• International Journal of Vascular Biomedical Engineering
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• 제3권2호
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• pp.10-16
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• 2005

Because patients with coronary artery disease (CAD) have depressed vagal modulation and the mortality risk from acute myocardial infarction is lower in patients with higher vagal modulation, methods that can increase vagal modulation are desirable in patients with CAD. We intended to inspect the effect of recumbent posture on vagal modulation. By using angiography, 33 patients with abnormal (CAD group) and 33 patients with normal coronary arteries (control group) were studied. The nonlinear as well as the linear characteristics of heart rate variability (HRV) were analyzed on these patients in three recumbent postures: namely, the supine, right lateral decubitus, and left lateral decubitus postures. The lower the normalized high-frequency power (nHF) in the supine or left lateral decubitus posture, the higher the increase in the nHF when the posture was changed from supine or left lateral decubitus to right lateral decubitus in both groups of patients. Right lateral decubitus posture can lead to the highest vagal modulation and the lowest sympathetic modulation among the three recumbent postures in both normal and patients with CAD. Therefore, the right lateral decubitus posture can be used as an effective physiologic vagal enhancer in patients with CAD.

• 고신대학교 의과대학 학술지
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• 제33권3호
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• pp.369-379
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• 2018

Objectives: Analysis of heart rate variability (HRV) has been used as a measure of cardiac autonomic function. According to the pNN50 statistic, the percentage of differences between successive normal RR intervals (RRI) that exceed 50 ms, has been known to reflect cardiac vagal modulation. Relatively little is known about the validity of pNN50 during general anesthesia (GA). Therefore, we evaluated the correlation of pNN50 with other variables such as HF, RMSSD, SD1 of HRV reflecting the vagal tone, and examined the validity of pNN50 in anesthetized patients. Methods: We assessed changes in RRI, pNN50, root mean square of successive differences of RRI (RMSSD), high frequency (HF) and standard deviation 1 (SD1) of $Poincar{\acute{e}}$ plots after GA using sevoflurane anesthesia. We also calculated the probability distributions for the family of pNNx statistics (x: 2-50 ms). Results: All HRV variables were significantly decreased during GA. HF power was not correlated with pNN50 during GA (r = 0.096, P = 0.392). Less than pNN47 was shown to have a correlation with other variables. Conclusions: These data suggest that pNN50 can not reflect the level of vagal tone during GA.

• 대한후두음성언어의학회지
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• 제27권2호
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• pp.73-77
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• 2016

Laryngopharyngeal reflux disease (LPRD) is different with gastroesophageal reflux disease (GERD). The lower esophageal sphincter (LES) possesses an intrinsic nervous plexus that allows the LES to have a considerable degree of independent neural control. Sympathetic control of the LES and stomach stems from cholinergic preganglionic neurons in the intermediolateral column of the thoracic spinal cord (T6 through T9 divisions), which impinge on postganglionic neurons in the celiac ganglion, of which the catecholaminergic neurons provide the LES and stomach with most of its sympathetic supply. Sympathetic regulation of motility primarily involves inhibitory presynaptic modulation of vagal cholinergic input to postganglionic neurons in the enteric plexus. The magnitude of sympathetic inhibition of motility is directly proportional to the level of background vagal efferent input. Recognizing that the LES is under the dual control of the sympathetic and parasympathetic nervous systems, we refer the reader to other comprehensive reviews on the role of the sympathetic and parasympatetic control of LES and gastric function. The present review focuses on the functionally dominant parasympathetic control of the LES and stomach via the dorsal motor nucleus of the vagus.

• 감성과학
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• 제8권2호
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• pp.95-101
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• 2005

본 연구는 관상동맥 질환(coronary artery disease : CAD) 환자의 심장 부교감신경 활성화가 감소하고, 만성 심부전(chronic heart failure : CHF) 환자의 심박동변이도(heart rate variability : HRV)에서 정상적 RR 간격의 분산(SDNN : standard deviation of all normal RR intervals)과 저주파수 대역의 전력스펙트럼(low-frequency power : LF),그리고 복잡성이 감소하며, CAD환자의 우측으로 누운 자세에서 HRV의 규격화된 고주파수대역의 전력스펙트럼(normalized high-frequency power : nHF)가 3가지 누운 자세 중에서 가장 높다는 사전 정보에 근거하였다. 세 가지 누운 자세에 대한 HRV의 비선형 특징은 알려진 바가 없으므로, 본 연구에서는 관상동맥질환 환자들을 대상으로 누운 자세에서 HRV의 선형과 비선형특성을 조사하였다. 이 목적을 위하여, 관상동맥질환군 29명과 통제군 23명을 대상으로 세 가지 누운 자세에서 심전도의 Lead II 채널을 측정한 뒤, 심전도로부터 심박동변이도의 선형특성(시간영역과 주파수영역)과 비선형특성을 분석하였다. 똑바로 누운 자세 또는 좌측으로 누운 자세에서 심박동변이도의 nHF가 더 작을수록, 이 자세들로부터 우측으로 누운 자세로 전환할 때 nHF가 더욱 증가하였다. 중증의 관상동맥질환 환자의 세 가지 누운 자세 중에서, 우측으로 누운 자세는 심장부교감신경계의 활성도를 가장 높게, 심장교감신경계의 활성도는 가장 낮게, 그리고 생체시스템의 복잡성은 가장 높게 유도함을 확인하였다.

• 대한한방부인과학회지
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• 제23권4호
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• pp.155-163
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• 2010

Purpose: The aim of the study was to compare the characteristics of the autonomic innervation of the heart in polycystic ovary syndrome(PCOS) patients with regulary cycling controls. Methods: We studied 21 patients visiting $\bigcirc\bigcirc$hospital from 25th June 2009 to 25th June 2010. The subjects were categorized in two groups, 11 PCOS patients and 10 healthy regularly cycling controls. We studied the difference of Heart rate variability (HRV) between two groups by Independent samples T-test using SPSS for windows(version 17.0). Results: The Standard deviation of all normal R-R intervals (SDNN), The spuare root of the sum of the spuare of difference between adjacent normal R-R intervals (RMS-SD) of PCOS group was non-significantly lower than non-PCOS group. High frequency power (HF) and Normalized high frequency power (HF norm) of PCOS group was significantly higher than non-PCOS group. Normalized low frequency power (LF norm) of PCOS was signficantly lower than non-PCOS group. The results means increased sympathetic and decreased vagal modulation. Total power (TP), Very low frequency power (VLF) of PCOS group was non-significantly lower than non-PCOS group. Low frequency power (LF), LF/HF ratio of PCOS group was non-significantly higher than non-PCOS group. Conclusion: The results suggest that PCOS can be related to decreased activity of parasympathetic nervous system.

• 감성과학
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• 제1권2호
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• pp.13-22
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• 1998

The sense of touch has both objective and subjective characteristics. During hand evaluation of the fabrics. psycho physiological processes such as emotion and stimulation. On other site, the mode of touch (passive vs. active) is also capable to modulate somatosensory responses. I.e., suppress somatocensory perception during active electrocortical responses to passive and active touch of the textiles with different subjective emotional preference. The study was carried out on 36 female college students. Physiological signals were acquired by Grass and BIOPAC 100 systems with AcqKnowledge variables, namely heart rate (HR), respiratory sinus arrhythmia (RSA), pulse transit time (PTT), respiration rate (RSP) and skin conductance parameters (SCL, amplitude, risetime and number of SCRs) were analyzed for baseline and stimulation conditions. Analysis was manifested in a form of moderate HR acceleration. RSP increase, RSA decrease (lowered vagal tone), decreased PTT and increased electrodermal activity (increased SCL, several SCRs) that reflects general sympathetic activation. Parietal EEG effects (on contra-lateral side to stimulated hand)were featured by short-term alpha-blocking, slightly reduced theta, significantly increased delta and enhanced fast beta activity with few variations across stimuli. The main finding of the study was that most and least preferred textures exhibited significant differences in autonomic (HR, RSP, PTT, SCR, and at less extent in RSA and SCL) and electrocortical responses (delta, slow and fast alpha, fast beta relative power). These differences were recorded both in passive and active stimulation modes, thus demonstrating reproducibility of distinction between most and least emotionally preferred tactile stimuli, suggesting influence of psychological factors, such as emotional property of stimulus, on physiological outcome.

• 감성과학
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• 제8권1호
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• pp.29-36
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• 2005

본 연구에서는 관상동맥질환 환자들의 누운 자세가 자율신경계의 균형에 미치는 효과를 알아보고자 하였다. 관상동맥질환군 43명과 통제군 31명을 대상으로 세 가지 자세-똑바로 누운 자세(supine), 왼쪽으로 누운 자세(left), 오른쪽으로 누운 자세(right) -에서의 심박동변이도(HRV)를 측정하였다. HRV 변수들에 대한 분석 결과, 오른쪽으로 누운 자세에서 normalized high-frequency power가 가장 높았고, normalized low-frequency power는 가장 낮았다. 즉, 오른쪽으로 누운 자세에서 심장교감신경계의 활성도를 나타내는 HRV 변수들은 가장 낮은 반면에 심장부교감신경계의 활성도를 나타내는 HRV 변수들은 가장 높은 것으로 나타났다.

• 수면정신생리
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• 제11권2호
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• pp.100-105
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• 2004

목 적：본 연구의 목적은 주요우울장애환자를 대상으로 Heart Rate Variability(HRV) 검사를 이용하여 비침습적으로 자율신경계의 기능, 심혈관조절체계 및 항상성을 측정하여 정상대조군과 비교해보고 생리학적, 임상적 의미를 고찰해보는 것이다. 방 법：DSM-Ⅳ의 진단기준에 의하여 주요우울장애로 진단받은 환자 30명과 정상대조군 30명을 대상으로 하였다. 검사는 SA-2000E 기기를 사용하여 HRV parameter를 측정한 후 시(time) 영역과 주파수(frequency)영역별로 분석하였다. 결 과：Heart rate(HR)는 환자군에서 유의하게 증가된 소견을 나타내었으며 the standard deviation of the NN interval(SDNN), the root square of successive differences(RMSSD)도 환자군에서 유의하게 낮은 소견을 보였다. Total power(TP) band, very low frequency(VLF：$0.003{\sim}0.04\;Hz$) band, low frequency(LF：$0.04{\sim}0.15\;Hz$) band, high frequency(HF：$0.15{\sim}0.4\;Hz$) band는 환자군에서 유의하게 낮은 수치를 보였고, LF/HF의 비는 유의한 차이를 나타내지 않았다. 결 론：우울증 환자는 심박수의 증가와 HRV의 감소를 보였으며, 교감 신경과 미주 신경의 불균형이 높은 심혈관계 사망률과 부분적으로 연관이 있는 것 같다. 우울증 환자들은 심장에서 자율신경기능의 이상을 나타내며 이렇게 교감/부교감 신경활성 조절능력이 저하되어 균형이 깨짐으로써 높은 심혈관계 사망률을 보인다고 할 수 있다.