with the VAV/BPFS. As a results, we recommends the VAV/BPFS as an alternative to conventional VAV systems.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6417-6421
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• 2015

Viscum album var (VAV) also known as mistletoe, has long been categorized as a traditional herbal medicine in Asia. In addition to its immunomodulating activities, mistletoe has also been used in the treatment of chronic hepatic disorders in China and Korea. There are numerous reports showing that VAV possesses anti-cancer effects, however influence on human hepatocarcinoma has never been elucidated. In the present study, hot water extracts of VAV was evaluated for its potential anti-cancer effect in vitro. SK-Hep1 cells were treated with VAV (50-400ug/ml) for both 24 and 48 hours then cell viability was measured by cell counting kit-8 (CCK-8). Flow cytometry analysis was used to measure the proportion of SK-Hep1 in the different stages of cell cycle. RT-PCR and Western blot analysis were conducted to measure expression of cell cycle arrest related genes and proteins respectively. VAV dose dependently inhibited the proliferation of SK-Hep1 cells without any cytotoxicity with normal Chang liver cell (CCL-13). Flow cytometry analysis showed that VAV extract inhibited the cell cycle of SK-Hep1 cells via G1 phase arrest. RT-PCR and Western blot analysis both revealed that cyclin dependent kinase 2 (Cdk2) and cyclin D1 gene expression were significantly down regulated while p21 was upregulated dose dependently by VAV treatment. Combined down regulation of Cdk2, Cyclin D1 and up regulation of p21 can result in cell death. These results indicate that VAV showed evidence of anti-cancer activity through G1 phase cell cycle arrest in SK-Hep1 cells.

• International Journal of High-Rise Buildings
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• v.8 no.1
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• pp.71-82
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• 2019

The purpose of this study is to evaluate the indoor air quality (IAQ) and energy benefits of a dedicated outdoor air system (DOAS) and compare them with a conventional variable air volume (VAV) system. The DOAS is a decoupled system that supplies only outdoor air, while reducing its consumption using an enthalpy wheel. The VAV system supplies air that is mixed outdoor and transferred indoor. The VAV has the issue of unbalanced ventilation in each room in multiple zones because it supplies mixing air. The DOAS does not have this problem because it supplies only outdoor air. That is, the DOAS is a 100% outdoor air system and the VAV is an air conditioning system. The transient simulations of carbon dioxide concentration and energy consumption were performed using a MATLAB program based on the thermal loads from the model predicted by the TRNSYS 18 program. The results indicated that when the air volume is large, such as in summer, the distribution of air is not appropriate in the VAV system. The DOAS however, supplies the outdoor air stably. Moreover, in terms of annual primary energy consumption, the DOAS consumed approximately 40% less energy than the VAV system.

• Journal of Chest Surgery
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• v.56 no.4
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• pp.274-281
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• 2023

Background: Patients who require initial venoarterial extracorporeal membrane oxygenation (VA ECMO) support may need to undergo veno-arteriovenous ECMO (VAV ECMO) conversion. However, there are no definitive criteria for conversion to VAV ECMO. We report 9 cases of VAV ECMO at Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine. Methods: Of 158 patients who received ECMO support between January 2017 and June 2019, 82 were supported by initial VA ECMO. We retrospectively reviewed the medical records of 9 patients (7 men and 2 women; age, 53.1±19.4 years) who had differential hypoxia and required VAV ECMO support. Percutaneous transaortic catheter venting was used to detect the differential hypoxia. Results: Among the 82 patients who received VA ECMO support, 9 (10.9%) had differential hypoxia and required conversion to VAV ECMO support. The mean time from VA ECMO support to VAV ECMO support and the mean duration of the VAV support were 2.1±2.2 days and 1.9±1.5 days, respectively. The average peak inspiratory pressure before and after VAV ECMO application was 23.89±3.95 cmH₂O and 20.67±5.72 cmH₂O, respectively, decreasing by an average of 3.2±3.5 cmH₂O (p=0.040). The PaO₂/FiO₂ ratio was kept below 100 mm Hg in survivors and non-survivors for 116±65.4 and 250±124.9 minutes, respectively (p=0.016). Six patients underwent extracorporeal cardiopulmonary resuscitation, of whom 4 survived (67%). The overall survival rate of patients who underwent conversion from VA ECMO to VAV ECMO was approximately 56%. Conclusion: Rapid detection of differential hypoxia is required when VA ECMO is applied, and efficient conversion to VAV ECMO may be critical for patient survival.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.7
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• pp.632-641
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• 2000

The present study concerns the simulation of supply-air control in a variable air volume (VAV) system. A stratified lumped thermal model (multi-zone model) is suggested to predict local thermal response of an air-conditioned space. The effects of various thermal parameters such as the cooling system capacity, the thermal mass of air-conditioned space, the time delay of thermal effect, and the building envelope heat transmission are investigated in detail. Further, the influence of control parameters, PI control factor and the sensor location on a VAV system is quantitatively delineated. The results obtained show that the previous homogeneous lumped thermal model (1-zone model) may predict a significantly different thermal response in the air-conditioned space according to the sensor location.

• International Journal of Air-Conditioning and Refrigeration
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• v.11 no.1
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• pp.10-16
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• 2003

The present study performs an experimental measurement on transient thermal response of an air-conditioned space by a variable air volume (VAV) system with a PI(pro-portional-integral) control logic. A thermal chamber with a PI controlled VAV unit is constructed to verify the previously suggested stratified multi-zone model. The effects of thermal parameters and control parameters such as supply air temperature and PI control factor are investigated by implementing the thermal chamber test. The experimental results obtained show that transient behavior of the air-conditioned space-temperature is in good accordance with the simulation results of the stratified thermal model.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.9 no.1
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• pp.1-13
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• 1997

This paper reports the dynamic analysis of energy consumption for an office building by heat resistance-capacitance method. If a building is divided into several wall components and the wall components is replaced by one thermal capacitance and several thermal resistances, the building becomes an electric circuit. By solving the simultaneous equations of the circuit, the dynamic heat transfer characteristics and the energy consumption rate of the building were predicted. Accuracy of modified BIN method was evaluated by the present resistance-capacitance method. The result shows that modified BIN method overpredicts the heating load of the office building 15%. Annual energy consumptions of equipments(fan, boiler, chiller) for various ventilating control system(CAV, VAV, FCU+VAV, FCU+CAV) were compared. FCU+CAV shows the minimum annual energy consumption.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.1 no.2
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• pp.9-14
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• 2000

State feedback with integral control for a variable air volume(VAV) unit which is recently taken notice of for the energy efficiency and saving in the building is studied to investigate the performance of the digital control methodology for the possible practical application. The digital controller which acquires the targat zone temperature and the air flow rate of the supplied air to the zone controls the opening of the damper in the VAV unit. Simulation results are performed for the conditions including reference changes and external thermal variations. In the simulation. simplified conditioned zone and the damper actuator modelling is considered. and relationships between controller gain Parameters and the system dynamics are investigated.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.11 no.1
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• pp.100-108
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• 1999

Variable air volume(VAV) system designed for improving interior environmental control has steadily evolved over the last 20 years. Major advantage of VAV system is that VAV technology allows a single system to provide simultaneous heating and cooling without a seasonal changeover. Research is carried out in order to study the influence on the energy consumption and ventilation performance of two kinds of office building with a mixing ventilation system. Data required for performance evaluation in these building is obtained from the central monitoring station and by measurement.