• Archives of Pharmacal Research
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• 제7권2호
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• pp.121-126
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• 1984

From the roots of Patrinia scabiosaefolia Valerianaceae), scopoletin (1), esculetin (2), oleanonic acid (3), 3-O-.alpha.-L-rhamnopyranosyl (1.rarw.2)-.alpha.-l-arabinopyranosyl oleanolic acid (4) and 3-O-.alpha.-L- rhamnopyranosyl (1 .rarw. 2)-.alpha.-L-arabinopyranosyl header agenin (5) were isolated and characterized by spectral data.

• 생약학회지
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• 제16권1호
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• pp.1-6
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• 1985

Effect of various fractions from the roots of Patrinia scabiosaefolia (Valerianaceae) and whole plants of Melandryum firmum (Caryophyllaceae) on enzyme activities in mice was investigated. The butanol fractions from both plants caused a significant elevation of serum transaminase activities when administered intraperitoneally, but did not, orally. Prolonged exposure by oral administration of both plants elevated hepatic cytochrome p-450 content, indicating the induction of drug metabolizing enzymes in liver.

• Archives of Pharmacal Research
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• 제24권5호
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• pp.416-417
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• 2001

A new triterpene lactose named patrinolide A (7) has been isolated from the roots of Patrinia scabiosaefolia (Valerianaceae). Its structure was determined to be 11$\beta$,21$\beta$-dihydroxy-3-oxooleanan-28,13$\beta$-olide on the basis of spectral analysis, including 2D-NMR techniques.

• 생약학회지
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• 제37권4호
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• pp.302-306
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• 2006

'Pae Jang (敗醬)' is one of Chinese crude drugs used mainly as a edema, abdominal pain and hemoptysis, etc. With regard to the botanical origin of 'Pae Jang', it has been considered to be Patrinia scabiosaefolia of Valerianaceae, but there has never been studied pharmacognostically. To clarify the botanical origin of the 'Pae Jang', we studied on the anatomical characteristics of the roots of three species growing in Korea. Through our studies, the botanical origin of 'Pae Jang' from Korea was proved to be the under ground portions of Patrinia scabiosaefolia and Patrinia villosa.

• 생약학회지
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• 제16권4호
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• pp.248-252
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• 1985

During the biological screening of Chinese drugs, it was found that alcoholic extract of the roots of Patrinia scabiosaefolia (Valerianaceae) caused a significant prolongation of hexobarbital-induced sleeping time and elevation of serum transaminase activities accompanied by severe histopathological changes in the hepatic tissues in mice on three day pretreatments. The systematic fractionation of the methanol extract monitoring by bioassay led to isolation of toxic saponins such as $3-O-{\alpha}-{_L}-arabinopyranosyl$ hederagenin $28-O-{\beta}-{_D}-glucopyranosyl\;(1{\rightarrow}6)-{\beta}-{_D}-glucopyranoside$ and its 2'-acetate and $3-O-{\beta}-{_D}-glucopyranosyl\;(1{\rightarrow}3)-{\alpha}-{_L}-rhamnopyranosyl\;(1{\rightarrow}2)-{\alpha}-{_L}-arabinopyranosyl$ oleanolic acid and its $28-O-{\beta}-{_D}-glucopyranosyl\;(1{\rightarrow}6)-{\beta}-{_D}-glucopyranoside$.

• Natural Product Sciences
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• 제19권2호
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• pp.77-119
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• 2013

The genus Patrinia, belonging to the Valerianaceae family, includes ca. 20 species of herbaceous plants with yellow or white flowers, distributed in Korea, China, Siberia, and Japan. Among them, P. scabiosaefolia (yellow Patrinia), P. saniculaefolia, P. villosa (white Patrinia), and P. rupestris are found in Korea. Several members of this genus have long been used in folk medicine for the treatment of inflammation, wound healing, ascetics, and abdominal pain after childbirth. Thus far, ca. 217 constituents, namely flavonoids, iridoids, triterpenes, saponins, and others have been identified in this genus. Crude extract and isolated compounds have been found to exhibit anticancer, anti-inflammatory, antioxidant, antifungal, antibacterial, cytotoxic activities, lending support to the rationale behind several of its traditional uses. The present review compiles information concerning the phytochemistry and biological activities of Patrinia, with particular emphasis on P. villosa, as studied by our research group.

• 생약학회지
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• 제26권2호
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• pp.175-178
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• 1995

The study was conducted to investigate the effect of cultivation area with different sea levels on essential oil in the root of Valeriana fauriei var. dasycarpa Hara (Valerianaceae). The total content of the essential oil was not different in various cultivation area, however, its composition varied. The major components were bornyl acetate and sesquiterpene alcohol in three cultivation areas. Among the valepotrate components known as major active components in Europe and Nepal valerian, valtrate was detected in a small amount, but the quantity was not changed.

• 식물분류학회지
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• 제38권2호
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• pp.163-177
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• 2008

마타리족(Patrinieae $H{\ddot{o}}ck$, Valerianaceae)에 속하는 마타리속과 Nardostachys속의 17분류군(14종과 추가된 2아종, 1변종)의 화분을 광학현미경과 주사전자현미경, 그리고 투과전자현미경으로 관찰하였다. 화분의 크기는 주로 중립($37.41{\times}43.60{\mu}m$ - $45.65{\times}48.50{\mu}m$)에서 대립($54.88{\times}59.41{\mu}m$ - $61.70{\times}71.00{\mu}m$)까지 나타나고, 발아구는 3구형이며 드물게 4구형이다. 화분립 발아구의 가장자리에는 'halo'라는 마타리과 화분에서 나타나는 공통적인 형질을 갖고 있으며, 화분립의 모양은 적도면에서 단구형에서 약장구형이고, 극축면은 3갈래로 갈라지거나 원형이다. 마타리족의 화분은 표면무늬에 따라서 크게 두가지 유형으로 구별되어진다; (1) Type I: 과립상돌기(verrucae)가 약간 발달하거나 거의 없고, 자상돌기(echinae)가 과립상돌기 위에 발달하며 미세자상돌기(microehinae)가 산재한 형태(Nardostachys속, 마타리속의 Paleopatrinia절, Monanadropatrinia절), (2) Type II: 과립상 돌기가 잘 발달하고, 자상돌기가 과립상돌기 위에 매우 크게 발달하며 미세자상돌기가 조밀하게 화분표면을 덮고 있는 형태(마타리속의 Centrotrinia절). 투과전자현미경을 이용한 연구에서 원주층은 기저층으로부터 과립상돌기로 연결되고, 표벽의 두께는 극과 적도에서 동일하다. 본 연구결과를 통해 마타리족의 분류체계가 검토되었다.

• 생약학회지
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• 제28권2호
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• pp.93-98
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• 1997

Rutin, ${\alpha}-hederin$ and kalopanax saponin B and a mixture of hederagenin and 23-hydroxyursolic acid were isolated from the aerial parts of Patrinia scabiosaefolia Fisch.

• Natural Product Sciences
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• 제14권4호
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• pp.249-253
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• 2008

Two oleanane-type triterpenes (1, 2) and their glycosides (4-6), and one ursane-type triterpene (3) have been isolated from a methanolic extract of Patrinia saniculaefolia Hemsley (Valerianaceae) through repeated silica gel and reversed-phase C-18 column chromatography. Their chemical structures were determined as oleanolic acid (1), oleanonic acid (2), 23-hydroxyursolic acid (3), 3-O-${\alpha}$-L-arabinopyranosyl-oleanolic acid (4), 3-O-${\beta}$-D-glucopyranosyl-oleanolic acid (5), and oleanolic acid 3-O-[${\alpha}$-D-xylopyranosyl-($1{\rightarrow}3$)-${\beta}$-D-glucuronopyranoside-6-O-butyl-ester] (6) on the basis of their MS, $^1H$-, and $^{13}C$-NMR spectral data. All compounds were isolated from the whole plant of the P. saniculaefolia for the first time. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 1 - 3 exhibited anti-complement activity with $IC_{50}$ values of 470.1, 212.2, and 121.0 ${\mu}M$, respectively, whereas compounds 4 - 6 were inactive. These results suggest that the carbonyl or hydroxy group at C-3 in the oleananeand/or ursane-triterpenes are important for the anti-complement activity against the classical pathway.