• 한국임상수의학회지
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• 제28권1호
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• pp.144-148
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• 2011

A Shihtzu (6-year-old, intact female) was referred to Konkuk University Teaching Animal Hospital for cystic calculus and hydronephrosis of right kiney. The dog was suspected to have ureteral rupture and peritonitis. Radiographic findings included cyctic calculi and right kidney enlargement. On ultrasonographic examination hyperechoic mass with severe acoustic shadowing was located in the right proximal ureter which was dilated. Hydronephrosis of the right kidney, right ureteral caculus and cytic calculus were confirmed by radiography and ultrasonography. Cystotomy for removal of calculus in the bladder and ureterotomy for removal of calculus in the right ureter were performed. Excretory urography (EU) performed one month after surgery revealed that the right ureter was homogeneously opacified and decreased to 3 to 6 mm in diameter. Surgical removal of ureteroliths was appropriate treatment for the ureteral and cystic calculi. The result suggests that ureterotomy is effective treament for the dilation and calculi of ureter.

• BMB Reports
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• 제53권11호
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• pp.594-599
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• 2020

Lin28a has diverse functions including regulation of cancer, reprogramming and regeneration, but whether it promotes injury or is a protective reaction to renal injury is unknown. We studied how Lin28a acts in unilateral ureteral obstruction (UUO)-induced renal fibrosis following unilateral ureteral obstruction, in a mouse model. We further defined the role of Lin28a in transforming growth factor (TGF)-signaling pathways in renal fibrosis through in vitro study using human tubular epithelium-like HK-2 cells. In the mouse unilateral ureteral obstruction model, obstruction markedly decreased the expression of Lin28a, increased the expression of renal fibrotic markers such as type I collagen, α-SMA, vimentin and fibronectin. In TGF-β-stimulated HK-2 cells, the expression of Lin28a was reduced and the expression of renal fibrotic markers such as type I collagen, α-SMA, vimentin and fibronectin was increased. Adenovirus-mediated overexpression of Lin28a inhibited the expression of TGF-β-stimulated type I collagen, α-SMA, vimentin and fibronectin. Lin28a inhibited TGF-β-stimulated SMAD3 activity, via inhibition of SMAD3 phosphorylation, but not the MAPK pathway ERK, JNK or p38. Lin28a attenuates renal fibrosis in obstructive nephropathy, making its mechanism a possible therapeutic target for chronic kidney disease.

• 대한한의학회지
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• 제39권2호
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• pp.1-12
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• 2018

Objectives: The objective of this study is to develop a new animal model with Kidney-hypofunction for Sasang Constitutional Medicine, especially for partial Soyangin(one of four constitution which has good digestive function and poor renal function) by Unilateral Ureteral Obstruction, and to estimate the factor related to obesity, dyslipidemia, and metabolic syndrome. Methods: The C57BL/6J mice were divided into 3 groups : normal group, high fat diet(HFD) control group, and HFD group with Unilateral Ureteral Obstruction(UUO). Then, the HFD control group and the experimental group were fed with high fat diet for 6 weeks. Food intake and body weight were measured at regular time by week. After the final experiment, blood was gathered for bloodchemical examination and organs(liver, fatty tissue) were remoed, weighted, and mRNA was analyzed with real-time PCR. Results: The weight growth rate with High fat diet went down by 8.35% in experimental group and had similar FER with the normal group, while HFD control group had higher weight growth rate and FER than any other groups. Also The experimental group had lower triglyceride and LDL cholesterol rate and higher glucose rate in serum. and in mRNA expression, GLUT-9, the protein related to excretion of uric acid and metabolic syndrome, expressed lower rate than that of HFD control group. and IL-6, a kind of cytokine related to obesity and metabolic syndrome, expressed more than HFD control group. Conclusions: It was found that Kidney-hypofunction animal-experimental model is susceptible to metabolic syndrome.

• Childhood Kidney Diseases
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• 제17권2호
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• pp.117-121
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• 2013

결석으로 인한 요관 폐쇄는 신후성 신부전의 주요한 원인으로 즉각적인 치료가 필요하다. 폐색 후 이뇨는 폐쇄성 요로 질환의 막힘 제거될 때 흔히 나타날 수 있는 증상으로 특별한 치료 없이 회복되는 경우가 많으나 저혈압이나 전해질 이상 등의 소견이 나타날 경우에는 수액 요법을 통한 치료가 필요하다. 단일신 환아에서 4 mm 크기의 작은 결석으로 인한 신후성 신부전이 발생하였으며 결석이 배출되고 발생한 폐쇄 후 이뇨는 보존적 치료로 회복되었다. 대부분의 4 mm 미만의 작은 결석은 저절로 배출 된다고 알려져 있으나 저자들은 4 mm 크기의 결석으로 생긴 신후성 신부전 및 폐쇄 후 이뇨가 발생한 예를 경험하였기에 보고하는 바이다.

• Korean Journal of Radiology
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• 제2권1호
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• pp.14-20
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• 2001

Objective: To compare the usefulness of unenhanced spiral CT (UCT) with that of excretory urography (EU) in patients with acute flank pain. Materials and Methods: Thirty patients presenting with acute flank pain underwent both UCT and EU. Both techniques were used to determine the presence, size, and location of urinary stone, and the presence or absence of secondary signs was also evaluated. The existence of ureteral stone was confirmed by its removal or spontaneous passage during follow-up. The absence of a stone was determined on the basis of the clinical and radiological evidence. Results: Twenty-one of the 30 patients had one or more ureteral stones and nine had no stone. CT depicted 22 of 23 calculi in the 21 patients with a stone, and no calculus in all nine without a stone. The sensitivity and specificity of UCT were 96% and 100%, respectively. EU disclosed 14 calculi in the 21 patients with a stone and no calculus in eight of the nine without a stone. UCT and EU demonstrated secondary signs of ureterolithiasis in 15 and 17 patients, respectively. Conclusion: For the evaluation of patients with acute flank pain, UCT is an excellent modality with high sensitivity and specificity. In near future it may replace EU.

• Childhood Kidney Diseases
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• 제2권2호
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• pp.169-177
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• 1998

목 적 : 중복요관은 전체 인구의 약 $0.8\%$에 이르는 비교적 발생 빈도가 높은 기형의 하나로 최근에는 산전 초음파를 통해 발견되기도 하지만, 혈뇨나 복통, 요로감염의 증상으로 진단되어지며, 다른 비뇨기 계통의 기형을 동반하는 경우가 있다. 저자들은 중복요관 환아들을 대상으로 진단의 단서가 되었던 임상양상과 동반 질환 여부 및 치료 등에 대하여 알아보고자 하였다. 방 법 : 18세 미만의 61례의 중복요관 환아를 대상으로 후향적 고찰을 시행하였다. 결 과 : 61명의 전체환아의 진단당시의 평균연령은 5.6세였고, 추적관찰의 평균기간은 3년 7개월이었으며, 여아가 42명이었고 남아가 19명으로 남녀 비는 1:2.2였다. 양측 중복요관 환아는 16명($26.2\%$), 완전 중복요관 환아는 24명($39.3\%$)이었다. 산전 초음파상 이상소견으로 발견된 경우가 8례($13\%$)있었고, 요로감염을 단서로 진단되었던 경우가 19례($31.1\%$)로 가장 많았다. 동반질환은 비뇨기 계통이 아닌 기형이나 질환이 11례($18\%$)있었고, 50명($82\%$)은 중복요관 이외의 비뇨기계 다른 질환을 동반하였다. 편측 중복요관환아 45명의 경우 좌측이 23명($51.1\%$)이었고, 이들중 21명($46.7\%$)이 완전 중복요관으로 진단되었다. 전체환아중 비뇨기계의 문제를 동반하여 수술을 받았던 환아는 37명($60.6\%$)이었고, 이 중 방광 요관역류를 동반한 예가 27명($44.3\%$)으로 가장 많았다. 결 론 : 중복요관 환아의 $60.6\%$가 수술을 요하는 비뇨기계의 다른 질환들을 동반하였으며, 특히 요로감염이 선행하는 경우가 많다는 것을 알 수 있었다. 비뇨기계증상 없이 산전진찰이나 우연히 발견되었던 경우가 전체 대상 환아의 $42.6\%$를 차지하므로, 따라서 산전초음파에서 비뇨기계의 비정상적인 소견이 발견되었거나 요로감염, 혈뇨, 복통 등의 증상이 있는 소아들은 반드시 방사선학적 검사를 통하여 중복요관 및 다른 기형이 동반되는지를 확인하여 조기진단 및 적절한 치료를 시행하고, 복부초음파, 배설성 방광요도조영술, 소변 배양검사 등의 주기적인 추적관찰로 향후 발생할수 있는 합병증을 예방할 수 있을 것으로 생각된다.

• Childhood Kidney Diseases
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• 제7권2호
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• pp.189-196
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• 2003

목적 : 중복 요관은 부검상 전인구의 0.9%에서 발견되는 비교적 흔한 비뇨기계 기형이다. 과거에는 발열, 복통, 혈뇨 등을 단서로 하여 발견되었으나, 최근에는 산전초음파에 의하여 조기 진단되고 있다. 저자들은 최근 5년간 본원에서 진단된 환아들의 임상 양상 및 산전초음파에 의한 조기 진단의 유용성에 대해 고찰하였다. 방법 : 1998년부터 2003년 7월까지 본원에 입원하여 진단된 18세 미만의 55례의 중복 요관 환아들을 대상으로 후향적 고찰을 시행하였다. 결과 : 진단 당시 평균 연령은 2.2세였고, 추적 기간의 평균은 14개월이었으며, 남녀비는 1:2.7이었다. 완전 중복 요관은 49례(89%)였다. 발열을 주소로 내원한 경우는 15례(27%)였고, 산전 진찰로 진단된 경우는 26례(47%)였다. 방광요관역류가 동반된 경우는 14례(28%)였고, 수신증은43례(88%)에서 동반되었다. 산전 진찰을 통해 진단된 군과 생후에 진단된 군의 비교시, DMSA 신주사상 결손의 비율은 각각 70.8%와 67.7%였으며, 환측 신장의 동위원소 섭취율은 각각 48.2%와 45.5%로 두 군간에 통계학적인 차이는 없었다. 결론 : 과거와 달리 최근 5년간 산전초음파로 중복 요관이 진단되는 비율은 47%로 증가하고 있으며, 이에 따라 진단시 연령이 낮아져(2.2세) 경과 추적이 조기에 시작될 수 있었다. 그 외의 임상적인 양상은 과거와 유사하였다. 산전초음파로 진단된 경우와 생후에 진단된 경우를 비교할 때, 두 군간에 신손상의 차이에 대한 통계적학적 유의성은 발견하지 못하였다. 산전 초음파가 조기 진단과 이에 따른 추적 관찰을 통해 치료시기를 적절히 결정하는 데에 도움이 될 것인지 알아보기 위하여 향후 광범위한 다기관 연구가 필요하다.

• 대한한의학방제학회지
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• 제31권3호
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• pp.133-144
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• 2023

Ureteral obstruction can be causes of renal dysfunction and renal injury at late period of kidney pathology. The purpose of this study was to determine the protective effects of Oryeongsan (ORS), Geumgwe-sinkihwan (GSH), and Jwagwieum (JGE) in rats with unilateral ureteral obstruction (UUO). The animal models were divided into five groups randomly at the age of 5 weeks; Control group: SD male rats (n=10), UUO group: SD male rats with UUO surgery (n=10), ORS group: SD male rats with UUO surgery + ORS 200 mg/kg/day (n=10), GSH group: SD male rats with UUO surgery + GSH 200 mg/kg/day (n=10), JGE group: SD male rats with UUO surgery + JGE 200 mg/kg/day (n=10). Treatment with ORS, GSH, and JGE significantly ameliorate creatinine clearance(Ccr). The present results also showed that ORS, GSH, and JGE improved the morphological aspects of renal tissues. These prescriptions also reduced the expression levels of cytokines such as TNF-α, IL-1β, and IL-6. In Kidney, UUO increased the expression levels of inflamasome markers such as NLRP3, ASC, and Caspase-1. However, ORS, GSH, and JGE suppressed these levele. Treatment with these prescriptions reduced kidney inflammation markers such as Neutrophil Gelatinase Associated Lipocalin (NGAL) and kidney injury molecule -1 (KIM-1). Therefore, these findings suggest that ORS, GSH, and JGE has a protective effect on renal injury by alleviating renal inflammation and improving renal function in rats with UUO.

• 대한영상의학회지
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• 제82권3호
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• pp.764-765
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• 2021

• Childhood Kidney Diseases
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• 제22권1호
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• pp.28-31
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• 2018

Ureteropelvic junction obstruction is one of the common causes of hydronephrosis in infancy and childhood. Most cases of ureteropelvic junction obstruction are diagnosed prenatally and are usually asymptomatic. Although less common, older children can experience ureteropelvic junction obstruction that presents with symptoms including flank or abdominal pain. Here, we present the case of a nine-year-old healthy girl who had repeated flank pain and abdominal symptoms, with mild left hydronephrosis, for several months. Computed tomography that was performed during the period of acute flank pain revealed aggravated hydronephrosis on her left kidney, which was secondary to an ureteropelvic junction obstruction. She underwent laparoscopic pyeloplasty, and a crossing vessel that passed the ureteropelvic junction was identified. In addition, we reviewed the current literature of this rare entity.