• Clinical and Experimental Reproductive Medicine
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• 제10권1호
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• pp.25-37
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• 1983

A group of 180 men who visited Urology Department of Severance hospital, including 115 patients with nongonococcal urethritis (N.G.U.), 27 patients with prostatitis, 13 patients with gonococcal urethritis (G.U.) and 25 healthy medical student controls were investigated for the isolation of Ureaplasma urealyticum (T-strain mycoplasma) from the specimen of ureaplasma discharge, urine and semen. Taylor-Robinson media of T-broth and T-agar was used for the isolation of Ureaplasma urealyticum. To the best of our knowledge, the study on the culture of Ureaplasma urealy ticum was reported for the first time in Korea. The followis g results were obtained: 1. The isolation rate of Ureaplasma urealyticum in nongonococcal urethritis (53.0%) revealed highest of those in the other three groups of prostatitis, gonococcal urethritis and control (40.7%,38.4% and 16.0% respectively). 2. As for the specimens, urethral discharge revelaed higher isolation rate of Ureaplasma urealyticum (54.6%) than first voided urine (50.0%). 3. The more consorts patients had, the higher positive culture rate of Ureaplasma urealyticum were revealed. The isolation rate in case of more than one causal in nongonococcal urethritis (27.8%) revealed much higher than in case of marital only (5.2%), one regular (6.1%) and one causal 03.9%). 4. 2.6% of isolation rate of Ureaplasma urealyticum revealed in patients with nongonococcal urethritis who visited the clinic in later than 4 weeks after the symptoms developed. However, the isolation rate in patients who visited within 4 weeks revealed 50.3%. The lower isolation rate of Ureaplasma in the late treatment seekers might be probably due to the suppression effect against Ureaplama urealyticum from the possible previous self antibiotic treatment. 5. Attachment of Ureaplasma urealyticum mostly to the neck and head portion of the spermatozoa seemed to playa role to affect the motility of sperms.

• Clinical and Experimental Pediatrics
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• 제56권11호
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• pp.477-481
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• 2013

Purpose: Ureaplasma colonization is related with perinatal complications in preterm infants. Little is known about the difference in virulence among various Ureaplasma urealyticum serovars. The aim of this study was to determine U. urealyticum serovars of preterm infants in order to assess whether any of the serovars were associated with bronchopulmonary dysplasia (BPD). Methods: Three hundred forty-four preterm infants with a gestational age less than 34 weeks admitted to Gangnam Severance Hospital neonatal intensive care unit from July 2011 to December 2012 were included in this study. Tracheal and gastric aspirations were conducted on infants to confirm Ureaplasma colonization. Ureaplasma colonization was confirmed in 9% of infants, of these, serovars were determined by real-time polymerase chain reaction. Results: A total of 31 infants (gestational age, $29.3{\pm}3.1$ weeks; birth weight, $1,170{\pm}790g$) were U. urealyticum positive. The Ureaplasma positive group treated for more days with oxygen and ventilation than the negative group (P<0.05). Histologic chorioamnionitis and moderate to severe BPD were more frequent in the Ureaplasma positive group than in the negative group (P<0.05). U. urealyticum isolates were either found to be a mixture of multiple serovars (32%), serovar 9 alone or combined with other serovars (39%), serovar 11 (26%), 2 (13%), 8 (10%), 10 (13%), and 13 (25%). No individual serovars were significantly associated with moderate to severe BPD and chorioamnionitis. Conclusion: This is the first study to describe the distribution of U. urealyticum serovars from Korean preterm infants. Ureaplasma -colonized infants showed higher incidence of BPD and chorioamnionitis.

• Neonatal Medicine
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• 제18권2호
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• pp.280-287
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• 2011

목적: 미숙아에서 위액 내 Ureaplasma urealyticum 의 검출이 미숙아의 특징과 임상적 예후에 어떤 영향을 주는지를 알아보고자 하였다. 방법: 미숙아를 대상으로 출생 후 30분 이내에 첫 위액은 채취하였고, 위액 내 U. urealyticum 이 검출되는지를 확인하기 위해 24시간 이내에 배양을 실시하였다. 그리고 U. urealyticum 이 검출된 군을 양성군으로, 검출되지 않은 군을 음성군으로 나누었다. 결과: 91명의 미숙아 중에서 17명(19%)에서 위액 내 U. urealyticum 이 검출되었다. U. urealyticum 양성군에서 음성군보다 통계학적으로 30주 미만의 미숙아 수가 더 많았고(P=0.02), 1분과 5분 아프가 점수가 더 높았으며(P=0.017과 P=0.048), 그리고 질식 분만이 더 많았다(P=0.000). 두 군간에 기관지폐이형성증의 발생률은 차이가 없었지만, 이전에 신생아호흡 곤란증 진단 없이 기관지폐이형성증의 발생한 빈도는 음성군(1%)보다 양성군 (11%)에서 의미 있게 높았다(P=0.03). 결론: 위액 내 U. urealyticum 검출은 임신 기간 30주 미만 미숙아에서 높게 관찰되고, 미숙아에서 선행되는 신생아호흡곤란증후군이 없이도 발생할 수 있는 기관지폐이형성증을 예측하는데 도움이 된다.

• Clinical and Experimental Pediatrics
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• 제53권12호
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• pp.989-993
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• 2010

Although numerous clinical observational studies have been conducted over a period of over 30 years, the clinical significance of $Ureaplasma$ infection is still under debate. The $Ureaplasma$ speices. is a commensal in the female genital tract and considered to have of low virulence; however, $Ureaplasma$ colonization has been associated with infertility, stillbirth, preterm delivery, histologic chorioamnionitis, and neonatal morbidities, including congenital pneumonia, meningitis, bronchopulmonary dysplasia, and perinatal death. Recently, $Ureaplasma$ was subdivided into 2 separate species and 14 serovars. $Ureaplasma$ $parvum$ is known as biovar 1 and contains serovars 1, 3, 6, and 14, and $Ureaplasma$ $urealyticum$ (biovar 2) contains the remaining serovars (2, 4, 5, and 7-13). The existence of differences in pathogenicities of these 14 serovars and 2 biovars is controversial. Although macrolides are the only antimicrobial agents currently available for use in neonatal ureaplasmal infections, in the current clinical field, it is difficult to make decisions regarding which antibiotics should be used. Future investigations involving large, multicenter, randomized, controlled studies are needed before proper recommendations can be made for clinical practice.

• Clinical and Experimental Pediatrics
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• 제56권11호
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• pp.474-476
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• 2013

• Neonatal Medicine
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• 제16권1호
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• pp.47-54
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• 2009

목적 : Urea plasma urealyticum (U. urealyticum) 집락은 조산아의 주산기 사망, 폐렴, 패혈증 및 기관지폐 형성이상과 관련이 있는 것으로 알려져 왔다. 출생 시 하부기도의 U. urealyticum 집락 여부가 조산아의 기관지폐 형성이상과 조발형 패혈증의 발생과 관련이 있는지 알아보기 위하여 본 연구를 시도하였다. 방법 : 2006년 9월부터 2008년 12월까지 분당차병원 신생아 집중치료실에 입원하여 인공 환기 치료를 받았던 35주 미만의 미숙아 176례를 대상으로 하였다. U. urealyticum 은 생후 24시간 이내의 기관흡인액을 중합 효소연쇄반응법으로 검사하였다. 기관지폐 형성이상은 Jobe와 Bancalari에 의한 분류법에 따라 정의하였고, 경증, 중등도, 중증으로 분류하였다. 결과 : 176례 중 37례에서 U. urealyticum 양성으로 21.0%의 양성률을 보였다. U. urealyticum 양성군에 재태연령($29^{+5}{\pm}2^{+5}$주 vs. $30^{+6}{\pm}2^+{-5}$, P=0.013)과 출생체중 (1.39${\pm}$0.44 kg vs. 1.59${\pm}$0.55 kg, P=0.037)이 U. urealyticum 음성군보다 낮았다. 조발형 패혈증(16.2% vs. 6.5%, P=0.045)과 기관지폐 형성이상(45.9% vs. 29.5%, P=0.04)의 발생빈도는 U. urealyticum 양성군에서 유의하게 높았으나, 기관지폐 형성이상의 중증도는 두 군 간의 차이를 보이지 않았다. 재태연령 등의 다양한 변수의 영향을 보정한 분석 결과 U. urealyticum 집락 양성과 조발형 패혈증과 기관지폐 형성이상의 발생사이의 연관성은 관찰되지 않았다. 결론 : 본 연구결과는 출생시 하부 기도의 U. urealyticum 집락이 조산아의 패혈증과 기관지폐이형성증의 발생에 직접적인 관련성은 없음을 시사한다.

• 한국미생물·생명공학회지
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• 제46권4호
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• pp.425-429
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• 2018

Ureaplasma urealyticum (UU) infection can spread rapidly across populations and is associated with cervical intraepithelial neoplasms, human papillomavirus infections, and newborn mortality. This study aimed to provide information that could be used to protect public health and decrease the incidence and transmission of sexually transmitted infections (STIs), particularly among childbearing women. We examined the epidemiology of UU infection in Cheonan, South Korea. During 2006-2017, 4,050 specimens were submitted for STI screening using a multiplex polymerase chain reaction (PCR) assay. Data were analyzed for UU infection cases using the R statistical program and categorical data were analyzed using the chi-square test, and p-values <0.05 were considered statistically significant. Positive PCR results were shown in 17.8% of the total specimens, in 9.0% of men, and in 18.7% of women. Individuals in their teenaged years and individuals aged 20-29 years accounted for the largest proportions of UU-positive specimens. Although Mycoplasma hominis was the most prevalent bacterium in 2006, it was superseded by UU in 2017. Of the 870 UU-positive specimens, 50.1%, 33.1%, 13.4%, and 2.8% had single, double, triple, and quadruple infection, respectively. UU was most common among Korean individuals aged 20-29 years, indicating a high risk of maternal-to-infant transmission that should be addressed through rapid diagnosis, treatment, and management.

• 대한미생물학회지
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• 제35권5_6호
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• pp.361-361
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• 2000

• 한국미생물·생명공학회지
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• 제46권1호
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• pp.85-90
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• 2018

성병(Sexually transmitted infection, STI)은 전세계적인 건강 문제이며 임산부의 유산, 조기 출산, 골반 내 감염과 같은 심각한 합병증을 유발할 수 있다. 따라서 정확한 진단 및 역학 동향에 대한 정보가 중요하다. 그러나 2012년 이후 천안의 STI 추세에 대한 연구는 이루어지지 않았다. 이에 저자들은 2012년 이후 천안의 STI 추이를 조사했다. 2011년 1월부터 2017 년 9월까지 단국대학교에 방문한 여성 환자에서 채취 한 3,362개의 자궁 경부 샘플을 multiplex PCR 방법으로 분석했다. 3,362개의 표본 중 1,281개가 STI 양성이었고(38.92%) 총 1,893개의 병원균이 검출되었다. Ureaplasma urealyticum, Mycoplasma hominis 및 Chlamydia trachomatis가 병원체 양성 검체에서 각각 36.29% (687/1,893), 30.16% (571/1,893) 그리고 19.97% (378/1,893)를 차지하는 가장 흔한 병원균이었다. 2009-2012년 분석에서는 M. hominis가 가장 흔하게 검출됐지만 이번 연구에서는 U. urealyticum가 가장 흔하게 검출됐다. 한국과 미국을 비롯한 많은 국가에서 STD 발병률이 증가하는 반면 천안에서는 감소하는 경향이 나타났다.

• Clinical and Experimental Reproductive Medicine
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• 제44권4호
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• pp.207-213
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• 2017

Objective: This study investigated the prevalence of infections with human papillomavirus, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, and Mycoplasma genitalium in the semen of Korean infertile couples and their associations with sperm quality. Methods: Semen specimens were collected from 400 men who underwent a fertility evaluation. Infection with above five pathogens was assessed in each specimen. Sperm quality was compared in the pathogen-infected group and the non-infected group. Results: The infection rates of human papillomavirus, C. trachomatis, U. urealyticum, M. hominis, and M. genitalium in the study subjects were 1.57%, 0.79%, 16.80%, 4.46%, and 1.31%, respectively. The rate of morphological normality in the U. urealyticum-infected group was significantly lower than in those not infected with U. urealyticum. In a subgroup analysis of normozoospermic samples, the semen volume and the total sperm count in the pathogen-infected group were significantly lower than in the non-infected group. Conclusion: Our results suggest that infection with U. urealyticum alone and any of the five sexually transmitted infections are likely to affect sperm morphology and semen volume, respectively.