• 대한물리의학회지
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• 제9권2호
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• pp.151-159
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• 2014

PURPOSE: The purpose of this study was to evaluate whether light-emitting diodes (LED) irradiation could be effective in a noninvasive, therapeutic device for the treatment of osteoarthritis(OA). METHODS: Twenty-four male Sprague-Dawley rats were divided into four groups: Vehicle control (saline); monosodium iodoacetate-injection (MIA); LED irradiation after MIA injection (MIA-LED); indomethacin-treatment after MIA injection (MIA-IMT). OA was induced by intra-articular injection of 3 mg MIA through the patellar ligament of the right knee. Vehicle control rats were injected with an equivalent volume of saline. The LED was irradiated for 15 min/day for a week after 7 days of MIA treatment. To compare with the effect of LED irradiation, the indomethacin was administrated 20 mg/kg twice a week orally after 7 days of MIA treatment. Knee joints were removed and fixed overnight in 10% neutral buffered formalin and decalcified by EDTA for 2 week before being embedded in paraffin. The assessment of OA induction were monitored by knee movement and radiographic finding. Histologic analysis were performed following staining with hematoxylin and eosin, safranin O-fast green, or toluidine blue, picrosirius red, and histologic changes were scored according to a modified Mankin system. Apoptotic cell in tissue sections was detected using TUNEL method. RESULTS: Radiographic examination could not show the differences between the MIA-treated and the MIA-LED-treated rats. In the histologic analysis, however, LED irradiation prevented cartilage damage and subchondral bone destruction, and significantly reduced mononuclear inflammatory cell infiltration and pannus formation. LED irradiation also reduced apoptosis of cartilage cells, but it prevented apoptosis of infiltrated inflammatory cells in synovium. In addition, LED irradiation showed an increase of collagen production in the meniscus. CONCLUSION: These results suggest that the 840 nm LED irradiation would be a suitable non-thermal phototherapy for the treatment of OA, as a cartilage protection and anti-inflammatory modality.

• Journal of Korean Neurosurgical Society
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• 제38권3호
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• pp.215-220
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• 2005

Objective : Many researchers believe that the hypothermia shows neuro-protective effect on brain injury. To understand the molecular mechanism of the hypothermic treatment, this study investigated its effects on the expression of cell death or survival related proteins such as p53, Bcl-2 and Bax in the rat traumatic brain injury[TBI] model. Methods : Twenty rats [Spraque Dawley, $200{\sim}250g$] were subjected to the brain injury of moderate severity [$2.4{\sim}2.6atm$] using the fluid percussion injury device and five rats were received only same surgery as controls. During 30minutes after the brain injury, the hypothermia group was maintained the body temperature around $34^{\circ}C$ while the control group were maintained that of $36^{\circ}C$. Five rats in each group were sacrificed 12h or 24h after brain injury and their brain sections was analyzed for physical damages by H-E stains and the extent of apoptosis by TUNEL assay and immunohistochemical stains. The tissue damage after TBI was mainly observed in the ipsilateral cortex and partly in the hippocampus. Results : Apoptosis was observed by TUNEL assay and the Bax protein was detected in both sample which harvested 12h and 24h after TBI. In the hypothermia treatment group, tissue damage and apoptosis were reduced in HE stains and TUNEL assay. In hypothermia treatment group rat shows more expression of the Bcl-2 protein and shows less expression of the Bax protein, at both 12h and 24h after TBI. Conclusion : These results show that the hypothermia treatment is an effective treatment after TBI, by reducing the apoptotic process. Therefore, it could be suggested that hypothermia has a high therapeutic value for treating tissue damages after TBI.

• Journal of Korean Neurosurgical Society
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• 제29권4호
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• pp.461-470
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• 2000

Objective : Many investigators have demonstrated the protective effects of hypothermia following traumatic brain injury(TBI) in both animals and humans. It has long been recognized that mild to moderate hypothermia improves neurologic outcomes as well as reduces histologic and biochemical sequelae after TBI. In this study, two immunohistochemical staining using terminal deoxynucleotidyl-transferase-mediated biotin dUTP nick end labeling(TUNEL), staining of apoptosis, and ${\beta}$-amyloid precursor protein(${\beta}$-APP), a marker of axonal injury, were done and the authors evaluated the protective effects of hypothermia on axonal and neuronal injury after TBI in rats. Material and Method : The animals were prepared for the delivery of impact-acceleration brain injury as described by Marmarou and colleagues. TBI is achieved by allowing of a weight drop of 450gm, 1 m height to fall onto a metallic disc fixed on the intact skull of the rats. Fourty Sprague-Dawley rats weighing 400 to 450g were subjected to experimental TBI induced by an impact-acceleration device. Twenty rats were subjected to hypothermia after injury, with their rectal temperatures maintained at $32^{\circ}C$ for 1 hour. After this 1-hour period of hypothermia, rewarming to normothermic levels was accomplished over 30-minute period. Following 12 hours, 24 hours, 1 week and 2 weeks later the animals were killed and semiserial sagittal sections of the brain were reacted for visualization of the apoptosis and ${\beta}$-APP. Results : The density of ${\beta}$-APP marked damaged axons within the corticospinal tract at the pontomedullary junction and apoptotic cells at the contused cerebral cortex were calculated for each animal. In comparison with the untreated controls, a significant reduction in ${\beta}$-APP marked damaged axonal density and apoptotic cells were found in all hypothermic animals(p<0.05). Conclusion : This study shows that the posttraumatic hypothermia result in substantial protection in TBI, at least in terms of the injured axons and neurons.

• 한국정보과학회논문지:소프트웨어및응용
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• 제33권6호
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• pp.580-587
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• 2006

최근에 PDA, IMT-2000, e-Book 등이 보편화되면서 이러한 기기들을 사용하는 사용자의 수가 크게 증가하고 있다. 그러나 아직도 사용 가능한 메모리의 크기는 데스크톱 컴퓨터에 비해 상당히 적은 편이다. 이런 제품들에서, 트루타입 폰트는 품질 좋은 글꼴을 요구하는 사용자들이 증가함에 따라 수요가 증가하고 있으며, Windows CE를 탐재한 제품들에서는 기본적으로 사용되고 있다. 하지만 트루타입 폰트의 크기는 PDA와 e-Book과 같은 적은 메모리를 가진 제품들의 상당히 많은 공간을 차지하게 된다. 그러므로 트루타입 폰트외 크기를 줄이려는 노력이 요구된다. 본 논문은 트루타입 폰트에 내장된 비트맵 데이타(EBDT) 중에 한글 부분만을 줄이기 위해 2 단계의 압축과정을 거친다. 1 단계에서는 비트맵을 초성, 중성, 종성의 형태로 분리하여 합성 비트맵으로 구성하고, 2 단계에서는 분리된 각각의 비트맵들의 중복을 조사하여 제거하게 된다. 본 논문은 한글 완성형과 조합형 트루타입에 내장된 비트맵을 압축하였으며, 완성형 폰트의 경우 35%, 조합형 폰트의 경우 7%의 압축률을 보인다. 또한 완성형 트루타입의 경우 전체 트루타입 폰트의 9.26%의 압축률을 보인다.

• 스마트미디어저널
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• 제6권2호
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• pp.42-49
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• 2017

IoT 에서는 인간과 사물, 사물과 사물들이 통신하며 공통적인 네트워크를 형성하여 자동화 서비스를 실현하는 것이 무엇보다 중요하다. 인간과 사물, 사물과 사물을 공통적인 네트워크로 공유하는 방식으로 웹은 가장 강력한 수단 중의 하나이다. 따라서 IoT에서 사용되는 각 디바이스와 웹과의 통신방식의 효율성은 IoT의 성패를 가름할 수 있다. 웹 응용에서 소프트웨어의 재사용은 소프트웨어의 고품질과 고생산성을 위한 최상의 방법으로 여겨진다. 모듈, 클래스, 패턴, 프레임워크, 비즈니스 컴포넌트들은 다양한 관점의 재사용 요소들이다. 컴포넌트는 잘 정의된 인터페이스를 통해서 다른 것들과 쉽게 플러깅함으로써 응용 개발의 근본 문제인 복잡성을 극복하고 개발과 운용의 다양성을 제공할 수 있다. IoT 및 Network Management를 위한 웹 기반의 분산 환경은 각 종 디바이스에서 수집되는 정보를 이용하는 응용의 개발과 활용을 위한 표준 아키텍처이다. 따라서 IoT 및 NM 응용에서 최상의 서비스 제어를 위해 구성 자원들을 관리, 체계화하는 네트워크 관리는 개별 응용 뿐 아니라 응용의 대부분에서 하부 계층 지원 서비스로 요구된다. 본 논문에서는 이질적인 인터 네트워크상에서 컴포넌트 기반 IOT 및 관련 네트워크 관리 시스템 개발을 목적으로 한다. 이를 위해 필요한 컴포넌트들의 분류 계층화를 위한 컴포넌트 아키텍처를 정의하고 네트워크 도메인에서 필요로 하는 컴포넌트를 식별, 분류하며 실제 네트워크 관리 시스템의 유형을 제시한다.

• Journal of Korean Neurosurgical Society
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• 제60권1호
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• pp.1-7
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• 2017

Objective : The diagnosis of shunt malfunction can be challenging since neuroimaging results are not always correlated with clinical outcomes. The purpose of this study was to evaluate the efficacy of a simple, minimally invasive cerebrospinal fluid (CSF) lumbar tapping test that predicts shunt under-drainage in hydrocephalus patients. Methods : We retrospectively reviewed the clinical and radiological features of 48 patients who underwent routine CSF lumbar tapping after ventriculoperitoneal shunt (VPS) operation using a programmable shunting device. We compared shunt valve opening pressure and CSF lumbar tapping pressure to check under-drainage. Results : The mean pressure difference between valve opening pressure and CSF lumbar tapping pressure of all patients were $2.21{\pm}24.57mmH_2O$. The frequency of CSF lumbar tapping was $2.06{\pm}1.26times$. Eighty five times lumbar tapping of 41 patients showed that their VPS function was normal which was consistent with clinical improvement and decreased ventricle size on computed tomography scan. The mean pressure difference in these patients was $-3.69{\pm}19.20mmH_2O$. The mean frequency of CSF lumbar tapping was $2.07{\pm}1.25times$. Fourteen cases of 10 patients revealed suspected VPS malfunction which were consistent with radiological results and clinical symptoms, defined as changes in ventricle size and no clinical improvement. The mean pressure difference was $38.07{\pm}23.58mmH_2O$. The mean frequency of CSF lumbar tapping was $1.44{\pm}1.01times$. Pressure difference greater than $35mmH_2O$ was shown in 2.35% of the normal VPS function group (2 of 85) whereas it was shown in 64.29% of the suspected VPS malfunction group (9 of 14). The difference was statistically significant (p=0.000001). Among 10 patients with under-drainage, 5 patients underwent shunt revision. The causes of the shunt malfunction included 3 cases of proximal occlusion and 2 cases of distal obstruction and valve malfunction. Conclusion : Under-drainage of CSF should be suspected if CSF lumbar tapping pressure is $35mmH_2O$ higher than the valve opening pressure and shunt malfunction evaluation or adjustment of the valve opening pressure should be made.

• 한국자기학회지
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• 제19권1호
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• pp.12-16
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• 2009

Z-Type 바리움 페라이트($Ba_{3}Co_{0.8}Zn_{1.2}Fe_{24}O_{41}$)를 공침법으로 제조하고 결정구조와 자기적 성질을 조사하였다. $Ba_{3+{\delta}}Co_{0.8}Zn_{1.2}Fe_{24}O_{41}$(${\delta}$ = 3, 5, 7, 13 wt%)와 $Ba_{3}Co_{0.8}Zn_{1.2}Fe_{{24}+{\delta}}O_{41}$(${\delta}$ = 5, 7, 10 wt%)의 조성을 가진 분말의 ${\delta}$ 값에 따른 자기적 성질의 변화를 조사하였다. 제조된 모든 바리움 페라이트에는 Z-type으로 상전이 하지 않은 M-type이 상당량 잔류하고 있었다. 포화자화는 Ba와 Fe의 과잉 첨가량 ${\delta}$가 각각 7 wt%와 5 wt% 일 때 최대로 나타났고 보자력은 조사된 모든 분말에서 다소 높게 나타났다. 높은 보자력은 M-type이 잔류하기 때문이다. 과잉의 Ba와 Fe 첨가에 따른 결정구조의 변화는 없었다. Z-type 바리움 페라이트의 연자성 특성을 향상시키기 위해서는 M-type이 Z-type 형성온도에서 상전이가 일어나도록 해야 함을 알았다.

• 한국환경농학회지
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• 제40권3호
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• pp.211-218
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• 2021

BACKGROUND: Fine particulate matter (PM_2.5) is produced by chemical reactions between various precursors. PM_2.5 has been found to create greater human risk than particulate matter (PM₁₀), with diameters that are generally 10 micrometers and smaller. Ammonia (NH₃) and nitrogen oxides (NOx) are the sources of secondary generation of PM_2.5. These substances generate PM_2.5 through some chemical reactions in the atmosphere. Through chemical reactions in the atmosphere, NH₃ generates PM_2.5. It is the causative agent of PM_2.5. In 2017 the annual ammonia emission recorded from the agricultural sector was 244,335 tons, which accounted for about 79.3% of the total ammonia emission in Korea in that year. To address this issue, the agricultural sector announced the inclusion of reducing fine particulate matter and ammonia emissions by 30% in its targets for the year 2022. This may be achieved through analyses of its emission characteristics by monitoring the PM_2.5 and NH₃. METHODS AND RESULTS: In this study, the PM_2.5 concentration was measured real-time (every 1 hour) by using beta radiation from the particle dust measuring device (Spirant BAM). NH₃ concentration was analyzed real-time by Cavity Ring-Down Spectroscopy (CRDS). The concentrations of ozone (O₃) and nitrogen dioxide (NO₂) were continuously measured and analyzed for the masses collected on filter papers by ultraviolet photometry and chemiluminescence. CONCLUSION: This study established air pollutant monitoring system in agricultural areas to analyze the NH₃ emission characteristics. The amount of PM_2.5 and NH₃ emission in agriculture was measured. Scientific evidence in agricultural areas was obtained by identifying the emission concentration and characteristics per season (monthly) and per hour.

• 한국방사선학회논문지
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• 제15권7호
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• pp.1065-1072
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• 2021

최근 복부 CT 검사 건수가 증가하고 있으며 이에 피폭선량을 감소시키기 위해 많은 노력이 요구되고 있다. 최근 도입된 반복적 재구성기법(Iterative Reconstruction, IR)을 복부 CT검사에 적용하여 기존 필터 보정 역투영법(Filtered Back Projection, FBP)과 화질 및 선량을 비교평가하여 유용성을 알아보고자 하였다. 반복적 재구성기법은 SIEMENS사의 ADMIRE, GE사의 ASIR-V를 이용하였고 화질평가를 위해 ACR phantom 영상을 이용하여 Noise, % Contrast, High contrast resolution를 측정하였다. 또한 선량평가는 CT장치에서 표시되는 CTDI_vol, DLP를 이용하였다. 필터 보정 역투영법과 반복적 재구성기법을 비교 평가한 결과 반복적 재구성기법 ADMIRE 2~5단계, ASIR-V 30, 50, 70, 90%를 적용한 경우, Noise가 ADMIRE에서 0.46~2.38, ASIR-V에서 0.51~2.5 감소하였다. % Contrast, High contrast resolution 유의한 차이가 없었다. 선량의 경우 반복적 재구성기법을 사용할 경우 ADMIRE에서 25.39%, ASIR-V에서 16.61% 감소시킬 수 있음을 알 수 있었다. 결론적으로 복부 CT검사 시 반복적 재구성기법을 적용한다면 화질을 유지함과 동시에 선량을 감소시킬 수 있을 것이라 사료된다.

• Ecology and Resilient Infrastructure
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• 제8권4호
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• pp.194-203
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• 2021

최근에 상하수관로, 지역난방 열공급관로 등의 유지보수가 증가하면서, 도로절단기에 의한 도로절단 작업도 급증하고 있다. 이러한 도로절단 작업은 소음과 함께 분진(절단슬러지)을 많이 발생시키므로, 저소음, 분진회수 등 친환경적인 기술이 적용될 필요가 있다. 기존에 이러한 문제점을 해결하고자 분진을 회수하는 장비가 개발된 사례가 있으나, 친환경성이 정량화되지 않았다는 한계가 있었다. 이에 본 연구에서는 소음 및 분진과 같은 환경위해요인의 발생원인을 근본적으로 제거할 수 있는 저소음·분진회수형 도로절단기를 개발하고, 이 절단기로 수행하는 도로절단작업 과정에 대한 친환경성을 평가하였다. 이를 위하여 본 연구에서는 진공장치와 슬러지흡입부로 구성된 수냉-슬러지회수 통합시스템을 개발하고, 개발된 시스템을 도로절단기에 적용하였다. 그리고 개발된 장비를 테스트 베드에 적용하고, 친환경성 관련 데이터를 수집하여, 친환경성을 평가하였다. 평가 결과, 개발된 장비의 절단슬러지 회수율은 83% 이상이었으며, 소음도는 82~83 dB, 음향파워레벨은 115 dB 수준이었다. 본 연구의 결과는 향후 도로절단기를 개선하는 과정에서 절단슬러지 회수성능과 저소음 성능을 향상시키는 데에 기초자료로 활용될 예정이다.