• Title/Summary/Keyword: University Archives

Search Result 5,943, Processing Time 0.026 seconds

Effects of Saponins on the Osmotic Behavior of Multilamellar Liposomes

  • Yu, Byung-Sul;Chung, Hyun-Ho;Kim, Aeri
    • Archives of Pharmacal Research
    • /
    • v.7 no.1
    • /
    • pp.17-22
    • /
    • 1984
  • Effects of total ginseng saponin, 20-S-protopanaxadiol saponin, 20-S-protopanaxatriol saponin and playcodon saponin on the osmotic behavior of liposomes were investigated by optical measurement. These saponins showed different activities on liposomal membrane, and cholesterol in liposomes was an important factor to this variation of saponin activities.

  • PDF

Effects of brazilin and haematoxylin on the lipidperoxidation in the rat liver mitochondria

  • Moon, Chang-Kiu;Ha, Bae-Jin;Lee, Chong-Chul
    • Archives of Pharmacal Research
    • /
    • v.7 no.1
    • /
    • pp.63-64
    • /
    • 1984
  • This major sites of liquidperoxidation-damage within the cell are at biomembrances, especially those of subcellular organells such as mitochondria and microsomes whose membranes contain relatively large amount of polyunsaturated fatty acids. Mitochondria are the power plants of eukaryotic cells. Hence their damage by liquid peroxidation can profoundly affect cellular function.

  • PDF

Pharmacological Study on Piperine

  • Lee, Eun-Bang;Shin, Kuk-Hyun;Woo, Won-Sick
    • Archives of Pharmacal Research
    • /
    • v.7 no.2
    • /
    • pp.127-132
    • /
    • 1984
  • Systematic pharmacological astudies on pipeline have revealed that this compound elicited diverse pharmacological activities; CNS depressant activity characterized by antagonism against electo shock seizure and by muscle relaxant activity in mice; antipyretic activity in tyyhoid vaccinated rabbits; analgesic activity as evaluated by tail-clip pressure and writhing syndrome in mice; antiinflammatory activity in carrageenin-induced edema in rats.

  • PDF

Aporphine and Tetrahydrobenzylisoquinoline Alkaloids from the Seeds of Zizyphus vulgaris var. spinosus

  • Hoon, Han-Byung;Park, Myung-Hwan;Han, Yonng-Nam
    • Archives of Pharmacal Research
    • /
    • v.12 no.4
    • /
    • pp.263-268
    • /
    • 1989
  • From the seeds of Zizyphus vulgaris var. spinosus, aporphine alkaloids : nuciferine, N-methylasimilobine, nornuciferine, norisocorydine, caaverine and tetrahydro benzylisoquinoline alkaloid : (+) coclaurine were isolated and identified. Zyzyphusine, a new quaternary aporphinium alkaloid form butanol soluble fraction was isolated and characterized by spectral data.

  • PDF

Isolation of 4,4^I-Dihydroxybenzyl Sulfoxide from Gastrodia elata

  • Yun, Hye-Sook;Choi, Hye-Sook;Pyo, Mi -Kyung
    • Archives of Pharmacal Research
    • /
    • v.20 no.1
    • /
    • pp.91-92
    • /
    • 1997
  • In the course of continous work on tubers of Gastrodia elata, a new constituent, 4, 4$^{I}$-dihydroxybenzyl sulfoxide was isolated from the ethyl acetate soluble fraction prepared from the methanol extract. The structure of the compound was identified from the elemental analytical and spectroscopic data in comparison with those of non-substituted benzyl sulfoxide.e.

  • PDF

DA-5018, a Novel Vanilloid Type Analgesic

  • Park, Young-Ho;You, Eun-Sook;Kim, Won-Bae;Lee, Sang-Sup
    • Archives of Pharmacal Research
    • /
    • v.20 no.1
    • /
    • pp.93-95
    • /
    • 1997
  • The aim of the present study was to elucidate the mechanism of action of DA-5018 and to compare it with those of capasaicin, resiniferatoxin (ultrapotent capasaicin analog), and olvanil (systemic antinociceptive agent equipotent with capasaicin developed by Proctor & Gamble) (fig.1).

  • PDF