• Clinical and Experimental Pediatrics
• /
• 제52권5호
• /
• pp.622-626
• /
• 2009

키쿠치(Kikuchi) 병, 키쿠치-후지모토(Kikuchi-Fujimoto) 병, 혹은 조직구 괴사성 림프선염은 1972년 일본에서 키쿠치와 후지모토 두 사람에 의해 처음 기술되었으며 흔히 아시아 지역에서 30세 미만의 여성들을 주로 침범하는 자가 관해 질환으로 기술되어져왔다. 이 질환의 병인은 여전히 잘 알려져 있지 않으나 감염성(EBV, HHV-6 and -8, HTLV-1, cytomegalovirus, varicella-zoster virus, tuberculosis, toxoplasmosis, yersiniosis, cat scratch disease), 자가면역성(SLE, Kawasaki disease), 그리고 종양성 질환(lymphoma)이 포함되는 것으로 간주된다. 가장 흔한 임상증상은 발열과 통증 없는 경부 림프선염이다. 진단은 생검을 통한 조직병리학적으로 하게 되는데, 주로 풍부한 핵파괴(karyorrhexis)를 가진 피질 주위 지역에서 나타나는 국소 괴사, 괴사 지역 주위로 비정형적인 단핵구들의 집합, 중성구 및 형질 세포의 결핍, 그리고 대개 림프절 캡슐의 보존 등으로 특징 지워진다. 절대적인 치료법은 없어 대증 치료를 하게 되며 치료 없이도 대개 1-6개월 안에 자가 관해되고 재발률도 3.3%에 불과하다. 키쿠치-후지모토 병의 합병증으로 피부, 심장, 골수 등을 침범할 수 있으며 간질환, 무균성 뇌수막염, 간비비대 등이 발생할 수 있으나 드물다. 본 증례에서는 입원 당시 결핵성 임파선염과 뇌수막염으로 오인되었던 무균성 뇌수막염을 동반한 키쿠치-후지모토 병을 경험하였기에 이에 보고하는 바이다.

• Journal of Oral Medicine and Pain
• /
• 제24권2호
• /
• pp.125-135
• /
• 1999

This study was performed to discover the underlining influences of Herpes Simplex virus (HSV) and Varicella Zoster virus (VZV), to detect the changes of whole protein and mucin level and to observe protein profiles in the saliva when recurrent aphthous ulcer (RAU) was present. Unstimulated whole saliva was collected from 23 patients who for over three years had a clinical history of RAU, in a group of 10 women and 13 men, ranging from 11 to 72 years of age, and 20 healthy subjects, in a group of 8 women and 12 men, who did not have the symptoms nor a past history of RAU. Through the means of Polymerization Chain Reaction, genomic DNA from the HSV and VZV was purified from the saliva samples for identifying precisely the two types of viruses, and the level of whole protein and sialic acids in the saliva and the ratio of sialic acid to whole protein were measured, and SDS-polyacrylamide gel electrophoresis was performed. The results obtained were as follows ; 1. 39.13% of patients showed 224 bp bands of VZV DNA, those were appeared more in patients than in control group (p<0.01), but there was no significant difference between patients and control group in HSV DNA (p>0.05). 2. The concentration of whole protein in men patients was lower than in men control group (p<0.05), but there were no significant differences between patients and control in other groups (p>0.05). 3. The concentration of sialic acids from patients was lower than control group in all groups (p<0.05). 4. The concentration of sialic acids in proportion to that of whole protein was lower in patients than in control group (p<0.05), and in the two women groups (p<0.01), but no noticeable difference was found between the two men groups (p>0.05). 5. There were no consistent differences observed in the protein profiles of patients with control group except that certain protein bands near 50 kDa was lower in patients than in control group. These results suggest that viruses such as HSV and VZV and reduction of salivary whole protein and mucin levels are related to development of RAU.