• Journal of the Korea Academia-Industrial cooperation Society
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• v.2 no.2
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• pp.81-89
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• 2001

Space systems are operating in a changing and uncertain space environment and are desired to have autonomous capability for long periods of time without frequent telecommunications from the ground station At the same time. requirements for new set of projects/systems calling for ""autonomous"" operations for long unattended periods of time are emerging. Since, by the nature of space systems, it is desired that they perform their mission flawlessly and also it is of extreme importance to have fault-tolerant sensor/actuator sub-systems for the purpose of validating science measurement data for the mission success. Technology innovations attendant on autonomous data validation and health monitoring are articulated for a growing class of autonomous operations of space systems. The greatest need is on focus research effort to the development of a new class of fault-tolerant space systems such as attitude actuators and sensors as well as validation of measurement data from scientific instruments. The characterization for the next step in evolving the existing control processes to an autonomous posture is to embed intelligence into actively control. modify parameters and select sensor/actuator subsystems based on statistical parameters of the measurement errors in real-time. This research focuses on the identification/demonstration of critical technology innovations that will be applied to Autonomous Spacecraft Health Monitoring/Data Validation Control Systems (ASHMDVCS). Systems (ASHMDVCS).

• Korean Journal of Radiology
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• v.21 no.6
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• pp.670-683
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• 2020

Objective: The presence of coagulative necrosis (CN) in clear cell renal cell carcinoma (ccRCC) indicates a poor prognosis, while the absence of CN indicates a good prognosis. The purpose of this study was to build and validate a radiomics signature based on preoperative CT imaging data to estimate CN status in ccRCC. Materials and Methods: Altogether, 105 patients with pathologically confirmed ccRCC were retrospectively enrolled in this study and then divided into training (n = 72) and validation (n = 33) sets. Thereafter, 385 radiomics features were extracted from the three-dimensional volumes of interest of each tumor, and 10 traditional features were assessed by two experienced radiologists using triple-phase CT-enhanced images. A multivariate logistic regression algorithm was used to build the radiomics score and traditional predictors in the training set, and their performance was assessed and then tested in the validation set. The radiomics signature to distinguish CN status was then developed by incorporating the radiomics score and the selected traditional predictors. The receiver operating characteristic (ROC) curve was plotted to evaluate the predictive performance. Results: The area under the ROC curve (AUC) of the radiomics score, which consisted of 7 radiomics features, was 0.855 in the training set and 0.885 in the validation set. The AUC of the traditional predictor, which consisted of 2 traditional features, was 0.843 in the training set and 0.858 in the validation set. The radiomics signature showed the best performance with an AUC of 0.942 in the training set, which was then confirmed with an AUC of 0.969 in the validation set. Conclusion: The CT-based radiomics signature that incorporated radiomics and traditional features has the potential to be used as a non-invasive tool for preoperative prediction of CN in ccRCC.

• Journal of the Institute of Convergence Signal Processing
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• v.20 no.3
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• pp.132-137
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• 2019

The amount of data generated from medical images is increasingly exceeding the limits of professional visual analysis, and the need for automated medical image analysis is increasing. For this reason, this study evaluated the classification and accuracy according to the presence or absence of tumor using Inception V3 deep learning model, using MRI medical images showing normal and tumor findings. As a result, the accuracy of the deep learning model was 90% for the training data set and 86% for the validation data set. The loss rate was 0.56 for the training data set and 1.28 for the validation data set. In future studies, it is necessary to secure the data of publicly available medical images to improve the performance of the deep learning model and to ensure the reliability of the evaluation, and to implement modeling by improving the accuracy of labeling through labeling classification.

• Bulletin of the Korean Chemical Society
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• v.30 no.11
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• pp.2717-2722
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• 2009

The use of the classification and regression tree (CART) methodology was studied in a quantitative structure-activity relationship (QSAR) context on a data set consisting of the binding affinities of 39 imidazobenzodiazepines for the α1 benzodiazepine receptor. The 3-D structures of these compounds were optimized using HyperChem software with semiempirical AM1 optimization method. After optimization a set of 1481 zero-to three-dimentional descriptors was calculated for each molecule in the data set. The response (dependent variable) in the tree model consisted of the binding affinities of drugs. Three descriptors (two topological and one 3D-Morse descriptors) were applied in the final tree structure to describe the binding affinities. The mean relative error percent for the data set is 3.20%, compared with a previous model with mean relative error percent of 6.63%. To evaluate the predictive power of CART cross validation method was also performed.

• Communications for Statistical Applications and Methods
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• v.12 no.2
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• pp.335-348
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• 2005

The rapid development of microarray technologies enabled the monitoring of expression levels of thousands of genes simultaneously. Recently, the time course gene expression data are often measured to study dynamic biological systems and gene regulatory networks. For the data, biologists are attempting to group genes based on the temporal pattern of their expression levels. We apply the consensus clustering algorithm to a time course gene expression data in order to infer statistically meaningful information from the measurements. We evaluate each of consensus clustering and existing clustering methods with various validation measures. In this paper, we consider hierarchical clustering and Diana of existing methods, and consensus clustering with hierarchical clustering, Diana and mixed hierachical and Diana methods and evaluate their performances on a real micro array data set and two simulated data sets.

• The Korean Journal of Applied Statistics
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• v.24 no.5
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• pp.871-881
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• 2011

In this paper we propose a logistic regression method to estimate the survival function and the median survival time in interval-censored data. The proposed method is motivated by the data augmentation technique with no sacrifice in augmenting data. In addition, we develop a cross validation criterion to determine the size of data augmentation. We compare the proposed estimator with other existing methods such as the parametric method, the single point imputation method, and the nonparametric maximum likelihood estimator through extensive numerical studies to show that the proposed estimator performs better than others in the sense of the mean squared error. An illustrative example based on a real data set is given.

• Proceedings of the Korea Association of Information Systems Conference
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• 2000.11a
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• pp.36-44
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• 2000

The purpose of this study is to introduce a more efficient forecasting technique, which could help result the reduction of cost in removing the waste of airline in-flight meals. We will use a neural network approach known to many researchers as the “Outstanding Forecasting Technique”. We employed a multi-layer perceptron neural network using a backpropagation algorithm. We also suggested using other related information to improve the forecasting performances of neural networks. We divided the data into three sets, which are training data set, cross validation data set, and test data set. Time lag variables are still employed in our model according to the general view of time series forecasting. We measured the accuracy of our model by “Mean Square Error”(MSE). The suggested model proved most excellent in serving economy class in-flight meals. Forecasting the exact amount of meals needed for each airline could reduce the waste of meals and therefore, lead to the reduction of cost. Better yet, it could enhance the cost competition of each airline, keep the schedules on time, and lead to better service.

• Journal of Biosystems Engineering
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• v.41 no.3
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• pp.208-220
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• 2016

Purpose: Fusel oil is a potent volatile aroma compound found in many alcoholic beverages. At low concentrations, it makes an essential contribution to the flavor and aroma of fermented alcoholic beverages, while at high concentrations, it induced an off-flavor and is thought to cause undesirable side effects. In this work, we introduce Fourier transform near-infrared (FT-NIR) spectroscopy as a rapid and nondestructive technique for the quantitative determination of fusel oil in the Korean alcoholic beverage "soju". Methods: FT-NIR transmittance spectra in the 1000-2500 nm region were collected for 120 soju samples with fusel oil concentrations ranging from 0 to 1400 ppm. The calibration and validation data sets were designed using data from 75 and 45 samples, respectively. The net analyte signal (NAS) was used as a preprocessing method before the application of the partial least-square regression (PLSR) and principal component regression (PCR) methods for predicting fusel oil concentration. A novel variable selection method was adopted to determine the most informative spectral variables to minimize the effect of nonmodeled interferences. Finally, the efficiency of the developed technique was evaluated with two different validation sets. Results: The results revealed that the NAS-PLSR model with selected variables ($R^2_{\upsilon}=0.95$, RMSEV = 100ppm) did not outperform the NAS-PCR model (($R^2_{\upsilon}=0.97$, RMSEV = 7 8.9ppm). In addition, the NAS-PCR shows a better recovery for validation set 2 and a lower relative error for validation set 3 than the NAS-PLSR model. Conclusion: The experimental results indicate that the proposed technique could be an alternative to conventional methods for the quantitative determination of fusel oil in alcoholic beverages and has the potential for use in in-line process control.

• International Journal of Aeronautical and Space Sciences
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• v.4 no.2
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• pp.61-68
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• 2003

The space systems are being operated in a uncertain space environment and are desired to have autonomous capability for long periods of time without frequent telecommunications with the ground station. At the same time, requirements for new set of satellite system set of projects/systems calling for "autonomous" operations for long unattended periods of time are emerging. Since, by the nature of space systems, it is desired to perform its mission flawlessly and also it is of extreme importance to have fault-tolerant sensors and actuators for the purpose of validating science measurement data for the mission success. This studies focused on the identification/demonstration of critical technology innovations that will be applied to the Validation Control System.

• Korean Journal of Radiology
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• v.22 no.3
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• pp.334-343
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• 2021

Objective: We aimed to develop a prediction model for diagnosing severe aortic stenosis (AS) using computed tomography (CT) radiomics features of aortic valve calcium (AVC) and machine learning (ML) algorithms. Materials and Methods: We retrospectively enrolled 408 patients who underwent cardiac CT between March 2010 and August 2017 and had echocardiographic examinations (240 patients with severe AS on echocardiography [the severe AS group] and 168 patients without severe AS [the non-severe AS group]). Data were divided into a training set (312 patients) and a validation set (96 patients). Using non-contrast-enhanced cardiac CT scans, AVC was segmented, and 128 radiomics features for AVC were extracted. After feature selection was performed with three ML algorithms (least absolute shrinkage and selection operator [LASSO], random forests [RFs], and eXtreme Gradient Boosting [XGBoost]), model classifiers for diagnosing severe AS on echocardiography were developed in combination with three different model classifier methods (logistic regression, RF, and XGBoost). The performance (c-index) of each radiomics prediction model was compared with predictions based on AVC volume and score. Results: The radiomics scores derived from LASSO were significantly different between the severe AS and non-severe AS groups in the validation set (median, 1.563 vs. 0.197, respectively, p < 0.001). A radiomics prediction model based on feature selection by LASSO + model classifier by XGBoost showed the highest c-index of 0.921 (95% confidence interval [CI], 0.869-0.973) in the validation set. Compared to prediction models based on AVC volume and score (c-indexes of 0.894 [95% CI, 0.815-0.948] and 0.899 [95% CI, 0.820-0.951], respectively), eight and three of the nine radiomics prediction models showed higher discrimination abilities for severe AS. However, the differences were not statistically significant (p > 0.05 for all). Conclusion: Models based on the radiomics features of AVC and ML algorithms may perform well for diagnosing severe AS, but the added value compared to AVC volume and score should be investigated further.