• Korean Journal of Veterinary Research
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• v.51 no.1
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• pp.37-46
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• 2011

Infectious bursal disease virus (IBDV) is a member of the Avibirnavirus genus of the Birnaviridae family which genome consists of two segments (A and B) of double stranded RNA. Segment A gene of KNU08010 isolate, which was isolated from a 15-day-old chicken flock in 2008, was sequenced and compared with other IBDV isolates including SH/92 strain, the first Korean very virulent (vv) IBDV isolate. The amino acid sequences of segment A gene showed that KNU08010 had 99.2% homology with SH92 strain. KNU08010 isolate had specific amino acids A222, I242, I256, I294 and S299 which are highly conserved among vvIBDV strains. Phylogenetic analysis based on the nucleotide sequences of variable region of the VP2 gene of 18 IBDV strains revealed that KNU08010 was grouped with vvIBDVs and was closely related to Korean vvIBDVs isolated from wild birds.

• Journal of KIISE
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• v.42 no.11
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• pp.1452-1458
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• 2015

Korean Morphological Analysis is a difficult process. Because Korean is an agglutinative language, one of the most important processes in Morphological Analysis is Morpheme Recovery. There are some methods using Heuristic rules and Pre-Analyzed Partial Words that were examined for this process. These methods have performance limits as a result of not using contextual information. In this study, we built a Korean morpheme recovery system using deep learning, and this system used word embedding for the utilization of contextual information. In '들/VV' and '듣/VV' morpheme recovery, the system showed 97.97% accuracy, a better performance than with SVM(Support Vector Machine) which showed 96.22% accuracy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.42-48
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• 2021

Recently, the defense industry has been improving high technology by developing convergence technology through the 4th industrial revolution. On the other hand, it is very difficult to guarantee the performance of high-tech weapon systems because the test for weapon systems has many risks and cannot perform in an actual operating environment. Therefore, M&S resources are needed to make sound weapon systems, but many people demand reliable M&S resources. Owing to the continuous demand and execution of the VV&A work, related rules have developed significantly, but tools and techniques for performing the work have not been developed. Hence, there are inefficient parts in the performance of work due to the absence of a systematic system. Accordingly, many risks may cause various safety accidents, such as security. This paper suggests a direction for the development of VV&A work procedures by improving efficiency and reducing risk.

• Molecules and Cells
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• v.41 no.4
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• pp.301-310
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• 2018

LysR-type transcriptional regulators (LTTRs) contain an N-terminal DNA binding domain (DBD) and a C-terminal regulatory domain (RD). Typically, LTTRs function as homotetramers. VV2_1132 was identified in Vibrio vulnificus as an LTTR that is a homologue of HypT (also known as YjiE or QseD) in Escherichia coli. In this study, we determined the crystal structure of full-length VV2_1132 at a resolution of $2.2{\AA}$, thereby revealing a novel combination of the domains in the tetrameric assembly. Only one DBD dimer in the tetramer can bind to DNA, because the DNA binding motifs of the other DBD dimer are completely buried in the tetrameric assembly. Structural and functional analyses of VV2_1132 suggest that it might not perform the same role as E. coli HypT, indicating that further study is required to elucidate the function of this gene in V. vulnificus. The unique structure of VV2_1132 extends our knowledge of LTTR function and mechanisms of action.

• IMMUNE NETWORK
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• v.16 no.4
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• pp.233-241
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• 2016

DCs, like the sensory neurons, express vanilloid receptor 1 (VR1). Here we demonstrate that the VR1 agonists, capsaicin (CP) and resiniferatoxin (RTX), enhance antiviral CTL responses by increasing MHC class I-restricted viral antigen presentation in dendritic cells (DCs). Bone marrow-derived DCs (BM-DCs) were infected with a recombinant vaccinia virus (VV) expressing OVA (VV-OVA), and then treated with CP or RTX. Both CP and RTX increased MHC class I-restricted presentation of virus-encoded endogenous OVA in BM-DCs. Oral administration of CP or RTX significantly increased MHC class I-restricted OVA presentation by splenic and lymph node DCs in VV-OVA-infected mice, as assessed by directly measuring OVA peptide SIINFEKL-K^b complexes on the cell surface and by performing functional assays using OVA-specific CD8 T cells. Accordingly, oral administration of CP or RTX elicited potent OVA-specific CTL activity in VV-OVA-infected mice. The results from this study demonstrate that VR1 agonists enhance anti-viral CTL responses, as well as a neuro-immune connection in anti-viral immune responses.

• IMMUNE NETWORK
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• v.11 no.5
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• pp.268-280
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• 2011

Background: Dengue virus, which belongs to the Flavivirus genus of the Flaviviridae family, causes fatal dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) with infection risk of 2.5 billion people worldwide. However, approved vaccines are still not available. Here, we explored the immune responses induced by alternating prime-boost vaccination using DNA vaccine, adenovirus, and vaccinia virus expressing E protein of dengue virus type 2 (DenV2). Methods: Following immunization with DNA vaccine (pDE), adenovirus (rAd-E), and/or vaccinia virus (VV-E) expressing E protein, E protein-specific IgG and its isotypes were determined by conventional ELISA. Intracellular CD154 and cytokine staining was used for enumerating CD4+ T cells specific for E protein. E protein-specific CD8+ T cell responses were evaluated by in vivo CTL killing activity and intracellular IFN-${\gamma}$ staining. Results: Among three constructs, VV-E induced the most potent IgG responses, Th1-type cytokine production by stimulated CD4+ T cells, and the CD8+ T cell response. Furthermore, when the three constructs were used for alternating prime-boost vaccination, the results revealed a different pattern of CD4+ and CD8+ T cell responses. i) Priming with VV-E induced higher E-specific IgG level but it was decreased rapidly. ii) Strong CD8+ T cell responses specific for E protein were induced when VV-E was used for the priming step, and such CD8+ T cell responses were significantly boosted with pDE. iii) Priming with rAd-E induced stronger CD4+ T cell responses which subsequently boosted with pDE to a greater extent than VV-E and rAd-E. Conclusion: These results indicate that priming with live viral vector vaccines could induce different patterns of E protein-specific CD4+ and CD8+ T cell responses which were significantly enhanced by booster vaccination with the DNA vaccine. Therefore, our observation will provide valuable information for the establishment of optimal prime-boost vaccination against DenV.

• Korean Journal of Remote Sensing
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• v.23 no.6
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• pp.501-506
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• 2007

Basic research is conducted to identify a target using corner reflectors which are commonly used in calibration of synthetic aperture radar (SAR) systems. At first, an omni-directional reflector is fabricated by combining four 15-cm rectangular trihedral corner reflectors. Then, its radar cross section (RCS) characteristics are measured at C-band (5.3 GHz) for vv-, hh-, hv-, and vh- polarizations at a range of horizontal angle, $-90^{\circ}{\le}{\phi}{\le}90^{\circ}$. The measured RCS angular variation of the omni-directional reflector is much smaller for vv-polarization than other polarizations, and the difference between the maximum and minimum RCSs for vv-polarization is about 8 dB. Peak RCS values are shown at $0^{\circ}$ (normal to plates) and $45^{\circ}$ (direction of bore sight). It is shown that the measurements agree quite well with numerical simulation and theoretical computation results.

• Bulletin of the Korean Space Science Society
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• 1992.10a
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• pp.14-14
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• 1992

The IUE archival spectra of VV Cephei were collected to investigate the eclipse nature in the ultraviolet. The temperature of the B star has been determined, as approximately30,OOOK, based en the flux distributions durstributions during egress, Light curves of VV Cephei were reduced from the spectrophotometry of the IUE archival spectra. Three light curves at the center wavelengths of 2350A,2550A and :!850A have been analyzed by the modified Wilson and Oevinney light curve program. the radii of the B star and M star were deduced to 0.05 and 0.22 of uint separation, respectively. The UV light curves show anevidence that the light was attenuated by the highly opaque atmosphere of the M star

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.44-46
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• 2003

In 1996, Thailand's participation in the Pacific Rim as a part of NASA's Mission to Planet Earth (MTPE) Program, was titled 'AIRSAR Thailand Project'. In this project the Department of Land Development utilized Topographic SAR (TOPSAR) which had multi-frequencies: C band, L band, and P band with multi-polarization: HH, VV, and HV as well as C band VV DEM. Satellite data such as LANDSAT TM was also utilized for optimal use. Results of AIRSAR image processing including data fusion among difference wavelength bands and polarization revealed the quality of AIRSAR that best suit for detection of agricultural land uses. The HH-L band AIRSAR was proven to be useful to distinguish among crop types when combined with appropriate data. The HH, VV, and HV-P band enhanced surface characteristics of swamp forest and wetland. In addition, TOPSAR has its great advantage for identification of salt farms and shrimp ponds.

• Journal of the Korea Safety Management & Science
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• v.16 no.4
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• pp.123-131
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• 2014

Modern weapon systems are getting more complex in terms of the functionality and also the conditions on the environment and range in which they are deployed and used. Therefore, many development programs can easily be exposed to a variety of risks, resulting in delayed schedules and cost overrun. As such, effective means are necessary to keep the defence budget at an affordable level while competitive edges on technological aspects are retained. As one way to meet those need, modeling and simulation (M&S) methods have widely been used, particularly in the test and evaluation (T&E) process for weapon systems development. The result of M&S-based systems development should be evaluated by the verification, validation & accreditation (VV&A) process to assure keeping reliability at a desired level. On the other hand, due to the explosiveness, the weapons systems development naturally requires to consider safety issues in both the T&E and operational periods. The purpose of this paper is to improve the VV&A process by reflecting the safety requirements therein. To do so, the VV&A process has been analyzed and graphically modeled first and then safety elements have been incorporated effectively. The use of the improved process in the war ships development has also been discussed. Based on the process proposed and the consequent database constructed, the target system can be expected to benefit from reducing development risks while assuring systems safety.