• Archives of Pharmacal Research
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• v.17 no.2
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• pp.104-108
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• 1994

trans-Ethyl 1, 2, 3, 4a, 5, 6, 8a-cotahydro-2-benzyl-4-hydroxy-6-methyl-5-isoquinoline-carboxylate was prepared by intramolecular Diels-Alder reaction as a precusor of newly designed aza-analogue of mevinolin.

• Archives of Pharmacal Research
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• v.17 no.2
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• pp.131-133
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• 1994

New istain-3-isonicotinylhydrazones, isationazine and its Mannich bases and spiro (indoline-3,2'-thiadiazoline)-2-one have been synthesized. These compounds have been screenced for their antibacterial activity against the Gram-positive and Gram-negative bacteria.

• Archives of Pharmacal Research
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• v.10 no.4
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• pp.208-211
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• 1987

Sedative activity of Zizyphi fructus was evaluated by potentiation of hexobarbital-induced hypnosis test and its active principles have been characterized as nornuciferine and lysicamine. A new cyclopeptide alkaloid, daechucyclopeptide-1 was isolated together with zizyphusine.

• Archives of Pharmacal Research
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• v.16 no.3
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• pp.251-253
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• 1993

Several new coumarinoyl and coumarionyl-1, 2, 4-triazole derivatives were synthesised via dipolar cycloaddition reactions with 3-coumainohydraziodoyl halide. Structure were based on elemental analysis and spectral data.

• Archives of Pharmacal Research
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• v.18 no.1
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• pp.62-63
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• 1995

• Archives of Pharmacal Research
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• v.18 no.6
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• pp.462-463
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• 1995

• Archives of Pharmacal Research
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• v.20 no.2
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• pp.197-199
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• 1997

In conclusion, benzotriazole analogs prepared in this research showed strong possibility to be photochemically activated DNA cleaving agents. Electrophilic groups such as haloacetoxy groups on the alkyl chain of benzotriazole analogs promote the DNA cleaving ability. Synthesis of 1-(2-Naphthoyl) Benzotriazoles.

• Archives of Pharmacal Research
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• v.23 no.4
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• pp.324-328
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• 2000

Three dimensional QSAR studies for antihistamine and antibradykinin effects of new piperazine derivatives were conducted using the comparative molecular field analysis. Electrostatic and steric factors, but not hydrophobic factor, of the synthesized compounds were correlated with the antagonistic effect.

• Archives of Pharmacal Research
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• v.23 no.5
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• pp.459-460
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• 2000

Separation of the alkaloids from the aerial part of Corydalis ochotensis afforded a new spirobenzylisoquinoline alkaloid, 8-O-acetylcorysolidine along with two known spirobenzylisoquinoline alkaloids, isoochotensine and corysolidine.

• Archives of Pharmacal Research
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• v.18 no.3
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• pp.206-212
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• 1995

New hypolipaemic agents, in which substituted indazole nucleus is connected to tetrahydro-4-hydroxy-2H-pyran-2-one by a two-carbon bridge, were designed and synthesized to show significant inhibitory activity against microsomal HMG-CoA reductase in rat liver.