• Microbiology and Biotechnology Letters
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• v.16 no.3
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• pp.238-245
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• 1988

Studies were made on the regulation of chorismate mutase and prephenate dehydratase of a species of Intrasporangium, a phenylalanine producing Actinomycete isolated from soil. Two distinctly regulated species of chorismate mutase, designated CM I and CM IIwere resolved by DEAE Cellulose and DEAE Sephadex A 50 chromatography. The activity of CM II was inhibited by L-tyrosine, whereas that of CM I appeared to be unregulated. Single species of prephenate dehydyatase was also separated in the same purification steps. The activity of the enzyme was strongly feedback inhibited by L-phenylalanine, but by L-tyrosine or L-methionine it was rather slightly stimulated. Synthesis of chorismate mutase was not influenced by the presence of phenylalanine, tyrosine or tryptophan, whereas prephenate dehydratase was found to be subject to strong feedback repression by L-phenylalanine. The rate of repression was 94% at the concentration of 1mM L-phenylalanine but the repression was completely offset by the presence of 5mM tyrosine. The critical regulatory site of the phenylalanine terminal biopathway was, therefore, proved to be the second reaction which was catalyzed by the L-phenylalanine inhibitable and repressible prephenate dehydratase.

• Nutritional Sciences
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• v.7 no.2
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• pp.83-87
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• 2004

To investigate the effects of dietary phytate reduction and zinc supplementation on biochemical iron parameters in elderly Korean women consuming inadequate iron, fifteen healthy women aged 64-75 years were recruited for a feeding study. A high-phytate diet (27.8 phytate:zinc molar ratio) was provided for 9 days, followed by a nine-day low-phytate diet(12.3) and a subsequent 28-day period of unregulated meals with zinc supplementation (22 mg/d as zinc gluconate). Serum iron increased significantly with the low-phytate diet (130.4 $\mu g$/L) but returned to the level observed during the high-phytate diet (113.0 $\mu g$ /L) period when subjects were taking zinc supplements (105.8 $\mu g$ /L). However, serum ferritin in the subjects decreased significantly with the low-phytate diet (73.8 $\mu g$ /L) as well as with zinc supplementation (57.2 $\mu g$ /L), compared to levels following consumption of the high-phytate diet (89.6 $\mu g$ /L). Transferrin receptor and transferrin saturation were unchanged with the treatments. In summary, zinc supplementation might result in deteriorated iron status in elderly Korean women who consume inadequate iron, while there was no significant effect from reducing dietary phytate.

• KIEE International Transactions on Power Engineering
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• v.3A no.1
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• pp.27-34
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• 2003

In this paper, the power conditioner composed of the stand-alone single-phase squirrel cage rotor type self-excited induction generator (SEIG) driven by prime movers such as a wind turbine and a micro gas turbine (MGT) is presented by using the steady-state circuit analysis based on the two nodal admittance approaches using the per-unit frequency in addition to a new state variable defined by the per-unit slip frequency along with its performance evaluations for the stand-alone energy utilizations. The stande-alone single-phase SEIG operating performances in unregulated voltage control loop are then evaluated on line under the conditions of the speed change transients of the prime mover and the stand-alone electrical passive load power variations with the simple theoretical analysis and the efficient computation processing procedures described in the part I of this paper. In addition, a feasuible PI controlled feedback closed-loop voltage regulation scheme of the stande-alone single-phase SEIG is designed on the basis of the static VAR compensate. (SVC) and discussed in experiment for the promising stand-alone power conditioner. The experimental operating performance results are illustrated and give good agreements with the simulation ones. The simulation and experimental results of the stand-alone single-phase SEIG with the simple SVC controller for its stabilized voltage regulation prove the practical effectiveness of the additional SVC control loop scheme including the PI controller with fast response characteristics and steady-sate performance improvements.

• Journal of Korea Water Resources Association
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• v.42 no.1
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• pp.1-8
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• 2009

In this study, based on the major activities which might have affected the ecological system of the Geum River, a conceptual model was proposed to guide scenario development for the eco-hydrological river evaluation. Also, an analysis method employing a set of models consisting, with other supporting programs, of KModSim for watershed network analysis and RAP for ecosystem analysis was developed for eco-hydrological river assessment. Then, hydrological analyses with various scenarios were conducted to examine the flow regime changes expected from the construction and operation of the Youngdam Multipurpose Dam (YMD) and Daecheong Multipurpose Dam (DMD) in the Geum River basin. The results indicated that the "Percentile 10" values for 10% exceeding time were decreased by 20.5% and 8.0% at Sutong downstream of YMD and Gongju downstream of DMD, respectively, while "Percentile 90" values for 90% exceeding time were increased by 56.3% and 340.8% at Sutong and Gongju, respectively, resulting in the reduction of the high flow variability typical for unregulated rivers in Korea. The results of eco-hydrological analyses will be presented in the following papers.

• Journal of Forest and Environmental Science
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• v.34 no.1
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• pp.31-45
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• 2018

At present the biodiversity of the riparian forest is under threat due to various anthropogenic pressures. Hence study was conducted along the three unprotected zones of riparian forest in Dikhu river, Nagaland, north-east India in order to compared the diversity, distribution and population structure of riparian trees. In each zone $100{\times}100m^2$ plot were marked and subdivided into 20 plots of $10{\times}10m^2$. 10 plots on each side of the river were taken randomly covering 0.02 ha. Only tree with dbh ${\geq}10cm$ and dbh above 1.5 m above ground level were recorded as individual species. A total of 29 tree species belonging to 18 families were recorded from the three zones of the river. Tree species richness was highest at the middle zone (19) followed by upper (14) and lower zone (7). The most abundant species and family recorded at upper, middle and lower zones were Melia azaderach of Euphorbiaceae ($380\;stems\;ha^{-1}$), Terminalia chebula of Euphorbiaceae ($432.5\;stems\;ha^{-1}$) and Duabanga grandiflora of Lythraceae ($365\;stems\;ha^{-1}$) respectively. The ranges of diversity indices observed in the three zones were: Shannon-Wiener index (1.25-0.73), Simpson diversity index (0.42-0.93), Evenness index (0.47-0.37) and Index of co-dominance (0.75-0.94). Rest of other indices were also estimated and compared. Distribution of trees shows the contagious pattern common in the upper and middle zones and regular in the lower zone. The girth size class analysis demonstrated that the riparian forest is in less mature succession stage. This study emphasize the need for management and conservation of riparian forest by developing policy to declare the riparian zone as protected area to prevent further degradation and loss of biodiversity from these unregulated zones along the river.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2741-2744
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• 2016

The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products act between chemokines and the transmembrane-4 superfamily. Located in several human chromosomes, the CMTMs CKLF and CMTM1 to CMTM8 may be unregulated in tumors and act as potential tumor suppressor genes with important roles in the immune, male reproductive and hematopoietic systems. In-depth studies in recent years established a close relation between CMTMs and tumorigenesis and metastasis. The CMTM family has a significant clinical value in diagnosis and treatment of diseases linked to tumors and the immune system.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.3
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• pp.407-416
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• 2016

The purpose of this study is to develop regional regression models to estimate mean low flow for ungauged basins. The unregulated streamflow data observed at 12 multipurpose dams and 4 irrigation dams were analyzed for determining mean low flows. Various types of regression models were developed using the relationship between mean low flows and various sets of watershed characteristics such as drainage area, average slope, drainage density, mean annual precipitation, runoff curve number. The performance of each regression model for estimating mean low flows was assessed by comparison with the results obtained from the observed data. It was found that a regional regression model explained by drainage area, the mean annual precipitation, and runoff curve number showed the best performance. The regression model presented in this study also gives better estimates of mean low flow than the estimates by the drainage-area ratio method and the previous regression model.

• Analytical Science and Technology
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• v.15 no.4
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• pp.346-359
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• 2002

The brominated flame retardants (BFRs) are one of the unregulated pollutants in Korea, which is recently highlighted the new pollutants of environmental contamination. In this study, the previous research papers related the BFRs were surveyed, and the analytical methods of BFRs were established. The results are followed; The 40 kinds of PBDEs standards were used to establish the analytical methods to perform the experiments of recoveries and detection limits in water and soil. The detection limits of PBDEs using GC/MS represented 5.0~10.0 pg/L for water and 0.5~2.0 ng/g for soil samples. The average recoveries of water samples were 89~98% with ethylacetate, n-hexane and dichloromethane, and 89~103% in combined solvent with n-hexane and acetone. In soxhlet extraction, the higher recoveries obtained the acetone:n-hexane(1:1) comparing with acetone:dichloromethane(1:1).

• Journal of Korean Society on Water Environment
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• v.23 no.6
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• pp.822-828
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• 2007

Perchlorate is an unregulated contaminant but recently many cases of perchlorate contamination have been reported in the US. In Japan, also, a couple of contamination incidents caused by perchlorate occurred. Against this backdrop, investigation on perchlorate was urgent for Korea. Accordingly, perchlorate investigation in tap water and river water was conducted one time a week for seven consecutive weeks at major water sources of Korea including Han River, Guem River, Yeong-san River, and Nak-dong River. Perchlorate was not found at Han River, Guem River, and Yeong-san River. However, all the 4 tap water samples in Nak-dong River recorded high level of perchlorate. Among others, NT1 located at Daegu posted the highest value of $22.3{\mu}g/L$. This level is lower than $24.5{\mu}g/L$, the threshold recommended by US EPA. Still, perchlorate contamination in drinking water can deal a heavy blow to nerve development of infants and children by causing iodine deficiency. At the 1st and 2nd investigations, perchlorate concentration reached $18.7{\sim}95.6{\mu}g/L$ and $4.0{\sim}25.6{\mu}g/L$ respectively, both of which are relatively higher. The high perchlorate concentration in Nak-dong River was possible because of the waste water discharged from LCD manufacturing factory which was located at NS3 in Gumi, Korea. Perchlorate concentration of waste water from the factory was $730{\sim}1,858{\mu}g/L$.

• Natural Product Sciences
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• v.17 no.3
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• pp.250-255
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• 2011

The immune system is finely balanced by the activities of pro-inflammatory and anti-inflammatory mediators or cytokines. Unregulated activities of these mediators can lead to the development of various inflammatory diseases. A variety of safe and effective anti-inflammatory agents are available with many more drugs under development. Of the natural compounds, the sesquiterpenes (nootkatone, ${\alpha}$-cyperone, valencene and ${\alpha}$-selinene) isolated from C. rotundus L. have received much attention because of their potential antiinflammatory effects. However, limited studies have been reported regarding the influence of sesquiterpene structure on anti-inflammatory activity. In the present study, the anti-inflammatory potential of four structurally divergent sesquiterpenes was evaluated in lipopolysaccaride (LPS)-stimulated RAW 264.7 cells, murine macrophages. Among the four sesquiterpenes, ${\alpha}$-cyperone and nootkatone, showed stronger anti-inflammatory and a potent NF-${\kappa}B$ inhibitory effect on LPS-stimulated RAW 264.7 cells. Molecular analysis revealed that various inflammatory enzymes (iNOS and COX-2) were reduced significantly and this correlated with downregulation of the NF-${\kappa}B$ signaling pathway. Additionally, electrophoretic mobility shift assays (EMSA) elucidated that nootkatone and ${\alpha}$-cyperone dramatically suppressed LPS-induced NF-${\kappa}B$-DNA binding activity using 32Plabeled NF-${\kappa}B$ probe. Hence, our data suggest that ${\alpha}$-cyperone and nootkatone are potential therapeutic agents for inflammatory diseases.