• 대한수의학회지
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• 제51권1호
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• pp.37-46
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• 2011

Infectious bursal disease virus (IBDV) is a member of the Avibirnavirus genus of the Birnaviridae family which genome consists of two segments (A and B) of double stranded RNA. Segment A gene of KNU08010 isolate, which was isolated from a 15-day-old chicken flock in 2008, was sequenced and compared with other IBDV isolates including SH/92 strain, the first Korean very virulent (vv) IBDV isolate. The amino acid sequences of segment A gene showed that KNU08010 had 99.2% homology with SH92 strain. KNU08010 isolate had specific amino acids A222, I242, I256, I294 and S299 which are highly conserved among vvIBDV strains. Phylogenetic analysis based on the nucleotide sequences of variable region of the VP2 gene of 18 IBDV strains revealed that KNU08010 was grouped with vvIBDVs and was closely related to Korean vvIBDVs isolated from wild birds.

• 정보과학회 논문지
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• 제42권11호
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• pp.1452-1458
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• 2015

한국어 형태소 분석은 교착어 특성상 난이도가 높은 작업이다. 그 중에서 형태소의 원형 복원 작업은 규칙이나 기분석 사전 정보 등을 활용하는 방법이 주로 연구되었다. 그러나 이러한 방법들은 어휘 수준의 문맥 정보를 보지 못하기 때문에 원형 복원에 한계가 있다. 본 논문에서는 최근 자연어처리에 연구되고 있는 기계학습 방법인 딥 러닝(deep learning)을 사용하여 형태소의 원형 복원 문제의 해결을 시도하였다. 문맥 정보를 보기 위해 단어 표현(word embedding)을 사용하여 기존의 방법들 보다 높은 성능을 보였다. 실험 결과, '들/VV'과 '듣/VV'의 복원 문제에 대해서 97.97%로 기존의 자연어처리에 쓰이는 기계학습 방법 중 하나인 SVM(Support Vector Machine)의 96.22% 보다 1.75% 높은 성능을 보였다.

• 한국산학기술학회논문지
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• 제22권4호
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• pp.42-48
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• 2021

최근 4차산업혁명을 통해 융합 기술이 발달하면서, 국방 분야에서도 이러한 흐름을 바탕으로 무기체계의 첨단화, 고도화 등을 모색하고 있다. 하지만 첨단 기술을 바탕으로 개발되는 무기체계의 성능시험은 여러 변수들이 존재하며, 실제 운용환경에서 시험을 수행하기에 많은 어려움이 따른다. 이러한 문제점을 극복하기 위한 방안으로 M&S 자원을 적극 활용하여 그 성능을 입증하고 있으나, 사용 중인 M&S 자원의 신뢰성을 보증할 수 있는 수단을 추가로 요구하고 있다. 이에 따라 위한 VV&A 업무 수행을 통해 M&S 자원의 신뢰성을 확보하고 있다. VV&A 업무의 지속적인 요구와 수행으로 인해 관련 제도 등은 많은 발전이 이루어졌지만, 업무 수행을 위한 도구나 기법 등은 제도에 맞추어 발전하지 못하여 업무 수행에 있어 비효율적인 부분이 존재하며, 체계적인 시스템의 부재로 인하여 보안 등 여러 안전사고가 발생할 수 있는 위험성을 다수 내포하고 있다. 본 논문에서는 수행중인 국방M&S VV&A 업무의 문제점 분석을 통해 보다 효율적이고 안전한 방법을 모색하고, 이를 기반으로 업무의 발전방향을 제시하고자 한다.

• Molecules and Cells
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• 제41권4호
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• pp.301-310
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• 2018

LysR-type transcriptional regulators (LTTRs) contain an N-terminal DNA binding domain (DBD) and a C-terminal regulatory domain (RD). Typically, LTTRs function as homotetramers. VV2_1132 was identified in Vibrio vulnificus as an LTTR that is a homologue of HypT (also known as YjiE or QseD) in Escherichia coli. In this study, we determined the crystal structure of full-length VV2_1132 at a resolution of $2.2{\AA}$, thereby revealing a novel combination of the domains in the tetrameric assembly. Only one DBD dimer in the tetramer can bind to DNA, because the DNA binding motifs of the other DBD dimer are completely buried in the tetrameric assembly. Structural and functional analyses of VV2_1132 suggest that it might not perform the same role as E. coli HypT, indicating that further study is required to elucidate the function of this gene in V. vulnificus. The unique structure of VV2_1132 extends our knowledge of LTTR function and mechanisms of action.

• IMMUNE NETWORK
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• 제16권4호
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• pp.233-241
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• 2016

DCs, like the sensory neurons, express vanilloid receptor 1 (VR1). Here we demonstrate that the VR1 agonists, capsaicin (CP) and resiniferatoxin (RTX), enhance antiviral CTL responses by increasing MHC class I-restricted viral antigen presentation in dendritic cells (DCs). Bone marrow-derived DCs (BM-DCs) were infected with a recombinant vaccinia virus (VV) expressing OVA (VV-OVA), and then treated with CP or RTX. Both CP and RTX increased MHC class I-restricted presentation of virus-encoded endogenous OVA in BM-DCs. Oral administration of CP or RTX significantly increased MHC class I-restricted OVA presentation by splenic and lymph node DCs in VV-OVA-infected mice, as assessed by directly measuring OVA peptide SIINFEKL-K^b complexes on the cell surface and by performing functional assays using OVA-specific CD8 T cells. Accordingly, oral administration of CP or RTX elicited potent OVA-specific CTL activity in VV-OVA-infected mice. The results from this study demonstrate that VR1 agonists enhance anti-viral CTL responses, as well as a neuro-immune connection in anti-viral immune responses.

• IMMUNE NETWORK
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• 제11권5호
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• pp.268-280
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• 2011

Background: Dengue virus, which belongs to the Flavivirus genus of the Flaviviridae family, causes fatal dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) with infection risk of 2.5 billion people worldwide. However, approved vaccines are still not available. Here, we explored the immune responses induced by alternating prime-boost vaccination using DNA vaccine, adenovirus, and vaccinia virus expressing E protein of dengue virus type 2 (DenV2). Methods: Following immunization with DNA vaccine (pDE), adenovirus (rAd-E), and/or vaccinia virus (VV-E) expressing E protein, E protein-specific IgG and its isotypes were determined by conventional ELISA. Intracellular CD154 and cytokine staining was used for enumerating CD4+ T cells specific for E protein. E protein-specific CD8+ T cell responses were evaluated by in vivo CTL killing activity and intracellular IFN-${\gamma}$ staining. Results: Among three constructs, VV-E induced the most potent IgG responses, Th1-type cytokine production by stimulated CD4+ T cells, and the CD8+ T cell response. Furthermore, when the three constructs were used for alternating prime-boost vaccination, the results revealed a different pattern of CD4+ and CD8+ T cell responses. i) Priming with VV-E induced higher E-specific IgG level but it was decreased rapidly. ii) Strong CD8+ T cell responses specific for E protein were induced when VV-E was used for the priming step, and such CD8+ T cell responses were significantly boosted with pDE. iii) Priming with rAd-E induced stronger CD4+ T cell responses which subsequently boosted with pDE to a greater extent than VV-E and rAd-E. Conclusion: These results indicate that priming with live viral vector vaccines could induce different patterns of E protein-specific CD4+ and CD8+ T cell responses which were significantly enhanced by booster vaccination with the DNA vaccine. Therefore, our observation will provide valuable information for the establishment of optimal prime-boost vaccination against DenV.

• 대한원격탐사학회지
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• 제23권6호
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• pp.501-506
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• 2007

본 연구에서는 합성개구레이더(synthetic aperture radar, SAR) 영상의 보정에 사용되고 있는 반사기(corner reflector, CR)를 이용하여 목표물의 식별과 인식을 위한 기초적인 연구를 실시하였다. 사각형 삼면 전파반사기를 기반으로 전방향(omni-directional) 반사기를 제작하였다. 여기서는 한 변의 길이가 15cm인 4-배열 사각형 삼면 전파반사기를 사용하여 C-밴드(주파수: 5.3 GHz) 의 편파별(VV, HH, VH, HV) RCS(radar cross section)특성을 해석하였다. 전파반사기는 대칭형이므로 방위각 180도 범위에 대해서 레이더 산란단면적 패턴을 측정하였다. VV편파의 경우, 방위각에 따른 RCS값의 차이가 8dB정도로 다른 편파보다 전방향 특성이 더 좋은 것으로 확인되었고, 방위각이 $0^{\circ}$ (단면과 동일 방향)와 $45^{\circ}$ (이웃하는 단면들의 중앙) 일 때, 가장 높은 RCS값을 보였다. 또한, 실험에서 얻어진 RCS값을 수치 해석 시뮬레이션과 이론적 계산과 비교를 실시한 결과, 서로 잘 일치하는 것으로 나왔다.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 1992년도 한국우주과학회보 제1권1호
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• pp.14-14
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• 1992

The IUE archival spectra of VV Cephei were collected to investigate the eclipse nature in the ultraviolet. The temperature of the B star has been determined, as approximately30,OOOK, based en the flux distributions durstributions during egress, Light curves of VV Cephei were reduced from the spectrophotometry of the IUE archival spectra. Three light curves at the center wavelengths of 2350A,2550A and :!850A have been analyzed by the modified Wilson and Oevinney light curve program. the radii of the B star and M star were deduced to 0.05 and 0.22 of uint separation, respectively. The UV light curves show anevidence that the light was attenuated by the highly opaque atmosphere of the M star

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.44-46
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• 2003

In 1996, Thailand's participation in the Pacific Rim as a part of NASA's Mission to Planet Earth (MTPE) Program, was titled 'AIRSAR Thailand Project'. In this project the Department of Land Development utilized Topographic SAR (TOPSAR) which had multi-frequencies: C band, L band, and P band with multi-polarization: HH, VV, and HV as well as C band VV DEM. Satellite data such as LANDSAT TM was also utilized for optimal use. Results of AIRSAR image processing including data fusion among difference wavelength bands and polarization revealed the quality of AIRSAR that best suit for detection of agricultural land uses. The HH-L band AIRSAR was proven to be useful to distinguish among crop types when combined with appropriate data. The HH, VV, and HV-P band enhanced surface characteristics of swamp forest and wetland. In addition, TOPSAR has its great advantage for identification of salt farms and shrimp ponds.

• 대한안전경영과학회지
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• 제16권4호
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• pp.123-131
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• 2014

Modern weapon systems are getting more complex in terms of the functionality and also the conditions on the environment and range in which they are deployed and used. Therefore, many development programs can easily be exposed to a variety of risks, resulting in delayed schedules and cost overrun. As such, effective means are necessary to keep the defence budget at an affordable level while competitive edges on technological aspects are retained. As one way to meet those need, modeling and simulation (M&S) methods have widely been used, particularly in the test and evaluation (T&E) process for weapon systems development. The result of M&S-based systems development should be evaluated by the verification, validation & accreditation (VV&A) process to assure keeping reliability at a desired level. On the other hand, due to the explosiveness, the weapons systems development naturally requires to consider safety issues in both the T&E and operational periods. The purpose of this paper is to improve the VV&A process by reflecting the safety requirements therein. To do so, the VV&A process has been analyzed and graphically modeled first and then safety elements have been incorporated effectively. The use of the improved process in the war ships development has also been discussed. Based on the process proposed and the consequent database constructed, the target system can be expected to benefit from reducing development risks while assuring systems safety.