• Korean Journal of Biological Psychiatry
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• v.15 no.2
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• pp.118-125
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• 2008

Objectives : The purpose of this study was to find brain regions in which gray matter volume was reduced and to show the capability of voxel-based morphpmetry(VBM) analysis for lateralizing clinically significant brain regions in dementia of Alzheimer's type patients compared to healthy group. Methods : MR T1-weighted images of the 20 dementia of Alzheimer's type patients were compared with those of the 20 normal controls. Images were transformed to standard MNI space. In order to observe gray matter volume change. Gray matter was smoothed with a Gaussian kernel. After these preprocessing, statistical analysis was performed using statistical parametric mapping software(SPM2). Results : Gray matter volume was significantly reduced in the bilateral parahippocampal gyri, Lt. anterior cingulate gyrus, Lt. posterior cingulate gyrus, bilateral superior temporal gyri Lt. middle temporal gyrus, Lt. superior, bilateral middle, Rt. anterior frontal gyri and Rt. precuneus in dementia of Alzheimer's type patient group. Conclusions : These VBM results confirm previous findings of temporal lobe and limbic lobe atrophic changes in dementia of Alzheimer's type, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.

• Investigative Magnetic Resonance Imaging
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• v.19 no.1
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• pp.1-9
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• 2015

Purpose: Several morphometric studies have been performed to investigate brain abnormalities in congenitally deaf people. But no report exists concerning structural brain abnormalities in congenitally deaf adolescents. We evaluated the regional volume changes in gray matter (GM) using voxel-based morphometry (VBM) in congenitally deaf adolescents. Materials and Methods: A VBM8 methodology was applied to the T1-weighted magnetic resonance imaging (MRI) scans of eight congenitally deaf adolescents (mean age, 15.6 years) and nine adolescents with normal hearing. All MRI scans were normalized to a template and then segmented, modulated, and smoothed. Smoothed GM data were tested statistically using analysis of covariance (controlled for age, gender, and intracranial cavity volume). Results: The mean values of age, gender, total volumes of GM, and total intracranial volume did not differ between the two groups. In the auditory centers, the left anterior Heschl's gyrus and both inferior colliculi showed decreased regional GM volume in the congenitally deaf adolescents. The GM volumes of the lingual gyri, nuclei accumbens, and left posterior thalamic reticular nucleus in the midbrain were also decreased. Conclusions: The results of the present study suggest that early deprivation of auditory stimulation in congenitally deaf adolescents might have caused significant underdevelopment of the auditory cortex (left Heschl's gyrus), subcortical auditory structures (inferior colliculi), auditory gain controllers (nucleus accumbens and thalamic reticular nucleus), and multisensory integration areas (inferior colliculi and lingual gyri). These defects might be related to the absence of general auditory perception, the auditory gating system of thalamocortical transmission, and failure in the maturation of the auditory-to-limbic connection and the auditorysomatosensory-visual interconnection.

• Investigative Magnetic Resonance Imaging
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• v.16 no.2
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• pp.115-123
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• 2012

Purpose : To evaluate white matter abnormalities on diffusion tensor imaging (DTI) in patients with mild Alzheimer disease (AD) and mild cognitive impairment (MCI), using tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM). Materials and Methods: DTI was performed in 21 patients with mild AD, in 13 with MCI and in 16 old healthy subjects. A fractional anisotropy (FA) map was generated for each participant and processed for voxel-based comparisons among the three groups using TBSS. For comparison, DTI data was processed using the VBM method, also. Results: TBSS showed that FA was significantly lower in the AD than in the old healthy group in the bilateral anterior and right posterior corona radiata, the posterior thalamic radiation, the right superior longitudinal fasciculus, the body of the corpus callosum, and the right precuneus gyrus. VBM identified additional areas of reduced FA, including both uncinates, the left parahippocampal white matter, and the right cingulum. There were no significant differences in FA between the AD and MCI groups, or between the MCI and old healthy groups. Conclusion: TBSS showed multifocal abnormalities in white matter integrity in patients with AD compared with old healthy group. VBM could detect more white matter lesions than TBSS, but with increased artifacts.

• Proceeding of EDISON Challenge
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• 2017.03a
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• pp.404-411
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• 2017

이 논문에서는 2차원 화합물 반도체인 Indium Selenide monolayer의 효과적인 도펀트 원소를 탐색해보았다. 총 4가지 종류의 원소를 도핑시켜 계산을 했다. In 자리에 Mg과 Sn을 도핑시켜 각각 p-type과 n-type으로 만들고 Se 자리에 As과 Br을 도핑시켜 각각 p-type과 n-type으로 만들었다. 변화한 성질을 알아보기 위해 전자 구조를 분석하고 band structure와 DOS를 살펴보았다. P-type 같은 경우, Mg doped InSe는 shallow defect level이 생겨 좋은 반도체로 쓰일 수 있지만 As을 도핑한 InSe는 deep defect states가 생겼다. VBM에서 약 0.67 eV만큼 떨어져있는데 이 수치는 실험값과 비슷한 값이다. N-type 경우에는 Sn doped InSe는 deep defect states가 생겼고, CBM 아래로 약 0.08eV만큼 defect가 생긴 것이 실험값과 비슷하다. Br doped InSe는 Sn doped InSe보다 안정적인 n형 반도체가 될 수 있다.

• International Journal of Naval Architecture and Ocean Engineering
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• v.6 no.4
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• pp.1082-1095
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• 2014

In this paper, a new criterion for the identification of slamming events is formulated. This criterion is based on the analysis of the high-frequency response, expressed in terms of the amidships VBM, which occurs after the slams. For this reason, it is named 'whipping' criterion underlining that is based on the analysis of global effects than on the kinematic description of the impact dynamics that was provided by Ochi criterion. Both the new 'whipping' criterion and the Ochi criterion are presented and compared also with respect to their practical application to the experimental data collected in the seakeeping tests with an elastic segmented model.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.232-239
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• 2002

경영환경의 변화를 예측하고, 변화를 창조하며 적극적으로 대응하고자 하는 오늘날 기업 활동의 노력은 전통적인 경영관리시스템(MIS, Management Information System)의 한계를 인식하고 있다. 테일러의 과학적 경영관리 기법을 근간으로 발전해온 MIS분야는 종래의 경영환경, 즉 변화 정도가 미약하거나 또는 예측 가능한 변화의 환경 속에서 기업관리 활동이 가능한 경우에 그 효과를 볼 수 있었다. 전략적 기업관리(SEM, Strategic Enterprise Management)는 기업의 가치창출을 위한 근본적인 프로세스에 관심을 가지고 있다. 이 연구에서는 기업의 가치중심 경영 기법과 연계되는 성과관리시스템의 새로운 설계 방안을 제시하고자 한다. 기업의 전략적 가치동인(value driver)을 도출하여 전략방향의 대안을 제시하고 그러한 전략대안을 달성하기 위한 균형성과지표를 개발한다. 향후 이 지표들은 다시 가치동인도에 반영되어 기업의 전략적 가치향상을 위한 지표 선정의 적정성을 검증하게 된다. 결국, 기업의 가치창출이라는 대명제 안에서 가치평가모델링(VBM, Value Based Management)과 균형성과 지표의 연계성을 강조하는 틀을 제시하게 될 것이다.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.23 no.54
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• pp.37-44
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• 2000

This study is focused on confirmation of the usefulness of EVA through the empiritical test of it which is used in practical business as the new performance measures of the VBM(value based management). The results of test are as followed : We could confirm the possibility that the EVA per share could be used as the useful performance measure as it shows the positive relation with the stock prices. The explanatory power showed especially higher than any other cases if the EPS shows positive and the EVA per share shows positive. When we interpret this study, we must keep in mind that the magnitude of the EVA is very different from by organs of publication in our country. Accordingly, the study to confirm the usefulness of EVA must be basically limited. Therefore, to get the useful result through the study related with the EVA, the publication of the trustful EVA must be proceeded by unified standard.

• Annual Conference of KIPS
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• 2020.11a
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• pp.1064-1065
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• 2020

본 연구는 한국인 뇌MRI영상을 이용하여 대뇌 영역별 분석 프로토콜과 정량 평가방법을 개발하여 정상인을 대상으로 뇌용적량을 정량 분석하고자 한다. 뇌MRI영상 분석 프로토콜을 최적화하기 위해 먼저 뇌용적 변화에 있어 평가방법을 선정하고, VBM 후처리과정은 MRI영상 신호불균질성 교정, 조직세분화 방법, 대뇌 표준영상 제작, 신호 편평화(smoothing) 과정을 단계별로 최적화하였다. 이 정량분석 프로토콜은 정상인과 뇌질환 환자의 뇌용적 비교뿐만 아니라 환자 약물 치료 전·후에 나타나는 용적 변화를 정량적으로 평가하는 연구에 활용할 수 있을 것으로 기대한다.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2004.11a
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• pp.91-95
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• 2004

Several MRI studies have reported reductions in temporal lobe volumes in Alzheimer's disease (AD). Measures have been usually obtained with regions-of-interest (ROI) drawn manually on selected medial and lateral portions of the temporal lobes, with variable choices of anatomical borders across different studies. We used the automated voxel-based morphometry (VBM) approach to investigate gray matter abnormalities over the entire extension of the temporal lobe in 10AD patients (MM5E 22)and 22 healthy controls. Foci of significantly reduced gray matter volume in AD patients were detected in both medial and lateral temporal regions, most significantly in the right and left posterior parahippocarmpal gyri. At a more flexible statistical threshold (P<0.01, uncorrected for multiple comparisons), circumscribed foci of significant gray matter reduction were also detected in the right amygdala/enthorinal cortex, the anterior and posterior borders of the superior temporal gyrus bilaterally, and the anterior portion of the left middle temporal gyrus. These VBM results confirm previous findings of temporal lobe atrophic changes in AD, and suggest that these abnormalities may be confined to specific sites within that lobe, rather than showing a widespread distribution.

• Korean Journal of Radiology
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• v.24 no.4
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• pp.324-337
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• 2023

Objective: The objective of this study was to analyze the different brain oxygen metabolism statuses in preeclampsia using magnetic resonance imaging and investigate the factors that affect cerebral oxygen metabolism in preeclampsia. Materials and Methods: Forty-nine women with preeclampsia (mean age 32.4 years; range, 18-44 years), 22 pregnant healthy controls (PHCs) (mean age 30.7 years; range, 23-40 years), and 40 non-pregnant healthy controls (NPHCs) (mean age 32.5 years; range, 20-42 years) were included in this study. Brain oxygen extraction fraction (OEF) values were computed using quantitative susceptibility mapping (QSM) plus quantitative blood oxygen level-dependent magnitude-based OEF mapping (QSM + quantitative blood oxygen level-dependent imaging or QQ) obtained with a 1.5-T scanner. Voxel-based morphometry (VBM) was used to investigate the differences in OEF values in the brain regions among the groups. Results: Among the three groups, the average OEF values were significantly different in multiple brain areas, including the parahippocampus, multiple gyri of the frontal lobe, calcarine, cuneus, and precuneus (all P-values were less than 0.05, after correcting for multiple comparisons). The average OEF values of the preeclampsia group were higher than those of the PHC and NPHC groups. The bilateral superior frontal gyrus/bilateral medial superior frontal gyrus had the largest size of the aforementioned brain regions, and the OEF values in this area were 24.2 ± 4.6, 21.3 ± 2.4, and 20.6 ± 2.8 in the preeclampsia, PHC, and NPHC groups, respectively. In addition, the OEF values showed no significant differences between NPHC and PHC. Correlation analysis revealed that the OEF values of some brain regions (mainly involving the frontal, occipital, and temporal gyrus) were positively correlated with age, gestational week, body mass index, and mean blood pressure in the preeclampsia group (r = 0.361-0.812). Conclusion: Using whole-brain VBM analysis, we found that patients with preeclampsia had higher OEF values than controls.