• 대한수의학회지
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• 제63권2호
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• pp.20.1-20.4
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• 2023

A 10-year-old, spayed female, Maltese dog presented with a 2-day history of severe left eye squint. Slit-lamp biomicroscopy showed a deep corneal defect stained into a doughnut shape together with hypopyon in the anterior chamber. Based on these results, a diagnosis of descemetocele and uveitis in the left eye was made. Deep keratotomy combined with a nictitating membrane flap effectively resolved the descemetocele without complications. The surgical procedures performed on this patient were easy and effective, and could be used as an alternative to graft surgery for descemetocele treatment.

• Journal of Korean Neurosurgical Society
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• 제48권2호
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• pp.181-184
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• 2010

A case of idiopathic hypertrophic cranial pachymeningitis (IHCP) misdiagnosed as an acute subdural hematoma is reported. A 37-year-old male patient presented with headache following head trauma 2 weeks earlier. Computerized tomography showed a diffuse high-density lesion along the left tentorium and falx cerebri. Initial chest X-rays revealed a small mass in the right upper lobe with right lower pleural thickening, which suggested lung cancer, such as an adenoma or mediastinal metastasis. During conservative treatment under the diagnosis of a subdural hematoma, left cranial nerve palsies were developed (3rd and 6th), followed by scleritis and uveitis involving both eyes. Magnetic resonance imaging (MRI) revealed an unusual tentorium-falx enhancement on gadolinium-enhanced T1-weighted images. Non-specific chronic inflammation of the pachymeninges was noticed on histopathologic examination following an open biopsy. Systemic steroid treatment was initiated, resulting in dramatic improvement of symptoms. A follow-up brain MRI showed total resolution of the lesion 2 months after steroid treatment. IHCP should be included in the differential diagnosis of subtentorial-enhancing lesions.

• Clinical and Experimental Pediatrics
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• 제53권11호
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• pp.921-930
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• 2010

Juvenile rheumatoid arthritis (JRA) is the most common rheumatic childhood disease; its onset is before 16 years of age and it persists for at least 6 weeks. JRA encompasses a heterogeneous group of diseases that is classified according to 3 major presentations: oligoarthritis, polyarthritis, and systemic onset diseases. These presentations may originate from the same or different causes that involve interaction with specific immunogenetic predispositions, and result in heterogeneous clinical manifestations. An arthritic joint exhibits cardinal signs of joint inflammation, such as swelling, pain, heat, and loss of function; any joint can be arthritic, but large joints are more frequently affected. Extra-articular manifestations include high fever, skin rash, serositis, and uveitis. The first 2 types of JRA are regarded as T helper 1 (Th1) cell-mediated inflammatory disorders, mainly based on the abundance of activated Th1 cells in the inflamed synovium and the pathogenetic role of proinflammatory cytokines that are mainly produced by Th1 cell-stimulated monocytes. In contrast, the pathogenesis of systemic onset disease differs from that of other types of JRA in several respects, including the lack of association with human leukocyte antigen type and the absence of autoantibodies or autoreactive T cells. Although the precise mechanism that leads to JRA remains unclear, proinflammatory cytokines are thought to be responsible for at least part of the clinical symptoms in all JRA types. The effectiveness of biologic therapy in blocking the action of these cytokines in JRA patients provides strong evidence that they play a fundamental role in JRA inflammation.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권1호
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• pp.80-83
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• 2008

소아 베체트병은 상당히 드문 질환으로 전체 베체트병의 약 2~3%에 해당한다. 이 중 장 점막과 관련된 경우는 2~50%까지 다양하게 보고되나, 대부분이 40~50대 성인에서 보고되는 내용이며 소아 베체트병 환자에서 장 천공이 보고된 증례는 극히 드물다. 본 증례는 4년 9개월된 남아로, 베체트병을 진단받은 후 약물 치료하며 추적 관찰 중, 지속되는 복통이 있어 시행한 대장 내시경상에 다발성 장점막 궤양이 관찰되었고, 이후 스테로이드 용량 감량하며 경과 관찰하던 중 장 천공이 발생하여 수술한 1예를 경험하였기에 보고하는 바이다.

• 한국임상수의학회지
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• 제31권4호
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• pp.344-349
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• 2014

A 5-year-old intact female Maltese, a 4-year-old neutered male Chihuahua, and a 5-year-old neutered male Maltese were referred to Veterinary Medical Teaching Hospital of Seoul National University for assessment of traumatic corneal laceration accompanied by anterior lens capsule disruption by cat claw. Severe uveitis, hypopyon, fibrinous exudate, diffuse corneal edema, and/or glaucoma were observed. B-mode ocular ultrasound showed lens capsule rupture and hyperechoic lens in all three cases. Despite aggressive treatments, the three eyes continued to deteriorate with endophthalmitis, leading to enucleation. Septic implantation syndrome associated with phakitis, severe pyogranulomatous endophthalmitis, and keratitis was confirmed by histopathological examination.

• Parasites, Hosts and Diseases
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• 제49권2호
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• pp.167-171
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• 2011

We report here the records of 10 consecutive Korean patients (10 eyes) with ocular toxoplasmosis which showed the typical clinical manifestations with seropositivity for Toxoplasma gondii specific IgG antibodies by micro-ELISA between 2006 and 2010. Nine patients were males and 1 was female; their age was $50.5{\pm}13.8$ years. The most common accompanying signs were vitritis (100%), anterior uveitis (70%), and scattered white deposit (80%). Pre-existing retinochoroidal scar was found in 1 (10%) patient. All patients received antiparasitic chemotherapy and systemic corticosteroid treatment, which resolved the presenting attack and recovered the visual acuity better than initial one in 9 patients and worse in 1. Optic atrophy, cataract, and retinal neovascularization were observed during the follow-up period and recurrence was detected in 3 eyes (30%) 6 to 20 months after the initial attack. In Korea, although rarely detected and reported, ocular toxoplasmosis needs more attention in clinical field of retinal diseases.

• Journal of Korean Neurosurgical Society
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• 제50권1호
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• pp.68-71
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• 2011

We present a case of Neuro-Behçet's disease with an unpredictable clinical course. A 47-year-old man was admitted to the neurosurgery department of our hospital with a mild headache. Three days after admission, his consciousness suddenly decreased and respiratory distress progressed rapidly. A brain MRI revealed that the previously observed abnormal signal had extended markedly to both the thalamic areas and the entire brain stem, and the surrounding brain parenchyma were compressed by cerebral edema. Based on the patient's symptoms of recurrent oral and genital ulcers, skin lesions, and uveitis, a rheumatologist made a diagnosis of Behçet's disease with CNS involvement. The patient was treated with high-dose methylprednisolone with respiratory assistance in the intensive care unit for 9 days and his neurologic symptoms improved remarkably. Neuro-Behçet's disease must be considered in the differential diagnosis in rapidly deteriorated young neurological patients along with a stroke, low-grade glioma, multiple sclerosis, and occlusive venous disease.

• The Korean Journal of Pain
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• 제22권1호
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• pp.104-106
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• 2009

Behcet's disease is a chronic relapsing vasculitis characterized by recurrent aphthous oral and genital ulcers with uveitis. Multiple organs can be involved. Entero-Behcet's disease is often uncontrollable, relapsing, and can cause acute intestinal bleeding, fistula formation, or perforation. Corticosteroids, immunosuppressors, and colchicines are used to treat Entero-Behcet's disease with varying degree of success. Thalidomide may also be feasible. We present a 29-year-old male Entero-Behcet's patient suffering from abdominal pain, diarrhea, and back pain. He did not respond to prior treatments, but responded to thalidomide.

• Journal of Chest Surgery
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• 제29권2호
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• pp.219-222
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• 1996

34세 남자가 복수 및 복부 팽 만감을 주소로 입원하였다. 단층촬영 및 하대정맥 조영술상 간정맥 직상부의 하대 정맥폐색이 의심되는 Budd-Chiari 증후군으로 진단되었다. 대증요법으로 간문맥고혈압과 하대정맥폐색증상이 호전이 안되어, 체외순환, 중등도저체온 및 정 상심박동하에 폐색부위절제술 및 하대정맥성형술을 10mm인조혈관을 사용하여 시행하였다. 술후 환자는 구강및 피부와 이학적 검사상 구강궤양, 피하 혈전성 정맥염, 모낭염성 병변, 피부의 자극성 항진 및 포도막염이 관찰되었고 상대정맥 폐색증상이 병발하였으며 Behcet씨 병으로 진단되었다.

• 한국임상수의학회지
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• 제22권2호
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• pp.163-165
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• 2005

An 18-month-old, female American Cocker Spaniel was presented with a cataract of left eye. The left eye was blind, and anterior uveitis was noted on ocular examination. Ultrasonography of the eye revealed a hyperechoic mass with distinct borders in the vitreous indicative of lens fiber or mass lesion extending from ciliary body. The eye was enucleated after ultrasonographic examination. On gross examination, rupture of posterior capsule was noted adjacent to the ciliary body.