• 제목/요약/키워드: Vaccination Rate

검색결과 336건 처리시간 0.03초

Improved immune responses and safety of foot-and-mouth disease vaccine containing immunostimulating components in pigs

  • Choi, Joo-Hyung;You, Su-Hwa;Ko, Mi-Kyeong;Jo, Hye Eun;Shin, Sung Ho;Jo, Hyundong;Lee, Min Ja;Kim, Su-Mi;Kim, Byounghan;Lee, Jong-Soo;Park, Jong-Hyeon
    • Journal of Veterinary Science
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    • 제21권5호
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    • pp.74.1-74.13
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    • 2020
  • Background: The quality of a vaccine depends strongly on the effects of the adjuvants applied simultaneously with the antigen in the vaccine. The adjuvants enhance the protective effect of the vaccine against a viral challenge. Conversely, oil-type adjuvants leave oil residue inside the bodies of the injected animals that can produce a local reaction in the muscle. The long-term immunogenicity of mice after vaccination was examined. ISA206 or ISA15 oil adjuvants maintained the best immunity, protective capability, and safety among the oil adjuvants in the experimental group. Objectives: This study screened the adjuvant composites aimed at enhancing foot-and-mouth disease (FMD) immunity. The C-type lectin or toll-like receptor (TLR) agonist showed the most improved protection rate. Methods: Experimental vaccines were fabricated by mixing various known oil adjuvants and composites that can act as immunogenic adjuvants (gel, saponin, and other components) and examined the enhancement effect on the vaccine. Results: The water in oil (W/O) and water in oil in water (W/O/W) adjuvants showed better immune effects than the oil in water (O/W) adjuvants, which have a small volume of oil component. The W/O type left the largest amount of oil residue, followed by W/O/W and O/W types. In the mouse model, intramuscular inoculation showed a better protection rate than subcutaneous inoculation. Moreover, the protective effect was particularly weak in the case of inoculation in fatty tissue. The initial immune reaction and persistence of long-term immunity were also confirmed in an immune reaction on pigs. Conclusions: The new experimental vaccine with immunostimulants produces improved immune responses and safety in pigs than general oil-adjuvanted vaccines.

Protective efficacy of a novel multivalent vaccine in the prevention of diarrhea induced by enterotoxigenic Escherichia coli in a murine model

  • Zhao, Hong;Xu, Yongping;Li, Gen;Liu, Xin;Li, Xiaoyu;Wang, Lili
    • Journal of Veterinary Science
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    • 제23권1호
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    • pp.7.1-7.14
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    • 2022
  • Background: Enterotoxigenic Escherichia coli (ETEC) infection is a primary cause of livestock diarrhea. Therefore, effective vaccines are needed to reduce the incidence of ETEC infection. Objectives: Our study aimed to develop a multivalent ETEC vaccine targeting major virulence factors of ETEC, including enterotoxins and fimbriae. Methods: SLS (STa-LTB-STb) recombinant enterotoxin and fimbriae proteins (F4, F5, F6, F18, and F41) were prepared to develop a multivalent vaccine. A total of 65 mice were immunized subcutaneously by vaccines and phosphate-buffered saline (PBS). The levels of specific immunoglobulin G (IgG) and pro-inflammatory cytokines were determined at 0, 7, 14 and 21 days post-vaccination (dpv). A challenge test with a lethal dose of ETEC was performed, and the survival rate of the mice in each group was recorded. Feces and intestine washes were collected to measure the concentrations of secretory immunoglobulin A (sIgA). Results: Anti-SLS and anti-fimbriae-specific IgG in serums of antigen-vaccinated mice were significantly higher than those of the control group. Immunization with the SLS enterotoxin and multivalent vaccine increased interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) concentrations. Compared to diarrheal symptoms and 100% death of mice in the control group, mice inoculated with the multivalent vaccine showed an 80% survival rate without any symptom of diarrhea, while SLS and fimbriae vaccinated groups showed 60 and 70% survival rates, respectively. Conclusions: Both SLS and fimbriae proteins can serve as vaccine antigens, and the combination of these two antigens can elicit stronger immune responses. The results suggest that the multivalent vaccine can be successfully used for preventing ETEC in important livestock.

독성을 제거한 재조합 리신 백신 개발 및 효능평가 (Development of Non-toxic Recombinant Ricin Vaccine and Evaluation of Vaccine Efficacy)

  • 윤형석;조혜은;송동현;유치호;송영조;허경행
    • 한국군사과학기술학회지
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    • 제27권2호
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    • pp.304-310
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    • 2024
  • Ricin is a highly toxic protein which is produced in the seeds of the castor oil plant. Ricin toxin A chain has ribosomal RNA N-glycosylase activity that irreversibly hydrolyses the N-glycosidic bond of the adenine residue at position 4324 within the 28S rRNA. In this study, we developed non-toxic recombinant ricin vaccine(R51) in E. coli expression system, and evaluated efficacy of the R51 according to adjuvants. When the R51 was administered using aluminum hydroxide as an adjuvant, the vaccine efficacy was higher than that of TLR agonists or aluminum phosphate. Because it is time-consuming to administer the vaccine three times at three-week intervals, we investigated the survival rate and antibody titer of mice according to the change of time interval of vaccination. Interestingly, there was no difference in survival rate and antibody titer when R51 was administered at 0, 1, and 3 weeks or 0, 2, and 4 weeks compared to when administered at 0, 3, and 6 weeks. Therefore, the developed R51 vaccine is promising to protect soldiers from Ricin attack.

Evaluating the knowledge, attitude, perception, and readiness of caregivers of under 5-year-old children to accept malaria vaccine in Nigeria

  • Blessing Nkechi Emmanuel;Abubakar Nuhu Ishaq;Olisaemeka Zikora Akunne;Umar Faruk Saidu
    • Clinical and Experimental Vaccine Research
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    • 제13권2호
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    • pp.121-131
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    • 2024
  • Purpose: The global burden of disease and mortality is greatly influenced by malaria, particularly in children. Nigeria alone accounts for about 25% of global malaria cases and fatalities. Despite efforts to control and eliminate malaria, conventional treatments have limitations, prompting the need for a vaccine. However, while efforts have focused on researching and developing malaria vaccines, less attention has been given to public acceptance and preparedness for vaccination. Materials and Methods: The study employed a cross-sectional approach to assess the knowledge, perceptions, and readiness of caregivers towards the malaria vaccine. Data were collected through a physical and online survey among a representative sample of caregivers across the six geopolitical regions of Nigeria. The data was analyzed using principal component analysis and percentages. Results: Out of 347 respondents, 180 (51%) men, 165 (46.6%) women, 2 (0.5%) transgender, 156 (45%) rural settlers, and 191 (55%) urban settlers were identified in this study. The study reported an overall acceptance rate of 78.4% and 21.6% resistance rate. The age group between 21-30 years recorded the highest 207 (59.6%). A significant number of participants, 252 (59.6%), held at least a higher or post-secondary certificate, out of which 193 (55.6%) demonstrated strong readiness to accept the malaria vaccine. The study showed that fear of adverse effects was the main reason for malaria vaccine resistance among caregivers. Conclusion: This study's findings offer valuable insights into caregivers' knowledge about the malaria vaccine, highlighting the factors that impact the acceptance of the malaria vaccine.

1993년도 성남지역에서 유행한 홍역 환아에서의 홍역 특이 항체 반응 (Response of Measles-specific Antibody in Children with Measles During Measles Epidemic in Seongnam, 1993)

  • 김지연;박윤형;김순기;최연화;이환종;손병관
    • Pediatric Infection and Vaccine
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    • 제4권1호
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    • pp.126-132
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    • 1997
  • 목 적 : 높은 예방접종율에도 불구하고 흥역이 계속 발생하는 것은 1차 백신 실패 또는 2 차 백신 실패 등의 논란을 자아내고 있다. 이에 저자들은 1993년 전국적으로 홍역이 유행하였을 당시 인구 밀집 대도시인 성남지역에서 그 당시 홍역에 이환되었던 일부 소아를 대상으로 특이 혈청학적 검사를 실시하였다. 대상 및 방법 : 1993년 홍역이 유행할 당시 임상진단 기준에 따라서 홍역으로 진단된 초등학교생을 대상으로 학교에 의뢰하여 93년 12월 10일부터 5일간 채혈한 후, 혈청을 분리한 후 $-20^{\circ}C$ 냉장고에 보관한 후 2개월 지나 검사하였다. Behring사의 시약을 사용하여 ELISA(Enzyme linked immunosorbent assay)방법에 의해 혈청내 홍역 특이 IgM 항체 (measles-specific IgM) 및 IgG를 검사하였다. 결 과 : 1) 총 126명 (남녀비=1:1)으로 발병시 연령은 5세 6명, 6세 11명, 7세 20명, 8세 39명, 9세 22명, 10세 11명, 11세 11명, 12세 6명으로 8세 전후에 가장 많은 빈도 보였다. 홍역은 여름에 발생하기 시작한 홍역은 9월부터 증가하기 시작하여 11월에 정점을 이루었다. 2) 홍역환자 126명중 99명(78.6%)에서 MMR접종력이 있었다. MMR접종자 99명 가운데 홍역 특이 IgM 항체에 양성은 80.8%(80/99)에서 관찰되었고, MMR 비접종자 27명 가운데 26명 (96.3%)에서 양성율을 보였다. 3) 홍역 특이 IgG 항체 반응결과 MMR 접종력이 있는 99명 중 90명(90.9%)에서, MMR 비접종군 27명중 23명(85.2%)에서 양성반응을 보였다. 흥역특이 IgG 항체반응은 MMR 접종력이 있는 아동 33명중 30례(90.1%)에서 양성을 보였다. 결 론 : MMR 접종력이 있는 아동의 상당수는 시간에 따른 항체가의 감소로 인해 홍역이 발생하였을 가능성을 배제할 수 없으나, 상당수의 환자가 IgM 항체 양성을 보인 것은 1차 백신 실패가 여전히 중요하다는 것을 의미하는 것으로 생각한다. 이를 확인하기 위해서는 보다 많은 아동을 대상으로 한 연구가 필요할 것으로 생각한다.

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경인 지역 소아의 A형 간염 항체 보유율 (Prevalence of Antibodies to Hepatitis A in the Healthy Children in Inchon-Kyunggi Prefecture)

  • 권영세;홍영진;최연호;김순기;손병관;강문수;배수환;홍광선
    • Pediatric Infection and Vaccine
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    • 제5권2호
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    • pp.239-244
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    • 1998
  • 목 적 : A형 간염은 수년동안 거의 발생 보고가 없었으나 최근 경인지역에서 A형 간염 발생이 증가하였다고 보고되고 있으며, 소아에서도 대전에서 집단 발생이 보고된 바가 있다. 이는 사회경제적으로 발전하고 주거환경이 좋아지면서 소아에서의 A형 간염에 대한 항체 보유율이 낮아진 결과, 감염원에 노출된 연장아와 성인에서 현증 감염이 증가된 것으로 추측된다. 이에 저자들은 경인 지역에서 건강한 소아의 A형 간염 항체 보유율을 조사하여 A형 간염의 역학적 특성을 이해하는데 도움이 되고자 이 연구를 시행하였다. 방 법 : 경인 지역의 l세 76명의 유아와 3세 78명 및 5세 58명의 유아원생과 11세, 13세, 15세, 17세의 초중고생 각각 100명씩을 채혈하였고 혈청을 분리하여 $-80^{\circ}C$에 보관하였다가 Abbott사의 AxSYM$^{(R)}$ HAVAB(Microparticle Enzyme Immunoassay : MEIA)를 이용하여 anti-HAV를 측정하였다. 결 과 : 1) 전부 612명을 검사하였고 남아 316, 여아 296명으로 남녀의 비는 1.1 : 1이었다. 2) 1세군에서는 10.5%(남아 6례, 여아 2 례)에서 anti-HAV가 양성이었고, 3, 5, 11, 13세 군에서는 전부 anti-HAV가 음성이었으며, 15세 군에는 6%(남학생 4례, 여학생 2례)에서 anti-HAV가 양성이었고, 17세 군에서는 11 %(남학생 7례, 여학생 4례)에서 양성이었으며 남녀간의 차이는 없었다. 결 론 : 경인 지역의 유아 및 학동기 소아에서 A형 간염 항체가 거의 형성되어 있지 않으므로 감염자와의 접촉이나 오염된 음식들을 통해 학동기 소아에서의 현증 환자 발생의 위험이 있어, A형 간염에 대한 관심을 가지고 진료에 임하는 것이 필요하며 예방 방법에 대한 지침이 만들어져야 될 것으로 생각된다.

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농촌(農村) 주민(住民)들의 의료필요도(醫療必要度)에 관(關)한 연구(硏究) (A Study Concerning Health Needs in Rural Korea)

  • 이성관;김두희;정종학;정극수;박상빈;최정헌;홍순호;라진훈
    • Journal of Preventive Medicine and Public Health
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    • 제7권1호
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    • pp.29-94
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    • 1974
  • Today most developed countries provide modern medical care for most of the population. The rural area is the more neglected area in the medical and health field. In public health, the philosophy is that medical care for in maintenance of health is a basic right of man; it should not be discriminated against racial, environmental or financial situations. The deficiency of the medical care system, cultural bias, economic development, and ignorance of the residents about health care brought about the shortage of medical personnel and facilities on the rural areas. Moreover, medical students and physicians have been taught less about rural health care than about urban health care. Medical care, therefore, is insufficient in terms of health care personnel/and facilities in rural areas. Under such a situation, there is growing concern about the health problems among the rural population. The findings presented in this report are useful measures of the major health problems and even more important, as a guide to planning for improved medical care systems. It is hoped that findings from this study will be useful to those responsible for improving the delivery of health service for the rural population. Objectives: -to determine the health status of the residents in the rural areas. -to assess the rural population's needs in terms of health and medical care. -to make recommendations concerning improvement in the delivery of health and medical care for the rural population. Procedures: For the sampling design, the ideal would be to sample according to the proportion of the composition age-groups. As the health problems would be different by group, the sample was divided into 10 different age-groups. If the sample were allocated by proportion of composition of each age group, some age groups would be too small to estimate the health problem. The sample size of each age-group population was 100 people/age-groups. Personal interviews were conducted by specially trained medical students. The interviews dealt at length with current health status, medical care problems, utilization of medical services, medical cost paid for medical care and attitudes toward health. In addition, more information was gained from the public health field, including environmental sanitation, maternal and child health, family planning, tuberculosis control, and dental health. The sample Sample size was one fourth of total population: 1,438 The aged 10-14 years showed the largest number of 254 and the aged under one year was the smallest number of 81. Participation in examination Examination sessions usually were held in the morning every Tuesday, Wenesday, and Thursday for 3 hours at each session at the Namchun Health station. In general, the rate of participation in medical examination was low especially in ages between 10-19 years old. The highest rate of participation among are groups was the under one year age-group by 100 percent. The lowest use rate as low as 3% of those in the age-groups 10-19 years who are attending junior and senior high school in Taegu city so the time was not convenient for them to recieve examinations. Among the over 20 years old group, the rate of participation of female was higher than that of males. The results are as follows: A. Publie health problems Population: The number of pre-school age group who required child health was 724, among them infants numbered 96. Number of eligible women aged 15-44 years was 1,279, and women with husband who need maternal health numbered 700. The age-group of 65 years or older was 201 needed more health care and 65 of them had disabilities. (Table 2). Environmental sanitation: Seventy-nine percent of the residents relied upon well water as a primary source of dringking water. Ninety-three percent of the drinking water supply was rated as unfited quality for drinking. More than 90% of latrines were unhygienic, in structure design and sanitation (Table 15). Maternal and child health: Maternal health Average number of pregnancies of eligible women was 4 times. There was almost no pre- and post-natal care. Pregnancy wastage Still births was 33 per 1,000 live births. Spontaneous abortion was 156 per 1,000 live births. Induced abortion was 137 per 1,000 live births. Delivery condition More than 90 percent of deliveries were conducted at home. Attendants at last delivery were laymen by 76% and delivery without attendants was 14%. The rate of non-sterilized scissors as an instrument used to cut the umbilical cord was as high as 54% and of sickles was 14%. The rate of difficult delivery counted for 3%. Maternal death rate estimates about 35 per 10,000 live births. Child health Consultation rate for child health was almost non existant. In general, vaccination rate of children was low; vaccination rates for children aged 0-5 years with BCG and small pox were 34 and 28 percent respectively. The rate of vaccination with DPT and Polio were 23 and 25% respectively but the rate of the complete three injections were as low as 5 and 3% respectively. The number of dead children was 280 per 1,000 living children. Infants death rate was 45 per 1,000 live births (Table 16), Family planning: Approval rate of married women for family planning was as high as 86%. The rate of experiences of contraception in the past was 51%. The current rate of contraception was 37%. Willingness to use contraception in the future was as high as 86% (Table 17). Tuberculosis control: Number of registration patients at the health center currently was 25. The number indicates one eighth of estimate number of tuberculosis in the area. Number of discharged cases in the past accounted for 79 which showed 50% of active cases when discharged time. Rate of complete treatment among reasons of discharge in the past as low as 28%. There needs to be a follow up observation of the discharged cases (Table 18). Dental problems: More than 50% of the total population have at least one or more dental problems. (Table 19) B. Medical care problems Incidence rate: 1. In one month Incidence rate of medical care problems during one month was 19.6 percent. Among these health problems which required rest at home were 11.8 percent. The estimated number of patients in the total population is 1,206. The health problems reported most frequently in interviews during one month are: GI trouble, respiratory disease, neuralgia, skin disease, and communicable disease-in that order, The rate of health problems by age groups was highest in the 1-4 age group and in the 60 years or over age group, the lowest rate was the 10-14 year age group. In general, 0-29 year age group except the 1-4 year age group was low incidence rate. After 30 years old the rate of health problems increases gradually with aging. Eighty-three percent of health problems that occured during one month were solved by primary medical care procedures. Seventeen percent of health problems needed secondary care. Days rested at home because of illness during one month were 0.7 days per interviewee and 8days per patient and it accounts for 2,161 days for the total productive population in the area. (Table 20) 2. In a year The incidence rate of medical care problems during a year was 74.8%, among them health problems which required rest at home was 37 percent. Estimated number of patients in the total population during a year was 4,600. The health problems that occured most frequently among the interviewees during a year were: Cold (30%), GI trouble (18), respiratory disease (11), anemia (10), diarrhea (10), neuralgia (10), parasite disease (9), ENT (7), skin (7), headache (7), trauma (4), communicable disease (3), and circulatory disease (3) -in that order. The rate of health problems by age groups was highest in the infants group, thereafter the rate decreased gradually until the age 15-19 year age group which showed the lowest, and then the rate increased gradually with aging. Eighty-seven percent of health problems during a year were solved by primary medical care. Thirteen percent of them needed secondary medical care procedures. Days rested at home because of illness during a year were 16 days per interviewee and 44 days per patient and it accounted for 57,335 days lost among productive age group in the area (Table 21). Among those given medical examination, the conditions observed most frequently were respiratory disease, GI trouble, parasite disease, neuralgia, skin disease, trauma, tuberculosis, anemia, chronic obstructive lung disease, eye disorders-in that order (Table 22). The main health problems required secondary medical care are as fellows: (previous page). Utilization of medical care (treatment) The rate of treatment by various medical facilities for all health problems during one month was 73 percent. The rate of receiving of medical care of those who have health problems which required rest at home was 52% while the rate of those who have health problems which did not required rest was 61 percent (Table 23). The rate of receiving of medical care for all health problems during a year was 67 percent. The rate of receiving of medical care of those who have health problems which required rest at home was 82 percent while the rate of those who have health problems which did not required rest was as low as 53 percent (Table 24). Types of medical facilitied used were as follows: Hospital and clinics: 32-35% Herb clinics: 9-10% Drugstore: 53-58% Hospitalization Rate of hospitalization was 1.7% and the estimate number of hospitalizations among the total population during a year will be 107 persons (Table 25). Medical cost: Average medical cost per person during one month and a year were 171 and 2,800 won respectively. Average medical cost per patient during one month and a year were 1,109 and 3,740 won respectively. Average cost per household during a year was 15,800 won (Table 26, 27). Solution measures for health and medical care problems in rural area: A. Health problems which could be solved by paramedical workers such as nurses, midwives and aid nurses etc. are as follows: 1. Improvement of environmental sanitation 2. MCH except medical care problems 3. Family planning except surgical intervention 4. Tuberculosis control except diagnosis and prescription 5. Dental care except operational intervention 6. Health education for residents for improvement of utilization of medical facilities and early diagnosis etc. B. Medical care problems 1. Eighty-five percent of health problems could be solved by primary care procedures by general practitioners. 2. Fifteen percent of health problems need secondary medical procedures by a specialist. C. Medical cost Concidering the economic situation in rural area the amount of 2,062 won per residents during a year will be burdensome, so financial assistance is needed gorvernment to solve health and medical care problems for rural people.

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국내 산란계의 주요 바이러스성 질병에 대한 혈청학적 모니터링 결과 및 분석 (Serological Survey for the Major Viral Diseases in the Layers)

  • 이혜림;김종만;김진형;김창문;소현희;이동우;하봉도;홍성철;모인필
    • 한국가금학회지
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    • 제37권4호
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    • pp.361-372
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    • 2010
  • 본 연구에서는 충북대학교 조류질병학실험실에 2009년 한 해동안 의뢰된 산란계의 혈청 검사 결과에 대해 분석하여, 산란계의 주요 질병에 대한 국내 산란계의 면역 상태 및 질병 감염 실태를 파악하였다. 검사 대상 질병은 AI, ND, IB, aMPV, EDS'76, IBD, CIA이었으며, 산란계의 성장 단계에 따라 주령 구간을 나누어 분석하였다. AI, ND, IB는 모체 이행항체가 감소한 후 산란 기간에 걸쳐 혈청 역가가 안정적으로 형성되는 특징을 보여 주었다. 그러나 AI는 모든 주령 구간에 걸쳐 음성인 계군이 존재하는 반면, ND는 3~10 주령 구간의 한 음성 계군을 제외하고 전 주령에 걸쳐 100%의 계군 양성률을 보이고, ND의 평균 GMT가 AI의 평균 GMT보다 높았는데, 이는 두 질병의 백신 정책의 차이에 기인한 것이다. IB의 산란기의 안정적인 역가는 백신 역가에 산란기 전반에 걸친 야외 감염 개체의 존재로 인한 야외 감염 역가가 더해진 것으로 판단된다. aMPV는 2009년에 백신을 실시하지 않았던 질병이므로, 양성 역가를 통해 aMPV의 야외 감염을 추적할 수 있었으며, GMT 변화 및 계군 내양성 개체율의 증가 경향을 통해 일령이 증가할수록 야외 감염률이 증가하는 양상을 파악할 수 있었다. EDS'76은 산란 기간에 걸쳐 높은 양성률과 낮은 변이계수를 보여 야외 감염이 아닌 백신에 의한 역가 형성이 대부분임을 알 수 있었다. IBD의 모체이행항체는 높은 수준으로 이행되는 것을 확인하였으며, CIA는 백신을 적용하지 않은 계군에서 양성과 음성 계군이 모두 존재하였으며, 그 차이는 차단 방역에 기인하는 것으로 판단되었다. 본 연구를 통하여 국내 산란계에서의 혈청 역가 분포를 파악하는데 많은 정보를 얻을수 있었으나, 향후 지속적인 야외 계군의 혈청학적 모니터링이 되어야 할 것으로 판단된다.

유전자 재조합 B형간염 백신의 10세이하 소아에서의 면역원성 및 안전성 (Immunogenicity and Safety of Recombinant Hepatitis B Vaccine(HG-IIR) in Healthy Infants and Children)

  • 김명아;최은하;장미숙;동은실;장성희;안영민;윤희상;손영모
    • Pediatric Infection and Vaccine
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    • 제4권1호
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    • pp.106-115
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    • 1997
  • 목 적 : B형 간염 바이러스 보균자가 많은 우리 나라에서는 모든 신생아에게 B형 간염에 대한 능동면역이 시행되고 있다. 혈장 백신은 공급원에 한계가 있고 전염성 질환이 전파될 가능성이 있으며 값이 비싸다는 문제점이 있어 이와는 다른 유전자 재조합 공법으로 생산된 HG-II$^{(R)}$백신의 면역원성과 안전성을 조사하고 BCG 선행군과 그렇지 않은 군에서의 면역원성을 비교하고자 본 연구를 시행하였다. 방 법 : 1995년 4월부터 1996년 6월까지 경상대학병원(Group A), 지방공사 강남병원 (Group B)과 영동 세브란스병원(Group C)에서 10세이하의 소아를 대상으로 하여 유전자 재조합 B형간염 백신(HG-II$^{(R)}$)$10{\mu}g$의 양을 0, 1, 6개월 접종 방식으로 3회 근주 하였다. 4군는 BCG를 간염 2차 접종하기 1주전에, B군은 1주후에 접종하였다. C군에서는 두가지 예방접종의 선후관계를 알 수 없었다. 3회 접종후 1개월에 채혈하여 anti-HBs Ab를 측정하였으며 부작용을 조사하였다. 결 과 : 1) 총 114례중 신생아는 104례였으며 이 중 55례는 간염 2차 접종하기 1주전에 BCG를 접종하였고 43례는 간염 2차 접종후에 BCG를 접종하였으며, 6례는 선후관계를 알 수 없었다. 2) 항체양전율은 99.1%였고 기하 평균 항체가는 131.2mIU/ml였다. 3) BCG를 간염 2차 접종하기 1주전에 접종한 군과 1주후에 접종한 군에서의 기하 평균 항체 가는 각각 105.5mIU/ml, 162.8mIU/ml였다(p<0.025). 4) 부작용은 국소 반응이 1.4%, 전신 반응이 7.8%였다. 결 론 : 유전자 재조합 간염 백신은 부작용이 적고 면역원성이 우수하였다. 간염 2차 접종 전에 BCG를 접종한 군에서의 기하 평균 항체가가 낮게 관찰된 바 향후 이에 대한 연구가 더 필요할 것으로 사료된다.

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2013년 경기 북부 한 병원에서 확인된 소규모 홍역 유행 (A Small Outbreak of Measles in 2013: In a Single Hospital in Northern Gyeonggi-do)

  • 김민재;김소현;김성언;장미진;이현승;김영훈;한지환;김진택;장필상
    • Pediatric Infection and Vaccine
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    • 제22권2호
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    • pp.63-68
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    • 2015
  • 목적: 저자들은 2013년 경기 북부의 한 병원에서 경험한 소규모 홍역 유행의 양상을 알아보기 위해 본 연구를 시행하였다. 방법: 2013년 8월부터 10월까지 가톨릭대학교 의정부성모병원에서 홍역으로 확진된 환아 15명의 의무기록을 후향적으로 분석하였다. 결과: 홍역으로 진단된 환아는 모두 15명으로, 신생아 1명, 영아 11명, 유아 3명이었으며 역전사 중합 효소연쇄반응법(RT-PCR)과 혈청 내 홍역 IgM 검사로 확진하였다. 모든 환아는 Measles-Mumps-Rubella (MMR) 접종을 받지 않았다. 홍역으로 확진된 환아의 바이러스 유전형은 모두 B3이었다. 9명(60%)의 환아가 원내 감염에 의해 홍역에 걸렸다. 잠복기는 8-15일이었고 발열은 접촉 후 평균 10일째 발생하여 평균 8일 동안 39도 이상으로 지속되는 양상을 보였다. 발진은 접촉 후 평균 13일째 발생하였다. 40%의 환아가 호흡기 합병증을 보였고 53%의 환아가 설사를 동반하였다. 결론: 우리나라는 꾸준한 접종 사업을 통해 홍역 퇴치 수준에 이르게 되었지만 홍역 재유행, 특히 영아에 대한 위험성을 간과할 수 없게 되었다. 영유아에서 홍역이 의심될 때에는 가속접종, 면역글로불린 투여와 같은 처치를 적극적으로 시행하는 것이 필요하다. 향후 홍역 유행을 막기 위한 첫 번째 단계로, 신생아, 영아, 가임기 여성의 홍역 IgG 항체가 재조사가 필요할 것으로 사료된다.